944,539 results match your criteria retrospective cohort


Associations between malignancy and cardiovascular complications following emergency laparotomy - A retrospective cohort study.

Surg Oncol 2021 May 5;38:101591. Epub 2021 May 5.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background: Systemic inflammation in patients with malignant disease has been associated with increased risk of cardiovascular events. The pro-inflammatory perturbations following surgical trauma may further promote adverse perioperative cardiovascular events and increase the risk of patients with cancer undergoing major surgery. Our objective was to estimate the association between malignant disease and postoperative cardiovascular complications. Read More

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Relapse protection following early CMV reactivation after HSCT is limited to HLA-C KIR ligand homozygous recipients.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria; Medical Faculty, Johannes Kepler University, Linz, Austria.

Background: While the risk for non-relapse mortality (NRM) associated with early cytomegalovirus (CMV) reactivation (CMVR) after allogeneic hematopoietic stem cell transplantation (HSCT) is well established, debate is ongoing on whether CMVR may reduce the risk of primary disease relapse.

Objective: Relapse protection following early CMV reactivation after HSCT in the context of the HLA-C KIR ligands of the recipients.

Study Design: In this retrospective, bi-centric study, 406 matched-related or unrelated transplants for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) were stratified by HLA-C KIRL groups (homozygous versus heterozygous) and were separately analyzed for the impact of early CMVR on the cumulative incidence of relapse, non-relapse mortality (NRM), acute and chronic graft-versus-host-disease (GVHD), using landmark and multi-state analyses. Read More

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Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Purpose: Retinal vascular occlusion is a leading cause of profound irreversible visual loss, but the understanding of the disease is insufficient. We systematically investigated the age, gender, and laterality at the onset of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) in the IRIS® Registry (Intelligent Research in Sight).

Design: A retrospective registry cohort. Read More

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Factors Associated with Postpartum Readmission for Hypertensive Disorders of Pregnancy.

Am J Obstet Gynecol MFM 2021 May 12:100397. Epub 2021 May 12.

The Permanente Medical Group, Kaiser Permanente Santa Clara Medical Center, Department of Obstetrics and Gynecology, Division of Obstetric Hospitalists, Santa Clara, CA.

Background: Postpartum readmission (PPR) has negative implications for patients and health systems. Prior studies suggest that up to 5% of women with hypertensive disorders of pregnancy (HDP) experience PPR. Studies examining factors associated with PPR for hypertension have had small sample sizes and conflicting results. Read More

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Perinatal Outcomes in Twin Pregnancies Complicated by Gestational Diabetes.

Am J Obstet Gynecol MFM 2021 May 12:100396. Epub 2021 May 12.

Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Magee-Womens Research Institute, Pittsburgh, Pennsylvania. Electronic address:

Background: Gestational diabetes in singleton pregnancies increases the risk of large for gestational age infants, hypertensive disorders of pregnancy, and neonatal morbidity.[1,2,3,4] Compared to singleton gestations, twin gestations are at increased risk for fetal growth abnormalities, hypertensive disorders and neonatal morbidity.[5] Whether gestational diabetes further increases the risk of these outcomes is unclear. Read More

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Disparities in Utilization and Outcomes with Continuous Subcutaneous Insulin Infusion in Young Adults with T1D.

Endocr Pract 2021 May 12. Epub 2021 May 12.

Department of Health & Clinical Outcomes Research, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Advanced HEAlth Data (AHEAD) Institute, Saint Louis University, St. Louis, Missouri, USA.

Objective: To evaluate what factors determine utilization patterns and outcomes of continuous subcutaneous insulin infusion (CSII) in young adults with type 1 diabetes (T1D).

Research Design & Methods: Utilizing the Optum® de-identified Electronic Health Record (EHR) dataset between 2008 to 2018 to perform a retrospective, cohort study, we identified 2104 subjects with T1D aged 18-30 years. We evaluated the effect of race on determining CSII utilization, HbA1c (%) and hospital admission for diabetic ketoacidosis (DKA). Read More

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Invasive Fungal Infections in Immunocompromised Children: Novel Insight Following a National Study.

