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Comparison of Needle, Ultrasonic, and Laser Irrigation for the Removal of Calcium Hydroxide from Mandibular Molar Root Canals.

Photobiomodul Photomed Laser Surg 2021 May 9;39(5):349-354. Epub 2020 Dec 9.

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.

This study aimed to compare the efficacy of conventional needle irrigation (CI), ultrasonically activated irrigation (UAI), photon-induced photoacoustic streaming (PIPS), and shock wave-enhanced emission photoacoustic streaming (SWEEPS) in removing calcium hydroxide [Ca(OH)] from root canals of mandibular molars using microcomputed tomography. Various adjunctive irrigation strategies have been recommended to improve the removal of Ca(OH). No reports have evaluated the SWEEPS laser-activated method for the removal of Ca(OH) from root canals of mandibular molars. Read More

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Improved AcroQoL scores in acromegaly after sagittal split ramus osteotomy with Le Fort I osteotomy.

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine.

Summary: Acromegaly is associated with a low quality of life (QoL), which is partially attributable to appearance. However, appearance changes are only partially reversible with treatments of growth hormone excess. This case study describes a 41-year-old Japanese man who presented with mandibular prognathism. Read More

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Comparison of Efficacy of Different Surgical Techniques for Benign Prostatic Obstruction.

Int Neurourol J 2021 May 5. Epub 2021 May 5.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: We compared success rates of three surgical techniques [holmium laser enucleation of the prostate (HoLEP), transurethral resection of the prostate (TURP), and photoselective laser vaporization prostatectomy (PVP)] for treatment of benign prostatic obstruction (BPO). We aimed to identify preoperative clinical variables and urodynamic parameters that predict surgical success.

Methods: A total of 483 patients who underwent surgical treatment for BPO at Samsung Medical Center between 2006 and 2017 were retrospectively analyzed; of these 361, 81, and 41 patients underwent HoLEP, TURP, and PVP, respectively. Read More

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Compound heterozygous p. Arg949Trp and p. Gly970Ala mutations deteriorated the function of PEX1p: A study on PEX1 in a patient with Zellweger syndrome.

J Cell Biochem 2021 May 6. Epub 2021 May 6.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Postal Code 81746-73441, Iran.

The peroxisome is responsible for a variety of vital pathways in primary metabolism, including the very long-chain fatty-acid oxidation and plasmalogen lipid biosynthesis. Autosomal recessive disorder of the Zellweger spectrum (ZSD) is a major subset of peroxisome biogenesis disorders (PBDs) that can be caused by mutations in any of the 14 PEX genes. Zellweger syndrome (ZS) is the foremost common and severe phenotype within the heterogeneous ZSD. Read More

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Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase.

Genetics 2019 Dec;213(4):1255-1269

Institute for Protein Research, Osaka University, 565-0871, Japan.

The number and distribution of meiotic crossovers (COs) are highly regulated, reflecting the requirement for COs during the first round of meiotic chromosome segregation. CO control includes CO assurance and CO interference, which promote at least one CO per chromosome bivalent and evenly-spaced COs, respectively. Previous studies revealed a role for the DNA damage response (DDR) clamp and the clamp loader in CO formation by promoting interfering COs and interhomolog recombination, and also by suppressing ectopic recombination. Read More

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December 2019

Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase.

Genetics 2019 Dec;213(4):1255-1269

Institute for Protein Research, Osaka University, 565-0871, Japan.

The number and distribution of meiotic crossovers (COs) are highly regulated, reflecting the requirement for COs during the first round of meiotic chromosome segregation. CO control includes CO assurance and CO interference, which promote at least one CO per chromosome bivalent and evenly-spaced COs, respectively. Previous studies revealed a role for the DNA damage response (DDR) clamp and the clamp loader in CO formation by promoting interfering COs and interhomolog recombination, and also by suppressing ectopic recombination. Read More

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December 2019

A rare case of a necrotized urethral prolapse in a postmenopausal woman with acute urinary retention.

Low Urin Tract Symptoms 2021 May 5. Epub 2021 May 5.

Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Case: Urethral prolapse (UP) is a rare condition with unknown etiology. We reported on an 86-year-old woman with a normal BMI and cystocele, presented with acute urinary retention and perineal pain. A residual urine of 950 mL was measured and released by an indwelling catheter. Read More

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Collateral ligament sprains of the metacarpophalangeal joint of the long fingers: Results of a surgical series of 15 patients.

Orthop Traumatol Surg Res 2021 May 2. Epub 2021 May 2.

Institut Montpelliérain de la Main et du Membre Supérieur, Clinique Saint-Roch, 560 Avenue du Colonel Pavelet, 34070 Montpellier, France.

