15,785 results match your criteria revealed hepatitis

Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis.

J Hepatol 2021 Jun 12. Epub 2021 Jun 12.

Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France. Electronic address:

Background & Aims: Alcoholic hepatitis (AH) is a life-threatening disease with limited therapeutic options, because understanding of the molecular drivers leading to death are not well understood. This study evaluates the Hippo/Yes-associated protein (YAP) pathway which has been shown to play a role in liver regeneration.

Method: The Hippo/YAP pathway was dissected in explants of patients transplanted for AH or alcoholic cirrhosis and in control livers, using RNA-Seq, real-time PCR, Western blot, immunohistochemistry (IHC) and transcriptome analysis after laser microdissection. Read More

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Atezolizumab and bevacizumab-induced encephalitis in advanced hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2021 06;100(24):e26377

Department of Hepatology and Gastroenterology.

Introduction: On the basis of the results of the IMBRAVE-150 trial, the combination of atezolizumab, a programmed cell death ligand 1 (PD-L1) antibody, as well as bevacizumab, a vascular endothelial growth factor (VEGF) antibody, represents a promising novel first-line therapy in patients with advanced hepatocellular carcinoma (HCC). Despite favorable safety data, serious adverse events have been described. However, central nervous system complications such as encephalitis have rarely been reported. Read More

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Evidence-based management of HCC: Systematic review and meta-analysis of randomized controlled trials (2002-2020).

Gastroenterology 2021 Jun 11. Epub 2021 Jun 11.

Mount Sinai Liver Cancer Program, [Division of Liver Diseases, RMTI, Dept of Radiology, Hematology/Medical Oncology,] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

Background And Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality with a rapidly changing landscape of treatments. In the past 20 years, numerous randomized controlled trials (RCT) have aimed at improving outcomes across disease stages. We aimed at analyzing the current evidence and identifying potential factors influencing response to therapies. Read More

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Malnutrition prevalence and associated biochemical factors among drug-resistance tuberculosis (DR-TB) patients at key treatment sites in Conakry City, Republic of Guinea.

Pan Afr Med J 2021 17;38:279. Epub 2021 Mar 17.

National AIDS and Hepatitis Control Program, Guinea.

Introduction: drug-resistant tuberculosis is a major global health problem and a threat to health security given the increase in the number of cases and the challenges associated with care. Besides, the relationship between poor nutritional status and tuberculosis is clearly established. For relevant and evidence-based public health decision-making regarding the management of malnutrition in patients with drug-resistant tuberculosis in the initial phase, it is essential to estimate the prevalence of malnutrition and understand the risk factors associated with it. Read More

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Correlation between the prognosis of chronic hepatitis B treated with interferon and the gene polymorphism of CGRP and its receptor.

Infect Genet Evol 2021 Jun 9:104968. Epub 2021 Jun 9.

Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human health, Shi Jiazhuang, PR China. Electronic address:

Objective: To investigate the relationship of the polymorphism of two gene loci (CGRP rs155209 and RAMP1 rs3754701) with the prognosis of interferon therapy for chronic hepatitis B (CHB) by case-control study.

Materials And Methods: 317 CHB patients using interferon for the first time alone were collected in northern China and peripheral blood samples were obtained, the single-nucleotide polymorphisms (SNPs) in CGRP rs155209 and RAMP1 rs3754701 were genotyped by MALDI-TOF-MS. Univariate and multivariate logistic regression methods were used to assess the correlation between the prognosis of CHB treated with interferon and the gene polymorphism of CGRP rs155209 and RAMP1 rs3754701. Read More

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Natural killer cells in antiviral immunity.

Nat Rev Immunol 2021 Jun 11. Epub 2021 Jun 11.

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Read More

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Multiple Roles of IL-6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis.

Cancer Res 2021 Jun 11. Epub 2021 Jun 11.

Goldyne-Savad Institute of Gene Therapy, Hadassah Hebrew University Hosptial

Hepatocellular carcinoma (HCC) typically develops on a background of chronic hepatitis for which the pro-inflammatory cytokine interleukin-6 (IL-6) is conventionally considered a crucial driving factor. Paradoxically, IL-6 also acts as a hepatoprotective factor in chronic liver injury. Here we used the multidrug-resistant gene 2 knockout (Mdr2-/-) mouse model to elucidate potential roles of IL-6 in chronic hepatitis-associated liver cancer. Read More

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Hepatitis B infections among blood donors in England between 2009 and 2018: Is an occult hepatitis B infection a risk for blood safety?

