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Radiologic Evaluation Criteria for Chronic Subdural Hematomas: Recommendations for Clinical Trials.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the Department of Diagnostic and Interventional Neuroradiolog (R.M., M.B., J.F., U.Z., S.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Embolization of the middle meningeal artery has gained substantial interest as a therapy for chronic subdural hematomas. For the results of the currently running chronic subdural hematoma trials to inform clinical practice, sufficient accuracy and matching definitions are necessary. We summarized the current practice in chronic subdural hematoma evaluation and derived suggestions on reporting standards using the {Nested} Knowledge AutoLit living review platform. Read More

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Application of 7T MRS to High-Grade Gliomas.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the Department of Neurosurgery (L.M., C.G.H.), Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York.

MRS, including single-voxel spectroscopy and MR spectroscopic imaging, captures metabolites in high-grade gliomas. Emerging evidence indicates that 7T MRS may be more sensitive to aberrant metabolic activity than lower-field strength MRS. However, the literature on the use of 7T MRS to visualize high-grade gliomas has not been summarized. Read More

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What's New in the Management of Neonatal Early-Onset Sepsis?

Arch Dis Child Fetal Neonatal Ed 2022 May 26. Epub 2022 May 26.

Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they serve and available resources. As advancements in EOS research continue and limitations with sepsis prediction tools are addressed, it is inevitable that our risk stratification and management guidelines will become more precise. Read More

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Immunosuppression in the Age of Precision Medicine.

Authors:
Steven Gabardi

Semin Nephrol 2022 Jan;42(1):86-98

Abdominal Organ Transplant Clinical Specialist, Department of Transplant Surgery, Brigham and Women's Hospital, Boston, MA. Electronic address:

The article focuses on immunosuppression pharmacology, adverse-event profile, clinical efficacy, and, when available, pharmacogenomic data. Read More

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January 2022

Transplantation in the Age of Precision Medicine: The Emerging Field of Treg Therapy.

Semin Nephrol 2022 Jan;42(1):76-85

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

Solid organ transplantation has experienced incredible success over the past half century in rescuing patients with end-stage organ failure and bestowing them with a high quality of life. This success in large part is the result of advances in immunosuppression, however, these regimens come with significant costs including opportunistic infections, and in some cases, direct toxicity to the newly transplanted organs. Further advances are needed. Read More

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January 2022

Emerging Concepts in Managing Malignancy in Kidney Transplant Patients.

Semin Nephrol 2022 Jan;42(1):63-75

Transplant Research Center, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Cancer remains a significant cause of morbidity and mortality in kidney transplant recipients, due to long-term immunosuppression. Salient issues to consider in decreasing the burden of malignancy among kidney transplant recipients include pretransplant recipient evaluation, post-transplant screening and monitoring, and optimal treatment strategies for the kidney transplant recipients with cancer. In this review, we address cancer incidence and outcomes, approaches to cancer screening and monitoring pretransplant and post-transplant, as well as treatment strategies, immunosuppressive management, and multidisciplinary approaches in the kidney transplant recipients with cancer. Read More

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January 2022

Histocompatibility Assessment in Precision Medicine for Transplantation: Towards a Better Match.

Authors:
Melissa Y Yeung

Semin Nephrol 2022 Jan;42(1):44-62

Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Human Leukocyte Antigen (HLA) diversity is the key driver of alloimmune responses. Ideally, patients would receive an allograft that is fully matched at the allelic level. However, the extensive polymorphism in the HLA loci renders this impractical. Read More

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January 2022

Glomerular Diseases of the Kidney Allograft: Toward a Precision Medicine Approach.

Semin Nephrol 2022 Jan;42(1):29-43

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY. Electronic address:

The continual development of potent immunosuppressive regimens has led to a decreased incidence of acute rejection and improvement of short-term kidney allograft survival. In contrast to acute rejection, glomerular diseases of the kidney allograft are being encountered more frequently and are emerging as leading causes of late kidney allograft failure. Although data on the pathogeneses of glomerular diseases in the kidney allograft are sparse, cumulative evidence suggests that post-transplant glomerular diseases may be the result of inherited predispositions and immunologic triggers. Read More

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January 2022

Novel Biomarkers in Kidney Transplantation.