J Pediatr 2021 May 12. Epub 2021 May 12.

Institute of Pediatric Hematology and Oncology, Hospices Civils de Lyon, University-Lyon1, Lyon, France; Apoptosis, Cancer and Development Laboratory - INSERM U1052-CNRS UMR5286, CRCL, Lyon, France.

Objective: To obtain a national overview of the epidemiology and management of invasive fungal infections (IFIs) in France for severe immunocompromised children who were treated for acute leukemia or had undergone an allogeneic hematopoietic stem cell transplantation (a-HSCT).

Study Design: We performed a national multicenter retrospective study to collect epidemiologic data for proven and probable IFI in children with acute leukemia under first line or relapse treatment or who had undergone an a-HSCT. We also conducted a prospective practice survey to provide a national overview of IFI management in pediatric hematology units. Read More

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Timing of Ocular Hypertension After Pediatric Closed-Globe Traumatic Hyphema: Implications for Surveillance.

Am J Ophthalmol 2021 May 12. Epub 2021 May 12.

Harvard Medical School, Boston, MA; Boston Children's Hospital, Boston, MA; Massachusetts Eye and Ear, Boston, MA. Electronic address:

Purpose: To evaluate the timing of ocular hypertension (OHT) after pediatric closed-globe injury (CGI) and traumatic hyphema. We hypothesize that OHT will occur at different times based on injury characteristics.

Design: Retrospective, cohort study. Read More

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Serum sodium level is inversely correlated with body temperature in children.

Pediatr Int 2021 May 15. Epub 2021 May 15.

Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

Background: Several studies have demonstrated that non-osmotic antidiuretic hormone activity contributes to the development of hyponatremia in children with common febrile diseases. However the relationship between hyponatremia and body temperature has remained unclear. Therefore, we examined this relationship in children with common diseases. Read More

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Development and Validation of a Clinical Predictive Model for Bacterial Infection in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

Infect Dis Ther 2021 May 15. Epub 2021 May 15.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, 430030, Hubei, China.

Introduction: Bacterial infection is one of the most frequent complications in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), which leads to high mortality. However, a predictive model for bacterial infection in HBV-ACLF has not been well established. This study aimed to establish and validate a predictive model for bacterial infection in two independent patient cohorts. Read More

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Disparities Among Limited English Proficient Patients in Colon Cancer Screening with Multi-target DNA Stool Test.

J Immigr Minor Health 2021 May 15. Epub 2021 May 15.

Community Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55902, USA.

Racial and language minority groups in the U.S. are at a higher risk for morbidity and mortality from colorectal cancer (CRC), partially due to lower screening rates. Read More

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Can MRI differentiate surrounding vertebral invasion from reactive inflammatory changes in superior sulcus tumor?

Eur Radiol 2021 May 15. Epub 2021 May 15.

Department of Radiology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, Paris, France.

Objectives: Vertebral invasion is a key prognostic factor and a critical aspect of surgical planning for superior sulcus tumors. This study aims to further evaluate MRI features of vertebral invasion in order to distinguish it from reactive inflammatory changes.

Methods: Between 2000 and 2016, a retrospective study was performed at a single institution. Read More

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Correlation between the lateral and anteroposterior sacral ratios in anorectal malformations.

Pediatr Radiol 2021 May 15. Epub 2021 May 15.

Department of Pediatric Colorectal and Pelvic Reconstruction Surgery, Nationwide Children's Hospital, 700 Children's Drive, FOB 6B, Columbus, OH, 43205, USA.

Background: The sacral ratio has been used as a tool for evaluating sacral development in patients with anorectal malformations. Sacral ratios can be calculated by obtaining sacral radiographs in the anteroposterior (AP) and lateral planes.