Introduction Collateral ligament sprains of the metacarpophalangeal joint (MP) of the long fingers are rare and mostly treated conservatively. Clinical examination to diagnose the severity of these injuries is mandatory. The purpose of our study is to report the results of 15 patients treated surgically. Read More

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Identification of RORγ as a favorable biomarker for colon cancer.

J Int Med Res 2021 May;49(5):3000605211008338

Department of Colorectal and Anal Surgery, the Affiliated Hospital of West Anhui Health Vocational College, Lu'an, China.

Objective: To evaluate the expression of retinoid-related orphan receptor gamma (RORγ) and its potential role in the prognosis of colon cancer.

Methods: The Cancer Genome Atlas and GSE117606 were used to evaluate to RORγ levels in colon cancer, and real-time quantitative polymerase chain reaction was applied for validation. UALCAN and MEXPRESS were used to analyze the associations of RORγ expression with clinical parameters. Read More

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Development and Clinical Evaluation of an Immunochromatography-Based Rapid Antigen Test (GenBody™ COVAG025) for COVID-19 Diagnosis.

Viruses 2021 04 29;13(5). Epub 2021 Apr 29.

Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University, Iksan 570749, Korea.

Antigen tests for SARS-CoV-2 diagnosis are simpler and faster than their molecular counterparts. Clinical validation of such tests is a prerequisite before their field applications. We developed and clinically evaluated an immunochromatographic immunoassay, GenBody™ COVAG025, for the rapid detection of SARS-CoV-2 nucleocapsid (NP) antigen in two different clinical studies. Read More

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Mechanical and Thermal Properties of Synthetic Polypropylene Fiber-Reinforced Renewable Oil Palm Shell Lightweight Concrete.

Materials (Basel) 2021 Apr 30;14(9). Epub 2021 Apr 30.

Department of Civil Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Cheras, Kajang 43000, Malaysia.

Oil palm shell (OPS) is an agricultural solid waste from the extraction process of palm oil. All these wastes from industry pose serious disposal issues for the environment. This research aims to promote the replacement of conventional coarse aggregates with eco-friendly OPS aggregate which offers several advantages, such as being lightweight, renewable, and domestically available. Read More

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Chlorine disinfection facilitates natural transformation through ROS-mediated oxidative stress.

ISME J 2021 May 3. Epub 2021 May 3.

Advanced Water Management Centre (AWMC), The University of Queensland, St Lucia, Brisbane, QLD, Australia.

The bacterial infection that involves antimicrobial resistance is a rising global threat to public health. Chlorine-based water disinfection processes can inactivate antibiotic resistant bacteria. However, at the same time, these processes may cause the release of antibiotic resistance genes into the water as free DNA, and consequently increase the risk to disseminate antibiotic resistance via natural transformation. Read More

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Comparison of the Siemens Atellica BRAHMS and the Abbott Architect BRAHMS Procalcitonin Assays.

Ann Clin Lab Sci 2021 Mar;51(2):241-244

Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA

Objective: In this study, we compared the Abbott Architect B.R.A. Read More

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Staged Repositioning in Endoscopic Endonasal Odontoidectomy Maximizes Decompression while Allowing Preservation of the C1 Anterior Arch: A Technical Note.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213. Electronic address:

Background: Preservation of the anterior arch of C1 in endoscopic endonasal odontoidectomy has been proposed as an alternative to complete C1 arch resections, potentially affording less destabilization of the craniocervical junction. Nonetheless, this approach may limit the decompression achieved. In this case, intra-operative repositioning allowed maximal decompression while preserving the anterior arch of C1. Read More

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Placement of a Zenith® Dissection Endovascular System in the Descending Thoracic Aorta Can Hamper Further Surgical Aortic Operations.

EJVES Vasc Forum 2020 29;48:1-4. Epub 2020 May 29.

Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Saga University, Saga, Japan.

Introduction: The efficacy of endovascular treatment for complicated Stanford type B acute aortic dissection is being established. However, aortic events sometimes occur, and some cases require surgical intervention.

Report: A 52 year old man underwent ascending aorta replacement for Stanford type A acute aortic dissection in August 2016. Read More

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Outcomes of Transvaginal Anterior Levatorplasty with Posterior Colporrhaphy for Symptomatic Rectocele.

J Anus Rectum Colon 2021 28;5(2):137-143. Epub 2021 Apr 28.

Department of Surgery, Fujita Health University School of Medicine, Toyoake, Japan.

Objectives: To clarify the long-term outcomes of transvaginal anterior levatorplasty with posterior colporrhaphy for symptomatic rectocele with defecographic changes.

Methods: Consecutive patients undergoing transvaginal anterior levatorplasty with posterior colporrhaphy for symptomatic rectocele were prospectively registered and retrospectively reviewed using medical records. Symptoms, fecal incontinence, and defecographic findings were evaluated before and after surgery. Read More

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The efficacy of Coenzyme Q10 and liquid paraffin oil in the management of acute aluminum phosphide poisoning.

