J Small Anim Pract 2021 May 24. Epub 2021 May 24.
From the Departments of Small Animal Clinical Sciences (Vincent, Langlois) and Large Animal Clinical Sciences (Sordillo, Gandy, Brown), and the Veterinary Diagnostic Laboratory (Smedley), College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Objectives: To evaluate biomarkers of oxidative stress in dogs with copper-associated hepatitis (CAH) as compared with healthy controls, and to evaluate if these markers correlate with hepatic copper concentrations and hepatic histopathologic features.
Materials And Methods: Prospective study. Plasma reactive metabolite concentrations, plasma antioxidant potential, and plasma and urine isoprostane concentrations were determined in Labrador retrievers with copper-associated hepatitis (n=9) as well as in breed- and sex-matched (n=9) and age- and sex-matched (n=9) healthy control populations. Read More