12,874 results match your criteria revealed dense

Suspected spontaneous hyperadrenocorticism in a young experimental beagle dog.

J Toxicol Pathol 2021 Jul 1;34(3):261-267. Epub 2021 Mar 1.

Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.

A 6-month-old female beagle dog, assigned to the low-dose group in a toxicity study, was evaluated for compound toxicity, and spontaneous hyperadrenocorticism was suspected. The animal had an externally apparent distended abdomen on clinical examination upon arrival. Pre-dose clinical pathology showed slightly higher erythroid parameters and stress leukogram on hematology; plasma biochemistry showed higher total protein, gamma-glutamyl transferase, total cholesterol, and triglyceride levels than the reference data. Read More

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An integrative study of genetic variants with brain tissue expression identifies viral etiology and potential drug targets of multiple sclerosis.

Mol Cell Neurosci 2021 Jul 17:103656. Epub 2021 Jul 17.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, USA. Electronic address:

Multiple sclerosis (MS) is a neuroinflammatory disorder leading to chronic disability. Brain lesions in MS commonly arise in normal-appearing white matter (NAWM). Genome-wide association studies (GWAS) have identified genetic variants associated with MS. Read More

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L-DOPA promotes striatal dopamine release through D1 receptors and reversal of dopamine transporter.

Brain Res 2021 Jul 17:147583. Epub 2021 Jul 17.

Department of Morphology, Surgery and Experimental Medicine, Section of Pharmacology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy. Electronic address:

Previous studies have pointed out that L-DOPA can interact with D1 or D2 receptors independent of its conversion to endogenous dopamine. The present study was set to investigate whether L-DOPA modulates dopamine release from striatal nerve terminals, using a preparation of synaptosomes preloaded with [H]DA. Levodopa (1 µM) doubled the K-induced [H]DA release whereas the D2/D3 receptor agonist pramipexole (100 nM) inhibited it. Read More

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Occurrence of postharvest snow rot caused by on Asian ginseng in China.

Plant Dis 2021 Jul 20. Epub 2021 Jul 20.

Chinese Academy of Agricultural Sciences, 12661, Institute of Special Wild Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China;

Asian ginseng () is a valuable medicinal plant that is commercially cultivated in China. A long postharvest storage period is required before ginseng is processed. From October 2019 to May 2020, snow rot was observed on the roots of 4- and 5-year-old fresh ginseng stored in three cold storage facilities located in Tonghua and Changbai cities in northeastern China, which are the most important regions for Asian ginseng production. Read More

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Battling the biotypes of balsam: the biological control of Impatiens glandulifera using the rust fungus Puccinia komarovii var. glanduliferae in GB.

Fungal Biol 2021 Aug 11;125(8):637-645. Epub 2021 Apr 11.

CABI Europe-UK, Bakeham Lane, Egham, Surrey, TW20 9TY, UK.

Impatiens glandulifera, or Himalayan balsam, is a prolific invader of riverine habitats. Introduced from the Himalayas for ornamental purposes in 1839, this annual species has naturalised across Great Britain (GB) forming dense monocultures with negative affects across whole ecosystems. In 2006 a programme exploring biocontrol as an alternative control method was initiated and to date, two strains of the rust fungus Puccinia komarovii var. Read More

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Unraveling Subcellular and Ultrastructural Changes During Vitrification of Human Spermatozoa: Effect of a Mitochondria-Targeted Antioxidant and a Permeable Cryoprotectant.

Front Cell Dev Biol 2021 2;9:672862. Epub 2021 Jul 2.

Department of Obstetrics and Gynaecology, Medical Faculty, Cologne University, Cologne, Germany.

Mitochondria-targeted antioxidants have great potential to counterbalance the generated reactive oxygen species (ROS) because they cross the inner membrane of the mitochondria. Still, their use was not reported in vitrified human spermatozoa. Our laboratory has successfully vitrified spermatozoa without the use of permeable cryoprotectants, but subcellular-level evidence was missing. Read More

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Smoothing temperature and ratio of casein to whey protein: Two tools to improve nonfat stirred yogurt properties.

