1,715,165 results match your criteria revealed hypopituitarism


Robot-assisted enucleation of a giant submucosal tumor in the upper esophagus.

Asian J Endosc Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

Few reports have demonstrated robotic surgery for large tumors in the upper esophagus. We report a case of a 52-year-old woman with a giant submucosal tumor in the upper esophagus successfully enucleated using robotic surgery. She presented with odynophagia and dysphagia, with subsequent evaluation revealing a submucosal mass measuring approximately 10 cm in diameter in the upper esophagus. Read More

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ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer.

Nanotechnology 2021 Jul 29. Epub 2021 Jul 29.

Department of Pharmaceutics, Harbin Medical University, 157, Baojian Road, Nangang District, Harbin City, China, Harbin, 150086, CHINA.

The combined application of paclitaxel (PTX) and tetrandrine (TET) is a promising avenue in drug-resistant cancer therapy. However, poor drug release and limited intracellular accumulation greatly impede the combinatorial antitumor practices. To address this problem, we successfully developed a tunable controlled release lipid platform for coordinated drug delivery. Read More

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A stability perspective of bio-inspired UAVs performing dynamic soaring optimally.

Bioinspir Biomim 2021 Jul 29. Epub 2021 Jul 29.

Air University, Aerospace & Aviation Campus, Air University, Aerospace & Aviation Campus, Kamra, 44200, PAKISTAN.

Dynamic soaring phenomenon, exhibited by soaring birds, has long been a biological inspiration for the aerospace and control engineering communities. If this fascinating phenomenon, which allows soaring birds to perform almost un-powered flights using wind shear, can be mimicked by Unmanned-Aerial-Vehicles (UAVs), then UAVs performance have a substantial potential to enhance technologically and economically as well. Even though there have been considerable amount of research covering the modeling, optimization, control and simulation aspects of different UAVs performing dynamic soaring, there is little to non conclusive work analyzing the stability of such UAVs about the soaring orbits. Read More

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NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

School of Stomatology, Wenzhou Medical University, Wenzhou 110013, China.

NudC domain containing 1 (NUDCD1) is an oncoprotein frequently activated or upregulated in various human cancers, but its role in pancreatic cancer (PC) remains unknown. Thus, we aimed to determine the function and mechanism of NUDCD1 in PC. We employed Western blot and quantitative real-time polymerase chain reaction to assess NUDCD1 expression in cells and PC tissues. Read More

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Biodegradation of isoprene by Arthrobacter sp. strain BHU FT2: Genomics-proteomics enabled novel insights.

Bioresour Technol 2021 Jul 22;340:125634. Epub 2021 Jul 22.

Molecular Ecology Laboratory, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address:

The bacterial degradation of isoprene is important for maintaining its atmospheric concentration in unpolluted environment. It may be possible to use natural isoprene degrading bacteria in engineered systems to eliminate or limit isoprene emissions from various sources. Biodegradation of isoprene by Arthrobacter sp. Read More

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Dynamic membrane bioreactor for high rate continuous biohydrogen production from algal biomass.

Bioresour Technol 2021 Jul 14;340:125562. Epub 2021 Jul 14.

School of Civil and Environmental Engineering, Yonsei University, Seoul 03722, Republic of Korea. Electronic address:

This study aimed to achieve continuous biohydrogen production from red algal biomass using a dynamic membrane bioreactor (DMBR). The DMBR was continuously fed with pretreated Echeuma spinosum containing 20 g/L hexose. The highest average hydrogen production rate (HPR) of 21. Read More

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White matter alterations in Parkinson's disease with levodopa-induced dyskinesia.

Parkinsonism Relat Disord 2021 Jul 24;90:8-14. Epub 2021 Jul 24.

Department of Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan. Electronic address:

Introduction: Levodopa-induced dyskinesia is a complication of levodopa therapy and negatively impacts the quality of life of patients. We aimed to elucidate white matter alterations in Parkinson's disease with levodopa-induced dyskinesia using advanced diffusion magnetic resonance imaging techniques.

