485,879 results match your criteria retrospective analysis


Long-Term Quality of Life in Patients Following Minimally Invasive Conjunctivodacryocystorhinostomy With StopLoss Jones Tube.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Ophthalmology, Jozef Strus City Hospital, Poznan, Poland Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To assess the long-term quality of life outcomes of minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes.

Methods: A retrospective interventional case series was performed on all patients diagnosed with proximal bicanalicular obstruction who underwent a minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes over a period of 5 years from October 2014 to September 2019. The procedure was performed as per standard published protocols of minimally invasive conjunctivodacryocystorhinostomy and StopLoss Jones tubes. Read More

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Systemic therapy and prognosis of older patients with stage II/III breast cancer: A large-scale analysis of the Japanese Breast Cancer Registry.

Eur J Cancer 2021 Jul 19;154:157-166. Epub 2021 Jul 19.

Department of Breast Oncology, Aichi Cancer Center, Nagoya, Japan. Electronic address:

Aim: This study aimed at investigating the real-world prognostic impact of systemic treatment in older patients with stage II/III breast cancer (BC).

Methods: This retrospective cohort study included patients with stage II/III primary BC, aged ≥55 years, and registered in the Japanese Breast Cancer Registry from 2004 to 2011. The clinicopathological characteristics, treatments, and prognosis of patients aged ≥75 years (older) were compared to those of younger patients. Read More

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Long term follow up in 183 high grade meningioma: A single institutional experience.

Clin Neurol Neurosurg 2021 Jul 10;207:106808. Epub 2021 Jul 10.

Neuro-oncology Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133 Milan, Italy.

Introduction: Meningiomas are usually considered benign lesions, however a proportion of them shows a more aggressive behavior, defined high-grade meningiomas (HGM). Effective medical treatments are lacking, especially at the time of recurrence.

Methods: Through a retrospective analysis, we examined epidemiological, diagnostic, therapeutic, recurrence information and survival data of HGM treated at our institution between 2010 and 2018. Read More

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Neurological presentations and cognitive outcome in Sturge-Weber syndrome.

Eur J Paediatr Neurol 2021 Jul 9;34:21-32. Epub 2021 Jul 9.

Great Ormond Street Hospital for Children Neurodisability Department, Great Ormond Street, UCL Great Ormond Street Institute of Child Health Clinical Neurosciences, London, United Kingdom.

Introduction: This study of children with Sturge-Weber syndrome (SWS) profiled neurological presentations; compared patients with (+) and without (-) port-wine stain (PWS); and determined risk factors for intellectual and language impairments.

Methods: A retrospective case note review was conducted at a national centre.

Results: This cohort (n = 140, male 72, median follow up 114 months) showed sex parity. Read More

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The predictive value of segmentation metrics on dosimetry in organs at risk of the brain.

Med Image Anal 2021 Jul 13;73:102161. Epub 2021 Jul 13.

ARTORG Center for Biomedical Research, University of Bern, Bern, Switzerland. Electronic address:

Background: Fully automatic medical image segmentation has been a long pursuit in radiotherapy (RT). Recent developments involving deep learning show promising results yielding consistent and time efficient contours. In order to train and validate these systems, several geometric based metrics, such as Dice Similarity Coefficient (DSC), Hausdorff, and other related metrics are currently the standard in automated medical image segmentation challenges. Read More

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Hematopoietic Stem Cell Transplantation For Patients With Autosomal Recessive Complete Interferon Gamma Receptor 2 Deficiency: Experience In Oman.

Transplant Cell Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of, Hematology, Sultan Qaboos University Hospital, Muscat, Oman; Apollo Hospital, Muscat, Oman. Electronic address:

Autosomal recessive complete interferon- gamma receptor-2 (IFN-γR2) deficiency is a rare potentially fatal primary immune deficiency that predisposes to disseminated mycobacterial disease.Hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment. Few patients had been reported so far. Read More

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Ciclesonide Impacts Clinicopathological Features of Eosinophilic Esophagitis.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine; Digestive Health Institute, Children's Hospital Colorado; Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Background: - Eosinophilic Esophagitis (EoE) is a chronic allergen-mediated disease of the esophagus. Pharmacologic treatment has largely relied on repurposing corticosteroids. Ciclesonide (CIC) is a corticosteroid for the treatment of asthma with biochemical properties that improve topical potency. Read More

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Association of periodontal disease with breed size, breed, weight, and age in pure-bred client-owned dogs in the United States.

Vet J 2021 Jul 19:105717. Epub 2021 Jul 19.