J Dairy Sci 2021 Jul 15. Epub 2021 Jul 15.

Department of Food Sciences, Université Laval, Quebec City, QC, Canada, G1V 0A6; STELA Dairy Research Centre and Institute of Nutrition and Functional Foods, Université Laval, Quebec City, QC, Canada, G1V 0A6. Electronic address:

Consumers are not always ready to compromise on the loss of texture and increased syneresis that nonfat stirred yogurts display compared with yogurts that contain fat. In this study, we investigated milk protein composition and smoothing temperature as a means to control nonfat yogurt microstructure, textural properties, and syneresis. Yogurts were prepared with different ratios of casein to whey protein (R1. Read More

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Spatiotemporal Mapping of Early Volume Loss in the Mouse Brain after Cranial Irradiation.

Radiat Res 2021 Jul 16. Epub 2021 Jul 16.

Departments of Medical Biophysics, University of Toronto, Ontario, Canada.

Sequelae after pediatric cranial radiotherapy (CRT) result in long-term changes in brain structure. While past evidence indicates regional differences in brain volume change, it remains unclear how these manifest in the time course of change after CRT. In this study, we spatiotemporally characterized volume losses induced by cranial irradiation in a mouse model, with a dense sampling of measurements over the first week postirradiation. Read More

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Reaction Kinetics Regulated Formation of Short-Range Order in an Amorphous Matrix during Zeolite Crystallization.

J Am Chem Soc 2021 Jul 16. Epub 2021 Jul 16.

Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

The crystallization of zeolites, a disorder-to-order transformation of aluminosilicates, has not been thoroughly understood because the nucleation events in the amorphous matrix are difficult to recognize from the diverse structural changes, especially for the dense hydrogel systems. Therefore, relationships between the synthesis conditions, the generated amorphous species, and the crystallization behavior of zeolites remain unclear. Herein, by comparatively investigating the structural evolution of the aluminosilicate matrix in a dense hydrogel system when different Si reactants (fumed silica and silicate solution) are employed, we demonstrate that the reactivity of the reactants and the kinetics of the condensation reaction is critical to the formation of short-range order in an amorphous matrix, which greatly influences the nucleation frequency of zeolites. Read More

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Tributyltin Oxide Exposure During Maturation Disrupts Oocyte Maturation and Subsequent Embryonic Developmental Competence in Pigs.

Front Cell Dev Biol 2021 28;9:683448. Epub 2021 Jun 28.

Department of Animal Sciences, College of Animal Sciences, Jilin University, Changchun, China.

Tributyltin oxide (TBTO), an organotin compound, has been demonstrated to have toxic effects on several cell types. Previous research has shown that TBTO impairs mouse denuded oocyte maturation. However, limited information is available on the effects of TBTO exposure on livestock reproductive systems, especially on porcine oocytes in the presence of dense cumulus cells. Read More

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Investigating Different DNA Methylation Patterns at the Resolution of Methylation Haplotypes.

Front Genet 2021 28;12:697279. Epub 2021 Jun 28.

School of Computer Science and Engineering, Yulin Normal University, Yulin, China.

Different DNA methylation patterns presented on different tissues or cell types are considered as one of the main reasons accounting for the tissue-specific gene expressions. In recent years, many methods have been proposed to identify differentially methylated regions (DMRs) based on the mixture of methylation signals from homologous chromosomes. To investigate the possible influence of homologous chromosomes on methylation analysis, this paper proposed a method (MHap) to construct methylation haplotypes for homologous chromosomes in CpG dense regions. Read More

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A novel algorithm for 3-D visualization of electrogram duration for substrate-mapping in patients with ischemic heart disease and ventricular tachycardia.

PLoS One 2021 14;16(7):e0254683. Epub 2021 Jul 14.

Department of Cardiology, Angiology and Intensive Care, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Düsseldorf, Germany.