Methods: The enrolled subjects included 26 clinically confirmed Parkinson's disease patients without levodopa-induced dyskinesia, 25 Parkinson's disease patients with levodopa-induced dyskinesia, and 23 healthy controls. Read More

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Survey of the operational status of twenty-six urban stormwater biofilter facilities in Sweden.

J Environ Manage 2021 Jul 26;297:113375. Epub 2021 Jul 26.

Dept. of Civil, Environmental, and Natural Resources Engineering, Luleå Univ. of Technology, 97187, Luleå, Sweden. Electronic address:

This study evaluates the operational status of twenty-six biofilter facilities across nine cities in Sweden, with respect to their functional design criteria, engineered design features (filter media composition, hydraulic conductivity, and drawdown time), and includes a visual inspection of the biofilter components (pre-treatment, in/outlet structures, filter media, and vegetation). These indicators were used to examine the performance level of each biofilter in achieving their design objectives set by the operators. Furthermore, it was investigated whether the biofilter facilities had been properly maintained to meet the objectives. Read More

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What is nursing work? A meta-narrative review and integrated framework.

Int J Nurs Stud 2021 Mar 28;122:103944. Epub 2021 Mar 28.

School of Health Sciences, Faculty of Health and Medical Sciences, University of Surrey, Duke of Kent Building, Guildford, GU2 7XH UK. Electronic address:

Background: There is ample evidence that modern nurses are under strain and that interventions to support the nursing workforce have not recognised the complexity inherent in nursing work. Creating a modern model of nursing work may assist nurses in developing workable solutions to professional problems. A new model may also foster cohesion among broad and diverse nursing roles. Read More

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Effects of ginseng soluble dietary fiber on serum antioxidant status, immune factor levels and cecal health in healthy rats.

Food Chem 2021 Jul 20;365:130641. Epub 2021 Jul 20.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, 130112 Changchun, Jilin, China. Electronic address:

As an important component of ginseng, the in vivo benefits of ginseng water-soluble dietary fiber (ginseng-SDF) have not been fully revealed. To explore these benefits, healthy rats were given ginseng-SDF (200, 400, and 800 mg/kg body weight/day) by gavage for 15 days. The results showed that ginseng-SDF significantly improved the rats' growth performance and serum antioxidant status. Read More

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Thymoma-associated autoimmune encephalitis with positive Titin antibodies: A case report.

J Neuroimmunol 2021 Jul 22;358:577670. Epub 2021 Jul 22.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address:

We report a case of thymoma-associated autoimmune encephalitis with positive Titin antibodies. The patient had cognitive dysfunction, psychiatric symptoms and symptomatic epilepsy. PET-CT indicated space-occupied lesion at the thoracic entrance. Read More

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Hydrogen-rich syngas from wet municipal solid waste gasification using Ni/Waste marble powder catalyst promoted by transition metals.

Waste Manag 2021 Jul 26;132:96-104. Epub 2021 Jul 26.

School of Environmental Science & Technology, Dalian University of Technology, Dalian, Liaoning, PR China.

Gasification of wet municipal solid waste (MSW) coupled with in-situ CO capture is an attractive option for MSW disposal, allowing chemical and energy recovery. In this study, the Ni-CaO based catalysts were prepared with waste marble powder (WMP) as an alternative to CaO and promoted by different transition metals (i.e. Read More

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Resources in women's social networks for food shopping are more strongly associated with better dietary quality than people: A cross-sectional study.

Soc Sci Med 2021 Jul 13;284:114228. Epub 2021 Jul 13.

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; National Institute for Health Research Southampton Biomedical Research, Centre, University of Southampton and University Hospital Southampton, NHS Foundation Trust, Southampton, SO16 6YD, UK; NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, 2 Venture Road, Chilworth, Southampton, SO16 7NP, UK. Electronic address:

When healthy people are part of an individual's social network, those individuals will have better dietary quality. Little, however, is known about whether social networks for food shopping, including both people and resources (e.g. Read More

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Photoelectrochemical aptasensor based on LaTiO/SbS and VO for effectively signal change strategy for cancer marker detection.