Semin Nephrol 2022 Jan;42(1):2-13

Transplant Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA. Electronic address:

Rejection remains a major cause of renal allograft failure. Current diagnostic studies, interrogating the blood or urine, lack the sensitivity and specificity for early detection of rejection. Transplant kidney biopsy remains the gold standard, but is associated with morbidity. Read More

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January 2022

The Complement System in the Modern Era of Kidney Transplantation: Mechanisms of Injury and Targeted Therapies.

Semin Nephrol 2022 Jan;42(1):14-28

Division of Nephrology, Department of Medicine, Boston University School of Medicine, Boston, MA. Electronic address:

Kidney transplantation remains the treatment of choice for patients with end-stage kidney disease. Significant progress has been made over the course of many years to improve both patient and graft outcomes after transplant. Modern immunosuppressive therapy has reduced the rate of acute rejection and resulted in excellent short- and long-term graft survival. Read More

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January 2022

A scoping review of the literature on professional learning for MTSS.

J Sch Psychol 2022 Jun 13;92:166-187. Epub 2022 Apr 13.

College of Education, University of South Florida, USA.

This article provides a scoping review of the nascent empirical literature on professional learning for MTSS. We used a systematic search strategy to find studies on the impact of professional learning on educator and implementation outcomes. Seventy-nine studies utilizing a variety of designs were included. Read More

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Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction.

Fertil Steril 2022 Jun;117(6):1144-1159

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom. Electronic address:

Implantation is a critical step in the establishment of a successful pregnancy, depending on a complex immune-endocrine dialogue between the developing embryo and maternal endometrium. Research suggests that altered immunity in the maternal decidua results in implantation impairment and failure. Immunomodulatory drugs have, thus, been widely used in assisted conception to aid embryo implantation, despite an absence of consensus on their effectiveness and safety. Read More

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Immune determinants of endometrial receptivity: a biological perspective.

Fertil Steril 2022 Jun;117(6):1107-1120

Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.

Immune cells are essential for endometrial receptivity to embryo implantation and early placental development. They exert tissue-remodeling and immune regulatory roles-acting to promote epithelial attachment competence, regulate the differentiation of decidual cells, remodel the uterine vasculature, control and resolve inflammatory activation, and suppress destructive immunity to paternally inherited alloantigens. From a biological perspective, the endometrial immune response exerts a form of "quality control"-it promotes implantation success when conditions are favorable but constrains receptivity when physiological circumstances are not ideal. Read More

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Call for Formalized Pathways in Vascular Medicine Training: JACC Review Topic of the Week.

J Am Coll Cardiol 2022 May;79(21):2129-2139

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

The burden of vascular diseases and complexity of their management have been growing. Vascular medicine specialists may help to bridge gaps in care, especially as part of multidisciplinary teams. However, there is a limited number of vascular medicine specialists because of constraints in training. Read More

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Affective disorders: eliminate WArning signs and REstore functioning-AWARE-a randomised controlled multimodule intervention study, presentation of design and intervention.

BMJ Open 2022 May 26;12(5):e058839. Epub 2022 May 26.

Research Unit, North Zealand Psychiatric Center, Hillerod, Copenhagen, Denmark.

Introduction: Affective disorders are associated with impaired overall functioning and quality of life (QoL). Despite different medical and psychological treatment options, the prognosis remains largely unchanged. Consequently, the field needs new intervention strategies especially targeting patient groups with impaired functioning. Read More

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Improving referrals to community mental health services in the liaison setting.

BMJ Open Qual 2022 May;11(2)

Newham Mental Health Liaison and Psychological Medicine Team, Barts Health NHS Trust, London, UK.

The East London Foundation Trust (ELFT) psychiatric liaison team (PLT) at Newham University Hospital (NUH) is responsible for referring adult patients they have reviewed, on to community mental health services on discharge where appropriate, and also to notify their existing team for follow-up on discharge when already under the care of a community service. This should then lead to appropriate ongoing management of the patient's mental health needs in terms of continued support and assessment of risk, further assessment of mental state, titration of medications and prevention of further admissions.Following an ELFT incident review where it was noted that a patient was not referred to community services on discharge, a retrospective case note review was undertaken over an 11-month period to define the baseline efficacy of current referrals. Read More

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The unintended consequences of COVID-19 vaccine policy: why mandates, passports and restrictions may cause more harm than good.

