148,359 results match your criteria review supplies

How COVID-19 vaccine supply chains emerged in the midst of a pandemic.

World Econ 2021 Aug 19. Epub 2021 Aug 19.

Council on Foreign Relations USA.

Many months after COVID-19 vaccines were first authorized for public use, still limited supplies could only partially reduce the devastating loss of life and economic costs caused by the pandemic. Could additional vaccine doses have been manufactured more quickly some other way? Would alternative policy choices have made a difference? This paper provides a simple analytical framework through which to view the contours of the vaccine value chain. It then creates a new database that maps the COVID-19 vaccines of Pfizer/BioNTech, Moderna, AstraZeneca/Oxford, Johnson & Johnson, Novavax and CureVac to the product- and location-specific manufacturing supply chains that emerged in 2020 and 2021. Read More

View Article and Full-Text PDF

Prevalence, environmental fate, treatment strategies, and future challenges for wastewater contaminated with SARS-CoV-2.

Remediation (N Y) 2021 Jul 9. Epub 2021 Jul 9.

PO Box 7718 Denver Colorado USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in untreated and treated wastewater and studies have shown that the concentration of SARS-CoV-2 is proportional to the prevalence of the coronavirus disease 2019 (COVID-19) in communities. This article presents a literature review of the prevalence of SARS-CoV-2 in wastewater, its environmental fate, recommended treatment strategies for contaminated wastewater, and treatment challenges to be faced in the future. The environmental fate of SARS-CoV-2 in wastewater is not straightforward because it can be a source of infection when present in the treated wastewater depending on the permeability of the wastewater treatment plant containment area, and can also leach into aquifers, which may serve as drinking water supplies. Read More

View Article and Full-Text PDF

Recent developments in filtration media and respirator technology in response to COVID-19.

MRS Bull 2021 Sep 15:1-10. Epub 2021 Sep 15.

Oak Ridge National Laboratory, Oak Ridge, TN USA.

Abstract: The COVID-19 pandemic triggered a surge in demand for N95 or equivalent respirators that the global supply chain was unable to satisfy. This shortage in critical equipment has inspired research that addresses the immediate problems and has accelerated the development of the next-generation filtration media and respirators. This article provides a brief review of the most recent work with regard to face respirators and filtration media. Read More

View Article and Full-Text PDF
September 2021

'Learn from the lessons and don't forget them': identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns.

BMJ Glob Health 2021 09;6(9)

UK Public Health Rapid Support Team, London School of Hygiene & Tropical Medicine/Public Health England, London, UK.

Introduction: COVID-19 vaccines are now being distributed to low- and middle-income countries (LMICs), with global urgency surrounding national vaccination plans. LMICs have significant experience implementing vaccination campaigns to respond to epidemic threats but are often hindered by chronic health system challenges. We sought to identify transferable lessons for COVID-19 vaccination from the rollout of three vaccines that targeted adult groups in Africa and South America: MenAfriVac (meningitis A); 17D (yellow fever) and rVSV-ZEBOV (Ebola virus disease). Read More

View Article and Full-Text PDF
September 2021

Non-invasive wearable chemical sensors in real-life applications.

Anal Chim Acta 2021 Sep 14;1179:338643. Epub 2021 May 14.

Metallurgy and Materials Science Research Institute, Chulalongkorn University, Soi Chula 12, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand; Center of Excellence in Responsive Wearable Materials, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address:

Over the past decade, non-invasive wearable chemical sensors have gained tremendous attention in the field of personal health monitoring and medical diagnosis. These sensors provide non-invasive, real-time, and continuous monitoring of targeted biomarkers with more simplicity than the conventional diagnostic approaches. This review primarily describes the substrate materials used for sensor fabrication, sample collection and handling, and analytical detection techniques that are utilized to detect biomarkers in different biofluids. Read More

View Article and Full-Text PDF
September 2021

Should we still worry about the safety of GMO foods? Why and why not? A review.

Food Sci Nutr 2021 Sep 27;9(9):5324-5331. Epub 2021 Jul 27.

School of Nutrition, Food Science and Technology College of Agriculture Hawassa University Sidama Ethiopia.

Global population is increasing at an alarming rate, posing a threat on the supplies of basic needs and services. However, population increase does not seem to be a common agendum of the global scientists and political leaders. People in the developed countries are more concerned about new technologies and their products. Read More

View Article and Full-Text PDF
September 2021

Reducing Operating Room Cost: Comparing Attending and Surgical Trainee Perception Regarding the Implementation of Supply Receipts.