Biosens Bioelectron 2021 Jul 21;192:113528. Epub 2021 Jul 21.

Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection; Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.

In this item, a high-efficiency signal "on-off-on" strategy photoelectrochemical (PEC) apatsensor was resoundingly developed for target ultrasensitive analysis. Primarily, the heterojunction formation between Cd: SbS and LaTiO was contributed to the first "signal-on" state to improve the stability of the PEC platform. Secondly, VO nanosphere act as a catalyst for HO was used to label on aptamer DNA to consume electron donor for achieving "signal-off" state. Read More

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Epilepsy in LAMA2-related muscular dystrophy: A systematic review of the literature.

Seizure 2021 Jul 21;91:425-436. Epub 2021 Jul 21.

Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy. Electronic address:

Epilepsy is a common, often severe, feature of LAMA2-related muscular dystrophy (LAMA2-RD) and could represent its onset and main manifestation, even in the absence of overt muscle involvement. To date, there is no systematic characterization of epilepsy in LAMA2-RD, and its impact on neurodevelopment and on the clinical course remains poorly established. In view of this knowledge gap, we conducted a systematic review of the literature and, as an illustrative example, reported the clinical case of a boy with late-onset LAMA2-related limb-girdle muscular dystrophy presenting with severe epilepsy. Read More

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Monoclonal antibody charge variant characterization by fully automated four-dimensional liquid chromatography-mass spectrometry.

J Chromatogr A 2021 Jul 14;1653:462409. Epub 2021 Jul 14.

RIC group, President Kennedypark 26, Kortrijk 8500, Belgium; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent B-9000, Belgium. Electronic address:

Fully automated characterization of monoclonal antibody (mAb) charge variants using four-dimensional liquid chromatography-mass spectrometry (4D-LC-MS) is reported and illustrated. Charge variants resolved by cation-exchange chromatography (CEX) using a salt- or pH-gradient are collected in loops installed on a multiple heart-cutting valve and consequently subjected to online desalting, denaturation, reduction and trypsin digestion prior to LC-MS based peptide mapping. This innovation which substantially reduces turnaround time, sample manipulation, loss and artefacts and increases information gathering, is described in great technical detail, and applied to characterize the charge heterogeneity associated with three therapeutic mAbs. Read More

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"Does that mean I can't use my phone to pay when I'm in the Maccas drive thru?": Younger drivers' uncertainty and attitude toward smartphone law and punishment.

Accid Anal Prev 2021 Jul 26;160:106314. Epub 2021 Jul 26.

Monash University Accident Research Centre, Monash University, Australia.

This study employed a mixed methods approach (a survey [n = 2,774] and focus groups [n = 16]) to understand the perceptions of younger drivers (18-25) on current smartphone laws in the Australian state of Victoria. First, by analysing quantitative data gathered from an online survey regarding smartphone laws, perceptions of punishment when breaking the law, and attitudes to both the law and fines, this study found younger drivers were less likely to understand the law around phone use while driving, even after direct or indirect experience with police. Additionally, the severity and impact of fines were perceived as more impactful and severe among younger drivers, women, and those on lower incomes, and the most common types of illegal use younger drivers engaged with were navigation, music applications, and hands-free calling, mostly facilitated through Bluetooth with their device placed out of sight. Read More

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Reversible Cerebral Vasoconstriction Syndrome Following Exposure to Oleoresin Capsicum "Pepper Spray".

J Stroke Cerebrovasc Dis 2021 Jul 26;30(10):106006. Epub 2021 Jul 26.

Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States.

Objectives: To report a case associating the use of Oleoresin Capsicum Pepper Spray (OCPS) during law enforcement training with development of Reversible Cerebral Vasoconstriction Syndrome (RCVS).