Background: Myocardial slow conduction is a cornerstone of ventricular tachycardia (VT). Prolonged electrogram (EGM) duration is a useful surrogate parameter and manual annotation of EGM characteristics are widely used during catheter-based ablation of the arrhythmogenic substrate. However, this remains time-consuming and prone to inter-operator variability. Read More

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The distribution, number and certain neurochemical identities of infracortical white matter neurons in the brains of a southern lesser galago, a black-capped squirrel monkey and a crested macaque.

J Comp Neurol 2021 Jul 14. Epub 2021 Jul 14.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Republic of South Africa.

In the current study we examined the number, distribution, and aspects of the neurochemical identities of infracortical white matter neurons, also termed white matter interstitial cells (WMICs), in the brains of a southern lesser galago (Galago moholi), a black-capped squirrel monkey (Saimiri boliviensis boliviensis) and a crested macaque (Macaca nigra). Staining for neuronal nuclear marker (NeuN) revealed WMICs throughout the infracortical white matter, these cells being most dense close to inner cortical border, decreasing in density with depth in the white matter. Stereological analysis of NeuN-immunopositive cells revealed estimates of approximately 1. Read More

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Dynamic Light Scattering Study of a Laser-Induced Phase-Separated Droplet of Aqueous Glycine.

J Phys Chem B 2021 Jul 14;125(28):7828-7839. Epub 2021 Jul 14.

Department of Chemical and Biomolecular Engineering, NYU Tandon School of Engineering, 6 Metrotech Center, Brooklyn, New York 11201, United States.

Tightly focusing a continuous-wave, near-infrared laser beam at the air/solution interface of a millimeter-thick layer of glycine in DO forms a crystal through a polymorphically and spatially controlled nucleation process known as gradient-force laser-induced nucleation or optical-tweezer laser-induced nucleation. However, when this same beam is focused at the glass/solution interface of a film of aqueous glycine, a highly concentrated laser-induced phase-separated (LIPS) solution droplet is formed that does not nucleate while the focusing beam remains on. Two competing theories have emerged about the nature of the LIPS droplet: one proposes that it is a merger of prenucleation metastable nanodroplets and clusters into one large homogeneous "dense liquid droplet", and the other stipulates that it is the result of the partitioning of larger droplets into the new phase, but not a merging of droplets, around the focal point of the beam. Read More

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Development of cavitary lung disease as a long-term complication of coronavirus disease 2019 in a young previously healthy patient: a case report.

J Med Case Rep 2021 Jul 13;15(1):377. Epub 2021 Jul 13.

Department of Internal Medicine, AMITA Health Saint Francis Hospital, 355 Ridge Ave, Evanston, IL, 60202, USA.

Background: Cavities are frequent manifestations of a wide variety of pathological processes involving the lung. There has been a growing body of evidence of coronavirus disease 2019 leading to a cavitary pulmonary disease.

Case Presentation: A healthy 29-year-old Filipino male presented to the hospital a couple of months after convalescence from coronavirus disease 2019 with severe pleuritic chest pain, fever, chills, and shortness of breath, and was found to have a cavitary lung lesion on chest computed tomography. Read More

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Multiple system atrophy variant with severe hippocampal pathology.

Brain Pathol 2021 Jul 13:e13002. Epub 2021 Jul 13.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

The striatonigral and olivopontocerebellar systems are known to be vulnerable in multiple system atrophy (MSA), showing neuronal loss, astrogliosis, and alpha-synuclein-immunoreactive inclusions. MSA patients who displayed abundant neuronal cytoplasmic inclusions (NCIs) in the regions other than the striatonigral or olivopontocerebellar system have occasionally been diagnosed with variants of MSA. In this study, we report clinical and pathologic findings of MSA patients characterized by prominent pathologic involvement of the hippocampus. Read More

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Possible spontaneous regression of hepatocellular carcinoma with unique histopathological features confirmed by surgical resection: a case report.

Surg Case Rep 2021 Jul 13;7(1):162. Epub 2021 Jul 13.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.

Background: Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, and its clinicopathological features and underlying mechanism are not fully understood.

