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Progress in the study of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) reversing multidrug resistance.

Colloids Surf B Biointerfaces 2021 Jun 8;205:111914. Epub 2021 Jun 8.

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

Currently, multidrug resistance (MDR) is one of the major reasons for failure in clinical cancer chemotherapy. Overexpression of the ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which significantly increases the efflux of anticancer drugs from tumor cells, enhances MDR. In the past few decades, four generations of P-gp inhibitors have appeared. Read More

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Interactive regulation of laryngeal cancer and neuroscience.

Biochim Biophys Acta Rev Cancer 2021 Jun 12;1876(1):188580. Epub 2021 Jun 12.

Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China. Electronic address:

Nerve fibres are distributed throughout the body along with blood and lymphatic vessels. The intrinsic morphological characteristics of nerves and the general characteristics of secretions in the tumour microenvironment provide a solid theoretical basis for exploring how neuronal tissue can influence the progression of laryngeal cancer (LC). The central nervous system (CNS) and the peripheral nervous system (PNS) jointly control many aspects of cancer and have attracted widespread attention in the study of the progression, invasion and metastasis of tumour tissue banks. Read More

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Ethnomedicine and Neuropsychopharmacology in Mesoamerica.

J Ethnopharmacol 2021 Jun 12:114243. Epub 2021 Jun 12.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042, Monserrato CA, Italy. Electronic address:

Ethnopharmacological Relevance: The burden of disease caused by mental and neurological disorders is increasing globally, to a disproportionate degree in Latin America. In contrast to the many psychoactive plants with a use history in Mesoamerican cultures, the translation to the wider population of knowledge around numerous botanicals used contemporarily by indigenous Mesoamerican societies to treat psychological and neurological disorders did not receive the same attention.

Material And Methods: We used the previously published Mesoamerican Medicinal Plant Database to extract species and associated botanical drugs used as treatments for illnesses associated with the nervous system by Mesoamerican cultures in Belize, Guatemala, and Mexico. Read More

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Stimuli-responsive surfaces for switchable wettability and adhesion.

J R Soc Interface 2021 Jun 16;18(179):20210162. Epub 2021 Jun 16.

Centre of Advanced Structural Ceramics, Department of Materials, Imperial College London, London SW7 2AZ, UK.

Diverse unique surfaces exist in nature, e.g. lotus leaf, rose petal and rice leaf. Read More

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SIRT7: a sentinel of genome stability.

Open Biol 2021 Jun 16;11(6):210047. Epub 2021 Jun 16.

Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University International Cancer Center, Marshall Laboratory of Biomedical Engineering, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518055, People's Republic of China.

SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes, ranging from gene regulation to genome stability, ageing and tumorigenesis. Read More

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Plasma-based ambient mass spectrometry: Recent progress and applications.

Mass Spectrom Rev 2021 Jun 15. Epub 2021 Jun 15.

College of Life Sciences, Sichuan University, Chengdu, China.

Ambient mass spectrometry (AMS) has grown as a group of advanced analytical techniques that allow for the direct sampling and ionization of the analytes in different statuses from their native environment without or with minimum sample pretreatments. As a significant category of AMS, plasma-based AMS has gained a lot of attention due to its features that allow rapid, real-time, high-throughput, in vivo, and in situ analysis in various fields, including bioanalysis, pharmaceuticals, forensics, food safety, and mass spectrometry imaging. Tens of new methods have been developed since the introduction of the first plasma-based AMS technique direct analysis in real-time. Read More

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Are photocatalytic processes effective for removal of airborne viruses from indoor air? A narrative review.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Nutrition Health Research Center, Health Sciences & Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.

A wide variety of methods have been applied in indoor air to reduce the microbial load and reduce the transmission rate of acute respiratory diseases to personnel in healthcare sittings. In recent months, with the occurrence of COVID-19 pandemic, the role of portable ventilation systems in reducing the load of virus in indoor air has received much attention. The present study delineates a comprehensive up-to-date overview of the available photocatalysis technologies that have been applied for inactivating and removing airborne viruses. Read More

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Biosynthesis pathways and strategies for improving 3-hydroxypropionic acid production in bacteria.

World J Microbiol Biotechnol 2021 Jun 15;37(7):117. Epub 2021 Jun 15.

Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.

3-Hydroxypropionic acid (3-HP) represents an economically important platform compound from which a panel of bulk chemicals can be derived. Compared with petroleum-dependent chemical synthesis, bioproduction of 3-HP has attracted more attention due to utilization of renewable biomass. This review outlines bacterial production of 3-HP, covering aspects of host strains (e. Read More

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Evolution of surgical attitudes to paediatric thalamic tumours: the alder hey experience.