Materials And Methods: RCVS is radiographically characterized by multifocal smooth narrowing of cerebral arteries heralded by clinical manifestations of recurrent thunderclap headaches. 70% of cases with RCVS have a clear precipitating factor and agents commonly implicated were cannabis, selective serotonin reuptake inhibitors, nasal decongestants, cocaine, postpartum state, eclampsia and strenuous physical/sexual activity. Read More

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Removal of hexavalent chromium by biochar derived from Azadirachta indica leaves: Batch and column studies.

Chemosphere 2021 Jul 17;286(Pt 1):131598. Epub 2021 Jul 17.

Department of BioNano Technology, Gachon University, Seongnam, 13120, Republic of Korea. Electronic address:

This report details the preparation, characterization, and applications of an inexpensive adsorbent obtained from Azadirachta indica leaves (Neem biochar (NBC)) and used to remove Cr(VI) from the synthetic waste water. The obtained NBC was characterized by XRD, FTIR, FESEM, EDX and Zeta potential measurements. Adsorption experiments conducted at various pH levels confirmed that 58. Read More

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Crystallization and melting properties studied by DSC and FTIR spectroscopy of goldenberry (Physalis peruviana) oil.

Food Chem 2021 Jul 21;366:130645. Epub 2021 Jul 21.

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan. Electronic address:

The chemical and thermal characteristics of goldenberry pomace oil (GPO) and goldenberry seed oil (GSO) were investigated. GPO and GSO contained high levels of unsaturated fatty acids (90.1% and 85. Read More

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Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects.

Phytochemistry 2021 Jul 26;190:112861. Epub 2021 Jul 26.

Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24-100, Puławy, Poland.

The study is based on phytochemical profiling and in vitro evaluation of biological effects of phenolic acid derivatives-rich Herniaria fractions, isolated from two rupturewort (Herniaria L.) species, i.e. Read More

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Predictive protein markers for depression severity in mood disorders: A preliminary trans-diagnostic approach study.

J Psychiatr Res 2021 Jul 24;142:63-72. Epub 2021 Jul 24.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. Electronic address:

Depression is a common symptom of many mental disorders, especially major depressive disorder (MDD) and bipolar disorder (BD). Previous studies have reported that these diseases share common pathophysiological pathways; therefore, this study elucidated whether the plasma levels of protein markers related to common depressive symptoms differed between patients with BD and those with MDD. Plasma samples of 71 patients with mood disorders and clinical manifestations were analyzed in this study. Read More

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Outcomes of SARS-CoV-2 infection in patients with pulmonary sarcoidosis: A multicenter retrospective research network study.

Respir Med 2021 Jul 22;187:106538. Epub 2021 Jul 22.

Department of Internal Medicine, Department of Medicine, West Virginia University, Morgantown, WV, USA. Electronic address:

Background: Analyses of COVID-19 infection outcomes in patients with preexisting pulmonary sarcoidosis are lacking and are limited to case reports or small case series with the largest study reporting outcomes of 37 patients.

Research Question: Retrospective cohort study to assess clinical outcomes of 945 patients with pulmonary sarcoidosis, presenting with COVID 19, compared to a propensity matched cohort of patients without sarcoidosis.

Study Design And Methods: Analysis of a multi-center research network TriNETX was performed including patients more than 16 years of age diagnosed with COVID-19. Read More

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Probing the transport of Ni(II) ions through the internal tunnels of the Helicobacter pylori UreDFG multimeric protein complex.

J Inorg Biochem 2021 Jul 22;223:111554. Epub 2021 Jul 22.

Laboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, viale G. Fanin 40, I-40127 Bologna, Italy. Electronic address:

The survival of several pathogenic bacteria, such as Helicobacter pylori (Hp), relies on the activity of the nickel-dependent enzyme urease. Nickel insertion into urease is mediated by a multimeric chaperone complex (HpUreDFG) that is responsible for the transport of Ni(II) from a conserved metal binding motif located in the UreG dimer (CPH motif) to the catalytic site of the enzyme. The X-ray structure of HpUreDFG revealed the presence of water-filled tunnels that were proposed as a route for Ni(II) translocation. Read More

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Specific toxicity of azithromycin to the freshwater microalga Raphidocelis subcapitata.