BMJ Glob Health 2022 May;7(5)

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

Vaccination policies have shifted dramatically during COVID-19 with the rapid emergence of population-wide vaccine mandates, domestic vaccine passports and differential restrictions based on vaccination status. While these policies have prompted ethical, scientific, practical, legal and political debate, there has been limited evaluation of their potential unintended consequences. Here, we outline a comprehensive set of hypotheses for why these policies may ultimately be counterproductive and harmful. Read More

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Assessing the burden of COVID-19 in developing countries: systematic review, meta-analysis and public policy implications.

BMJ Glob Health 2022 May;7(5)

Western Sydney Diabetes, Western Sydney Local Health District, Blacktown, New South Wales, Australia

Introduction: The infection fatality rate (IFR) of COVID-19 has been carefully measured and analysed in high-income countries, whereas there has been no systematic analysis of age-specific seroprevalence or IFR for developing countries.

Methods: We systematically reviewed the literature to identify all COVID-19 serology studies in developing countries that were conducted using representative samples collected by February 2021. For each of the antibody assays used in these serology studies, we identified data on assay characteristics, including the extent of seroreversion over time. Read More

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Optimizing Post-Acute Care Patient Safety: A Scoping Review of Multifactorial Fall Prevention Interventions for Older Adults.

J Appl Gerontol 2022 May 26:7334648221104375. Epub 2022 May 26.

Department of Sociology, 14669California State University Los Angeles, Los Angeles, CA, USA.

Accidental falls are preventable adverse events for older post-acute care (PAC) patients. Yet, due to the functional and medical care needs of this population, there is little guidance to inform multidisciplinary prevention efforts. This scoping review aims to characterize the evidence for multifactorial PAC fall prevention interventions. Read More

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Design and application of DNA nanostructures for organelle-targeted delivery of anticancer drugs.

Expert Opin Drug Deliv 2022 May 26. Epub 2022 May 26.

Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 305108, China.

Introduction: DNA nanostructures targeting organelles are of great significance for the early diagnosis and precise therapy of human cancers. This review is expected to promote the development of DNA nanostructure-based cancer treatment with organelle-level precision in the future.

Areas Covered: In this review, we introduce the different principles for targeting organelles, summarize the progresses in the development of organelle-targeting DNA nanostructures, highlight their advantages and applications in disease treatment, and discuss current challenges and future prospects. Read More

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The clean water act and biosolids: A 45-Year chronological review of biosolids land application research in Colorado.

J Environ Qual 2022 May 26. Epub 2022 May 26.

Department of Soil and Crop Sciences, Colorado State University, C127 Plant Sciences Building, Fort Collins, Colorado, 80523-1170, USA.

The 1972 U.S. Clean Water Act (CWA) set forth the generation of biosolids. Read More

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Video Review of Simulated Pediatric Cardiac Arrest to Identify Errors/Latent Safety Threats: A Mixed Methods Study.

Simul Healthc 2022 May 25. Epub 2022 May 25.

From the Departments of Family Medicine (D.G.-J.) and Pediatrics (D.N.), Cumming School of Medicine, University of Calgary, Calgary; and Department of Critical Care Medicine (E.G.), The Hospital for Sick Children, Toronto, Canada.

Introduction: Outcomes from pediatric in-hospital cardiac arrest depend on the treatment provided as well as resuscitation team performance. Our study aimed to identify errors occurring in this clinical context and develop an analytical framework to classify them. This analytical framework provided a better understanding of team performance, leading to improved patient outcomes. Read More

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PREVALENCE AND IMPACT OF COMORBIDITIES IN INDIVIDUALS WITH COPD: A SYSTEMATIC REVIEW.

Tuberc Respir Dis (Seoul) 2022 May 27. Epub 2022 May 27.

State University of Bahia (UNEB), Brazil.

Objectives: To describe the frequency of comorbidities associated with COPD and their relation with relevant outcomes.

Methods: A systematic review based on the PRISMA methodology was performed. The systematic search was carried until July 2021, using the MEDLINE, Lilacs and Scielo databases to identify studies related to COPD and its comorbidities. Read More

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Bereavement support programs in the Intensive Care Unit: a systematic review.

J Pain Symptom Manage 2022 May 23. Epub 2022 May 23.

Department of Intensive Care Medicine, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands. Electronic address:

Objectives: The death of a loved-one in the intensive care unit (ICU) may have a psychological impact on relatives of deceased ICU patients. The first aim of this review is to give an overview of different bereavement support strategies and possible different effects on anxiety, depression, Post Traumatic Stress Disorder (PTSD) and complicated grief. Secondly to assess if there is a difference in organisation among bereavement support strategies mentioned in literature. Read More

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