Toxicol Res (Camb) 2020 Jul 2;9(4):444-453. Epub 2020 Jul 2.

Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.

Aluminum phosphide (AlP) poisoning had high morbidities and mortalities with absence of a standardized approach for the treatment. The present study investigated the efficiency of GIT decontamination methods and Coenzyme Q10(Co Q10) (Ubiquinone) in improving the outcome of acute AlP poisoning. A total of 90 patients were included and all patients received immediately supportive measures, then they distributed into three equal groups: In group I, gastric lavage was done using KMNO solution (1:10 000); group II received 250-500 ml liquid paraffin oil orally; group III received 300 mg of Co Q10 dissolved in liquid paraffin. Read More

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Factors associated with adjacent-level tumor progression in patients receiving surgery followed by radiosurgery for metastatic epidural spinal cord compression.

Neurosurg Focus 2021 May;50(5):E15

Departments of1Neurosurgery.

Objective: Separation surgery followed by spine stereotactic radiosurgery (SSRS) has been shown to achieve favorable rates of local tumor control and patient-reported outcomes in patients with metastatic epidural spinal cord compression (MESCC). However, rates and factors associated with adjacent-level tumor progression (ALTP) in this population have not yet been characterized. The present study aimed to identify factors associated with ALTP and examine its association with overall survival (OS) in patients receiving surgery followed by radiosurgery for MESCC. Read More

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ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.

J Exp Clin Cancer Res 2021 Apr 30;40(1):149. Epub 2021 Apr 30.

Department of Radiotherapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.

Background: Radiotherapy is a conventional and effective local treatment for breast cancer. However, residual or recurrent tumors appears frequently because of radioresistance. Novel predictive marker and the potential therapeutic targets of breast cancer radioresistance needs to be investigated. Read More

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First Direct Evidence of Interpartner Hydride/Deuteride Exchanges for Stored Sodiated Arginine/Fructose-6-phosphate Complex Anions within Salt-Solvated Structures.

J Am Soc Mass Spectrom 2021 Apr 30. Epub 2021 Apr 30.

Sorbonne Université, Faculté des Sciences et de l'Ingénierie, Institut Parisien de Chimie Moléculaire (IPCM), F-75005 Paris, France.

Mass spectrometric investigations of noncovalent binding between low molecular weight compounds revealed the existence of gas-phase (GP) noncovalent complex (NCC) ions involving zwitterionic structures. ESI MS is used to prove the formation of stable sodiated NCC anions between fructose (F6P) and arginine (R) moieties. Theoretical calculations indicate a folded solvated salt (i. Read More

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Inadequate spinal cord expansion in intraoperative ultrasound after decompression may predict neurological recovery of degenerative cervical myelopathy.

Eur Radiol 2021 Apr 30. Epub 2021 Apr 30.

Guangdong Provincial Biomedical Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopedic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China.

Objective: To compare the neurological recovery between patients with adequate and inadequate immediate spinal cord expansion after sufficient decompression in degenerative cervical myelopathy (DCM).

Methods: Twenty-seven patients subjected to French-door laminoplasty underwent the guidance of intraoperative ultrasound (IOUS) and were prospectively included. The modified Japanese Orthopedic Association (mJOA) score was evaluated before surgery and at 12 months postoperatively. Read More

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Functional Analysis of an Essential GSP1/Ran Ortholog Gene, , from the Chestnut Blight Fungus Using a Heterokaryon.

J Fungi (Basel) 2021 Apr 25;7(5). Epub 2021 Apr 25.

Department of Molecular Biology, Institute for Molecular Biology and Genetics, Jeonbuk National University, 567 Baekje-daero, Jeonju, Chonbuk 54896, Korea.

Functional analysis of a GSP1/Ran ortholog, , from was conducted. Genotype analysis revealed that the putative -null mutant was a heterokaryotic transformant harboring two different types of nuclei, one with the wild-type allele and the other with the -null mutant allele. The mycelial growth and colony morphology of the heterokaryotic transformant was normal. Read More

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Cardiorespiratory Fitness in Volleyball Athletes Following a COVID-19 Infection: A Cross-Sectional Study.

Int J Environ Res Public Health 2021 04 12;18(8). Epub 2021 Apr 12.

Faculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia.

Athletes' lifestyles have been dramatically affected by the coronavirus disease 2019 (COVID-19) pandemic. Since COVID-19 primarily affects the respiratory system and to a lesser degree the cardiovascular system, the goal of this study was to examine the effects of COVID-19-caused detraining on cardiorespiratory fitness (CRF) of recently recovered volleyball athletes. Sixteen experienced volleyball athletes (age 24 ± 4. Read More

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Change of 0.34Cr-1Ni-Mo-Fe Steel Dislocation Structure in Plasma Electrolyte Hardening.

