143,293 results match your criteria revealed multiple


Physiological and pathological functions of βB2-crystallins in multiple organs: a systematic review.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Changhai Hospital, Naval Military Medical University, Yangpu, Shanghai 200433, China.

Crystallins, the major constituent proteins of mammalian lenses, are significant not only for the maintenance of eye lens stability, transparency, and refraction, but also fulfill various physiopathological functions in extraocular tissues. βB2-crystallin, for example, is a multifunctional protein expressed in the human retina, brain, testis, ovary, and multiple tumors. Mutations in the βB2 crystallin gene or denaturation of βB2-crystallin protein are associated with cataracts, ocular pathologies, and psychiatric disorders. Read More

View Article and Full-Text PDF

Pesticides are the dominant stressors for vulnerable insects in lowland streams.

Water Res 2021 May 17;201:117262. Epub 2021 May 17.

Department of River Ecology, Helmholtz Centre for Environmental Research, UFZ, 04318 Leipzig, Germany.

Despite elaborate regulation of agricultural pesticides, their occurrence in non-target areas has been linked to adverse ecological effects on insects in several field investigations. Their quantitative role in contributing to the biodiversity crisis is, however, still not known. In a large-scale study across 101 sites of small lowland streams in Central Europe, Germany we revealed that 83% of agricultural streams did not meet the pesticide-related ecological targets. Read More

View Article and Full-Text PDF

Is a cloud-based platform useful for diabetes management in Colombia? The Tidepool experience.

Comput Methods Programs Biomed 2021 May 27;208:106205. Epub 2021 May 27.

Hospital Universitario San Ignacio, Carrera 7 No 40 - 62, Bogotá, Colombia.

Background: There are several medical devices used in Colombia for diabetes management, most of which have an associated telemedicine platform to access the data. In this work, we present the results of a pilot study evaluating the use of the Tidepool telemedicine platform for providing remote diabetes health services in Colombia across multiple devices.

Method: Individuals with Type 1 and Type 2 diabetes using multiple diabetes devices were recruited to evaluate the user experience with Tidepool over three months. Read More

View Article and Full-Text PDF

Expression profiling, immune functions, and molecular characteristics of the tetraspanin molecule CD63 from Amphiprion clarkii.

Dev Comp Immunol 2021 Jun 9:104168. Epub 2021 Jun 9.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:

CD63, a member of the tetraspanin family, is involved in the activation of immune cells, antiviral immunity, and signal transduction. The economically important anemonefishes Amphiprion sp. often face disease outbreaks, and the present study aimed to characterize CD63 in Amphiprion clarkii (denoted AcCD63) to enable better disease management. Read More

View Article and Full-Text PDF

Nurse turnover: A longitudinal survival analysis of the Korea Nurses' Health Study.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.

Aims: To identify factors influencing turnover among Korean female nurses from a longitudinal perspective.

Design: A national cohort study called the Korea Nurses' Health Study (2013-2020) was used.

Methods: A national sample of female nurses from module 1 (N = 20,613, 2013-2014), module 5 (N = 11,527, 2016-2017), module 7 (N = 8,658, 2018-2019) and module 8 (N = 10,253, 2019-2020) was used. Read More

View Article and Full-Text PDF

Fecal microbial composition and functional diversity of Wuzhishan pigs at different growth stages.

AMB Express 2021 Jun 12;11(1):88. Epub 2021 Jun 12.

State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

The mammalian gut microbiome participates in almost all life processes in the host. In addition to diet, the breed is the main factor affecting changes in the swine gut microbiota. The composition of the gut microbiota changes significantly during different growth stages. Read More

View Article and Full-Text PDF

Factors predicting coping in older people with dementia: A cross-sectional study.

Nurs Health Sci 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Nursing Chiang Mai University, Chiang Mai, Thailand.