Objective: The objective of the study was to determine the correlation and agreement in sacral ratio calculations. Read More

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PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.

J Cell Mol Med 2021 May 15. Epub 2021 May 15.

Division of Cancer and Stem Cells, Nottingham Breast Cancer Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.

Cyclic AMP-dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine- and cAMP-regulated phosphoprotein 32 kD (DARPP-32). Using immunohistochemistry, PKA and PP1 expression was determined in a large primary breast tumour cohort to evaluate associations between clinical outcome and clinicopathological criteria (n > 1100). Read More

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Hemodynamically significant prosthesis-patient mismatch can be predicted and is associated with early prosthetic valve dysfunction in aortic bioprosthesis.

Echocardiography 2021 May 15. Epub 2021 May 15.

Cardiac Surgery Department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.

Objectives: To evaluate the accuracy of predicted prosthesis-patient mismatch (PPM) regarding actual PPM measured postoperatively. To assess the association between PPM and prosthetic valve dysfunction.

Methods: Retrospective cohort study including adult patients after aortic valve replacement surgery with a biological prosthesis. Read More

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Risk factors for return to work in colorectal cancer survivors.

Cancer Med 2021 May 14. Epub 2021 May 14.

Division of Environmental Health and Occupational Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: The increasing incidence of colorectal cancer among individuals in the productive age-group has adversely affected the labor force and increased healthcare expenses in recent years. Return to work (RTW) is an important issue for these patients. In this study, we explored the factors that influence RTW and investigated the influence of RTW on survival outcomes of patients with colorectal cancer. Read More

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What Links Maternal Prepregnancy BMI to Early Childhood BMI: A Serial Mediation Analysis.

Obesity (Silver Spring) 2021 May 14. Epub 2021 May 14.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: The aim of this study was to explore the potential impact of maternal gestational weight gain (GWG), infant birth weight, and postnatal weight change (ΔWAZ) on the relationship between maternal prepregnancy BMI (ppBMI) and childhood BMI.

Methods: This retrospective cohort study analyzed a data set from Wuhan, China. The mediation effect of targeted mediators on the association between maternal BMI and childhood BMI at the age of 2 years was analyzed. Read More

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Low LDL-C levels are associated with risk of mortality in a Chinese cohort study.

Endocrine 2021 May 14. Epub 2021 May 14.

Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Zhejiang, 310058, Hangzhou, China.

Background And Aims: Although low-density lipoprotein cholesterol (LDL-C) has been considered as a risk factor of atherosclerotic cardiovascular disease, limited studies can be available to evaluate the association of LDL-C with risk of mortality in the general population. This study aimed to examine the association of LDL-C level with risk of mortality using a propensity-score weighting method in a Chinese population, based on the health examination data.

Methods: We performed a retrospective cohort study with 65,517 participants aged 40 years or older in Ningbo city, Zhejiang. Read More

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Traumatic cerebral dural sinus vein thrombosis/stenosis in pediatric patients-is anticoagulation necessary?

Childs Nerv Syst 2021 May 14. Epub 2021 May 14.

Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Introduction: Cerebral dural vein thrombosis/stenosis (CDVT/S) is a condition that affects the venous drainage of the brain. Risk factors and causes associated with CDVT/S include systemic risk factors that cause hypercoagulability, or local factors such as head trauma. While consensus is that non-traumatic sinus vein thrombosis should be treated with anticoagulation therapy, treatment of patients with TBI-induced CDVT is not yet established. Read More

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The value of serum amylase and drain fluid amylase to predict postoperative pancreatic fistula after pancreatoduodenectomy: a retrospective cohort study.

Langenbecks Arch Surg 2021 May 14. Epub 2021 May 14.

Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Purpose: Serum and drain amylase have been identified as important predictors of postoperative pancreatic fistula (POPF) and might be useful to guide postoperative drain management after pancreatoduodenectomy. We aimed to determine and compare the value of serum amylase and drain fluid amylase to predict postoperative pancreatic fistula after pancreatoduodenectomy.

Methods: This retrospective cohort study included patients after pancreatoduodenectomy from 2012 to 2019. Read More

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Cervical mucus patterns and the fertile window in women without known subfertility: a pooled analysis of three cohorts.

Hum Reprod 2021 May 15. Epub 2021 May 15.

Office of Cooperative Reproductive Health, Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA.

Study Question: What is the normal range of cervical mucus patterns and number of days with high or moderate day-specific probability of pregnancy (if intercourse occurs on a specific day) based on cervical mucus secretion, in women without known subfertility, and how are these patterns related to parity and age?

Summary Answer: The mean days of peak type (estrogenic) mucus per cycle was 6.4, the mean number of potentially fertile days was 12.1; parous versus nulliparous, and younger nulliparous (<30 years) versus older nulliparous women had more days of peak type mucus, and more potentially fertile days in each cycle. Read More

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Epidemiology of Pediatric Meningitis in South Korea From 2010 to 2018: A Population-based Retrospective Cohort Study.

Pediatr Infect Dis J 2021 May 7. Epub 2021 May 7.

From the Department of Pediatrics, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Gangdong-gu, Seoul, Republic of Korea.

Background: Studies evaluating the epidemiology of pediatric meningitis are limited in our region. This study aimed to describe recent trends in the incidence of pediatric meningitis.

Methods: We estimated national trends in hospitalization rates for pediatric meningitis (<18 years) by analyzing data from the Health Insurance Review and Assessment database between 2010 and 2018. Read More

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Interprofessional Healthcare Students' Attitudes, Skills, and Knowledge After Comprehensive Pain Assessment Training in Verbal and Nonverbal Patients.

J Hosp Palliat Nurs 2021 May 12. Epub 2021 May 12.

Heather Cook, PharmD, is palliative care clinical pharmacist, Medstar Franklin Square Medical Center, Baltimore, MD. Karen Snow Kaiser, PhD, RN, is pain and palliative care coordinator, Quality and Safety Department, University of Maryland Capitol Region Health, Cheverly, MD. Kathryn A. Walker, PharmD, BCPS, CPE, is senior clinical director of palliative care, MedStar Health, Associate Professor, University of Maryland School of Pharmacy, Baltimore, MD Mary Lynn McPherson, PharmD, MA, MDE, BCPS, is professor and executive director, Advanced Post-Graduate Education in Palliative Care, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy.

A comprehensive pain assessment is the first step in safe, effective pain management. Few studies have explored variations of strategies and measures for multidimensional pain assessment education in both verbal and nonverbal patients. In this retrospective cohort study, interprofessional health care students enrolled in a palliative care curriculum completed a pain assessment training, which taught the PQRSTA ("palliating factors, precipitating factors, previous treatments, quality, region, radiation, severity, temporal factors and associated symptoms") mnemonic as a strategy for assessing pain in verbal patients and the Pain Assessment in Advance Dementia and Checklist of Nonverbal Pain Indicators measures for nonverbal patients. Read More

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Using the AHEC Scholars Program to Enhance Health Professions Learners' Self-Efficacy for Practice Transformation.

Am J Med Qual 2021 May 12. Epub 2021 May 12.

Indiana AHEC Network, Indiana University School of Medicine, Indianapolis, IN.

The Indiana Area Health Education Centers Scholars program is a 2-year leadership program designed to supplement health professions students' academic training and enhance practice readiness around 6 core topic areas including practice transformation. The study was a retrospective cohort study assessing learners' reported level of self-efficacy on a set of 6 competencies around practice transformation and quality improvement. A total of 68 students graduating in the first cohort responded to the competency questions. Read More

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Effect of preoperative cannabis use on perioperative outcomes: a retrospective cohort study.