J Am Coll Surg 2021 Sep 10. Epub 2021 Sep 10.

Department of Surgery, Washington University, Saint Louis, Missouri 63110; Perioperative Services, Barnes Jewish Hospital, Saint Louis, Missouri 63110.

Background: As operating room (OR) expenditures increase, faculty and surgical trainees will play a key role in curbing future costs. However, supply cost utilization varies widely among providers and, despite requirements for cost education during surgical training, little is known about trainees' comfort discussing these topics. To improve OR cost transparency, our institution began delivering real-time supply "receipts" to faculty and trainees after each surgical case. Read More

View Article and Full-Text PDF
September 2021

A Road Map to GMP Readiness for Protein Therapeutics - Drug Product Process Development for Clinical Supply.

J Pharm Sci 2021 Sep 13. Epub 2021 Sep 13.

Chemical Pharmaceutical Development - Department of Pharmaceutical Technologies, Merck KGaA, D-64293 Darmstadt, Germany.

Biopharmaceuticals for human use present unique challenges during manufacturing, storage, shipment, and administration. Not all drug product process development aspects can and should be studied in detail before entering in first-in human studies (FIH) due to limited resources and the need for new drug candidates to enter phase 1 clinical studies quickly. Whilst activities for formulation development studies are well defined in literature, there is a lack of regulatory guidance for phase appropriate process development studies for clinical supplies. Read More

View Article and Full-Text PDF
September 2021

Study of solid waste (municipal and medical) management during the COVID-19 pandemic: a review study.

Rev Environ Health 2021 Sep 15. Epub 2021 Sep 15.

Department of Environmental Health Engineering, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.

The COVID-19 pandemic has resulted in a global emergency crisis and created waste management challenges worldwide. Such a critical point has changed solid waste (municipal and medical) management prospects and posed fact challenges to the health decision-makers and policy-makers to make decisions to ensure sustainable management of the environment. One of the most negative prospects of COVID-19 pandemic is the increased waste generation, especially plastic waste in developing and developed countries. Read More

View Article and Full-Text PDF
September 2021

One abutment one time vs. repeatable abutment disconnections in implants, restored with cemented / screw retained fixed partial dentures: Marginal bone level changes. A systematic review and meta-analysis.

Stomatologija 2021 ;23(2):35-40

Institute of Odontology, Faculty of Medicine, Vilnius University, Zalgirio str. 115/117, LT- 08217, Vilnius, Lithuania.

Purpose: The aim of this systematic review and meta-analysis is to evaluate the impact of abutment disconnections / reconnections on peri-implant marginal bone loss changes in partially edentulous patients.

Methods: Clinical studies were selected via electronic and hand searches in English language journals until January 1, 2020. Only randomized clinical trials (RCGTs) and prospective controlled clinical trials (CCTs) showing direct comparison between the definitive implant abutments and multiple abutment replacements in the same patient or different patient groups in the partially edentulous patients were considered. Read More

View Article and Full-Text PDF
September 2021

[Use of endovascular drug-coated devices in lesions of femoropopliteoltibial arteries].

Angiol Sosud Khir 2021 ;27(3):165-172

Department of Vascular Surgery, Centre of Cardiovascular and Endovascular Surgery, Federal Clinical Centre of High Medical Technologies of the Federal Medical and Biological Agency of the RF Ministry of Public Health, Khimki, Russia.

Endovascular intervention is one of the main methods of treatment in atherosclerotic lesions of the infrainguinal segment in patients with chronic lower limb ischaemia. Recent years have witnessed active use of drug-eluting techniques, significantly improving the long-term outcomes of peripheral reconstructions. This article is a review of publications on the results of using modern drug-eluting balloon catheters and stents in the femoropopliteoltibial position. Read More

View Article and Full-Text PDF
September 2021

[Use of drug-coated balloons for interventions on bifurcation lesions of coronary arteries].

Angiol Sosud Khir 2021 ;27(3):46-52

Department of Endovascular Diagnosis and Treatment, National Medical Research Centre named after Academician E.N. Meshalkin under the RF Ministry of Public Health, Novosibirsk, Russia.