Coping can buffer the effect of stress on well-being. The information about factors predicting coping is essential knowledge for developing programs to promote effective coping among older people with dementia and serves as basic knowledge for further study. The cross-sectional study design was employed to investigate the associated and predictive factors of coping. Read More

View Article and Full-Text PDF

Molecular genetic analysis of Mi -positive hybrid glycophorins revealed two novel alleles of GP.Vw and multiple variant transcripts of GYPB existing in both the homozygous GP.Mur and wild-type GPB individuals.

Transfusion 2021 Jun 12. Epub 2021 Jun 12.

Institute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, People's Republic of China.

Background: The hybrid glycophorins of MNS blood group system express a series of low incidence antigens including Mi , which are commonly found in Southeast Asian populations. In this study, the molecular basis of Mi -positive hybrid glycophorins was firstly clarified in the Chinese Southern Han population. RNA transcripts of GYPB gene in the homozygous GP. Read More

View Article and Full-Text PDF

Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation.

Cancer Gene Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.

Cabozantinib is a potent tyrosine kinase inhibitor with multiple targets including MET, VEGFR2, RET, KIT, and FLT3. Cabozantinib is widely used for the treatment of medullary thyroid cancer and renal cell carcinoma. We recently suggested cabozantinib as a potential therapeutic alternative for acute myeloid leukemia (AML) patients with FLT3-internal tandem duplication (FLT3-ITD). Read More

View Article and Full-Text PDF

Enhancing fatigue life by ductile-transformable multicomponent B2 precipitates in a high-entropy alloy.

Nat Commun 2021 Jun 11;12(1):3588. Epub 2021 Jun 11.

Department of Materials Science and Engineering, The University of Tennessee, Knoxville, TN, USA.

Catastrophic accidents caused by fatigue failures often occur in engineering structures. Thus, a fundamental understanding of cyclic-deformation and fatigue-failure mechanisms is critical for the development of fatigue-resistant structural materials. Here we report a high-entropy alloy with enhanced fatigue life by ductile-transformable multicomponent B2 precipitates. Read More

View Article and Full-Text PDF

IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform.

Cell Death Discov 2021 Jun 11;7(1):139. Epub 2021 Jun 11.

Department of Pediatrics, Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.

The long-term prognosis of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) is still unsatisfactory even after the emergence of tyrosine kinase inhibitors (TKIs) against chimeric BCR-ABL, and this is associated with the high incidence of genetic alterations of Ikaros family zinc finger 1 (IKZF1), most frequently the hemi-allelic loss of exons 4-7 expressing a dominant-negative isoform Ik6. We found that lenalidomide (LEN), a representative of immunomodulatory drugs (IMiDs), which have been long used for the treatment of multiple myeloma, specifically induced accumulation of Ik6 with the disappearance of functional isoforms within 24 h (i.e. Read More

View Article and Full-Text PDF

Multiple Roles of IL-6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis.

Cancer Res 2021 Jun 11. Epub 2021 Jun 11.

Goldyne-Savad Institute of Gene Therapy, Hadassah Hebrew University Hosptial

Hepatocellular carcinoma (HCC) typically develops on a background of chronic hepatitis for which the pro-inflammatory cytokine interleukin-6 (IL-6) is conventionally considered a crucial driving factor. Paradoxically, IL-6 also acts as a hepatoprotective factor in chronic liver injury. Here we used the multidrug-resistant gene 2 knockout (Mdr2-/-) mouse model to elucidate potential roles of IL-6 in chronic hepatitis-associated liver cancer. Read More

View Article and Full-Text PDF

Early gastrogastric fistula after Roux-en-Y gastric bypass: successful fistula treatment with self-expandable endoscopic stent.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Department of Visceral Surgery, Clarunis University Center for Gastrointestinal and Liver Diseases, Basel, Switzerland.

A 25-year-old patient underwent laparoscopic Roux-en-Y gastric bypass surgery with an initially uneventful postoperative course. Two weeks postoperatively, the patient presented with acute abdominal pain. CT scan revealed a gastrogastric fistula from the gastric pouch to the gastric remnant. Read More

View Article and Full-Text PDF

A cross-sectional survey on community pharmacists readiness to fight COVID-19 in a developing country: knowledge, attitude, and practice in Lebanon.