Childs Nerv Syst 2021 Jun 14. Epub 2021 Jun 14.

Department of Paediatric Neurosurgery, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Purpose: Attitudes to surgery for paediatric thalamic tumours have evolved due to improved preoperative imaging modalities and the advent of intraoperative MRI (iMRI) as well as enhanced understanding of tumour biology. We review the developments in our local practice over the last three decades with particular attention to the impact of iMRI.

Methods: We identified all paediatric patients from a prospectively maintained neuro-oncology database who received surgery for a thalamic tumour (n = 30). Read More

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MXene and black phosphorus based 2D nanomaterials in bioimaging and biosensing: progress and perspectives.

J Mater Chem B 2021 Jun 15. Epub 2021 Jun 15.

Center for Biomedical Photonics & College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Bioimaging and biosensing have garnered interest in early cancer diagnosis due to the ability of gaining in-depth insights into cellular functions and providing a wide range of diagnostic parameters. Emerging 2D materials of multielement MXenes and monoelement black phosphorous nanosheets (BPNSs) with unique intrinsic physicochemical properties such as a tunable bandgap and layer-dependent fluorescence, high carrier mobility and transport anisotropy, efficient fluorescence quenching capability, desirable light absorption and thermoelastic properties, and excellent biocompatibility and biosafety properties provide promising nano-platforms for bioimaging and biosensing applications. In view of the growing attention on the rising stars of the post-graphene age in the progress of bioimaging and biosensing, and their common feature characteristics as well as complementarity for constructing complexes, the main objective of this review is to reveal the recent advances in the design of MXene or BPNS based nanoplatforms in the field of bioimaging and biosensing. Read More

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Mapping Ethics Education in Accounting Research: A Bibliometric Analysis.

J Bus Ethics 2021 Jun 10:1-22. Epub 2021 Jun 10.

School of Economics and Business, University of Ljubljana, Kardeljeva pl. 17, 1000 Ljubljana, Slovenia.

The attention being paid to ethics education in accounting has been increasing, especially after the corporate accounting scandals at the turn of the century. This paper provides a comprehensive overview of the existing research in the field of ethics education in accounting. To synthesize past research, a bibliometric analysis that references 134 primary studies is performed and three bibliometric methods are applied. Read More

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The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article.

J Antibiot (Tokyo) 2021 Jun 15. Epub 2021 Jun 15.

President, Association "Naso Sano" Onlus, Umbria Regional Registry of volunteer activities, Corciano, Italy.

Considering the urgency of the ongoing COVID-19 pandemic, detection of various new mutant strains and future potential re-emergence of novel coronaviruses, repurposing of approved drugs such as Ivermectin could be worthy of attention. This evidence-based review article aims to discuss the mechanism of action of ivermectin against SARS-CoV-2 and summarizing the available literature over the years. A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications have been proposed. Read More

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Pediatric sepsis biomarkers for prognostic and predictive enrichment.

Authors:
Hector R Wong

Pediatr Res 2021 Jun 14. Epub 2021 Jun 14.

Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, OH, USA.

Sepsis is a major public health problem in children throughout the world. Given that the treatment guidelines emphasize early recognition, there is interest in developing biomarkers of sepsis, and most attention is focused on diagnostic biomarkers. While there is a need for ongoing discovery and development of diagnostic biomarkers for sepsis, this review will focus on less well-known applications of sepsis biomarkers. Read More

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Palliative Radiotherapy for Diffuse Large B-cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2021 May 19. Epub 2021 May 19.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

Recent improvements in chemoimmunotherapies, targeted agents, hematopoietic stem cell transplants, and cellular therapies have revolutionized treatment paradigms for patients with diffuse large B-cell lymphoma (DLBCL). Even in the relapsed or refractory setting, contemporary treatment options are delivered with curative intent and can lead to lasting remissions. Although such therapies have improved overall outcomes, they have increasingly led to a wide variety of presentations of recurrent tumors in need of palliation. Read More

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Prospects and challenges of anticancer agents' delivery via chitosan-based drug carriers to combat breast cancer: a review.

Carbohydr Polym 2021 Sep 13;268:118192. Epub 2021 May 13.

The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address:

Breast cancer (BC) is considered as one the most prevalent cancers worldwide. Due to its high resistance to chemotherapy and high probability of metastasis, BC is one of the leading causes of cancer-related deaths. The controlled release of chemotherapy drugs to the precise site of the tumor tissue will increase the therapeutic efficacy and decrease side effects of systemic administration. Read More

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September 2021

An overview of zinc oxide nanoparticles produced by plant extracts for anti-tuberculosis treatments.

Curr Med Chem 2021 Jun 14. Epub 2021 Jun 14.

Department of Clinical Immunology, Institute of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, 523808, China.

