Ultrasound Obstet Gynecol 2022 Jun 25. Epub 2022 Jun 25.
Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, "Aretaieion" University Hospital, 76 Vas. Sofias Av., 11528, Athens, Greece.
Objective: To compare the reported events of congenital anomalies of newborns and perinatal outcomes of pregnancies resulting from blastocyst and cleavage-stage embryo transfers following assisted reproduction, through a pairwise meta-analysis, and the same outcomes between pregnancies resulting from fresh-blastocyst, frozen-blastocyst, fresh-cleavage and frozen-cleavage embryo transfers, through a network meta-analysis.
Methods: A search was performed in PubMed, Scopus, and CENTRAL and registers for ongoing studies, from inception to February 2022 for randomized controlled trials (RCTs) with any sample size and cohort studies including at least 100 live births per cohort, comparing events of congenital anomalies of the newborns and perinatal outcomes of pregnancies following fresh/frozen embryo transfer at cleavage stage (D2-3) vs. transfer at blastocyst stage (D5-7). Read More