Materials (Basel) 2021 Apr 12;14(8). Epub 2021 Apr 12.

Research Center Surface Engineering and Tribology, Sarsen Amanzholov East-Kazakhstan University, Ust-Kamenogorsk 070000, Kazakhstan.

This work deals with the study of changes in the dislocation structure and quantitative characteristics, as well as morphological components, of 0.34Cr-1Ni-Mo-Fe steel before and after plasma electrolytic hardening. According to the electron microscopic studies of the fine structure of 0. Read More

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Elevated-Temperature Performance, Combustibility and Fire Propagation Index of Fly Ash-Metakaolin Blend Geopolymers with Addition of Monoaluminium Phosphate (MAP) and Aluminum Dihydrogen Triphosphate (ATP).

Materials (Basel) 2021 Apr 15;14(8). Epub 2021 Apr 15.

Geopolymer and Green Technology, Center of Excellence (CEGeoGTech), Universiti Malaysia Perlis, Kangar 01000, Malaysia.

Thermal performance, combustibility, and fire propagation of fly ash-metakaolin (FA-MK) blended geopolymer with the addition of aluminum triphosphate, ATP (Al(HPO)), and monoaluminium phosphate, MAP (AlPO) were evaluated in this paper. To prepare the geopolymer mix, fly ash and metakaolin with a ratio of 1:1 were added with ATP and MAP in a range of 0-3% by weight. The fire/heat resistance was evaluated by comparing the residual compressive strengths after the elevated temperature exposure. Read More

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Identification of Potential Leukocyte Biomarkers Related to Drug Recovery of CFTR: Clinical Applications in Cystic Fibrosis.

Int J Mol Sci 2021 Apr 10;22(8). Epub 2021 Apr 10.

Department of Experimental Medicine (DIMES), University of Genova, 16126 Genova, Italy.

The aim of this study was the identification of specific proteomic profiles, related to a restored cystic fibrosis transmembrane conductance regulator (CFTR) activity in cystic fibrosis (CF) leukocytes before and after ex vivo treatment with the potentiator VX770. We used leukocytes, isolated from CF patients carrying residual function mutations and eligible for Ivacaftor therapy, and performed CFTR activity together with proteomic analyses through micro-LC-MS. Bioinformatic analyses of the results obtained revealed the downregulation of proteins belonging to the leukocyte transendothelial migration and regulation of actin cytoskeleton pathways when CFTR activity was rescued by VX770 treatment. Read More

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On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI.

Curr Oncol 2021 Apr 7;28(2):1437-1446. Epub 2021 Apr 7.

Department of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, Germany.

Primary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth (mGBM), is associated with very poor prognosis. Several clinical parameters have been identified to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the influence of radiological parameters on survival for mGBM cohorts is scarce. This study evaluated the prognostic value of several volumetric parameters derived from magnetic resonance imaging (MRI). Read More

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Uniaxial Tensile Behavior, Flexural Properties, Empirical Calculation and Microstructure of Multi-Scale Fiber Reinforced Cement-Based Material at Elevated Temperature.

Materials (Basel) 2021 Apr 7;14(8). Epub 2021 Apr 7.

School of Civil Engineering and Architecture, Zhengzhou University of Aeronautics, Zhengzhou 450046, China.

Fire is one of the most unfavorable conditions that cement-based composites can face during their service lives. The uniaxial tensile and flexural tensile properties of the steel-polyvinyl alcohol fiber-calcium carbonate whisker (CW) multi-scale fiber reinforced cement matrix composites (MSFRCs) under high temperatures are studied, including strength, deformation capacity, energy dissipation capacity, and its ability to be assessed through the empirical calculation method. The study showed that with the increase of the treatment temperature, the MSFRC residual bending strength, bending toughness, and tensile strength decreased overall, but the decline was slow at 600 °C. Read More

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Lost small envelope protein expression from naturally occurring preS1 deletion mutants of hepatitis B virus is often accompanied by increased HBx and core protein expression as well as genome replication.

J Virol 2021 Apr 28. Epub 2021 Apr 28.

Department of Pathobiology, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China

Hepatitis B virus (HBV) transcribes co-terminal mRNAs of 0.7-3.5kb from the 3. Read More

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Multidisciplinary surgical approach to renal cancer with vena cava invasion and pulmonary embolism.

Rozhl Chir 2021 ;100(2):88-93

Introduction: Renal cancer is unique for many reasons. One reason is that renal cell carcinoma can grow directly into the drainage veins of the kidney, which enter the inferior vena cava leading to the heart. This growth of tumor cells into the veins is called a tumor thrombus and is a locally aggressive renal cancer. Read More

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