427 results match your criteria retrieve mechanism

Evolutionary patterns of nucleotide substitution rates in plastid genomes of .

Ecol Evol 2021 Oct 30;11(19):13401-13414. Epub 2021 Aug 30.

Key Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation College of Biology and the Environment Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry University Nanjing China.

Molecular evolution, including nucleotide substitutions, plays an important role in understanding the dynamics and mechanisms of species evolution. Here, we sequenced whole plastid genomes (plastomes) of , , , and and compared them with 14 other plastomes to explore their evolutionary relationships using 67 shared protein-coding sequences. While many previously identified evolutionary relationships were found, our findings do not support previous research which retrieve subg. Read More

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October 2021

LitCovid-AGAC: cellular and molecular level annotation data set based on COVID-19.

Genomics Inform 2021 Sep 30;19(3):e23. Epub 2021 Sep 30.

Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, 430070 Wuhan, China.

Currently, coronavirus disease 2019 (COVID-19) literature has been increasing dramatically, and the increased text amount make it possible to perform large scale text mining and knowledge discovery. Therefore, curation of these texts becomes a crucial issue for Bio-medical Natural Language Processing (BioNLP) community, so as to retrieve the important information about the mechanism of COVID-19. PubAnnotation is an aligned annotation system which provides an efficient platform for biological curators to upload their annotations or merge other external annotations. Read More

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September 2021

Novel Symbiotic Genome-Scale Model Reveals 's Arboviral Pathogen Blocking Mechanism in Aedes aegypti.

mBio 2021 Oct 12:e0156321. Epub 2021 Oct 12.

Centre for Biotechnology and Bioengineering (CeBiB), Department of Chemical Engineering, Biotechnology and Materials, University of Chilegrid.443909.3, Santiago, Chile.

are endosymbiont bacteria known to infect arthropods causing different effects, such as cytoplasmic incompatibility and pathogen blocking in Aedes aegypti. Although several strains have been studied, there is little knowledge regarding the relationship between this bacterium and their hosts, particularly on their obligate endosymbiont nature and its pathogen blocking ability. Motivated by the potential applications on disease control, we developed a genome-scale model of two strains: Mel and the strongest Dengue blocking strain known to date: MelPop. Read More

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October 2021

A natural language processing pipeline to synthesize patient-generated notes toward improving remote care and chronic disease management: a cystic fibrosis case study.

JAMIA Open 2021 Jul 29;4(3):ooab084. Epub 2021 Sep 29.

IT Research and Innovation, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.

Objectives: Patient-generated health data (PGHD) are important for tracking and monitoring out of clinic health events and supporting shared clinical decisions. Unstructured text as PGHD (eg, medical diary notes and transcriptions) may encapsulate rich information through narratives which can be critical to better understand a patient's condition. We propose a natural language processing (NLP) supported data synthesis pipeline for unstructured PGHD, focusing on children with special healthcare needs (CSHCN), and demonstrate it with a case study on cystic fibrosis (CF). Read More

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Prediction of the Molecular Mechanism of Eucommiae Cortex - Achyranthis Bidentatae Radix in the treatment of Osteoarthritis: Network Pharmacology and Molecular Docking.

Drug Dev Ind Pharm 2021 Sep 30:1-16. Epub 2021 Sep 30.

Shenyang Orthopedics Hospital, NO.115, Dongbei Road, Dadong District, Shenyang City, Liaoning Province, China.

Objective: To retrieve the core drug of osteoarthritis in clinic using Data Mining, predict the drug molecular action target through the Network Pharmacology, identify the key nodes of the interaction by combining with the related targtes of osteoarthritis, explore the pharmacological mechanism of Traditional Chinese Medicine against osteoarthritis and other possible mechanisms of actions.

Methods: to retrieve the commonly used therapeutic formulations for osteoarthritis patients in clinical with PubMed, CNKI, VIP, CBM, WanFang Database and other databases, and screen out the core drugs through the Ancient and Modern Medical Case Cloud Platform and software Gephi, filter out the core drug molecules and targets combined with TCMSP database and the targets of osteoarthritis in Genecard and OMIM database, plunge those data into R project and Cytoscape to construct the intersection model of Drug molecule-osteoarthritis, establish PPI network and GO and conduct KEGG enrichment analysis with String database. Vina molecular docking was finally implemented to draw molecular docking diagram, and the results were analyzed after comprehensive analysis. Read More

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September 2021

Eye-movements reveal the serial position of the attended item in verbal working memory.

