52,572 results match your criteria review highlights


Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review.

Dent J (Basel) 2021 Sep 4;9(9). Epub 2021 Sep 4.

Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Via S. Allende, Baronissi, 84081 Salerno, Italy.

Hyperlipidemia is a well-recognized risk factor for cardiovascular disease, which, in turn, acts as a contributory factor in periodontitis development. Periodontitis has been associated with benign tumors and cancers and withseveral disorders, including hyperlipidemia. Correspondingly, periodontal treatment may exert a positive effect on lipid metabolism, although opposite evidence has also been reported. Read More

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September 2021

Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration.

Acta Biomater 2021 Sep 22. Epub 2021 Sep 22.

Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy. Electronic address:

Successful tissue regeneration requires a scaffold with tailorable biodegradability, tissue-like mechanical properties, structural similarity to extracellular matrix (ECM), relevant bioactivity, and cytocompatibility. In recent years, injectable hydrogels have spurred increasing attention in translational medicine as a result of their tunable physicochemical properties in response to the surrounding environment. Furthermore, they have the potential to be implanted via minimally invasive procedures while enabling deep penetration, which is considered a feasible alternative to traditional open surgical procedures. Read More

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September 2021

Liquid biopsy: state of reproductive medicine and beyond.

Hum Reprod 2021 Sep 25. Epub 2021 Sep 25.

Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Read More

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September 2021

The Pediatric Inflammatory Bowel Disease Medical Home: A Proposed Model.

Inflamm Bowel Dis 2021 Sep 25. Epub 2021 Sep 25.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, OH, USA.

Care for patients with inflammatory bowel disease (IBD) can be complex and costly. Care delivery models to address these challenges and improve care quality are essential. The patient-centered medical home (PCMH), which was developed in the primary care setting, has recently been applied successfully to the adult IBD population. Read More

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September 2021

From competition to cooperation: Visual neglect across the hemispheres.

Authors:
P Bartolomeo

Rev Neurol (Paris) 2021 Sep 21. Epub 2021 Sep 21.

Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, hôpital de la Pitié-Salpêtrière, 75013 Paris, France. Electronic address:

Visuospatial neglect is a frequent and disabling consequence of injuries to the right hemisphere. Patients with neglect show signs of impaired attention for left-sided events, which depends on dysfunction of fronto-parietal networks. After unilateral injury, such as stroke, these networks and their contralateral homologs can reorganize following multiple potential trajectories, which can be either adaptive or maladaptive. Read More

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September 2021

Bacterial cellulose-based composites for biomedical and cosmetic applications: Research progress and existing products.

Carbohydr Polym 2021 Dec 27;273:118565. Epub 2021 Aug 27.

Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:

Bacterial cellulose (BC) is a promising unique material for various biomedical and cosmetic applications due to its morphology, mechanical strength, high purity, high water uptake, non-toxicity, chemical controllability, and biocompatibility. Today, extensive investigation is into the manufacturing of BC-based composites with other components such as nanoparticles, synthetic polymers, natural polymers, carbon materials, and biomolecules, which will allow the development of a wide range of biomedical and cosmetic products. Moreover, the addition of different reinforcement substances into BC and the organized arrangement of BC nano-fibers have proven a promising improvement in their properties for biomedical applications. Read More

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December 2021

Gastroparesis.

Curr Opin Gastroenterol 2021 Sep 24. Epub 2021 Sep 24.

Division of Gastroenterology & Hepatology, Mayo Clinic, Jacksonville, Florida, USA.

Purpose Of Review: This review highlights recent research advances regarding the pathophysiology and treatment of gastroparesis.

Recent Findings: Differences in brain activity have been identified on functional MRI imaging in gastroparesis patients with nausea. Abdominal pain is common in patients with gastroparesis and does not correlate with the severity of gastric emptying delay, though may be associated with depression and anxiety. Read More

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September 2021

A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease.

Phytomedicine 2021 Sep 6;92:153709. Epub 2021 Sep 6.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. Electronic address:

Background: Inflammatory bowel disease (IBD) is a chronic idiopathic disease that is characterized by inflammation of the gastrointestinal tract. Proper management of IBD requires both early diagnosis and novel therapies and management programs. Many reports have suggested that Chinese medicine has unique properties favorable to the treatment of IBD. Read More

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September 2021

Environmental benefit assessment of steel slag utilization and carbonation: A systematic review.

Sci Total Environ 2021 Sep 11;806(Pt 1):150280. Epub 2021 Sep 11.

Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10673, Taiwan, ROC.

The rapid increase in steel slag generation globally highlights the urgent need to manage the disposal or utilization processes. In addition to conventional landfill disposal, researchers have successfully reused steel slag in the construction, chemical, and agricultural fields. With the large portions of alkaline silicate mineral content, steel slag can also be used as a suitable material for carbon capture to mitigate global warming. Read More

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September 2021

Hippuric acid: Could became a barometer for frailty and geriatric syndromes?

Ageing Res Rev 2021 Sep 21:101466. Epub 2021 Sep 21.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. Electronic address:

Aging is a natural biological event that has some downsides such as increased frailty, decline in cognitive and physical functions leading to chronical diseases, and lower quality of life. There is therefore a pressing need of reliable biomarkers to identify populations at risk of developing age-associated syndromes in order to improve their quality of life, promote healthy ageing and a more appropriate clinical management, when needed. Here we discuss the importance of hippuric acid, an endogenous co-metabolite, as a possible hallmark of human aging and age-related diseases, summarizing the scientific literature over the last years. Read More

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September 2021

Comminuted Distal Radius Fracture with Concomitant Median Nerve Transection: A Case Report and Literature Review.

JBJS Case Connect 2021 Sep 24;11(3). Epub 2021 Sep 24.

Department of Orthopaedic Surgery, Division of Hand and Microvascular Surgery, Mayo Clinic, Rochester, Minnesota.

Case: A 41-year-old woman sustained a distal radius fracture with concomitant median nerve transection. The wound was consistent with an inside-to-outside mechanism with noted metaphyseal bone loss at the level of the median nerve injury. The median nerve was not amenable to primary repair, and given concern for inability to define the zone of the injury, the patient underwent delayed reconstruction of the nerve. Read More

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September 2021

Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system.

Biofactors 2021 Sep 24. Epub 2021 Sep 24.

Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica Del Sacro Cuore, Rome, Italy.

Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. Read More

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September 2021

Role of Cholesterol-Associated Steatohepatitis in the Development of NASH.

Hepatol Commun 2021 Aug 24. Epub 2021 Aug 24.

Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related cirrhosis in the United States and globally highlights the need to better understand the mechanisms causing progression of hepatic steatosis to fibrosing steatohepatitis and cirrhosis in a small proportion of patients with NAFLD. Accumulating evidence suggests that lipotoxicity mediated by hepatic free cholesterol (FC) overload is a mechanistic driver for necroinflammation and fibrosis, characteristic of nonalcoholic steatohepatitis (NASH), in many animal models and also in some patients with NASH. Diet, lifestyle, obesity, key genetic polymorphisms, and hyperinsulinemia secondary to insulin resistance are pivotal drivers leading to aberrant cholesterol signaling, which leads to accumulation of FC within hepatocytes. Read More

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Immunomodulatory Functions of TRPM7 and its Implications in Autoimmune Diseases.

Immunology 2021 Sep 24. Epub 2021 Sep 24.

Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, 230601, China.

Autoimamune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure to self-antigens. It often leads to structural and functional damage to organs as well as systemic disorders. To date, there are no effective interventions to prevent the progression of autoimmune diseases. Read More

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September 2021

Porphyrins as building blocks for single-molecule devices.

Nanoscale 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, University of Basel, St Johanns-Ring 19, 4056 Basel, Switzerland.

Direct measurement of single-molecule electrical transparency by break junction experiments has become a major field of research over the two last decades. This review specifically and comprehensively highlights the use of porphyrins as molecular components and discusses their potential use for the construction of future devices. Throughout the review, the features provided by porphyrins, such as low level misalignments and very low attenuation factors, are shown with numerous examples, illustrating the potential and limitations of these molecular junctions, as well as differences emerging from applied integration/investigation techniques. Read More

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September 2021

Physical activity of children and adolescents from the Czech Republic, Hungary, Poland, and Slovakia: A systematic review.

Ann Agric Environ Med 2021 Sep 5;28(3):385-390. Epub 2020 Aug 5.

Poznan University of Physical Education, Poznań, Poland.

Introduction And Objective: Systematic monitoring of physical activity of young populations from different regions may be useful for making international comparisons, better understanding trends in physical activity and designing public health interventions to increase physical activity. Thus, the aim of the study was to comprehensively review studies examining the level of physical activity of children and adolescents from the Visegrád countries, and indicate the percentage of children and adolescents meeting the recommended level of physical activity.

Material And Methods: A systematic search of the published literature was conducted. Read More

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September 2021

Transfusion management of trauma from the 2019 El Paso mass shooting incident.