J Pharm Policy Pract 2021 Jun 11;14(1):51. Epub 2021 Jun 11.

INSPECT-LB: Institut National de Santé Publique, d'Épidémiologie Clinique et de Toxicologie, Beirut, Lebanon.

Background: Lebanon, a developing Middle Eastern country, was hit by the COVID-19 pandemic that occurred amid a severe national economic crisis. Community pharmacists are responsible for dispensing appropriate medications and products in addition to counseling, informing and educating the public, and promoting disease prevention and infection control.

Objective: This study aimed to assess community pharmacists' knowledge, attitude, and practice towards the COVID-19 pandemic and evaluate behavior changes and safety measures. Read More

View Article and Full-Text PDF

Papillary thyroid microcarcinoma with lung metastases: a case report and review of the literature.

Thyroid Res 2021 Jun 11;14(1):15. Epub 2021 Jun 11.

Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Distant metastasis from papillary thyroid microcarcinoma (PTMC) is rare. Here we report a case of PTMC with multiple lung metastases.

Case Presentation: A 64-year-old man presented to our hospital with abdominal pain. Read More

View Article and Full-Text PDF

Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea.

BMC Womens Health 2021 Jun 11;21(1):239. Epub 2021 Jun 11.

Medical Imaging College, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Background: Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. Read More

View Article and Full-Text PDF

Exome sequencing reveals novel rare variants in Iranian familial multiple sclerosis: The importance of POLD2 in the disease pathogenesis.

Genomics 2021 Jun 8. Epub 2021 Jun 8.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The prevalence of familial multiple sclerosis (FMS) is increasing worldwide which endorses the heritability of the disease. Given that many genome variations are ethnicity-specific and consanguineous marriage could affect genetic diseases, hereditary disease gene analysis among FMS patients from Iran, a country with high rates of parental consanguinity, could be highly effective in finding mutations underlying disease pathogenesis. To examine rare genetic mutations, we selected three Iranian FMS cases with ≥3 MS patients in more than one generation and performed whole exome sequencing. Read More

View Article and Full-Text PDF

Prediction of underwater residual lung volume in healthy men and women.

Clin Physiol Funct Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Kinesiology, University of Alabama, Tuscaloosa, AL, USA.

Regression equations are commonly used to predict residual lung volume (RV) during underwater weighing when measurement is not practical. However, the equations currently available were derived from on-land measures of RV and may account for changes in lung capacity during submersion, thus leading to inaccuracies in assessment of percent body fat (%BF). The purpose of this study was to 1) develop a new equation (RV ) for the prediction of underwater RV, 2) cross-validate RV and compare it to existing RV equations, and 3) compare the effects of RV and existing equations on underwater %BF. Read More

View Article and Full-Text PDF

Harmful Use of Alcohol as Predictor of Presex Drinking in Mexican Young College Women.

J Addict Nurs 2021 Jun 11. Epub 2021 Jun 11.

Miguel A. Villegas-Pantoja, MNSc, DNSc, Nursing School of Nuevo Laredo, Universidad Autonoma de Tamaulipas, Mexico. Martha D. Mendez-Ruiz, MNSc, DNSc, Nursing School of Nuevo Laredo, Universidad Autonoma de Tamaulipas, Mexico. Lucrecia Sánchez-López, MNSc, Nursing School of Nuevo Laredo, Universidad Autonoma de Tamaulipas, Mexico. José Manuel Herrera-Paredes, MNSc, DNSc, Celaya-Salvatierra Campus: Division of Health Sciences and Engineering, Universidad de Guanajuato, Mexico. Alicia Álvarez-Aguirre, MNSc, DNSc, Celaya-Salvatierra Campus: Division of Health Sciences and Engineering, Universidad de Guanajuato, Mexico.

Alcohol use presents a serious risk to women's health. Of particular interest is the association of harmful alcohol consumption and risky behaviors, such as drinking before sexual intercourse, an understudied phenomenon in the Mexican population.

