3,605 results match your criteria revealed well-differentiated

Robot-assisted enucleation of a giant submucosal tumor in the upper esophagus.

Asian J Endosc Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

Few reports have demonstrated robotic surgery for large tumors in the upper esophagus. We report a case of a 52-year-old woman with a giant submucosal tumor in the upper esophagus successfully enucleated using robotic surgery. She presented with odynophagia and dysphagia, with subsequent evaluation revealing a submucosal mass measuring approximately 10 cm in diameter in the upper esophagus. Read More

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Nihon Hinyokika Gakkai Zasshi 2020 ;111(3):102-106

Department of Urology, Teikyo University School of Medicine.

A 39-year-old man was referred to us for further examination of a right inguinal mass. He had noticed the mass several months prior and had undergone positron emission tomography/computed tomography, which revealed a mass with an SUVmax of 1.48 at the right inguinal subcutis. Read More

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January 2020

Risk factors for lymph node metastasis in rectal neuroendocrine tumors: A recursive partitioning analysis based on multicenter data.

J Surg Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Background: The well-differentiated rectal neuroendocrine tumors (RNETs) can also have lymph node metastasis (LNM). Large multicenter data were reviewed to explore the risk factors for LNM in RNETs. Further, we developed a model to predict the risk of LNM in RNETs. Read More

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Total thyroidectomy can still remain the method of choice in some Bethesda III cases.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jul 20. Epub 2021 Jul 20.

Institute of Pathology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: The latest WHO classification of tumours of endocrine organs defines new units of borderline thyroid tumours (BTT). The aim of our study was to evaluate ultrasonographic and cytological features, mutation profile and surgery treatment in rare thyroid tumours.

Methods: An analysis of 8 BTT out of 487 patients, who underwent thyroid surgery between June 2016 and June 2020. Read More

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First case of huge classic papillary thyroid cancer rupturing spontaneously leading to ischemic necrosis, perforation and inflammation of overlying skin: Case report and review of the literature.

Int J Surg Case Rep 2021 Jun 29;85:106136. Epub 2021 Jun 29.

Department of General Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

Introduction: Papillary thyroid cancer (PTC) is the commonest form of well-differentiated endocrine carcinoma. It is categorized into indolent and aggressive, where the indolent subtypes (classic, follicular) rarely demonstrate aggressive behavior. We present a classic PTC presenting with a rapidly growing huge anterior neck mass that subsequently spontaneously ruptured subcutaneously resulting in ischemia, necrosis, and perforation of overlying skin leading to inflammation. Read More

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Sentinel Lymph Node Mapping in Endometrial Cancer: A Comprehensive Review.

Front Oncol 2021 29;11:701758. Epub 2021 Jun 29.

Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, China.

Endometrial cancer (EC) is known as a common gynecological malignancy. The incidence rate is on the increase annually. Lymph node status plays a crucial role in evaluating the prognosis and selecting adjuvant therapy. Read More

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Increased thyroid malignancy in patients with primary hyperparathyroidism.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

L Sheng, Department of Thyroid Surgery, Shandong University Qilu Hospital, Jinan, China.

Background: Multiple studies have reported increased incidence of thyroid cancer in patients with primary hyperparathyroidism (PHPT). However, the underlying risk factors of concomitant thyroid cancer in patients with PHPT remain unknown. The primary aim of this study was to examine the records of patients with PHPT to identify characteristics that correlated with the presence of coexisting thyroid nodules, and which may have an implication for the prediction of thyroid cancer. Read More

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A Case of Profound Secretory Diarrhea Revealing 2 Primary Neuroendocrine Tumors.

ACG Case Rep J 2021 Jul 8;8(7):e00625. Epub 2021 Jul 8.

Department of Gastroenterology, SUNY Upstate Medical University, Syracuse, NY.

Neuroendocrine tumors (NETs) are unusual neoplasms with a diverse spectrum of clinical presentations. There is a lack of literature on cases of 2 primary histologically distinct NETs. We report a case of a 40-year-old man who presented with chronic diarrhea. Read More

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Possible spontaneous regression of hepatocellular carcinoma with unique histopathological features confirmed by surgical resection: a case report.

Surg Case Rep 2021 Jul 13;7(1):162. Epub 2021 Jul 13.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.

Background: Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, and its clinicopathological features and underlying mechanism are not fully understood.

Case Presentation: An 84-year-old female with hepatitis C virus infection and diabetes mellitus was referred to our hospital for further examination. Abdominal ultrasonography showed a 3. Read More

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Contrasting Phylogeographic Patterns in Mangroves Across the Indo-West Pacific.