Waltham Petcare Science Institute, Freeby Lane, Waltham-on-the-Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK.

Despite periodontal disease (PD) being amongst the most common diagnoses in primary-care practice, the disease is generally underdiagnosed. However, the millions of clinical records generated by pet hospitals each year provide unique opportunities to generate insights about disease risk across large numbers of dogs. The objective of this study was to undertake a retrospective analysis of medical records to ascertain which sizes and breeds of dog are most frequently diagnosed with PD. Read More

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Prognostic value of lymphovascular invasion in early-stage Merkel cell carcinoma: a retrospective analysis in the National Cancer Database.

J Am Acad Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Veterans Affairs Palo Alto Healthcare System, Palo Alto, California; Department of Dermatology, Stanford University School of Medicine, Palo Alto, California. Electronic address:

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Outcomes for infants with congenital diaphragmatic hernia: A single campus review with low extracorporeal membrane oxygenation utilisation.

J Paediatr Child Health 2021 Jul 22. Epub 2021 Jul 22.

Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Aim: To report the outcome for infants with congenital diaphragmatic hernia (CDH) and identify clinical factors affecting outcome from a tertiary perinatal surgical campus where extracorporeal membrane oxygenation (ECMO) is available however rarely utilised.

Methods: A retrospective cohort study of infants with CDH born in a co-located perinatal neonatal intensive care unit (NICU) or retrieved into and managed at a surgical NICU: 2003-2018.

Results: One hundred and fifty-nine infants with CDH were identified. Read More

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Factors associated with the use and composition of two-drug regimens in a large single-centre HIV cohort.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.

Objectives: We aimed to assess the clinical characteristics associated with the use of two-drug regimens (2DRs) and the factors associated with specific antiretrovirals in 2DRs in a large single-centre HIV cohort.

Methods: Retrospective analysis of demographics, HIV characteristics and AIDS events, antiretroviral prescription, virological failure and genotypic resistance testing, and laboratory results from all adult people with HIV (PWH) prospectively followed at the Hospital Clinic of Barcelona who were receiving a 3DR or a 2DR in January 2020. We assessed factors associated with the probability of receiving 2DRs relative to three-drug regimens (3DRs) using a logistic regression model, controlling for age, sex and year of HIV diagnosis. Read More

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Clinical characteristics and management of olecranon and prepatellar septic bursitis in a multicentre study.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

Rheumatology Department, CHU Nantes, Nantes, France.

Background: No current guidelines are available for managing septic bursitis (SB).

Objectives: To describe the clinical characteristics and management of olecranon and prepatellar SB in five French tertiary care centres.

Methods: This is a retrospective observational multicentre study. Read More

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Long-term effect of botulinum toxin A on the hip and spine in cerebral palsy: A national retrospective cohort study in Taiwan.

PLoS One 2021 22;16(7):e0255143. Epub 2021 Jul 22.

School of Public Health, National Defense Medical Center, Taipei, Taiwan.

Objectives: To investigate the effect of botulinum toxin A (BTA) on the development of hip dislocation and scoliosis, surgical rates for hip and spine, and mortality in cerebral palsy (CP).

Study Design: A cohort study was conducted using CP data from a Taiwan National Insurance Health Research Database. Diagnoses were defined using the International Classification of Diseases codes, 9th revision. Read More

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Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study.

PLoS One 2021 22;16(7):e0254246. Epub 2021 Jul 22.

Hamad Medical Corporation, Doha, Qatar.

Context: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated risks of COVID-19 infection in dialysis patients in the state of Qatar.

Methods: This was an observational, analytical, retrospective, nationwide study. Read More

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The influence of propofol-based total intravenous anesthesia on postoperative outcomes in end-stage renal disease patients: A retrospective observation study.

PLoS One 2021 22;16(7):e0254014. Epub 2021 Jul 22.

Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital Seoul, Seoul, Republic of Korea.

Background: To determine whether the anesthetic method of propofol total intravenous anesthesia (TIVA) is associated with postoperative outcome in ESRD patients, we evaluated the incidence of postoperative major adverse cardiac events (MACE), comparing propofol TIVA versus anesthesia with volatile anesthesia in ESRD patients.

Methods: Retrospectively, we identified cases with ESRD patients who underwent surgery under general anesthesia. Patients were divided into those who received only volatile anesthesia (volatile group) and those who received only propofol TIVA (TIVA group). Read More

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Efficacy and safety of palbociclib and ribociclib in patients with estrogen and/or progesterone receptor positive, HER2 receptor negative metastatic breast cancer in routine clinical practice.