Aim: The aim of this study was to identify whether the harmful use of alcohol is associated with an increased probability of presex drinking in Mexican young women. Read More

View Article and Full-Text PDF

Leishmanicidal potentials of extract and its fractions on in a murine model: parasite burden, gene expression, and histopathological profile.

J Med Microbiol 2021 Jun;70(6)

Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Leishmaniasis is a neglected tropical and subtropical disease caused by over 20 protozoan species. Treatment of this complex disease with traditional synthetic drugs is a major challenge worldwide. Natural constituents are unique candidates for future therapeutic development. Read More

View Article and Full-Text PDF

Mammary Lobular Carcinoma-Like Salivary Gland Carcinoma: Report of a Rare Case.

Head Neck Pathol 2021 Jun 11. Epub 2021 Jun 11.

Department of Pathology, Stanford University Medical Center, Palo Alto, USA.

Salivary and mammary glands are both exocrine organs sharing multiple tumorigenic processes. To the best of our knowledge, salivary gland tumors mimicking invasive lobular carcinoma of the breast have not yet been described. Herein, we report a case of a 62-year-old male who presented with progressive facial paralysis. Read More

View Article and Full-Text PDF

Multiplex CRISPR/Cas9-mediated genome editing of the FAD2 gene in rice: a model genome editing system for oil palm.

J Genet Eng Biotechnol 2021 Jun 11;19(1):86. Epub 2021 Jun 11.

Advanced Biotechnology and Breeding Centre (ABBC) Division, Malaysian Palm Oil Board (MPOB), 6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Selangor, Malaysia.

Background: Genome editing employing the CRISPR/Cas9 system has been widely used and has become a promising tool for plant gene functional studies and crop improvement. However, most of the applied CRISPR/Cas9 systems targeting one locus using a sgRNA resulted in low genome editing efficiency.

Results: Here, we demonstrate the modification of the FAD2 gene in rice using a multiplex sgRNA-CRISPR/Cas9 genome editing system. Read More

View Article and Full-Text PDF

Acid base disorders in patients with COVID-19.

Int Urol Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Clinic of Infectious Diseases, University Hospital of Modena, Modena, Italy.

Purpose: Acid-base derangement has been poorly described in patients with coronavirus disease 2019 (COVID-19). Considering the high prevalence of pneumonia and kidneys injury in COVID-19, frequent acid-base alterations are expected in patients admitted with SARS-Cov-2 infection. The study aimed to assess the prevalence of acid-base disorders in symptomatic patients with a diagnosis of COVID-19. Read More

View Article and Full-Text PDF

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.

Acta Neuropathol 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy and Neurosciences, Clinical Neuroanatomy and Biobanking, Amsterdam Neuroscience, Amsterdam UMC, Location VU University Medical Center, O2 building, room 13 E11, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.

Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)-including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn-accumulate in Lewy bodies (LBs) in different regions of the Parkinson's disease (PD) brain. Insight into the distribution of these proteoforms within LBs and subcellular compartments may aid in understanding the orchestration of Lewy pathology in PD. We applied epitope-specific antibodies against CTT and Ser129-p aSyn proteoforms and different aSyn domains in immunohistochemical multiple labelings on post-mortem brain tissue from PD patients and non-neurological, aged controls, which were scanned using high-resolution 3D multicolor confocal and stimulated emission depletion (STED) microscopy. Read More

View Article and Full-Text PDF

Probing the Chiral Domains and Excitonic States in Individual WS Tubes by Second-Harmonic Generation.

Nano Lett 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures (MOE), and Department of Physics, Fudan University, Shanghai 200433, People's Republic of China.

Distinct from carbon nanotubes, transition-metal dichalcogenide (TMD) nanotubes are noncentrosymmetric and polar and can exhibit some intriguing phenomena such as nonreciprocal superconductivity, chiral shift current, bulk photovoltaic effect, and exciton-polaritons. However, basic characterizations of individual TMD nanotubes are still quite limited, and much remains unclear about their structural chirality and electronic properties. Here we report an optical second-harmonic generation (SHG) study on multiwalled WS nanotubes on a single-tube level. Read More

View Article and Full-Text PDF

Self-Constructed Multiple Plasmonic Hotspots on an Individual Fractal to Amplify Broadband Hot Electron Generation.