Vox Sang 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Background And Objectives: Mortality rates, transfusion ratios, trauma management logistics, and assault characteristics from the El Paso mass shooting incident (MSI) are evaluated in comparison to other MSIs. In 2019, El Paso, TX experienced the eighth-deadliest MSIs in modern US history. In this 21st mass killing in the United States of 2019, 19 people died immediately, and four of 27 injured, later died from ballistic injuries. Read More

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September 2021

Associations between Disability in Activities of Daily Living and Social Capital aspects among older adults: a scoping review.

J Frailty Sarcopenia Falls 2021 Sep 1;6(3):119-130. Epub 2021 Sep 1.

University of West Attica, Department of Nursing, Athens, Greece.

Social capital aspects are playing an important role in activities of daily living (ADL) performance, thus on independent living. This paper was aimed to present an overview of the associations and adverse effects between social capital aspects and disability in ADL and health-related quality of life (HRQoL) in an older population aged 65 years old and over. Α scoping review was designed following the guidelines of PRISMA Extension for Scoping Reviews (PRISMA-ScR) and the review was conducted by 3 authors. Read More

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September 2021

A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2020.

Open Forum Infect Dis 2021 Sep 13;8(9):ofab422. Epub 2021 Aug 13.

Department of Pharmacy, University of South Carolina College of Pharmacy, Columbia, South Carolina, USA.

The number of articles related to antimicrobial stewardship published each year has increased significantly over the last decade. Keeping up with the literature, particularly the most innovative, well-designed, or applicable to one's own practice area, can be challenging. The Southeastern Research Group Endeavor (SERGE-45) network reviewed antimicrobial stewardship-related, peer-reviewed literature from 2020 that detailed actionable interventions. Read More

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September 2021

Clinical factors associated with increased length of stay and readmission in patients with medication-related hospital admissions: a retrospective study.

Res Social Adm Pharm 2021 Sep 14. Epub 2021 Sep 14.

The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, NSW, Australia; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Australia; Aging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. Electronic address:

Background: Adverse drug events (ADEs) remain a key contributor to hospitalisations, resulting in long hospital stays and readmissions. Information pertaining to the specific medications and clinical factors associated with these outcomes is limited. Hence, a better understanding of these factors and their relationship to ADEs is required. Read More

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September 2021

Management of sinus graft infection-a systematic review.

Int J Oral Maxillofac Surg 2021 Sep 20. Epub 2021 Sep 20.

Université de Lille, CHU Lille, INSERM, Service de Chirurgie Maxillo-Faciale et Stomatologie, U1008 - Controlled Drug Delivery Systems and Biomaterial, Lille, France.

Sinus graft infections are rare but serious complications, as they are associated with significant morbidity and sinus graft loss. The aim of this study was to systematically review the management of sinus graft infection in order to define which protocols should be implemented. The terms searched in each database were "sinus graft infection management", "maxillary sinus lift infection", "maxillary sinus graft infection", "maxillary sinus elevation infection", and "maxillary sinus augmentation infection". Read More

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September 2021

Emerging agents for the treatment and prevention of stroke: progress in clinical trials.

Expert Opin Investig Drugs 2021 Sep 24. Epub 2021 Sep 24.

Second Department of Neurology, National & Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.

Introduction: Recent years have witnessed unprecedented progress in stroke care, but unmet needs persist regarding the efficacy of acute treatment and secondary prevention. Novel approaches are being tested to enhance the efficacy of thrombolysis or provide neuroprotection in non-thrombolized patients.

Areas Covered: The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acute, subacute, and chronic phase post-stroke. Read More

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September 2021

Prospects and future perspectives of selenium nanoparticles: An insight of growth promoter, antioxidant and anti-bacterial potentials in productivity of poultry.

Authors:
Tanmoy Rana

J Trace Elem Med Biol 2021 Sep 20;68:126862. Epub 2021 Sep 20.

Department of Veterinary Clinical Complex (V.M.E.J.), West Bengal University of Animal & Fishery Sciences, Kolkata, India(1). Electronic address:

Nanoparticles have been attracted attention in poultry research due to their low toxicity, higher bio-availability, high surface area with sustained drug release. Dietary supplementation with selenium nanoparticles (Se-NPs) plays a regulatory role in maintaining growth performance, feed conversion ratio (FCR), antioxidant defense as well as microbial control. Se-NPs have emerging importance in modulating intestinal health through the maintenance of beneficial microbes (microflora) as well as the production of short-chain fatty acids (SCFA). Read More

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September 2021

Road map to the treatment of neglected tropical diseases: Nanocarriers interventions.