Front Plant Sci 2021 23;12:637009. Epub 2021 Jun 23.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Mangroves are ecologically important forest communities in tropical and subtropical coasts, the effective management of which requires understanding of their phylogeographic patterns. However, these patterns often vary among different species, even among ecologically similar taxa or congeneric species. Here, we investigated the levels and patterns of genetic variation within consisting of two species ( and ) with nearly sympatric ranges across the Indo-West Pacific (IWP) region by sequencing three chloroplast DNA regions (for both species) and genotyping 11 nuclear microsatellite loci (for ). Read More

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[Preoperative diagnosis of small intestinal cancer associated with Crohn's disease: a case report].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(7):645-651

Department of Gastroenterology, Kitasato University School of Medicine.

The patient was a 46-year-old woman with a history of Crohn's disease for several years. At 45 years of age, a colonoscopy was performed, and a protruding lesion in the terminal ileum was detected. Pathological analysis of a biopsy specimen noted high suspicion for a well differentiated adenocarcinoma. Read More

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Off Clamping Laparoscopic Resection of An Extreme Rare Renal Mesenchymal Tumor: An Angiomyolipoma of Renal Capsule.

Urol J 2021 07 11. Epub 2021 Jul 11.

Assistant professor of pathology department of Shiraz University of medical science.

Objective: Renal mesenchymal tumors are described as neoplasms with vascular, fibrous and adipose tissues. The renal lipoma is extremely rare renal mesenchymal tumor, typically originating from renal capsule and it is usually presented as well circumscribed homogenous fat containing mass. Angiomyolipoma (AML) is the most common benign mesenchymal renal tumor which is composed mature epithelioid cell. Read More

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Hepatic Cavernous Hemangioma Mimicking Metastasis of Midgut Neuroendocrine Neoplasia on 18F-Fluorodihydroxyphenylalanine PET/CT.

Clin Nucl Med 2021 Jul 6. Epub 2021 Jul 6.

From the Department of Nuclear Medicine, Faculty of Medicine of Comenius University, St Elisabeth's Cancer Institute Department of Heart Failure and Transplantation, National Institute for Cardiovascular Diseases, Bratislava Departments of Surgery Pathological Anatomy, Jessenius Faculty of Medicine in Martin, Comenius University of Bratislava, Martin, Slovakia.

Abstract: A 61-year-old man after resection of well-differentiated midgut neuroendocrine neoplasia (NEN) was referred to 18F-fluorodihydroxyphenylalanine PET/CT for localization of recurrent midgut NEN in the context of clinical symptoms and mild elevation of serum CgA (chromogranin A) levels. Isolated hepatic focus of increased 18F-Fluorodihydroxyphenylalanine uptake was detected. The biopsy of this focus, followed by radiofrequency ablation, revealed a hepatic cavernous hemangioma. Read More

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Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness.

Cancers (Basel) 2021 Jun 22;13(13). Epub 2021 Jun 22.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

Liposarcoma (LPS) is an adult soft tissue malignancy that arises from fat tissue, where well-differentiated (WD) and dedifferentiated (DD) forms are the most common. DDLPS represents the progression of WDLPS into a more aggressive high-grade and metastatic form. Although a few DNA copy-number amplifications are known to be specifically found in WD- or DDLPS, systematic genetic differences that signify subtype determination between WDLPS and DDLPS remain unclear. Read More

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Gastroenteropancreatic neuroendocrine tumor of the accessory papilla of the duodenum: a case report.

Surg Case Rep 2021 Jun 30;7(1):156. Epub 2021 Jun 30.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: Contrary to the increasing incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), GEP-NETs of the accessory papilla of the duodenum are extremely rare. Furthermore, there have been no recommendations regarding the treatment strategy for GEP-NETs of the accessory papilla of the duodenum. We present a case of GEP-NET of the accessory papilla of the duodenum successfully treated with robotic pancreatoduodenectomy. Read More

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A Rare Collision Tumor: Adenocarcinoma in the Ampulla of Vater and Neuroendocrine Tumor in the Lower Part of the Common Bile Duct.

Cureus 2021 Jun 24;13(6):e15882. Epub 2021 Jun 24.

Diagnostic Pathology Clinic, Pathos Tsutsumi, Inazawa, JPN.

