81,455 results match your criteria review aims

White matter hyperintensities in patients with Parkinson's disease: A systematic review and meta-analysis.

J Neurol Sci 2021 May 4;426:117481. Epub 2021 May 4.

Department of Medicine, Division of Neurology, University of Alberta, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada.

Introduction: Mechanisms driving neurodegeneration in Parkinson's disease (PD) are unclear and neurovascular dysfunction may be a contributing factor. White matter hyperintensities (WMH) are commonly found on brain MRI in patients with PD. It is controversial if they are more prevalent or more severe in PD compared with controls. Read More

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An overview on the role of plant-derived tannins for the treatment of lung cancer.

Phytochemistry 2021 May 8;188:112799. Epub 2021 May 8.

Department of Biochemistry, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India. Electronic address:

Lung cancer is the leading cause of cancer-related death globally. Despite many advanced approaches to treat cancer, they are often ineffective due to resistance to classical anti-cancer drugs and distant metastases. Currently, alternative medicinal agents derived from plants are the major interest due to high bioavailability and fewer adverse effects. Read More

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A review of surrogate safety measures and their applications in connected and automated vehicles safety modeling.

Accid Anal Prev 2021 May 8;157:106157. Epub 2021 May 8.

School of Transportation, Southeast University, China. Electronic address:

Surrogate Safety Measures (SSM) are important for safety performance evaluation, since crashes are rare events and historical crash data does not capture near crashes that are also critical for improving safety. This paper focuses on SSM and their applications, particularly in Connected and Automated Vehicles (CAV) safety modeling. It aims to provide a comprehensive and systematic review of significant SSM studies, identify limitations and opportunities for future SSM and CAV research, and assist researchers and practitioners with choosing the most appropriate SSM for safety studies. Read More

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Return to work after medial unicompartmental knee arthroplasty: A systematic review.

Knee 2021 May 7;30:254-266. Epub 2021 May 7.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

Introduction: This study aims to evaluate the current literature with regard to the average time to and overall rate of return to work (RTW) following medial unicompartmental knee arthroplasty (UKA).

Methods: A systematic search was conducted on MEDLINE (Ovid), Embase, Pubmed, CINAHL, Web of Science, Scopus, and the Cochrane Library to identify studies reporting RTW after UKA. Primary outcomes were the rate and time to RTW after UKA. Read More

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A critical review of the mechanisms involved in the occurrence of growth-related abnormalities affecting broiler chicken breast muscles.

Poult Sci 2021 Apr 20;100(6):101180. Epub 2021 Apr 20.

Department of Agricultural and Food Sciences, Alma Mater Studiorum - University of Bologna, Italy.

In the past decade, the poultry industry has faced the occurrence of growth-related muscular abnormalities that mainly affect, with a high incidence rate, the Pectoralis major of the fast-growing genotypes selected for their production performances (high growth rate and breast yield). These myopathies are termed as White Striping, Wooden Breast, and Spaghetti Meat and exhibit distinctive phenotypes. A spatiotemporal distribution has been demonstrated for these disorders as in the early stage they primarily affect the superficial area in the cranial portion of the muscle and, as the birds grow older, involve the entire tissue. Read More

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Dermanyssus gallinae in non-avian hosts: A case report in a dog and review of the literature.

Parasitol Int 2021 May 8:102378. Epub 2021 May 8.

Department of Agriculture, Food, Natural Resources and Engineering (DAFNE), University of Foggia, 71121, Italy. Electronic address:

Non-avian attacks of the worldwide distributed mite Dermanyssus gallinae are occasionally reported. However, it is widely accepted that their occurrence is underestimated. The present study aims to describe the first Italian case of dermanyssosis in a dog, to molecularly characterize the mites collected from the patient and the animal enclosure, where poultry and dog were confined, and to review the current literature on the non-avian attacks by D. Read More

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Massage therapy as a non-pharmacological analgesia for procedural pain in neonates: A scoping review.

Complement Ther Med 2021 May 8:102735. Epub 2021 May 8.

Faculty of Nursing, Universitas Padjadjaran Bandung, Indonesia.

Introduction: Neonates who undergo painful medical procedures should be given analgesics to reduce future adverse risks. The evidence for massage therapy (MT) as an analgesic method still varies, both in its terminology and implementation. Only a few studies on this topic have been conducted using a standardised trial approach. Read More

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Second-generation hormonotherapy in prostate cancer and bone microenvironment.

Endocr Relat Cancer 2021 May 1. Epub 2021 May 1.

A Guillot, Medical oncology, Institut de Cancérologie de la Loire, Saint Priest en Jarez, France.