Psychon Bull Rev 2021 Sep 28. Epub 2021 Sep 28.

Department of Experimental Psychology, Ghent University, H. Dunantlaan 2, 9000, Ghent, Belgium.

The problem of how the mind can retain sequentially organized information has a long research tradition that remains unresolved. While various computational models propose a mechanism of binding serial order information to position markers, the representational nature and processes that operate on these position markers are not clear. Recent behavioral work suggests that space is used to mark positions in serial order and that this process is governed by spatial attention. Read More

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September 2021

Semantic knowledge attenuates age-related differences in event segmentation and episodic memory.

Mem Cognit 2021 Sep 22. Epub 2021 Sep 22.

College of Arts and Sciences, Psychological Sciences, Kansas State University, Manhattan, KS, USA.

While semantic and episodic memory may be distinct memory systems, their interdependence is substantial. For instance, decades of work have shown that semantic knowledge facilitates episodic memory. Here, we aim to clarify this interactive relationship by determining whether semantic knowledge facilitates the acquisition of new episodic memories, in part, by influencing an encoding mechanism, event segmentation. Read More

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September 2021

Synthetic lethality theory approaches to effective substance discovery and functional mechanisms elucidation of anti-cancer phytomedicine.

Phytomedicine 2021 Oct 20;91:153718. Epub 2021 Aug 20.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China. Electronic address:

Background: Longstanding, successful use of combinations of phytopharmaceuticals in traditional Chinese medicine (TCM) has caught the attention of several pharmacologists to natural medicines. However, the development and popularisation of TCM is mainly limited because of the unavailability of reports clarifying the mechanisms of action and pharmacologically active ingredients in such formulations. Previous studies on natural medicines have mostly focused on their dominant components using forward pharmacology which often neglects trace components. Read More

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October 2021

Highly Efficient Quasi-2D Perovskite Light-Emitting Diodes Incorporating a TADF Dendrimer as an Exciton-Retrieving Additive.

ACS Appl Mater Interfaces 2021 Sep 12;13(37):44585-44595. Epub 2021 Sep 12.

School of Physical Science and Technology, MOE Key Laboratory on Luminescence and Real Time Analysis, Southwest University, Chongqing 400715, China.

Although small organics or polymer additives have been introduced to enhance film formation and radiative recombination of perovskite light-emitting diodes (PeLEDs), the exciton utilization and quantum efficiency need further optimization. Here, we introduce a thermal-activated delayed fluorescence (TADF) dendrimer as an additive to enhance the surface coverage and reduce the trap state of the grain boundary. More importantly, the TADF nature of such an additive can retrieve the exciton dissociated from perovskite or trapped by the grain boundary and then transfer the energy back to emissive perovskite through the Förster energy transfer process. Read More

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September 2021

Semantic Interference through Multiple Distractors in Picture Naming in People with Aphasia.

J Cogn Neurosci 2021 07;33(8):1612-1633

Humboldt-Universität zu Berlin.

When we refer to an object or concept by its name, activation of semantic and categorical information is necessary to retrieve the correct lexical representation. Whereas in neurotypical individuals it is well established that semantic context can interfere with or facilitate lexical retrieval, these effects are much less studied in people with lesions to the language network and impairment at different steps of lexical-semantic processing. Here, we applied a novel picture naming paradigm, where multiple categorically related and unrelated words were presented as distractors before a to-be-named target picture. Read More

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Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B.

J Cell Sci 2021 Sep 6. Epub 2021 Sep 6.

Department of Neurology, University Medical Center Göttingen, Robert Koch Straße 40, 37075 Göttingen, Germany.