Ecotoxicol Environ Saf 2021 Jul 26;222:112553. Epub 2021 Jul 26.

Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, Oslo 0349, Norway.

Pharmaceuticals are produced to inflict a specific physiological response in organisms. However, as only partially metabolized after administration, these types of compounds can also originate harmful side effects to non-target organisms. Additionally, there is still a lack of knowledge on the toxicological effects of legacy pharmaceuticals such as the antibiotic azithromycin. Read More

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The role of depression and anxiety in the relationship between poor sleep quality and subjective cognitive decline in Chinese elderly: Exploring parallel, serial, and moderated mediation.

J Affect Disord 2021 Jul 19;294:464-471. Epub 2021 Jul 19.

Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, China. Electronic address:

Background: Poor sleep quality exacerbates subjective cognitive decline (SCD). Mental health may play an important role in the relationship, but the potential underlying mechanisms remain unknown.

Methods: A cross-sectional study was conducted on older adult residents in Guangdong province, south China from November 2020 to March 2021. Read More

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Investigation of aliphatic hydrocarbons in core sediments of Brunei Bay, East Malaysia.

Mar Pollut Bull 2021 Jul 26;171:112736. Epub 2021 Jul 26.

Institute of Oceanography and Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia; School of Marine and Environmental Sciences, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.

The distribution of aliphatic hydrocarbons in three sediment cores from Brunei Bay was investigated in order to understand their sources and the biogeochemical processes of these hydrocarbons. The total concentrations of C to Cn-alkanes ranged from 0.70 to 16. Read More

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Patterns of pharmaceuticals use during the first wave of COVID-19 pandemic in Athens, Greece as revealed by wastewater-based epidemiology.

Sci Total Environ 2021 Jul 21;798:149014. Epub 2021 Jul 21.

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. Electronic address:

Since 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), impaired public health with considerable morbidity and mortality due to the lack of vaccines and effective treatment. The severe disease mainly harmed adults with predisposing medical comorbidities (such as heart disease, hypertension, chronic lung disease), while it can occur in healthy individuals that may be asymptomatic. Wastewater-based Epidemiology (WBE), a non-invasive, objective, chemical tool was used to monitor and estimate the changes in drug's consumption and prescription patterns under normal conditions (2019) and under COVID-19 pandemic conditions (2020). Read More

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A systematic review and meta-analysis of the association between expressive suppression and positive affect.

Clin Psychol Rev 2021 Jul 14;88:102068. Epub 2021 Jul 14.

Georgia State University, Department of Psychology, 140 Decatur St SE, 1172 Urban Life, Atlanta, GA, United States of America. Electronic address:

People differ in their self-reported propensities to experience positive affect (PA). Even those prone to internalizing symptoms show varied proclivities to PA; social anxiety (SA), for instance, unlike other types of anxiety, shows a strong negative association with PA that cannot be explained by diminished reward sensitivity. Heightened reliance on suppression of emotional displays (expressive suppression; ES) may be an alternate contributor to attenuated PA among people with elevated SA, relative to people with other types of anxiety. Read More

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Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy: a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and H-MR spectroscopy compared with histology (subgroup in the RAXO trial).

ESMO Open 2021 Jul 26;6(4):100208. Epub 2021 Jul 26.

Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Colorectal cancer liver metastases respond to chemotherapy and targeted agents not only by shrinking, but also by morphologic and metabolic changes. The aim of this study was to evaluate the value of advanced magnetic resonance imaging (MRI) methods in predicting treatment response and survival.

Patients And Methods: We investigated contrast-enhanced MRI, apparent diffusion coefficient (ADC) in diffusion-weighted imaging and H-magnetic resonance spectroscopy (H-MRS) in detecting early morphologic and metabolic changes in borderline or resectable liver metastases, as a response to first-line neoadjuvant or conversion therapy in a prospective substudy of the RAXO trial (NCT01531621, EudraCT2011-003158-24). Read More

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