Interventions on bifurcation lesions of the coronary bed are one of the most complicated tasks of interventional cardiology. Recent trends are toward active study of using drug-eluting balloons for interventions in this type of lesions. Using such technique makes it possible to minimize the risks associated with implantation of stents in sites of coronary artery bifurcations with good angiographic results. Read More

View Article and Full-Text PDF
September 2021

Assessment of health equity consideration in masking/PPE policies to contain COVID-19 using PROGRESS-plus framework: a systematic review.

BMC Public Health 2021 09 16;21(1):1682. Epub 2021 Sep 16.

School of Pharmacy, University of Utah, Salt Lake City, UT, USA.

Introduction: There is increasing evidence that COVID-19 has unmasked the true magnitude of health inequity worldwide. Policies and guidance for containing the infection and reducing the COVID-19 related deaths have proven to be effective, however the extent to which health inequity factors were considered in these policies is rather unknown. The aim of this study is to measure the extent to which COVID-19 related policies reflect equity considerations by focusing on the global policy landscape around wearing masks and personal protection equipment (PPE). Read More

View Article and Full-Text PDF
September 2021

[Insecticide-Treated Net Use In Sub-Saharan Africa: Systematic Review and Meta-Analysis].

Ig Sanita Pubbl 2021 Jul-Aug;78(4):564-582

Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.

Background: Countries in sub-Saharan Africa remain the most affected by malaria, with nearly 93% of cases and 94% of deaths in 2018 according to the World Health Organization (WHO). According to the WHO, in order to significantly reduce malaria- related incidence and mortality, at least 80% of the population should be covered with insecticide-treated mosquito nets (ITNs). Hence our objective which was on the one hand to determine the rates in terms of possession and use of ITNs in countries located in Sub- Saharan Africa between January 2015 and January 2020, and to determine the impact of the use of ITNs on the probability of being infected with malaria. Read More

View Article and Full-Text PDF
September 2021

Occupational Health and Safety Measures in Healthcare Settings During COVID-19: Strategies for Protecting Staff, Patients and Visitors.

Disaster Med Public Health Prep 2021 Sep 14:1-27. Epub 2021 Sep 14.

Department of Medical Physics, Grand River Regional Cancer Centre, Kitchener, ON, Canada.

The COVID-19 (SARS-CoV-2) pandemic has profoundly impacted almost every aspect of healthcare systems worldwide, placing the health and safety of frontline healthcare workers at risk and still continues to remain an important public health challenge. Several hospitals have put in place strategies to manage space, staff, and supplies in order to continue to deliver optimum care to patients while at the same time protecting the health and safety of staff and patients. However, the emergence of the second and third waves of the virus with the influx of new cases continue to add an additional level of complexity to the already challenging situation of containing the spread and lowering the rate of transmission and thus pushing healthcare systems to the limit. Read More

View Article and Full-Text PDF
September 2021

Recent advances in polymeric nanostructured ion selective membranes for biomedical applications.

Talanta 2021 Dec 19;235:122815. Epub 2021 Aug 19.

School of Engineering, Macquarie University, Sydney, NSW, 2109, Australia. Electronic address:

Nano structured ion-selective membranes (ISMs) are very attractive materials for a wide range of sensing and ion separation applications. The present review focuses on the design principles of various ISMs; nanostructured and ionophore/ion acceptor doped ISMs, and their use in biomedical engineering. Applications of ISMs in the biomedical field have been well-known for more than half a century in potentiometric analysis of biological fluids and pharmaceutical products. Read More

View Article and Full-Text PDF
December 2021

Recent achievements and advances in optical and electrochemical aptasensing detection of ATP based on quantum dots.

Talanta 2021 Dec 31;235:122753. Epub 2021 Jul 31.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The design and fabrication of high sensitive and selective biosensing platforms areessential goals to precisely recognize biomaterials in biological assays. In particular, determination of adenosine triphosphate (ATP) as the main energy currency of the cells and one of the most important biomolecules in living organisms is a pressing need in advanced biological detection. Recently, aptamer-based biosensors are introduced as a new direct strategy in which the aptamers (Apts) directly bind to the different targets and detect them on the basis of conformational changes and physical interactions. Read More

View Article and Full-Text PDF
December 2021

Sensory materials for microfluidic paper based analytical devices - A review.

Talanta 2021 Dec 24;235:122733. Epub 2021 Jul 24.

