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AMPAR interacting protein CPT1C enhances surface expression of GluA1-containing receptors.

Front Cell Neurosci 2014 2;8:469. Epub 2015 Feb 2.

Laboratori de Neurobiologia, Area de Neurobiologia Cellular i Molecular, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL L'Hospitalet de Llobregat, Spain ; Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona L'Hospitalet de Llobregat, Spain.

AMPARs mediate the vast majority of fast excitatory synaptic transmission in the brain and their biophysical and trafficking properties depend on their subunit composition and on several posttranscriptional and posttranslational modifications. Additionally, in the brain AMPARs associate with auxiliary subunits, which modify the properties of the receptors. Despite the abundance of AMPAR partners, recent proteomic studies have revealed even more interacting proteins that could potentially be involved in AMPAR regulation. Read More

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February 2015
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