20,861 results match your criteria revealed infiltration

High S100A9 cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.

S100A9 is differentially expressed in various cell types and is associated with the development, progression and metastasis of various cancers. However, the expression, distribution, and clinical significance of S100A9 in hepatocellular carcinoma (HCC) remain unclear. In the present study, The Cancer Genome Atlas (TCGA) database was used to examine gene expression in HCC; we found that expression was associated with HCC prognosis. Read More

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Yes-associated protein regulates the hepatoprotective effect of vitamin D receptor activation through promoting adaptive bile duct remodeling in cholestatic mice.

J Pathol 2021 Jun 22. Epub 2021 Jun 22.

Department of Cell Biology, School of Medicine, Taizhou University, Taizhou, PR China.

Mounting clinical evidence has revealed that vitamin D receptor (VDR) is associated with cholestatic liver injury, although the functions of VDR in this condition remain largely unexplored. Here, we investigated the effects of VDR activation on bile duct ligation (BDL) mice, and the underlying mechanisms were further investigated. A low-calcemic VDR agonist, paricalcitol (PAL, 200 ng/kg), was intraperitoneally injected into BDL mice every other day for 5 days or 28 days. Read More

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2,4,6-Trihydroxy-3-geranyl acetophenone suppresses vascular leakage and leukocyte infiltration in lipopolysaccharide-induced endotoxemic mice.

Pharm Biol 2021 Dec;59(1):732-740

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Context: Lipopolysaccharide (LPS) exacerbates systemic inflammatory responses and causes excessive fluid leakage. 2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) has been revealed to protect against LPS-induced vascular inflammation and endothelial hyperpermeability

Objective: This study assesses the protective effects of tHGA against LPS-induced systemic inflammation and vascular permeability in endotoxemic mice.

Materials And Methods: BALB/c mice were intraperitoneally pre-treated with tHGA for 1 h, followed by 6 h of LPS induction. Read More

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December 2021

Predictors of Lymph Node Metastasis in Siewert Type II T1 Adenocarcinoma of the Esophagogastric Junction: A Population-Based Study.

Cancer Control 2021 Jan-Dec;28:10732748211026668

Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Endoscopic resection has been introduced as an alternative treatment for superficial adenocarcinoma of the esophagogastric junction (AEG), but is limited by positive nodal status. We aimed to investigate the predictors of lymph node metastasis (LNM) in patients with Siewert type II T1 AEG.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify eligible patients with Siewert type II T1 AEG. Read More

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Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy.

Oncogene 2021 Jun 21. Epub 2021 Jun 21.

Tumor Immunotherapy and Microenvironment (TIME) group, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.

Hypoxia is a key factor responsible for the failure of therapeutic response in most solid tumors and promotes the acquisition of tumor resistance to various antitumor immune effectors. Reshaping the hypoxic immune suppressive tumor microenvironment to improve cancer immunotherapy is still a relevant challenge. We investigated the impact of inhibiting HIF-1α transcriptional activity on cytotoxic immune cell infiltration into B16-F10 melanoma. Read More

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An epithelial pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Systems Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India;

Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module mediates controlled nuclear activation of RelA dimers from the latent cytoplasmic complexes. What provokes pathological RelA activity in the colitogenic gut remains unclear. Read More

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Appendiceal globet cell adenocarcinoma: a rare cause of acute appendicitis.

Rev Esp Enferm Dig 2021 Jun 22. Epub 2021 Jun 22.

Patología, Hospital Universitario del Caribe, Colombia.

We present the case of a 70-year-old man who consulted for abdominal pain, vomiting, fever, and signs of peritoneal irritation. Histopathology showed goblet-like cells organized in nests, without tubules, with transmural infiltration. Immunohistochemistry revealed positivity for synaptophysin and chromogranin, diagnosing grade 3 goblet cell adenocarcinoma (GCA). Read More

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Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments.