Case Presentation: An 84-year-old female with hepatitis C virus infection and diabetes mellitus was referred to our hospital for further examination. Abdominal ultrasonography showed a 3. Read More

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Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):19

Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, The Netherlands.

Purpose: Classical alleles of the human leukocyte antigen (HLA) complex have been linked to specific entities of pediatric noninfectious uveitis, yet genetic predisposition encoded by the HLA super-locus across the patient population remains understudied.

Methods: We performed next-generation full-length sequencing of HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQB1, and HLA-DRB1 in 280 cases. Dense genotype data from 499 Dutch controls from Genome of the Netherlands were imputed using an HLA-specific reference panel (n = 5225 samples from European ancestry). Read More

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Analysis of the Complex Quadrupole Hyperfine Patterns for Two Chlorine Nuclei in the Rotational Spectrum of 2,5-Dichlorothiophene.

J Phys Chem A 2021 Jul 13;125(28):6089-6095. Epub 2021 Jul 13.

Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

The rotational spectrum of 2,5-dichlorothiophene (DCT) was measured for the first time using Fourier transform microwave spectroscopy from 5.5-19 GHz. Dense hyperfine splitting patterns due to the two quadrupolar chlorine nuclei ( = 3/2) were resolved and assigned for the Cl-Cl, Cl-Cl, and Cl-Cl isotopologues and for the two C and one S analogues with two Cl atoms, allowing derivation of their respective nuclear quadrupole coupling tensors. Read More

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The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities.

Front Aging Neurosci 2021 23;13:670463. Epub 2021 Jun 23.

The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.

Objective: White matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is frequently presumed to be secondary to cerebral small vessel disease (CSVD) and associated with cognitive decline. The cerebellum plays a key role in cognition and has dense connections with other brain regions. Thus, the aim of this study was to investigate if cerebellar abnormalities could occur in CSVD patients with WMHs and the possible association with cognitive performances. Read More

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The Aryne-Abramov Reaction as a 1,2-Benzdiyne Platform for the Generation and Solvent-Dependent Trapping of 3-Phosphonyl Benzynes.

J Org Chem 2021 Jul 8. Epub 2021 Jul 8.

Chemistry Department, Ripon College, 300 West Seward Street, Ripon, Wisconsin 54971, United States.

Synthetic methodology utilizing two aryne intermediates (i.e., a formal benzdiyne) enables the rapid generation of structurally complex molecules with diverse functionality. Read More

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Ultrastructural identification of developing proximal tubules based on three-dimensional reconstruction.

Vet Med Sci 2021 Jul 8. Epub 2021 Jul 8.

Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China.

Background: The cellular mechanisms involved in the development of proximal tubules are not only associated with morphogenesis in fetal life, but also with restoration of damaged tubules in adulthood. Knowledge about morphological features of cell differentiation and proliferation along the developing tubule is insufficient, which hinders identification of the cellular origin.

Objectives: This study aimed to investigate ultrastructures of the proximal tubule at different stages of nephrogenesis. Read More

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Late presentation of extrauterine adenomyomas after laparoscopic morcellation at hysterectomy: a case report.

BMC Womens Health 2021 07 7;21(1):269. Epub 2021 Jul 7.

College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Healthcare City, Building 14, 505055, Dubai, United Arab Emirates.

Background: An adenomyoma is a well circumscribed form of adenomyosis and can be located within the myometrium, in the endometrium as a polyp, or extrauterine with the last being the rarest presentation amongst the three. With the ongoing advancement in gynecological surgery, the use of electromechanical morcellators have made the removal of large and dense specimens possible with minimally invasive techniques. However, it has also caused an increase in complications which were previously rare. Read More

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Recreating the shear band evolution in nanoscale metallic glass by mimicking the atomistic rolling deformation: a molecular dynamics study.

J Mol Model 2021 Jul 7;27(8):220. Epub 2021 Jul 7.

Department of Metallurgical and Materials Engineering, National Institute of Technology Rourkela, Rourkela, 769008, India.