Transfusion 2021 Jun 11. Epub 2021 Jun 11.

Microbiology Services, NHS Blood and Transplant, London, UK.

Introduction: Hepatitis B virus (HBV) is one of the most frequent infections identified in blood donors in England and represents an ongoing blood safety risk. We have analyzed markers of HBV infections in blood donors in England between 2009 and 2018 and used these to estimate the likelihood of non-detection of occult HBV infection (OBI).

Methods: We collected epidemiological, virological, and genotyping information on HBV cases identified in England, 2009-2018. Read More

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Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus Infection.

Front Immunol 2021 25;12:684424. Epub 2021 May 25.

Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Whether hepatitis B virus (HBV) activates or represses innate immunity continues to be debated. Toll-like receptor (TLR) 2 has been identified to recognize HBV particles in human hepatocytes. The Hippo pathway, known for growth control, is suggested to play a vital role in immune regulation. Read More

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Immune activation induces telomeric DNA damage and promotes short-lived effector T cell differentiation in chronic HCV infection.

Hepatology 2021 Jun 10. Epub 2021 Jun 10.

Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City.

Background And Aims: Hepatitis C virus (HCV) leads to a high rate of chronic infection and T cell dysfunction. While it is well-known that chronic antigenic stimulation is a driving force for impaired T cell functions, the precise mechanisms underlying immune activation-induced T cell dysfunctions during HCV infection remain elusive.

Approach And Results: Here, we demonstrated that circulating CD4 T cells from chronically HCV-infected patients exhibit an immune activation status, as evidenced by the overexpression of cell activation markers HLA-DR, GLUT1, Granzyme B, and the short-lived effector marker CD127 KLRG1 . Read More

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Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population.

Hum Genome Var 2021 Jun 8;8(1):22. Epub 2021 Jun 8.

Department of Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.

Genome-wide association studies have been performed to identify common genetic variants associated with hepatitis B (HB). However, little is known about copy number variations (CNVs) in HB. In this study, we performed a genome-wide CNV analysis between 1830 healthy controls and 1031 patients with HB infection after quality control. Read More

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Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication.

Cell Biosci 2021 Jun 7;11(1):106. Epub 2021 Jun 7.

Center for Food Animal Health, Department of Animal Sciences, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Wooster, OH, 44691, USA.

Background: Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to replication fidelity. It has been reported that CoVs exhibit variable sensitivity to nsp14-ExoN deficiency. Betacoronavirus murine hepatitis virus (MHV) and severe acute respiratory syndrome (SARS)-CoV were viable upon nsp14-ExoN deficiency. Read More

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Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 .

Antimicrob Agents Chemother 2021 Jun 7:AAC0268020. Epub 2021 Jun 7.

Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Antivirals targeting SARS-CoV-2 could improve treatment of COVID-19. We evaluated efficacy of clinically relevant hepatitis C virus (HCV) NS3 protease inhibitors (PI) against SARS-CoV-2 and their interactions with remdesivir, the only direct-acting antiviral approved for COVID-19 treatment. HCV PI showed differential potency in short-term treatment assays based on detection of SARS-CoV-2 Spike protein in VeroE6 cells. Read More

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[Severe Hepatitis E virus infection in a patient with rheumatoid arthritis treated with baricitinib].

Z Rheumatol 2021 Jun 7. Epub 2021 Jun 7.

Medizinische Klinik 3, Rheumatologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg und Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.

A patient with rheumatoid arthritis (RA) was presented, who developed an infection with the hepatitis E virus (HEV) under treatment with the Janus kinase (JAK) 1 and 2 inhibitor baricitinib. In the 3‑month routine check-up the patient had clearly elevated transaminase levels with an inconspicuous physical examination. The investigations detected antibodies of IgM and IgG classes against HEV and an elevated C‑reactive protein (CRP) level as well as HEV-RNA by real-time PCR, which is indicative of a recent HEV infection. Read More

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The lipid peroxidation derived DNA adduct γ-OHPdG levels in paraneoplastic liver tissues predict postoperative outcomes of hepatoma.

J Cancer 2021 13;12(13):4064-4074. Epub 2021 May 13.

Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Chronic necroinflammation in liver induces lipid peroxidation and oxidative stress, which contributes to hepatocellular carcinoma (HCC) development. Gamma-hydroxy-1, N2-propanodeoxyguanosine (γ-OHPdG), a promutagenic DNA adduct, is derived from lipid peroxidation. Little is known about the clinical roles of γ-OHPdG in relationship to HCC progression. Read More

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Identification of Prognostic Biomarkers and Correlation With Immune Infiltrates in Hepatocellular Carcinoma Based on a Competing Endogenous RNA Network.

Front Genet 2021 20;12:591623. Epub 2021 May 20.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Recently, competing endogenous RNAs (ceRNA) have revealed a significant role in the progression of HCC. Herein, we aimed to construct a ceRNA network to identify potential biomarkers and illustrate its correlation with immune infiltration in HCC. Read More

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Label-free quantitative proteomic analysis of serum extracellular vesicles differentiating patients of alcoholic and nonalcoholic fatty liver diseases.

J Proteomics 2021 Jun 2;245:104278. Epub 2021 Jun 2.

Department of Chemistry, Chungnam National University, Daejeon, Republic of Korea; Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, Republic of Korea. Electronic address:

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are typically asymptomatic and slow-progressing but potentially fatal diseases that are common causes of liver cirrhosis and related complications. Exosomes are nano-sized extracellular vesicles that have been linked to various intercellular communication processes and can carry biological materials reflecting the state and severity of disease. In this study, shotgun proteomic analysis of the protein expression profiles of extracellular vesicles, including exosomes and microvesicles, enriched from human serum samples of 24 patients diagnosed with various fatty liver diseases was performed using liquid chromatography tandem mass spectrometry (LC-MS/MS) followed by protein identification and label-free quantification using the MaxQuant platform. Read More

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Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 26;261:120008. Epub 2021 May 26.

Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt. Electronic address:

Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR). The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques. The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7. Read More

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Emergence of fowl aviadenovirus C-4 in a backyard chicken flock in California.

J Vet Diagn Invest 2021 Jun 4:10406387211019962. Epub 2021 Jun 4.

California Animal Health and Food Safety Laboratory System, Davis Branch, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.

Fowl aviadenovirus (FAdV) species D and E are associated with inclusion body hepatitis (IBH); species C, serotype 4 (hereafter, FAdV4) is associated with hepatitis-hydropericardium syndrome (HHS) in young chickens. Outbreaks of HHS have led to significant losses in the poultry industry in several countries, predominantly in China. In April 2020, FAdV4 was detected in a remote backyard flock in California. Read More

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The association between hepatitis C virus infection and renal function.

J Chin Med Assoc 2021 Jun 1. Epub 2021 Jun 1.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Department of Medical Research and Development, PubMend Medical Research Center, Ulaanbaatar, Mongolia Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia Hepatobiliary Section, Department of Internal Medicine & Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Department of Public Health and Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsin-Chu, Taiwan, ROC.

Background: It is controversial that the association of hepatitis C virus (HCV) infection and chronic kidney disease (CKD). We wanted to investigate whether HCV really affect to renal function, also to analyze the association between clinical effects of CHC and decreased kidney function assessed by estimated glomerular filtration rate (eGFR) level.

Methods: The 3360 patients with hepatitis C virus infection and 3360 age and sex matched community based control individuals without HCV were enrolled (1:1, case and control ratio) in this study between 2004 and 2016. Read More

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Development of a Tetraplex qPCR for the Molecular Identification and Quantification of Human Enteric Viruses, NoV and HAV, in Fish Samples.

Microorganisms 2021 May 27;9(6). Epub 2021 May 27.

ITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.

Human enteric viruses such as norovirus (NoV) and hepatitis A virus (HAV) are some of the most important causes of foodborne infections worldwide. Usually, infection via fish consumption is not a concern regarding these viruses, since fish are mainly consumed cooked. However, in the last years, raw fish consumption has become increasingly common, especially involving the use of seabass and gilthead seabream in dishes like sushi, sashimi, poke, and carpaccio. Read More

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Virus-Driven Carcinogenesis.

Cancers (Basel) 2021 May 27;13(11). Epub 2021 May 27.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Cancer arises from the accumulation of genetic and epigenetic alterations. Even in the era of precision oncology, carcinogens contributing to neoplastic process are still an important focus of research. Comprehensive genomic analyses have revealed various combinations of base substitutions, referred to as the mutational signatures, in cancer. Read More

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Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Department of Emergency Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.

Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis, steatohepatitis, hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The progression of ALD is mainly associated with the amount and duration of alcohol usage; however, it is also influenced by genetic, epigenetic, and environmental factors. The definite diagnosis of ALD is based on a liver biopsy, although several non-invasive diagnostic tools and serum biomarkers have emerging roles in the early detection of ALD. Read More

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The Prognostic Correlation of Heart Rate Variability at Diagnosis with Survival of Patients with Hepatocellular Carcinoma.

Diagnostics (Basel) 2021 May 17;11(5). Epub 2021 May 17.

Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Background: Heart rate variability (HRV) indices have been shown to be associated with prognosis in various types of cancer. This study aims to assess the ability of these indices to predict survival in hepatocellular carcinoma (HCC) patients after diagnosis.

Methods: We retrospectively collected data from 231 patients diagnosed with HCC between January 2014 and March 2018. Read More

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Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria.

Viruses 2021 May 21;13(6). Epub 2021 May 21.

Department of Infectious Diseases, Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Robert Koch Institute, 13353 Berlin, Germany.

Avian hepatitis E virus (aHEV) is the major etiological agent of hepatitis-splenomegaly syndrome (HSS), big liver and spleen disease (BLSD), and hepatic rupture hemorrhage syndrome (HRHS) in chickens. Infections with aHEV cause a significant decrease in egg production and increased mortality in chickens worldwide. However, studies on the prevalence of aHEV in Nigeria are scarce. Read More

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Hepatitis C Prevalence and Validation of a Clinical Prediction Score for Targeted Screening among People Living with HIV in Ghana.

J Int Assoc Provid AIDS Care 2021 Jan-Dec;20:23259582211022469

37463Institute of Tropical Medicine, Antwerp, Belgium.

WHO recommends hepatitis C (HCV) screening for all people living with HIV (PLHIV). Yet, HCV coinfection was shown to be rare in some Sub-Saharan HIV cohorts, and targeted testing was suggested more efficient for such settings. We studied HCV prevalence among Ghanaian PLHIV, and assessed the external validity of a score to guide targeted testing. Read More

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Diffuse gallbladder wall thickening in autoimmune hepatitis: an unusual presentation.

BMJ Case Rep 2021 May 31;14(5). Epub 2021 May 31.

Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A 63-year-old woman presented with jaundice and epigastric pain for 2 weeks. Physical examination revealed marked jaundice, and palpable gallbladder with right upper quadrant tenderness. Liver function test was remarkable for hepatocellular injury pattern. Read More

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Four novel picornaviruses detected in Magellanic Penguins (Spheniscus magellanicus) in Chile.

Virology 2021 Aug 25;560:116-123. Epub 2021 May 25.

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden. Electronic address:

Members of the Picornaviridae family comprise a significant burden on the poultry industry, causing diseases such as gastroenteritis and hepatitis. However, with the advent of metagenomics, a number of picornaviruses have now been revealed in apparently healthy wild birds. In this study, we identified four novel viruses belonging to the family Picornaviridae in healthy Magellanic penguins, a near threatened species. Read More

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Resolution of primary hepatic marginal zone lymphoma in a hepatitis C virus-infected patient treated with a direct-acting antiviral.

Oxf Med Case Reports 2021 May 24;2021(5):omab022. Epub 2021 May 24.

Hematology Unit, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.

The favorable impact of antiviral therapy on low-grade hepatitis C virus (HCV)-related non-Hodgkin lymphoma manifesting as marginal zone lymphoma (MZL) has been reported in some clinical studies. However, primary HCV-related marginal zone lymphomas (MZLs) confined to the liver have not been described in the literature nor have the resolution of liver lymphoma through anti-HCV eradication treatment. The authors report a genotype 1b HCV-positive patient with chronic hepatitis who exhibited lesions involving both hepatic lobes resembling hepatocellular carcinoma. Read More

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The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19?

Front Immunol 2021 13;12:662266. Epub 2021 May 13.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.

IL-36 is a member of the interleukin 1 cytokine family, which is currently experiencing a renaissance due to the growing understanding of its context-dependent roles and advances in our understanding of the inflammatory response. The immunological role of IL-36 has revealed its profound and indispensable functional roles in psoriasis, as well as in several inflammatory diseases, including inflammatory bowel disease (IBD), systemic lupus erythematosus, rheumatoid arthritis (RA) and cancer. More recently, an increasing body of evidence suggests that IL-36 plays a crucial role in viral, bacterial and fungal infections. Read More

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