Eur J Cancer 2021 Jun 18;153:98-108. Epub 2021 Jun 18.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. Electronic address:

Purpose: OBP-301 (Telomelysin) is an attenuated type-5 adenovirus that contains the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 sensitises human cancer cells to ionising radiation by inhibiting DNA repair, and radiation enhances coxsackievirus and adenovirus receptor-mediated OBP-301 infection on the contrary. We assessed OBP-301 with radiotherapy in oesophageal cancer patients unfit for standard chemoradiation treatments. Read More

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Fluorofenidone protects liver against inflammation and fibrosis by blocking the activation of NF-κB pathway.

FASEB J 2021 Jul;35(7):e21497

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, P.R. China.

Despite the increasing understanding of the pathophysiology of hepatic fibrosis, the therapies to combat it remain inadequate. Fluorofenidone (AKF-PD) is a novel pyridone agent able to ameliorate hepatic fibrosis in an experimental hepatic fibrosis model induced by dimethylnitrosamine. However, the underlying mechanism remains to be further elucidated. Read More

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Identification of immune cell infiltration pattern and related critical genes in metastatic castration-resistant prostate cancer by bioinformatics analysis.

Cancer Biomark 2021 Jun 19. Epub 2021 Jun 19.

Department of Urology, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Metastatic castration-resistant prostate cancer (mCRPC) is the lethal stage of prostate cancer and the main cause of morbidity and mortality, which is also a potential target for immunotherapy.

Method: In this study, using the Approximate Relative Subset of RNA Transcripts (CIBERSORT) online method, we analysed the immune cell abundance ratio of each sample in the mCRPC dataset. The EdgeR (an R package) was used to classify differentially expressed genes (DEGs). Read More

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CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report.

Front Oncol 2021 2;11:672660. Epub 2021 Jun 2.

The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.

A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI. Five years earlier, he had undergone curative enucleation of his left eye for uveal melanoma. Read More

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Integrated Analysis of Cell Cycle-Related and Immunity-Related Biomarker Signatures to Improve the Prognosis Prediction of Lung Adenocarcinoma.

Front Oncol 2021 4;11:666826. Epub 2021 Jun 4.

Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Lung adenocarcinoma (LUAD) is a leading malignancy and has a poor prognosis over the decades. LUAD is characterized by dysregulation of cell cycle. Immunotherapy has emerged as an ideal option for treating LUAD. Read More

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A Poliovirus Receptor (CD155)-Related Risk Signature Predicts the Prognosis of Bladder Cancer.

Front Oncol 2021 3;11:660273. Epub 2021 Jun 3.

Department of Urology, Xiangya Hospital, Central South University (CSU), Changsha, China.

Background: Bladder cancer is an aggressive and heterogeneous disease associated with high morbidity and mortality. And poliovirus receptor ( or ) played crucial roles in tumor immune microenvironment and cancer development. However, their association remains obscure. Read More

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Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1.

Front Immunol 2021 4;12:681615. Epub 2021 Jun 4.

Laboratorio de Fisiopatología de la Inmunidad Innata, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.

Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is usually accompanied by phenotypic changes, analysis of such alterations might lead to the identification of novel biomarkers and/or targets in immuno-oncology. Consequently, we performed a phenotypic analysis of peripheral blood NK cells (PBNK) and tumor-infiltrating NK cells (TINK) from ccRCC patients. Read More

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Horizontal MicroRNA Transfer by Platelets - Evidence and Implications.

Front Physiol 2021 3;12:678362. Epub 2021 Jun 3.

Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

For decades, platelets have been known for their central role in hemostasis and their ability to release bioactive molecules, allowing inter-platelet communication and crosstalk with the immune system and vascular cells. However, with the detection of microRNAs in platelets and platelet-derived microvesicles (MVs), a new level of inter-cellular regulation was revealed. By shedding MVs from their plasma membrane, platelets are able to release functional microRNA complexes that are protected from plasma RNases. Read More

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Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.

Front Physiol 2021 3;12:671250. Epub 2021 Jun 3.

Brain Science and Engineering Institute, Kyungpook National University, Daegu, South Korea.