Rolling processes are extensively used to induce network of shear bands (SBs) in the bulk metallic glasses, which in turn enhances the overall plasticity of the specimen. However, the atomic-level understanding of shear band formation/propagation mechanism during mechanical processing is still limited. In this perspective, we have developed a molecular dynamics (MD) simulation model to recreate the rolling deformation process and investigate the SB formation in Cu-Zr metallic glass (MG) specimen. Read More

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Repeat and single dose administration of gadodiamide to rats to investigate concentration and location of gadolinium and the cell ultrastructure.

Sci Rep 2021 Jul 6;11(1):13950. Epub 2021 Jul 6.

GE Healthcare, Pollards Wood, Nightingales lane, Chalfont St. Giles, UK.

Gadolinium based contrast agents (GBCA) are used to image patients using magnetic resonance (MR) imaging. In recent years, there has been controversy around gadolinium retention after GBCA administration. We sought to evaluate the potential toxicity of gadolinium in the rat brain up to 1-year after repeated gadodiamide dosing and tissue retention kinetics after a single administration. Read More

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Histological and proteome analyses of -mediated decrease in arsenic toxicity in .

3 Biotech 2021 Jul 16;11(7):336. Epub 2021 Jun 16.

Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Malaysia.

Arsenic (As) is an increasing threat across the globe, widely known as a non-threshold carcinogen, and it is reaching harmful values in several areas of the world. In this study, the effect of plant growth promoting bacteria () on inorganic arsenic (Arsenate) phytoremediation by plants was investigated through histological analysis and proteome profiling of the plants. Two-dimensional gel electrophoresis and transmission electron microscopy were used to conduct the proteome and histological analysis. Read More

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Differentiation of vascular claudication due to bilateral common iliac artery stenosis versus neurogenic claudication with spinal stenosis.

Surg Neurol Int 2021 17;12:231. Epub 2021 May 17.

Norton Neuroscience Institute, Norton Healthcare, Louisville, Kentucky, United States.

Background: Differentiating between neurogenic and vascular claudication may be difficult. Vascular claudication due to aortic and iliac artery occlusions may present as low back, hip, and buttock pain while walking short distances. These findings are often very similar to those seen for neurogenic claudication attributed to lumbar stenosis. Read More

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Microbial Communities on Plastic Polymers in the Mediterranean Sea.

Front Microbiol 2021 16;12:673553. Epub 2021 Jun 16.

Department of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, Texel, Netherlands.

Plastic particles in the ocean are typically covered with microbial biofilms, but it remains unclear whether distinct microbial communities colonize different polymer types. In this study, we analyzed microbial communities forming biofilms on floating microplastics in a bay of the island of Elba in the Mediterranean Sea. Raman spectroscopy revealed that the plastic particles mainly comprised polyethylene (PE), polypropylene (PP), and polystyrene (PS) of which polyethylene and polypropylene particles were typically brittle and featured cracks. Read More

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[Optimization of rituximab dosing schedule in R-CHOP therapy for diffuse large B-cell lymphoma].

Rinsho Ketsueki 2021 ;62(6):641-648

Department of Internal Medicine, Division of Hematology and Oncology, Tokai University School of Medicine.

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and nearly 70% of patients may be cured by administering R-CHOP therapy. However, R-CHOP is found to be inadequate in approximately one-third of the DLBCL cases, and refractory disease to R-CHOP is usually associated with a major cause of mortality. Therefore, it is essential to improve the efficacy of initial treatment in order to avoid unfavorable outcomes in patients with refractory DLBCL. Read More

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A case of primary carcinosarcoma of the liver with combined hepatocellular carcinoma and cholangiocarcinoma.

Clin J Gastroenterol 2021 Jul 2. Epub 2021 Jul 2.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Primary carcinosarcoma of the liver is extremely rare. Here, we report an unusual case of carcinosarcoma of the liver containing combined hepatocellular carcinoma and cholangiocarcinoma. A 66-year-old man with a history of viral hepatitis B was admitted for investigation of multiple liver masses. Read More

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