Tuberculosis (TB), induced by Mycobacterium tuberculosis (MTB), is a fatal infectious disease that kills millions of lives worldwide. The emergence of drug-resistant and multidrug-resistant cases is regarded as one of the most challenging threats to TB control due to the low cure rate. Therefore, TB and drug-resistant TB epidemics urge us to explore more effective therapies. Read More

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Assessing the Extent to Which Art Therapy Can Be Used with Victims of Childhood Sexual Abuse: A Thematic Analysis of Published Studies.

J Child Sex Abus 2021 Jun 15:1-22. Epub 2021 Jun 15.

Centre for Gender and Violence Research, University of Bristol, UK.

In a 2015-2016 UK survey of 35, 248 adults, 7% reported experiencing sexual abuse as children. This review considers the value of Art Therapy (AT) in recognizing individual needs and experiences and supporting victims to manage the lasting impact of abuse. Three main bodies of research were identified: the use of AT in childhood sexual abuse (CSA) investigations; the use of art therapy in the treatment of the psychological sequelae of CSA victims in childhood and adulthood; and an assessment of how art therapy compares to other therapeutic approaches for CSA victims. Read More

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Iron-carbon microelectrolysis for wastewater remediation: Preparation, performance and interaction mechanisms.

Chemosphere 2021 Sep 3;278:130483. Epub 2021 Apr 3.

School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, 453007, China.

Rapid industrialization and urbanization have produced a lot of hazardous substances in water and wastewater, which has turned into a crucial issue to the environment and the public health. Recently, iron carbon microelectrolysis (IC-ME) has attracted extensive attention in environmental remediation due to its low costs and excellent performance. Nevertheless, there is still a lack of a more systematic review on IC-ME preparation methods, their performance, and the interaction mechanisms of IC-ME in the remediation of wastewater. Read More

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September 2021

Activation of biochar through exoenzymes prompted by earthworms for vermibiochar production: A viable resource recovery option for heavy metal contaminated soils and water.

Chemosphere 2021 Sep 2;278:130458. Epub 2021 Apr 2.

Cancer Nanomedicine Laboratory, Department of Zoology, School of Life Sciences, Periyar University, Salem, 636 011, Tamil Nadu, India.

The industrial revolution and indiscriminate usage of a wide spectrum of agrochemicals account for the dumping of heavy metals in the environment. In-situ/ex-situ physical, chemical, and bioremediation strategies with pros and cons have been adopted for recovering metal contaminated soils and water. Therefore, there is an urgent requirement for a cost-effective and environment-friendly technique to combat metal pollution. Read More

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September 2021

Activatable molecular agents for cancer theranostics.

Chem Sci 2019 Nov 22;11(3):618-630. Epub 2019 Nov 22.

School of Chemical and Biomedical Engineering, Nanyang Technological University Singapore 637457

Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. Read More

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November 2019

Heritable consequences of paternal nicotine exposure: From phenomena to mechanisms.

Biol Reprod 2021 Jun 14. Epub 2021 Jun 14.

Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA.

Our understanding of the interactions between genetic and environmental factors in shaping behavioral phenotypes has expanded to include environment-induced epigenetic modifications and the intriguing possibility of their association with heritable behavioral phenotypes. The molecular basis of heritability of phenotypes arising from environment-induced epigenetic modifications is not well defined yet. However, phenomenological evidence in favor of it is accumulating rapidly. Read More

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Structural exploration of multifunctional monoamine oxidase B inhibitors as potential drug candidates against Alzheimer's disease.

Bioorg Chem 2021 Jun 8;114:105070. Epub 2021 Jun 8.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, Zhejiang University of Technology, Hangzhou, PR China; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, PR China. Electronic address:

AD is one of the most typical neurodegenerative disorders that suffer many seniors worldwide. Recently, MAO inhibitors have received increasing attention not only for their roles involved in monoamine neurotransmitters metabolism and oxidative stress but also for their additional neuroprotective and neurorescue effects against AD. The curiosity in MAO inhibitors is reviving, and novel MAO-B inhibitors recently developed with ancillary activities (e. Read More

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Molecular dynamics simulation for membrane separation and porous materials: A current state of art review.

J Mol Graph Model 2021 Jun 5;107:107947. Epub 2021 Jun 5.

Department of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, Saskatchewan, S7N 5A9, Canada; Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, Saskatchewan, S7N 5A9, Canada. Electronic address:

Computational frameworks have been under specific attention within the last two decades. Molecular Dynamics (MD) simulations, identical to the other computational approaches, try to address the unknown question, lighten the dark areas of unanswered questions, to achieve probable explanations and solutions. Owing to their complex microporous structure on one side and the intricate biochemical nature of various materials used in the structure, separative membrane materials possess peculiar degrees of complications. Read More

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Stop touching your face! A systematic review of triggers, characteristics, regulatory functions and neuro-physiology of facial self touch.