The blood-brain barrier (BBB) regulates the traffic of micromolecules and macromolecules between the peripheral blood and the central nervous system, to maintain brain homeostasis. BBB disruption and dysfunction accompany a variety of neurological disorders and are closely related with the neuroinflammatory cascades that are triggered by leukocyte infiltration and glial activation. Here, we explored the role of complement component 8 gamma (C8G) in the maintenance of BBB integrity. Read More

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[A 81-year old man of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody-positive myopathy associated with lung adenocarcinoma cancer].

Rinsho Shinkeigaku 2021 Jun 18. Epub 2021 Jun 18.

Department of Clinical Neuroscience and Neurology, Yamaguchi University Graduate School of Medicine.

An 81-year-old man, who had no history of taking statins, developed progressive muscle weakness of the limbs and dysphagia. Laboratory tests showed a high level of CK and positivity for serum 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies. Tests for other autoantibodies to ARS and SRP were negative. Read More

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A rat model of polymicrobial infection in full-thickness excision wounds.

J Tissue Viability 2021 Jun 10. Epub 2021 Jun 10.

Department of Drug Development, Institute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Marg, Delhi, 110054, India. Electronic address:

Aim: A reproducible animal model is required to study the pathophysiology of wound infections and for development of effective therapeutic interventions. The objective of this study was to produce an infected skin wound model utilizing the cecal microbiota in non-immunocompromised rats.

Materials And Methods: An excision wound was created on the dorsal surface of rats and inoculated with different concentration of cecal slurry (CS). Read More

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Oral administration of D-serine prevents the onset and progression of colitis in mice.

J Gastroenterol 2021 Jun 20. Epub 2021 Jun 20.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.

Background: L-amino acids are the predominant forms of organic molecules on the planet, but recent studies have revealed that various foods contain D-amino acids, the enantiomers of L-amino acids. Though diet plays important roles in both the development and progression of inflammatory bowel disease (IBD), to our best knowledge, there has been no report on any potential interactions between D-amino acids and IBD. In this report, we aim to assess the effects of D-serine in a murine model of IBD. Read More

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Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma.

Virchows Arch 2021 Jun 19. Epub 2021 Jun 19.

Breast and Thyroid Surgical Department, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China.

Lymph node metastases are strongly associated with unfavorable prognosis in papillary thyroid carcinoma (PTC) patients. However, there are few sensitive or specific indicators that can diagnose or predict lymph node metastases in PTC. The objective of our study was to identify reliable indicators for the diagnosis and prediction of lymph node metastases of PTC. Read More

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S100A gene family: immune-related prognostic biomarkers and therapeutic targets for low-grade glioma.

Aging (Albany NY) 2021 Jun 8;13(11):15459-15478. Epub 2021 Jun 8.

Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, P.R. China.

Background: Despite the better prognosis given by surgical resection and chemotherapy in low-grade glioma (LGG), progressive transformation is still a huge concern. In this case, the S100A gene family, being capable of regulating inflammatory responses, can promote tumor development.

Methods: The analysis was carried out via ONCOMINE, GEPIA, cBioPortal, String, GeneMANIA, WebGestalt, LinkedOmics, TIMER, CGGA, R 4. Read More

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PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice.

Ecotoxicol Environ Saf 2021 Jun 17;221:112433. Epub 2021 Jun 17.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address:

Fine particulate matter (PM2.5) is one of the most important components of environmental pollutants and is associated with lung injury. Pyroptosis, a form of programmed cell death mainly mediated by the NLRP3 inflammasome, has been reported to be involved in sepsis-induced or ischemia/reperfusion-induced lung injury. Read More

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Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis.

Free Radic Biol Med 2021 Jun 15. Epub 2021 Jun 15.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui, 323000, China; Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. Electronic address:

Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic recurrent and incurable gastrointestinal diseases with an unknown etiology that leads to a high risk of developing colitis-associated colorectal cancer (CRC).

Objectives: In this study, we measured the expression characteristics of MELK in IBD and CRC tissues and explored the regulatory effect of OTSSP167 (a MELK-selective inhibitor) on the mice models of colitis and colitis-associated carcinogenesis and analyzed the specific molecular mechanisms.