Prostate cancer (Pca) is the most commonly diagnosed cancer affecting men in France. Before the age of 75 years old, 1 in 8 French men will have Pca. Androgen deprivation therapies (ADT) remain the standard of care. Read More

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A review and perspective on the assessment, management and prevention of fragility fractures in patients with osteoporosis and chronic kidney disease.

Endocrine 2021 May 11. Epub 2021 May 11.

Department of Medicine, Holbæk Hospital, Holbæk, Denmark.

This article aims to review the methods used for the assessment of fracture risk and the use of osteoporosis medications for fracture prevention in the population with CKD, and highlights the difficulties faced by clinicians in the management of these patients and the latest recommendations and guidelines. Chronic kidney disease (CKD) and osteoporosis often co-exist in older adults, and they present a major healthcare challenge. CKD mineral and bone disorder (CKD-MBD) occurs as renal function declines and this syndrome affects most patients in CKD stages 4 and 5. Read More

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Flap Reconstruction of Perineal Defects after Pelvic Exenteration: A Systematic Description of Four Choices of Surgical Reconstruction Methods.

Plast Reconstr Surg 2021 May 10. Epub 2021 May 10.

From the Departments of Surgery and Plastic, Reconstructive, and Hand Surgery, Amsterdam University Medical Center; the Department of Plastic Surgery, Leiden University Medical Center; and the Department of Gastrointestinal Surgery, Ghent University Hospital.

Background: The treatment of locally advanced or recurrent anorectal cancer requires radical surgery such as extralevator abdominoperineal resection and pelvic exenteration. Larger defects require flap reconstruction. The authors evaluated outcomes of different perineal reconstruction techniques. Read More

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Pharmacological strategies for treating presbyopia.

Curr Opin Ophthalmol 2021 May 10. Epub 2021 May 10.

Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Farmacología Centro de Investigación Avanzada para la Presbicia, Buenos Aires, Argentina.

Purpose Of Review: Presbyopia is the normal progressive loss of accommodation, which leads to the inability to focus clearly on objects located at different distances. Some of the accepted methods for treating this condition are glasses, contact lenses, and surgery. Pharmacological treatments are a new and promising noninvasive option for dealing with presbyopia. Read More

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The different hypoglycemic effects between East Asian and non-Asian type 2 diabetes patients when treated with SGLT-2 inhibitors as an add-on treatment for metformin: a systematic review and meta-analysis of randomized controlled trials.

Aging (Albany NY) 2021 May 11;13. Epub 2021 May 11.

Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Ji-nan, Shandong 250014, China.

Aims: To investigate the efficacy and safety of SGLT-2 inhibitors as an add-on treatment for metformin between Asian and non-Asian T2DM.

Methods: A systematic literature search of PubMed, EMBASE, and the Cochrane Library was performed through August 2020 with the following keywords: Sodium-Glucose Transporter 2 Inhibitors, Sodium Glucose Transporter 2 Inhibitors, SGLT2 inhibitor, SGLT-2 inhibitors, type 2 diabetes, and randomized controlled trials. Double-blinded RCTs comparing SGLT-2 inhibitors as an add-on treatment for metformin and metformin monotherapy in adults with type 2 diabetes were included. Read More

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Preclinical studies conducted on nanozyme antioxidants: shortcomings and challenges based on US FDA regulations.

Nanomedicine (Lond) 2021 May 11. Epub 2021 May 11.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The wide prevalence of oxidative stress-induced diseases has led to a growing demand for antioxidant therapeutics worldwide. Nanozyme antioxidants are drawing enormous attention as practical alternatives for conventional antioxidants. The considerable body of research over the last decade and the promising results achieved signify the potential of nanozyme antioxidants to secure a place in the expanding market of antioxidant therapeutics. Read More

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Indocyanine green versus technetium-99m with blue dye for sentinel lymph node detection in early-stage cervical cancer: A systematic review and meta-analysis.

Cancer Rep (Hoboken) 2021 May 11:e1401. Epub 2021 May 11.

Department of Gynecologic Oncology, Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: The fluorescent dye indocyanine green (ICG) has emerged as a promising tracer for intraoperative detection of sentinel lymph nodes (SLNs) in early-stage cervical cancer. Although researchers suggest the SLN detection of ICG is equal to the more conventional combined approach of a radiotracer and blue dye, no consensus has been reached.

Aims: We aimed to assess the differences in overall and bilateral SLN detection rates with ICG versus the combined approach, the radiotracer technetium-99m ( Tc) with blue dye. Read More

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Selective oestrogen receptor modulators (SERMs) for endometriosis.