Neurosci Biobehav Rev 2021 Jun 11. Epub 2021 Jun 11.

University of Leipzig, Paul-Flechsig-Institute for Brain Research, Haptic Research Lab, 04103 Leipzig, Germany. Electronic address:

Spontaneous face touching (sFST) is an ubiquitous behavior that occurs in people of all ages and all sexes, up to 800 times a day. Despite their high frequency, they have rarely been considered as an independent phenomenon. Recently, sFST have sparked scientific interest since they contribute to self-infection with pathogens. Read More

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Racial Diversity Among American Cardiologists: Implications for the Past, Present, and Future.

Circulation 2021 Jun 14;143(24):2395-2405. Epub 2021 Jun 14.

School of Medicine (A.E.J., M.B.T., E.B., A.J.C., E.M.D., P.K.D., L.M.D.C., U.R.E., A.M.G., M.V.H., A.J.J., C.R.J., N.L.J., L.M., M.A.N., G.S.N., O.O., S.O.-A., A.J.C.S., T.L.S., O.T., R.T., E.U., J.D.W., J.E.S.-P.).

In the United States, race-based disparities in cardiovascular disease care have proven to be pervasive, deadly, and expensive. African American/Black, Hispanic/Latinx, and Native/Indigenous American individuals are at an increased risk of cardiovascular disease and are less likely to receive high-quality, evidence-based medical care as compared with their White American counterparts. Although the United States population is diverse, the cardiovascular workforce that provides its much-needed care lacks diversity. Read More

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Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer.

EMBO Mol Med 2021 Jun 14:e08253. Epub 2021 Jun 14.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Anti-angiogenic drugs targeting the VEGF pathway are most effective in advanced metastatic disease settings of certain types of cancers, whereas they have been unsuccessful as adjuvant therapies of micrometastatic disease in numerous phase III trials involving early-stage (resectable) cancers. Newer investigational anti-angiogenic drugs have been designed to inhibit the Angiopoietin (Ang)-Tie pathway. Acting through Tie2 receptors, the Ang1 ligand is a gatekeeper of endothelial quiescence. Read More

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Cell dynamics in human villous trophoblast.

Hum Reprod Update 2021 Jun 14. Epub 2021 Jun 14.

Maternal and Fetal Health, University of Manchester, Manchester Academic Health Sciences Centre, St Mary's Hospital, Manchester, UK.

Background: Villous cytotrophoblast (vCTB) is a precursor cell population that supports the development of syncytiotrophoblast (vSTB), the high surface area barrier epithelium of the placental villus, and the primary interface between maternal and fetal tissue. In light of increasing evidence that the placenta can adapt to changing maternal environments or, under stress, can trigger maternal disease, we consider what properties of these cells empower them to exert a controlling influence on pregnancy progression and outcome.

Objective And Rationale: How are cytotrophoblast proliferation and differentiation regulated in the human placental villus to allow for the increasing demands of the fetal and environmental challenges and stresses that may arise during pregnancy?

Search Methods: PubMed was interrogated using relevant keywords and word roots combining trophoblast, villus/villous, syncytio/syncytium, placenta, stem, transcription factor (and the individual genes), signalling, apoptosis, autophagy (and the respective genes) from 1960 to the present. Read More

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Assessing Violence Risk in Adolescents in the Pediatric Emergency Department: Systematic Review and Clinical Guidance.

West J Emerg Med 2021 May 19;22(3):533-542. Epub 2021 May 19.

Columbia University Irving Medical Center, Department of Psychiatry, New York, New York.

Introduction: Violence risk assessment is one of the most frequent reasons for child and adolescent psychiatry consultation with adolescents in the pediatric emergency department (ED). Here we provide a systematic review of risk factors for violence in adolescents using the risk factor categories from the MacArthur Violence Risk Assessment study. Further, we provide clinical guidance for assessing adolescent violence risk in the pediatric ED. Read More

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Wireless Technologies for Energy Harvesting and Transmission for Ambient Self-Powered Systems.

ACS Nano 2021 Jun 14. Epub 2021 Jun 14.

School of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, P.R. China.

The era of the Internet of Things (IoT) requires sustainable and convenient methods to power widely distributed sensing devices. Self-powered systems have emerged as a potential solution that utilizes ambient energy from environmental sources such as electromagnetic fields, mechanical motion, solar power, and temperature gradients. Recently, the integration of wireless technologies with self-powered systems has attracted significant attention as a way to address challenges in energy harvesting and transport without the cost and inherent physical constraints of wires. Read More

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