PLoS One 2021 22;16(7):e0253722. Epub 2021 Jul 22.

Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Background: There is scant data from India on efficacy and safety of palbociclib and ribociclib in routine clinical practice.

Methods: This retrospective, observational, single institution study included patients with estrogen and/or progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative metastatic breast cancers, who received palbociclib or ribociclib with any partner endocrine therapy in any line of treatment between January 2016 and June 2019. Data were analyzed for progression-free survival (PFS), overall survival (OS) and toxicity. Read More

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Online Search Trends Influencing Anti-Coagulation in COVID-19: An Observational Study.

JMIR Form Res 2021 Apr 11. Epub 2021 Apr 11.

Department of Infectious Diseases, Beaumont Hospital, Beaumont Road, Dublin, IE.

Background: Background: Early evidence of Coronavirus Disease (COVID-19) associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The rapid online spread of case reports was followed by online interim guidelines, discussions and worldwide online searches for further information. The impact of the global online search trends and online discussion on local approach to coagulopathy in COVID-19 patients has not been studied. Read More

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Septic Arthritis of the Acromioclavicular Joint: A Single-Center, 11-Year Retrospective Review.

Orthopedics 2021 Jul-Aug;44(4):e493-e497. Epub 2021 Jul 1.

Septic arthritis of the smaller acromioclavicular joint is uncommon, with only a few reports and case series available in the literature. The aim of this outcomes analysis was to determine the prevalence of shoulder girdle septic arthritis within the authors' institution, with a particular focus on describing the authors' experience with acromioclavicular joint septic arthritis. A retrospective outcomes analysis was conducted of patients admitted to a single tertiary referral center from 2008 to 2018 with acromioclavicular joint septic arthritis. Read More

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Factors Associated With Surgical Treatment of Isolated, Displaced Midshaft Clavicle Fractures.

Orthopedics 2021 Jul-Aug;44(4):e515-e520. Epub 2021 Jul 1.

Given the current available evidence, surgical treatment of isolated, displaced midshaft clavicle fractures is discretionary. The aim of this study was to determine whether there are identifiable factors associated with the surgical treatment of isolated, displaced midshaft clavicle fractures. A retrospective cohort study of 150 patients who underwent nonoperative treatment and 290 patients who underwent surgical treatment of isolated, displaced midshaft clavicle fractures from January 2010 to March 2019 at 2 level I trauma centers was performed. Read More

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Risk Factors for Mortality After Uncemented Bipolar Hemiarthroplasty for Geriatric Displaced Femoral Neck Fracture.

Orthopedics 2021 Jul-Aug;44(4):e570-e576. Epub 2021 Jul 1.

Uncemented bipolar hemiarthroplasty (UBHA) has been widely used to treat geriatric displaced femoral neck fracture (GDFNF), which results in a high 30-day mortality rate among the elderly. To date, few studies have focused on the risk factors for mortality after UBHA for GDFNF. In this retrospective study, elderly patients (age ≥70 years) who underwent UBHA for GDFNF were studied in order to provide helpful insight into the risk factors for mortality postoperatively. Read More

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Use of 3D Navigation Versus Traditional Fluoroscopy for Posterior Pelvic Ring Fixation.

Orthopedics 2021 Jul-Aug;44(4):229-234. Epub 2021 Jul 1.

Unstable pelvic ring disruption is most commonly treated with closed reduction and percutaneous screw fixation. Traditional methods involve screw placement under fluoroscopic imaging, but with recent technologic advances, intraoperative 3D navigation can now be used to help with the insertion of sacroiliac screws. Various cadaver studies have shown that placement of sacroiliac screws under 3D navigation is more accurate than placement under traditional fluoroscopic guidance. Read More

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Impact of patients' gender on microvascular lower extremity reconstruction.

J Plast Surg Hand Surg 2021 Jul 22:1-6. Epub 2021 Jul 22.

Division of Hand, Plastic and Aesthetic Surgery, University Hospital, LMU Munich, Munich, Germany.

The physiological differences between genders have significant implications for health and disease. With regard to microsurgery, results remain elusive as to whether male or female gender is an independent risk factor for free flap reconstruction. This study evaluated the impact of gender on outcomes of lower-extremity free-flap reconstructions. Read More

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Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease.

J Int Med Res 2021 Jul;49(7):3000605211033495

Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, China.

Objective: To investigate the predictive value of hyperhomocysteinaemia (HHcy) for obstructive coronary artery disease (CAD) in an Asian population in northern China.