Axonal survival and growth requires signalling from tropomyosin receptor kinases (Trks). To transmit their signals, receptor-ligand complexes are endocytosed and retrogradely trafficked to the soma where downstream signalling occurs. Vesicles transporting neurotrophic receptors to the soma are reported to be Rab7-positive late endosomes/multi vesicular bodies where receptors localize within so-called intraluminal vesicles. Read More

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September 2021

Narrative review of intraductal papillary mucinous neoplasms: pathogenesis, diagnosis, and treatment of a true precancerous lesion.

Gland Surg 2021 Jul;10(7):2313-2324

Department of Pancreatic-Biliary Surgery, First Hospital of China Medical University, Shenyang, China.

Objective: Although considerable progress has been made in our understanding of intraductal papillary mucinous neoplasm (IPMN) of the pancreas, there are still some problems to be solved.

Background: IPMN is one of the most important precancerous lesions of pancreatic cancer, but the relationship between IPMN and pancreatic cancer, and the specific mechanism of the development from IPMN to invasive carcinoma, remain to be explored in depth. With the development of imaging, the detection rate of IPMN has been greatly improved. Read More

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The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review.

Front Cell Dev Biol 2021 27;9:681163. Epub 2021 Jul 27.

Department of Urology, Jinshan Hospital, Fudan University, Shanghai, China.

Prostate cancer is one of the most common malignant tumors that threaten the health of men. It is urgent to explore new molecular targets and develop new drugs for the treatment of prostate cancer. Circular RNAs (circRNAs) are aberrantly expressed in various malignant tumors. Read More

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COVID term: a bilingual terminology for COVID-19.

BMC Med Inform Decis Mak 2021 08 3;21(1):231. Epub 2021 Aug 3.

Institute of Medical Information/Library, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.

Background: The coronavirus disease (COVID-19), a pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown its destructiveness with more than one million confirmed cases and dozens of thousands of death, which is highly contagious and still spreading globally. World-wide studies have been conducted aiming to understand the COVID-19 mechanism, transmission, clinical features, etc. A cross-language terminology of COVID-19 is essential for improving knowledge sharing and scientific discovery dissemination. Read More

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Effects of Atorvastatin on T-Cell Activation and Apoptosis in Systemic Lupus Erythematosus and Novel Simulated Interactions With C-Reactive Protein and Interleukin 6.

ACR Open Rheumatol 2021 Sep 23;3(9):642-653. Epub 2021 Jul 23.

Karolinska Institutet, Stockholm, Sweden.

Objective: We study activation of T helper 17 (Th17) and regulatory T (Treg) cells and induction of apoptosis in cells from patients with systemic lupus erythematosus (SLE) compared with controls and effects of atorvastatin and its simulated interactions with other compounds.

Methods: Mononuclear cells from 10 patients with SLE and 10 controls were cultured in conditions that induce Th17 and/or Treg cell polarization and/or apoptosis and were studied by FACScan. Gene expression was determined by quantitative real-time reverse transcription-polymerase chain reaction. Read More

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September 2021

Exciting Opportunities for Solid-State Mo NMR Studies of MoS Nano-structures in Materials Research from Low to Ultra-high Magnetic Field (35.2 T).

J Phys Chem C Nanomater Interfaces 2021 Apr 1;125(14):7824-7838. Epub 2021 Apr 1.

National High Magnetic Field Laboratory, 1860 East Paul Dirac Drive, Tallahassee, FL 32310, USA.

Solid-state, natural-abundance Mo NMR experiments of four different MoS materials have been performed on a magnet = 19.6 T and on a new Series Connected Hybrid (SCH) magnet at 35.2 T. Read More

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Development of an application concerning fast healthcare interoperability resources based on standardized structured medical information exchange version 2 data.

Comput Methods Programs Biomed 2021 Sep 8;208:106232. Epub 2021 Jun 8.

Department of Medical Informatics, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan; Medical Information Technology Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address:

Background And Objective: A mobile application for personal health records (PHR) would allow patients to access their clinical data easily. When PHR connects with multiple electronic health records (EHRs), doctors and patients can exchange large quantities of patient data from the EHR (e.g. Read More

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September 2021

Possibility of information encoding/decoding using the memory effect in fractional-order capacitive devices.