Department of Chemistry, Vel Tech Rangarajan Dr Sagunthala R & D Institute of Science and Technology, Avadi, Chennai, 600 062, Tamil Nadu, India. Electronic address:

The microfluidic paper-based analytical devices (μPADs) have grown-up swiftly over the decade due to its low cost, simple fabrication procedure, resource-limitedness, non-toxicity and their environmentally benign nature. The μPADs, also identified as point-of-care devices or health care devices have successfully applied in several fields such as diagnostics, biological, food safety, environmental, electrochemical and most importantly colorimetric/fluorimetric sensors, owing to the attractive passive motions of analyte without any external forces. In recent years, a large number of colorimetric and fluorimetric probes have been reported that can selectively recognize the analytes in μPADs. Read More

View Article and Full-Text PDF
December 2021

Patients, procedures, and PPE: Safe office-based anesthesia recommendations in the COVID-19 era.

Best Pract Res Clin Anaesthesiol 2021 Oct 20;35(3):415-424. Epub 2020 Nov 20.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, USA; Institute for Safety in Office-Based Surgery, Boston, MA, USA.

The growth of office-based surgery (OBS) has been due to ease of scheduling and convenience for patients; office-based anesthesia safety continues to be well supported in the literature. In 2020, the Coronavirus Disease 19 (COVID-19) has resulted in dramatic shifts in healthcare, especially in the office-based setting. The goal of closing the economy was to flatten the curve, impacting office-based and ambulatory practices. Read More

View Article and Full-Text PDF
October 2021

Principles of supply chain management in the time of crisis.

Best Pract Res Clin Anaesthesiol 2021 Oct 16;35(3):369-376. Epub 2020 Nov 16.

Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address:

Hospitals face catastrophic financial challenges in light of the coronavirus disease 2019 (COVID-19) pandemic. Acute shortages in materials such as masks, ventilators, intensive care unit capacity, and personal protective equipment (PPE) are a significant concern. The future success of supply chain management involves increasing the transparency of where our raw materials are sourced, diversifying of our product resources, and improving our technology that is able to predict potential shortages. Read More

View Article and Full-Text PDF
October 2021

Clinical recommendations for in-hospital airway management during aerosol-transmitting procedures in the setting of a viral pandemic.

Best Pract Res Clin Anaesthesiol 2021 Oct 8;35(3):333-349. Epub 2020 Dec 8.

Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can lead to severe pneumonia and multiorgan failure. While most of the infected patients develop no or only mild symptoms, some need respiratory support or even invasive ventilation. The exact route of transmission is currently under investigation. Read More

View Article and Full-Text PDF
October 2021

Economic impact of COVID-19 pandemic on healthcare facilities and systems: International perspectives.

Best Pract Res Clin Anaesthesiol 2021 Oct 17;35(3):293-306. Epub 2020 Nov 17.

Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address:

International hospitals and healthcare facilities are facing catastrophic financial challenges related to the COVID-19 pandemic. The American Hospital Association estimates a financial impact of $202.6 billion in lost revenue for America's hospitals and healthcare systems, or an average of $50. Read More

View Article and Full-Text PDF
October 2021

Practice among Healthcare Workers Regarding the Use of Respiratory Protective Equipment during COVID-19 Pandemic in a Tertiary Care Center: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Apr 30;59(236):361-364. Epub 2021 Apr 30.

Department of Pediatrics, National Academy of Medical Sciences, Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal.

Introduction: Healthcare workers are always at the risk of exposure to different diseases like respiratory illness including COVID-19. Using appropriate face mask or respiratory protective equipment correctly can prevent transmission of diseases from and to healthcare workers while caring for patients. The study aimed to find out the practice regarding use of face masks during the COVID-19 pandemic in a tertiary care center. Read More

View Article and Full-Text PDF

Median Duration of Hospital Stay after Early Removal of Foley's Catheter among Patients Undergoing Transurethral Resection of Prostate: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Jul 30;59(239):688-691. Epub 2021 Jul 30.

Department of Surgery, National Medical College, Birgunj, Nepal.

Introduction: Transurethral resection of the prostate requires a catheter in situ post-surgery. Early removal of catheter can reduce the length of hospital stay reducing the healthcare cost. It can also reduce the risk of infection due to prolonged catheterization. Read More

View Article and Full-Text PDF

Study of Intraocular Pressure following Neodynium Yttrium Aluminium Garnet Laser Capsulotomy with the Use of Brimonidine: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Jan 31;59(233):15-18. Epub 2021 Jan 31.