ACS Nano 2021 Jun 11. Epub 2021 Jun 11.

School of Materials Science and Engineering, Tianjin University, Tianjin 300350, P.R. China.

Plasmonic nanoparticles are ideal candidates for hot-electron-assisted applications, but their narrow resonance region and limited hotspot number hindered the energy utilization of broadband solar energy. Inspired by tree branches, we designed and chemically synthesized silver fractals, which enable self-constructed hotspots and multiple plasmonic resonances, extending the broadband generation of hot electrons for better matching with the solar radiation spectrum. We directly revealed the plasmonic origin, the spatial distribution, and the decay dynamics of hot electrons on the single-particle level by using simulation, dark-field spectroscopy, pump-probe measurements, and electron energy loss spectroscopy. Read More

View Article and Full-Text PDF

Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.

Arthritis Rheumatol 2021 Jun 11. Epub 2021 Jun 11.

UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Ireland.

Objectives: To identify serum protein biomarkers which might separate early inflammatory arthritis (EIA) patients with psoriatic arthritis (PsA) from those with rheumatoid arthritis (RA) and may be used to support appropriate early intervention.

Methods: The serum proteome of patients with PsA and RA was interrogated using nano-flow liquid chromatography mass spectrometry (nLC-MS/MS) (n=64 patients), an aptamer-based assay (SOMAscan) targeting 1,129 proteins (n=36 patients) and a multiplexed antibody assay (Luminex) for 48 proteins (n=64 patients). Multiple reaction monitoring assays (MRM) were developed to evaluate the performance of putative markers using the discovery cohort (n=60) and subsequently an independent cohort of PsA and RA patients (n=167). Read More

View Article and Full-Text PDF

Genome-wide Identification of U-box Genes and Protein Ubiquitination under PEG-induced Drought Stress in Potato.

Physiol Plant 2021 Jun 10. Epub 2021 Jun 10.

Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, People's Republic of China.

Protein ubiquitination is one of the most important post-translational modifications in eukaryotic cells, and it is involved in a variety of biological processes, including abiotic stress response. The ubiquitination modification is highly specific, which depends on the accurate recognition of substrate proteins by ubiquitin ligase. Plant U-box (PUB) proteins are a class of ubiquitin ligases, multiple members of which have shown to participate in water-deficit stress in Arabidopsis and rice. Read More

View Article and Full-Text PDF

Outcomes of sustained fetal tachyarrhythmias after transplacental treatment.

Heart Rhythm O2 2021 Apr 9;2(2):160-167. Epub 2021 Mar 9.

Obstetric and Maternal Fetal Medicine and EA7328.

Background: Fetal tachyarrhythmia is a condition that may lead to cardiac dysfunction, hydrops, and death. Despite a transplacental treatment, failure to obtain or maintain sinus rhythm may occur.

Objective: We aimed to analyze the perinatal outcomes of sustained fetal tachyarrhythmias after in utero treatment. Read More

View Article and Full-Text PDF

Involving patients as key stakeholders in the design of cardiovascular implantable electronic device data dashboards: Implications for patient care.

Heart Rhythm O2 2020 Jun 11;1(2):136-146. Epub 2020 May 11.

Parkview Mirro Center for Research and Innovation, Parkview Health, Fort Wayne, Indiana.

Background: Data from remote monitoring (RM) of cardiovascular implantable electronic devices (CIEDs) currently are not accessible to patients despite demand. The typical RM report contains multiple pages of data for trained technicians to read and interpret and requires a patient-centered approach to be curated to meet individual user needs.

Objective: The purpose of this study was to understand which RM data elements are important to patients and to gain design insights for displaying meaningful data in a digital dashboard. Read More

View Article and Full-Text PDF