Cochrane Database Syst Rev 2021 May 11;5:CD011169. Epub 2021 May 11.

Isala Hospitals Zwolle, Zwolle, Netherlands.

Background: Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. This chronic and recurring condition occurs in women of reproductive age. It is a common cause of pain or infertility and can cause non-specific symptoms such as lower back pain, dyspareunia (pain during or after intercourse), and dysmenorrhoea (menstrual pain). Read More

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Treatment of epilepsy for people with Alzheimer's disease.

Cochrane Database Syst Rev 2021 May 11;5:CD011922. Epub 2021 May 11.

Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.

Background: Any type of seizure can be observed in Alzheimer's disease. Antiepileptic drugs seem to prevent the recurrence of epileptic seizures in most people with Alzheimer's disease. There are pharmacological and non-pharmacological treatments for epilepsy in people with Alzheimer's disease, however there are no current systematic reviews to evaluate the efficacy and tolerability of these treatments. Read More

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[Pathway design and key enzyme analysis of diosgenin biosynthesis].

Sheng Wu Gong Cheng Xue Bao 2021 Apr;37(4):1178-1188

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

As a naturally occurring steroid sapogenin, diosgenin acts as the precursor of hundreds of steroid medicines, and thereby has important medicinal value. Currently, industrial production of diosgenin relies primarily on chemical extraction from plant materials. Clearly, this strategy shows drawbacks of excessive reliance on plant materials and farmland as well as environment pollution. Read More

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Models of support to family members during the trajectory of cancer: A scoping review.

J Clin Nurs 2021 May 10. Epub 2021 May 10.

Faculty of Health and Society, Department of Care Science, Malmö University, Malmö, Sweden.

Aims And Objectives: To map the existing literature on support models provided to family members during the cancer trajectory.

Background: Cancer diagnosis, treatment and survivorship have a profound influence on the surrounding family members. This scoping review is part of the development of a support model for family members of persons diagnosed with colorectal cancer. Read More

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How Prevalent Is Cancer in Confirmed Cases with Coronaviruses and Severe Acute Respiratory Syndromes?

Adv Exp Med Biol 2021 ;1318:293-313

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Novel coronavirus disease 2019 (COVID-19) has posed a crucial hazard to global health. The new species share similarities with the two previously emerged entities: severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) that have caused outbreaks in 2002 and 2012, respectively. Interestingly, all of these coronaviruses can cause potentially fatal respiratory syndromes, though behave differently in patients with cancer compared to patients without cancer. Read More

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January 2021

Microsurgical resection of foramen magnum meningioma: multi-institutional retrospective case series and proposed surgical risk scoring system.

J Neurooncol 2021 May 10. Epub 2021 May 10.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Purpose: Foramen magnum meningiomas (FMMs) are a major surgical challenge, due to relevant surgical morbidity and mortality. The paper aims to review the clinical (symptomatic improvement, complication rate, length of hospital stay) and radiological outcome (completeness of resection) of microsurgical resection of FMMs, and to identify predictors of complications.

Methods: A multi-institutional retrospective review of prospectively maintained database of FMMs included 51 patients (74. Read More

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Retinal Migraine: Evaluation and Management.

Curr Neurol Neurosci Rep 2021 May 11;21(7):35. Epub 2021 May 11.

Division of Neurology, University of Toronto, Toronto, Canada.

Purpose Of Review: This review aims to summarize the last 15 years of literature and case reports detailing retinal migraine-an uncommon and somewhat poorly understood migraine variant.

Recent Findings: In the last 15 years, only 12 cases of retinal migraine have been outlined. Similar to other migraine statistics, retinal migraine appears to affect women more so than men and presents with unilateral headache which tends to be ipsilateral to the side of vision loss. Read More

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Domestic violence, women's health, and the sustainable development goals: integrating global targets, India's national policies, and local responses.

J Public Health Policy 2021 May 10. Epub 2021 May 10.

Department of Public Policy and Governance, Management Development Institute, Gurgaon, Haryana, 122007, India.

Domestic violence (DV) is a serious public health concern, affecting women's health and well-being. An international governance framework, through the United Nations' Sustainable Development Goals and national policies in India have committed the country to attempt elimination of violence against women. Even so, efforts remain starkly inadequate for altering conditions under which women experience DV. Read More

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A Review of the Global Impact of the COVID-19 Pandemic on Public Mental Health, with a Comparison Between the USA, Australia, and Poland with Taiwan and Thailand.

Med Sci Monit 2021 May 11;27:e932220. Epub 2021 May 11.