In the biliary tree, only three cases of neuroendocrine tumor (NET) synchronous with adenocarcinoma have been reported so far. We experienced a case of NET, grade 2 (G2), of the common bile duct associated with adenocarcinoma of the ampulla of Vater (AoV). A Japanese man at his 60's visited a local doctor, and obstructive jaundice was pointed out. Read More

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18F-FDG PETCT and 68Ga-DOTA PETCT mismatch with in vivo histopathological characterization of low-grade neuroendocrine pancreatic tumor.

Eur J Hybrid Imaging 2021 May 10;5(1). Epub 2021 May 10.

Oncology Center, Hospital Sírio-Libanês (HSL), Rua Dona Adma Jafet, 91, São Paulo, 01308-050, Brazil.

Background: Pancreatic neuroendocrine tumor (PNET) is a subgroup of neuroendocrine tumor (NET) that has unique biology and natural history. The histological classification has a major role in the management of this pathology, but in recent years Gallium 68 dotatate (68Ga-DOTA) scanning is at the center of a discussion about how these imaging technologies can modify clinical management of neuroendocrine tumors and how their results are correlated to Ki67 index.

Method: We hereby describe a case of a patient that investigated an unspecific stable pancreatic nodule suspected of high-grade NET after evaluation with 68Ga-DOTATOC positron emission tomography-computed tomography (PETCT) and F-Fluorodeoxyglucose (F-FDG) PETCT. Read More

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Rectal Squamous Cell Cancer.

Cureus 2021 May 20;13(5):e15133. Epub 2021 May 20.

Radiation Oncology, AdventHealth Florida, Sebring, USA.

Squamous cell carcinoma occurring in the rectum is one of the rare malignancies that has been discovered. Most squamous cell carcinomas that surface in the gastrointestinal tract tend to occur in either the esophagus or the anal canal. However, the rare incidence of rectal squamous cell carcinomas has raised quite a few questions on the hypothetical etiologies, prognosis, and optimal treatment sequence of such a disease course in modern medicine. Read More

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Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2.

Emerg Infect Dis 2021 07;27(7):1811-1820

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, and the number of worldwide cases continues to rise. The zoonotic origins of SARS-CoV-2 and its intermediate and potential spillback host reservoirs, besides humans, remain largely unknown. Because of ethical and experimental constraints and more important, to reduce and refine animal experimentation, we used our repository of well-differentiated airway epithelial cell (AEC) cultures from various domesticated and wildlife animal species to assess their susceptibility to SARS-CoV-2. Read More

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Concomitant hilar cholangiocarcinoma with choledochal cyst and cholelithiasis in an asymptomatic patient: A case report.

Int J Surg Case Rep 2021 Jul 11;84:106094. Epub 2021 Jun 11.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal.

Introduction And Importance: Choledochal cyst is an important risk factor for cholangiocarcinoma. Concomitant hilar cholangiocarcinoma with choledochal cyst with cholelithiasis is a rare finding.

Case Presentation: A 52-year-old male presented with non-specific complaints of generalized weakness for 3 months. Read More

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Feasibility and Outcomes of Multivisceral Resection in Locally Advanced Colorectal Cancer: Experience of a Tertiary Cancer Center in North-East India

Ann Coloproctol 2020 07 3;37(3):174-178. Epub 2020 Jul 3.

Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India.

Purpose: Locally advanced colorectal cancer may require an en bloc resection of surrounding organs or structures to achieve complete tumor removal. This decision must weigh the risk of complications of multivisceral resection against the potential survival benefit. The purpose of this study is to review a single-center experience of feasibility of en bloc multivisceral resections for locally advanced colorectal carcinoma and to examine the effect of surgical experience on immediate outcome and rate of R0 resections. Read More

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COVID-19 vaccination may cause FDG uptake beyond axillary area.

Eur J Hybrid Imaging 2021 1;5(1):11. Epub 2021 Jun 1.

Department of Nuclear Medicine, ICO Gauducheau Cancer Center, Boulevard Monod, 44805 Saint-Herblain Cedex,, France.

Background: The vaccination immune response may induce false-positive F-FDG PET/CT uptake.

Case Presentation: An extended supraclavicular lymph nodal activation after coronavirus disease 2019 (COVID-19) vaccination revealed on F-FDG PET/CT mimics a Virchow nodule in a patient with medical history of well-differentiated appendicular adenocarcinoma.

Conclusion: This case highlights a nodal activation beyond axillary area and the importance of documenting vaccination history at the time of scanning to avoid false-positive results. Read More

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Well-Differentiated Thyroid Cancer Invading the Trachea in a Pediatric Patient.

AACE Clin Case Rep 2021 May-Jun;7(3):207-210. Epub 2021 Mar 23.