J Control Release 2021 Sep 20. Epub 2021 Sep 20.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS (Deemed to be University), Mumbai 400056, India. Electronic address:

Neglected tropical disease (NTD) is a set of 20 deadliest endemic diseases which shows its presence in most of the developing countries worldwide. Nearly 1 billion of the population are affected by it and suffered from poverty yearly. These diseases offer their own unique challenges and limitations towards effective prevention and treatment methods. Read More

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September 2021

An overview of the fatty acid biosynthesis in the protozoan parasite Leishmania and its relevance as a drug target against leishmaniasis.

Mol Biochem Parasitol 2021 Sep 20:111416. Epub 2021 Sep 20.

Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India. Electronic address:

Leishmaniasis is one of the fast-growing parasitic diseases worldwide. The treatment of this fatal disease presents a daunting challenge because of its adverse effects, necessity for long-term treatment regime, unavailability of functional drugs, emergence of drug resistance and the related expenditure. This calls for an urgent need for novel drugs and the evaluation of new targets. Read More

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September 2021

Physical health programs and interventions with women during incarceration: a scoping review.

Int J Prison Health 2021 Sep;ahead-of-print(ahead-of-print)

College of Nursing, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: The USA outpaces most other countries in the world in the rates at which it incarcerates its citizens. The one million women held in US jails and prisons on any day in the USA face many physical health challenges, yet interventional work to address physical health in carceral settings is rare. This study's purpose was to summarize the literature on programs and interventions implemented with women in US carceral settings (jail or prison) that primarily addressed a physical health issue or need. Read More

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September 2021

Systematic review on the association between respiratory virus real-time PCR cycle threshold values and clinical presentation or outcomes.

J Antimicrob Chemother 2021 Sep;76(Supplement_3):iii33-iii49

Université de Paris, IAME, INSERM, Paris, France.

Objectives: It is unclear whether real-time (rt)-PCR cycle threshold (Ct) values can be utilized to guide clinical and infection-control decisions. This systematic review assesses the association between respiratory pathogen rt-PCR Ct values and clinical presentation or outcomes.

Methods: We searched MEDLINE, EMBASE and Cochrane library databases on 14-17 January 2020 for studies reporting the presence or absence of an association between Ct values and clinical presentation or outcomes, excluding animal studies, reviews, meta-analyses, and non-English language studies. Read More

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September 2021

Impact of COVID-19 and other infectious conditions requiring isolation on the provision of and adaptations to fundamental nursing care in hospital in terms of overall patient experience, care quality, functional ability, and treatment outcomes: systematic review.

J Adv Nurs 2021 Sep 23. Epub 2021 Sep 23.

College of Medicine and Health, University of Exeter, Exeter, UK.

Aim: This systematic review identifies, appraises and synthesizes the evidence on the provision of fundamental nursing care to hospitalized patients with a highly infectious virus and the effectiveness of adaptations to overcome barriers to care.

Design: Systematic review.

Data Sources: In July 2020, we searched Medline, PsycINFO (OvidSP), CINAHL (EBSCOhost), BNI (ProQuest), WHO COVID-19 Database (https://search. Read More

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September 2021

Artificial night light alters ecosystem services provided by biotic components.

Biol Futur 2021 Jun 7;72(2):169-185. Epub 2021 Jan 7.

Department of Plant Physiology, Institute of Agriculture Sciences, Banaras Hindu University, Varanasi, U.P, 221005, India.

The global catastrophe of natural biodiversity and ecosystem services are expedited with the growing human population. Repercussions of artificial light at night ALAN are much wider, as it varies from unicellular to higher organism. Subsequently, hastened pollution and over exploitation of natural resources accelerate the expeditious transformation of climatic phenomenon and further cause global biodiversity losses. Read More

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A Review of Interventional Trials in Youth-Onset Type 2 Diabetes: Challenges and Opportunities.

Diabetes Ther 2021 Sep 23. Epub 2021 Sep 23.

Eli Lilly and Company, Indianapolis, IN, USA.

Introduction: In recent decades, the dramatic rise of obesity among youth in the US has been accompanied by a rise in the prevalence of type 2 diabetes (T2D) in this population. This alarming trend underscores the importance of conducting trials to evaluate new therapies in children with T2D.

Methods: A targeted review of peer-reviewed literature and trials registered on www. Read More

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September 2021