Methods: DSS-induced colitis and colitis-associated carcinogenesis (CAC) model were treated with MELK inhibitor OTSSP167 then the fight against effect of OTSSP167 in the clinical symptoms of colitis and CAC was measured. Read More

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Glatiramer Acetate Enhances Tumor Retention and Innate Activation of Immunostimulants.

Int J Pharm 2021 Jun 15:120812. Epub 2021 Jun 15.

Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; Department of Bioengineering, University of Kansas, Lawrence, KS; Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS. Electronic address:

Cancer immunotherapy aims to stimulate immune cells to recognize and attack tumor tissue. The immunostimulatory polyanions polyI:C and CpG induce potent pro-inflammatory immune responses as TLR3 and TLR9 agonists, respectively. Clinical trials of TLR agonists, however, have been fraught with immune-related adverse events, even when injecting intratumorally in an effort to minimize systemic exposure. Read More

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Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma.

Mol Ther Oncolytics 2021 Jun 29;21:288-302. Epub 2021 Apr 29.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai 201321, China.

Although the successful clinical trials of immunotherapy show promising strategies for many cancers, its application in glioma has lagged in comparison with the progress seen in other cancers. Both isocitrate dehydrogenase (IDH) mutations and 1p/19q codeletions are critical molecular alterations affecting therapeutic response in lower-grade glioma (LGG). The systematic and comprehensive characterization of the immunological phenotypes with different molecular subtypes is key to improving our understanding and application of immunotherapies in LGG. Read More

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A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage.

Mol Ther Methods Clin Dev 2021 Jun 4;21:681-692. Epub 2021 Feb 4.

Department of Neurorehabilitation, Tangshan People's Hospital, Tangshan 063000, P.R. China.

Microglial cell activation and neuroinflammation after intracerebral hemorrhage (ICH) lead to secondary brain damage. Ubiquitin-specific protease 11 (USP11) has been correlated with ICH-induced neuron apoptosis. This study aims to explore the molecular mechanism of USP11 regulating neuroinflammation in ICH. Read More

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Eosinophilic gastroenteritis with abdominal pain and ascites: A case report.

World J Clin Cases 2021 Jun;9(17):4238-4243

Department of Gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

Background: Eosinophilic gastroenteritis (EGE) is a rare disease that presents many unspecific gastroenterological symptoms. The disease includes three types depending on the depth of eosinophil infiltration in the gastrointestinal tract. The serosal type is the most rare, presenting as ascites. Read More

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Why mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort.

World J Clin Cases 2021 Jun;9(17):4143-4158

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.

Background: , encoding cancer antigen 125, is a frequently mutated gene in gastric cancer. In addition, mutations seem to result in a better prognosis in gastric cancer. However, the mechanisms that lead to a better prognosis by mutations have not yet been clarified. Read More

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Differential analysis revealing APOC1 to be a diagnostic and prognostic marker for liver metastases of colorectal cancer.

World J Clin Cases 2021 Jun;9(16):3880-3894

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: Colorectal cancer (CRC) is one of the most malignant gastrointestinal cancers worldwide. The liver is the most important metastatic target organ, and liver metastasis is the leading cause of death in patients with CRC. Owing to the lack of sensitive biomarkers and unclear molecular mechanism, the occurrence of liver metastases cannot be predicted and the clinical outcomes are bad for liver metastases. Read More

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High PHD Finger Protein 19 (PHF19) expression predicts poor prognosis in colorectal cancer: a retrospective study.

PeerJ 2021 1;9:e11551. Epub 2021 Jun 1.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Colorectal cancer (CRC) is the third most common cancer all around the world, and it seriously threats human health. PHF19 has been proved to be closely related to the prognosis of patients in a variety of malignant tumors, but the effect of PHF19 on the prognosis evaluation of CRC patients has not been confirmed.

Methods: In our study, we used GEO, TCGA database and IHC to verify the PHF19 expression in CRC samples. Read More

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