Methods: This retrospective study enrolled patients at their first cardiac assessment and assigned them to an obstructive CAD group or a non-obstructive CAD group according to the coronary angiography results. HHcy was defined as a homocysteine (Hcy) level > 15 µmol/l. Read More

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Association of dexmedetomidine with recovery room and hospital discharge times: a retrospective cohort analysis.

Paediatr Anaesth 2021 Jul 22. Epub 2021 Jul 22.

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.

Background: Dexmedetomidine is a useful anesthetic adjunct, increasingly popular during pediatric surgery and procedural sedation. Its half-life of 2-3 hours might prolong recovery and discharge times when compared with an un-supplemented propofol anesthetic. This may create an additional burden in a busy post-anesthetic care unit (PACU). Read More

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Outcomes of pregnancy in simultaneous pancreas and kidney transplant recipients: A single-center retrospective study.

Clin Transplant 2021 Jul 22. Epub 2021 Jul 22.

Department of Nephrology and Transplantation, London, UK.

Simultaneous pancreas and kidney (SPK) transplantation, in uremic women with insulin-dependent diabetes, increases the chance of a successful pregnancy and minimizes the risk to infants. The aim of this study was to document pregnancy and explore the challenges in this cohort of women. Retrospective analysis of women who underwent pancreas transplantation between 01/01/1998 and 01/08/2019 was conducted. Read More

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Retrospective analysis of 23 Chinese children with congenital hyperinsulinemia undergoing pancreatectomy.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Genetics and Metabolism Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.

Objectives: The clinical data of 23 cases of congenital hyperinsulinemia (CHI) treated by pancreatectomy were retrospectively analyzed, and the therapeutic effect and prognosis of pancreatectomy in the treatment of CHI were discussed.

Methods: A total of 23 Chinese children with CHI who had undergone pancreatectomy between February 2002 and March 2020 were selected as the study objects. The clinical data, the results of the 18Fluoro-L-3-4 dihydroxyphenylalanine positron emission tomography/computerized tomography (18F-DOPA PET/CT) scanning, and the diagnosis, treatment, and follow-up were analyzed retrospectively. Read More

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Adrenal "nonadenoma" - clinical characteristic and risk of malignancy.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, Clinic of Surgical Oncology and Neuroendocrine Tumors, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska15, 02-034 Warsaw, Poland.

Introduction: There is an increasing number of adrenal tumours discovered incidentally during imaging examinations performed for many different indications. Based on imaging results, it is possible to differentiate benign from malignant adrenal masses, although there is still a number of equivocal imaging findings. Our study presents 77 cases of adrenal tumours in which imaging was inconclusive and the final diagnosis was stated only after surgery and histopathological examination. Read More

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Portal vein thrombosis associated with high 14-day and 6-week rebleeding in patients after oesophageal variceal band ligation: a retrospective, multicentre, nested case-control study.

Hepatol Int 2021 Jul 22. Epub 2021 Jul 22.

Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong Province, People's Republic of China.

Background And Aims: The association between prognosis of variceal bleeding and portal vein thrombosis (PVT) is unclear. In this multicentre study, we determined the effect of PVT on rebleeding and mortality in patients with acute variceal bleeding (AVB) after oesophageal variceal band ligation (EVL).

Methods: Cirrhotic patients with AVB who had undergone EVL were included. Read More

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The Outcomes of Laparoscopic Biliopancreatic Diversion with Duodenal Switch on Gastro-esophageal Reflux Disease: the Mayo Clinic Experience.

Obes Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Purpose: The outcomes of laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) on gastro-esophageal reflux disease (GERD) are not well elucidated.

Material/methods: This retrospective review included patients undergoing laparoscopic primary BPD-DS at Mayo Clinic from 2009 to 2019. GERD parameters analyzed included subjective symptom report/anti-reflux medication intake and/or endoscopic findings. Read More

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Comparison of myopia progression between children wearing three types of orthokeratology lenses and children wearing single-vision spectacles.

Jpn J Ophthalmol 2021 Jul 22. Epub 2021 Jul 22.

Department of Frontier Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Purpose: To evaluate factors related to myopia progression in children wearing either orthokeratology (OK) lenses or single-vision spectacles (SVS) for 2 years.

Study Design: Pooled-analysis retrospective intervention study.

Methods: This study involved 105 school-aged children wearing SVS who participated in the multi-center Myovision Study and 89 school-aged children wearing one of 3 OK lens types [Menicon Z Night (M, n = 27), αORTHO-K (A, n = 32), and Emerald (E, n = 30)]. Read More

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