Reg Anesth Pain Med 2021 May 14. Epub 2021 May 14.

Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada

Introduction: The reported use of cannabis within surgical population is increasing. Cannabis use is potentially associated with increased harms and varied effects on pain control. These have important implications to perioperative care. Read More

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Multicentre derivation and validation of a colitis-associated colorectal cancer risk prediction web tool.

Gut 2021 May 14. Epub 2021 May 14.

Department of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.

Objective: Patients with ulcerative colitis (UC) diagnosed with low-grade dysplasia (LGD) have increased risk of developing advanced neoplasia (AN: high-grade dysplasia or colorectal cancer). We aimed to develop and validate a predictor of AN risk in patients with UC with LGD and create a visual web tool to effectively communicate the risk.

Design: In our retrospective multicentre validated cohort study, adult patients with UC with an index diagnosis of LGD, identified from four UK centres between 2001 and 2019, were followed until progression to AN. Read More

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Uptake of influenza vaccination among persons with inflammatory bowel disease, multiple sclerosis or rheumatoid arthritis: a population-based matched cohort study.

CMAJ Open 2021 Apr-Jun;9(2):E510-E521. Epub 2021 May 14.

Department of Internal Medicine (Marrie, Hitchon, Marriott, Bernstein), Department of Community Health Sciences (Marrie, Lix, Katz), Manitoba Centre for Health Policy (Walld, Katz), Department of Psychiatry (Bolton, Sareen), Department of Family Medicine (Singer, Katz), Department of Clinical Health Psychology (El-Gabalawy) and Department of Anesthesiology and Perioperative and Pain Medicine (El-Gabalawy), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Man.; Department of Community Health Sciences (Patten), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Departments of Psychiatry (Fisk), of Psychology and Neuroscience (Fisk) and of Medicine (Fisk), Dalhousie University, Halifax, NS.

Background: Individuals with immune-mediated inflammatory diseases, such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, are at increased risk for influenza and related complications. We examined and compared the uptake of influenza vaccination among people with and without these diseases, as well as the influence of psychiatric comorbidity on vaccine uptake.

Methods: Using administrative data from Apr. Read More

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Barriers to HIV treatment adherence among adults living with HIV in the eastern Dominican Republic.

Int J STD AIDS 2021 May 14:9564624211014102. Epub 2021 May 14.

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, 14640University of Pennsylvania, Philadelphia, PA, USA.

Despite access to nationally supplied antiretroviral treatment, viral load suppression rates remain suboptimal in the Dominican Republic. Counseling and support services are available but mainly targeted to those identified as having the most need. At Clínica de Familia La Romana (CFLR) in La Romana, all patients undergo a structured baseline interview including exploration of expected barriers to care. Read More

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Criteria for oral appliance and/or supine avoidance therapy selection based on outcome optimization and cost-effectiveness.

J Med Econ 2021 May 14. Epub 2021 May 14.

Sleep Data, LLC, San Diego, CA, USA.

Produce empirical support for further enhancements to a therapy selection protocol for obstructive sleep apnea (OSA) patients intolerant of positive airway pressure. A retrospective analysis was conducted in 101 men and 69 women patients. Two-night home sleep apnea studies were conducted at baseline and with a trial oral appliance. Read More

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Safety of lateral access to the concave side for adult spinal deformity.

J Neurosurg Spine 2021 May 14:1-5. Epub 2021 May 14.

1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and.

Objective: Minimally invasive surgery (MIS) techniques, particularly lateral lumbar interbody fusion (LLIF), have become increasingly popular for adult spinal deformity (ASD) correction. Much discussion has been had regarding theoretical and clinical advantages to addressing coronal curvature from the convex versus concave side of the curve. In this study, the authors aimed to broadly evaluate the clinical outcomes of addressing ASD with circumferential MIS (cMIS) techniques while accessing the lumbar coronal curvature from the concave side. Read More

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