Department of General Ophthalmology, Lumbini Eye Institute and research centre, Bhairahawa, Nepal.

Introduction: Posterior capsular opacification is a common complication after cataract surgery. Neodynium Yttrium Aluminium Garnet laser capsulotomy is still the preferred treatment for posterior capsular opacification. This study was done to determine the use of Brimonidine eye drop in preventing the rise of intraocular pressure post-Neodynium Yttrium Aluminium Garnet laser capsulotomy. Read More

View Article and Full-Text PDF
January 2021

Survival of Resin-Bonded Fixed Metal-Ceramic Dental Prostheses Placed in the Anterior Region: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 May 25;59(237):494-497. Epub 2021 May 25.

Department of Prosthodontics, College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Introduction: Resin-bonded fixed dental prostheses have an advantage over conventional fixed dental prostheses in terms of conservation of tooth structure but many clinicians refrain from using this treatment plan over the concern of the retention of those prostheses. In anterior region, it has better survival rate because of the less masticatory force. This study was conducted to find out the survival of resin-bonded fixed metal-ceramic dental prostheses placed in anterior region of a tertiary care hospital. Read More

View Article and Full-Text PDF

Refractive Outcomes Using Intraoperative Aberrometry for Highly Myopic, Highly Hyperopic, and Post-refractive Eyes.

J Refract Surg 2021 Sep 1;37(9):609-615. Epub 2021 Sep 1.

Purpose: To evaluate whether intraoperative aberrometry improves the accuracy of refractive outcomes after cataract surgery in highly myopic, highly hyperopic, and post-refractive eyes.

Methods: This single-center, retrospective review compared the spherical equivalent of postoperative refraction to that predicted by the Barrett Universal II formula versus Optiwave Refractive Analysis (ORA) (Alcon Laboratories, Inc) for highly myopic and hyperopic eyes and to the Barrett True K formula versus ORA for post-refractive eyes. The number and magnitude of lens changes were analyzed and used to determine in how many cases refractive surprises were affected by ORA, with additional subanalysis of outcomes based on average keratometry values. Read More

View Article and Full-Text PDF
September 2021

Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials.

Sensors (Basel) 2021 Sep 1;21(17). Epub 2021 Sep 1.

Dipartimento di Fisica, Università degli studi di Milano-Bicocca, 20126 Milano, Italy.

The possibility to shape stimulus-responsive optical polymers, especially hydrogels, by means of laser 3D printing and ablation is fostering a new concept of "smart" micro-devices that can be used for imaging, thermal stimulation, energy transducing and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. In light of the increasing demand for micro-devices for nanomedicine and personalized medicine, interest is growing in the combination of composite and hybrid photo-responsive materials and digital micro-/nano-manufacturing. Read More

View Article and Full-Text PDF
September 2021

Performance and Characteristics of Wearable Sensor Systems Discriminating and Classifying Older Adults According to Fall Risk: A Systematic Review.

Sensors (Basel) 2021 Aug 31;21(17). Epub 2021 Aug 31.

School of Innovation, Design and Engineering, Mälardalen University, 722 20 Västerås, Sweden.

Sensor-based fall risk assessment (SFRA) utilizes wearable sensors for monitoring individuals' motions in fall risk assessment tasks. Previous SFRA reviews recommend methodological improvements to better support the use of SFRA in clinical practice. This systematic review aimed to investigate the existing evidence of SFRA (discriminative capability, classification performance) and methodological factors (study design, samples, sensor features, and model validation) contributing to the risk of bias. Read More

View Article and Full-Text PDF

Survey: Vulnerability Analysis of Low-Cost ECC-Based RFID Protocols against Wireless and Side-Channel Attacks.

Sensors (Basel) 2021 Aug 30;21(17). Epub 2021 Aug 30.

Electronic and Micro-Electronic Laboratory, Faculty of Sciences of Monastir, University of Monastir, Monastir 5019, Tunisia.

The radio frequency identification (RFID) system is one of the most important technologies of the Internet of Things (IoT) that tracks single or multiple objects. This technology is extensively used and attracts the attention of many researchers in various fields, including healthcare, supply chains, logistics, asset tracking, and so on. To reach the required security and confidentiality requirements for data transfer, elliptic curve cryptography (ECC) is a powerful solution, which ensures a tag/reader mutual authentication and guarantees data integrity. Read More

View Article and Full-Text PDF