University of Michigan, Department of Otolaryngology-Head and Neck Surgery, Ann Arbor, Michigan.

Objectives: Pediatric thyroid cancer is rare. Most cases are well-differentiated thyroid cancers (WDTCs). However, gross laryngotracheal invasion of WDTCs is unusual. Read More

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Quantitative analysis of KLF4 and SOX2 expression in oral carcinomas reveals independent association with oral tongue subsite location and histological grade.

Cancer Biomark 2021 May 28. Epub 2021 May 28.

Surgical Pathology Laboratory, Oral Pathology Department, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.

Background: Stemness factors associated with tumorigenesis in different types of cancers have not been specifically studied in oral tongue SCC (OTSSC). Here, we aimed to quantify expression levels and distribution of KLF4 and SOX2, two relevant stemness factors, in oral SCC including OTSCC samples from different subsites.

Methods And Results: We determined KLF4 and SOX2 expression levels by immunostaining 35 biopsies of OSCC. Read More

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Wiad Lek 2021 ;74(5):1277-1280


The authors have analyzed medical histories of two patients, treated in health care facilities of Kharkiv region from 2008 to 2020. These patients underwent urgent appendectomy, given the existing clinic of acute appendicitis. Morphological examination of the surgical material allowed us to diagnose adenocarcinoma in one case, and neuroendocrine tumor in combination with endometriosis in the other case. Read More

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Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification.

Head Neck Pathol 2021 Jun 4. Epub 2021 Jun 4.

Department of Laboratory Medicine and Pathology, Anatomic Pathology Division, Hamad Medical Corporation, Doha, Qatar.

Well-differentiated liposarcoma (WDL) is one of the most common soft tissue sarcomas in adults. It has a predilection for middle-aged males and arises in deep-seated locations such as retroperitoneum, mediastinum, and spermatic cord. Its occurrence in young individuals at the hypopharyngeal region is an exceedingly rare event. Read More

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Carcinoma Cuniculatum of the Oral Cavity: A Series of 6 Cases and Review of Literature.

Head Neck Pathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, 400012, India.

Carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma (SCC) that is characterized by minimal cytologic atypia and a unique deeply infiltrative growth pattern resembling rabbit burrows (cuniculi). With less than 75 cases reported in the head and neck, the clinical and pathologic spectrum of this entity remains poorly understood. A retrospective review of the clinical and pathologic features of archival cases of oral CC was performed. Read More

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The Expression of Selected Wnt Pathway Members (FZD6, AXIN2 and β-Catenin) in Canine Oral Squamous Cell Carcinoma and Acanthomatous Ameloblastoma.

Animals (Basel) 2021 May 29;11(6). Epub 2021 May 29.

Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 602 00 Brno, Czech Republic.

The Wnt signaling pathway is well known to be involved in many types of human cancer; however, in veterinary medicine, the investigation of individual Wnt members' expression, and their role in or association with oral tumor pathogenesis, is still underevaluated. We aim to determine the expression pattern of Frizzled-6 (FZD6) as one of the Wnt receptors in two of the most common canine oral neoplastic lesions-canine oral squamous cell carcinoma (COSCC) and canine acanthomatous ameloblastoma (CAA). While COSCC is a malignant tumor with aggressive biological behavior and a tendency to metastasize, CAA is a benign tumor with high local invasiveness. Read More

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Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells.

Virulence 2021 12;12(1):1111-1121

Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany.

Coronaviruses and influenza viruses are circulating in humans and animals all over the world. Co-infection with these two viruses may aggravate clinical signs. However, the molecular mechanisms of co-infections by these two viruses are incompletely understood. Read More

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December 2021

68Ga-DOTATATE PET/CT Distinguishes Neuroendocrine Tumor Mesenteric Lymph Node Metastasis From an Extensive IgG4-Positive Fibrosis Surrounding It.

Clin Nucl Med 2021 May 26. Epub 2021 May 26.

From the Departments of Nuclear Medicine Digestive Oncology, University Hospitals Leuven, Leuven Department of Gastroenterology, Imelda Hospital, Bonheiden Department of Anatomical Pathology, University Hospitals Leuven, Leuven Department of Anatomical Pathology, Imelda Hospital, Bonheiden, Belgium.

Abstract: A 56-year-old woman presented with right iliac fossa pain. Abdominal CT showed a mesenteric mass in the right iliac fossa, adjacent to the vena cava inferior and right ureter. Biopsy of the mass revealed a well-differentiated neuroendocrine tumor. Read More

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