Department of Adult Psychiatry, Medical University of Łódź, Łódź, Poland.

Coronavirus may have a negative impact not only on physical, but also on mental wellbeing. Despite the different approaches of countries to stop the spread of the virus and different infection rates, the dynamically developing pandemic has already affected the entire world. The consequences of the coronavirus for our mental health can be divided into those related to strategies for the prevention of infection, like isolation, quarantine, limitation of social contacts, and remote work, and those related to the direct impact of infection on our nervous system. Read More

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Postoperative Rehabilitation of Posterior Cruciate Ligament Surgery: A Systematic Review.

Sports Med Arthrosc Rev 2021 Jun;29(2):81-87

Medstar Health, Timonium, MD.

Posterior cruciate ligament (PCL) injuries can be debilitating knee injuries, having involvement in up to 44% of traumatic knee injuries. However, isolated PCL injuries are relatively infrequent. Therefore, effective evidence-based rehabilitation protocols have proven to be elusive. Read More

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MHC multimer: A Molecular Toolbox for Immunologists.

Jun Chang

Mol Cells 2021 May 4. Epub 2021 May 4.

Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.

The advent of the major histocompatibility complex (MHC) multimer technology has led to a breakthrough in the quantification and analysis of antigen-specific T cells. In particular, this technology has dramatically advanced the measurement and analysis of CD8 T cells and is being applied more widely. In addition, the scope of application of MHC multimer technology is gradually expanding to other T cells such as CD4 T cells, natural killer T cells, and mucosal-associated invariant T cells. Read More

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Transperitoneal versus extraperitoneal laparoscopic aortic lymph nodal staging for locally advanced cervical cancer: A systematic review and meta-analysis.

Eur J Surg Oncol 2021 May 1. Epub 2021 May 1.

Department of Gynecologic Oncology, ARNAS Civico Di Cristina Benfratelli, Palermo, Italy.

Cervical cancer is the fourth most common neoplasm in women. In locally advanced cervical cancers, the international guidelines recommend nodal aortic assessment. Two techniques have been described to perform laparoscopic aortic lymphadenectomy: transperitoneal laparoscopic lymphadenectomy (TLL) and extraperitoneal laparoscopic lymphadenectomy (ELL). Read More

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Strategies to optimize aged care volunteer recruitment and retention: A systematic review.

J Gerontol Soc Work 2021 May 11:1-18. Epub 2021 May 11.

Quality, Outcomes and Research, Benetas, Melbourne, Victoria, Australia.

Population aging and resource constraints in aged care indicate an ever increasing need for volunteers in this growing sector. Volunteers in aged care have different expectations and experiences, as they typically form longer and closer relationships with residents, and perform important social support functions that may otherwise not be delivered. Tailored strategies to recruit and retain these volunteers are needed. Read More

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Impact of Direct-Acting Antivirals (daas) on cardiovascular diseases in patients with chronic hepatitis C.

Minerva Gastroenterol (Torino) 2021 May 10. Epub 2021 May 10.

Section of Gastroenterology and Hepatology, Dipartimento Di Promozione Della Salute, Materno Infantile, Medicina Interna e Specialistica Di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.

In the last years the hepatitis C virus (HCV) infection was a relevant public health problem due to the large number of affected people worldwide and the impact on hepatic and extrahepatic complications. The availability of direct-acting antivirals (DAAs) and the very high rate of sustained virological response (SVR) after treatment has radically changed the course of HCV chronic infection. Robust evidence showed a close link between HCV infection and development of cardiovascular disease (CVD), as result of the atherogenic effect of the virus. Read More

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Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Digestion 2021 May 10:1-9. Epub 2021 May 10.

Department of Pediatrics, Pediatric Infectious Disease Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations.

Objectives: This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD.

Methods: Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. Read More

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Overview of the latest developments in the role of probiotics, prebiotics and synbiotics in shrimp aquaculture.

Fish Shellfish Immunol 2021 May 7. Epub 2021 May 7.

Ocean College, Zhejiang University, Zhoushan, 316021, China. Electronic address:

With the growing world population, the demand for food has increased, leading to excessive and intensive breeding and cultivation of fisheries, simultaneously exacerbating the risk of disease. Recently, shrimp producers have faced major losses of stocks due to the prevalence of periodical diseases and inappropriate use of antibiotics for disease prevention and treatment, leading to bacterial resistance in shrimp, along with imposing health hazards on human consumers. Strict regulations have been placed to ban or reduce the use of prophylactic antibiotics to lessen their detrimental effects on aquatic life. Read More

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