Sci Rep 2021 Jun 25;11(1):13306. Epub 2021 Jun 25.

Department of Electrical Engineering, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates.

In this study, we show that the discharge voltage pattern of a supercapacitor exhibiting fractional-order behavior from the same initial steady-state voltage into a constant resistor is dependent on the past charging voltage profile. The charging voltage was designed to follow a power-law function, i.e. Read More

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Formation of frameshift-stimulating RNA pseudoknots is facilitated by remodeling of their folding intermediates.

Nucleic Acids Res 2021 07;49(12):6941-6957

Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 10617, Taiwan.

Programmed -1 ribosomal frameshifting is an essential regulation mechanism of translation in viruses and bacteria. It is stimulated by mRNA structures inside the coding region. As the structure is unfolded repeatedly by consecutive translating ribosomes, whether it can refold properly each time is important in performing its function. Read More

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Resilience in Adult Health Science Revisited-A Narrative Review Synthesis of Process-Oriented Approaches.

Front Psychol 2021 3;12:659395. Epub 2021 Jun 3.

Department of Psychosomatic Medicine and Psychotherapy, University Hospital Bonn, Bonn, Germany.

This article aims to identify how the term "resilience" is addressed in adult health science due to ongoing criticism about the lack of consistency in its conceptualization. Two databases (PubMed and PsycArticles) were searched to retrieve reviews published from 2015 up until 2020 on the general conceptualization of resilience. All reviews had to meet specific inclusion criteria, which resulted in the inclusion of 18 articles. Read More

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PD-1 Coexpression Gene Analysis and the Regulatory Network in Endometrial Cancer Based on Bioinformatics Analysis.

Biomed Res Int 2021 25;2021:9923434. Epub 2021 May 25.

Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin, China.

Gynecological malignancies are tumors of the female reproductive system, mainly cervical cancer, endometrial cancer, and ovarian cancer. Endometrial cancer (EC) is the most common gynecological malignant tumor in developed countries. The aim of this study was to construct a network of programmed cell death protein 1 (PD-1) coexpressed genes through bioinformatics analysis and screen the potential biomarkers of PD-1 in endometrial cancer. Read More

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September 2021

Spatio-Temporal Sequential Memory Model With Mini-Column Neural Network.

Front Neurosci 2021 28;15:650430. Epub 2021 May 28.

School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.

Memory is an intricate process involving various faculties of the brain and is a central component in human cognition. However, the exact mechanism that brings about memory in our brain remains elusive and the performance of the existing memory models is not satisfactory. To overcome these problems, this paper puts forward a brain-inspired spatio-temporal sequential memory model based on spiking neural networks (SNNs). Read More

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Delivery sheath tip invagination - An unusual cause of failure to retrieve duct occluder.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):242-243. Epub 2021 Apr 10.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Transcatheter closure of patent ductus arteriosus is the standard of care. Retrieval of a duct occluder device is generally easy until it is detached from the delivery cable. We report two instances of failed retrieval of the device due to sheath tip invagination. Read More

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Potential value of MicroRNA-21 as a biomarker for predicting the prognosis of patients with breast cancer: A protocol for meta-analysis and bioinformatics analysis.

Medicine (Baltimore) 2021 Jun;100(22):e25964

Department of Breast Surgery, Huzhou Central Hospital, Affiliated Central Hospital HuZhou University, Huzhou, Zhejiang Province, China.

Background: The latest global cancer data from 2020 shows that breast cancer has replaced lung cancer as the number one cancer in the world. Searching for new biomarkers of breast cancer has important clinical significance for early diagnosis, prediction of prognosis, and targeted therapy. MicroRNA-21 (miRNA-21) can be used as a new molecular marker for early diagnosis, prognosis, and treatment of tumors. Read More

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The active ingredients and mechanisms of Longchai Jiangxue Formula in treating PV, based on UPLC/Q-TOF-MS/MS, systematic pharmacology, and molecular biology validation.

Biomed Pharmacother 2021 Aug 28;140:111767. Epub 2021 May 28.

Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address:

Background: Polycythemia vera (PV) is a refractory hematological disease that lack of effective therapy. Chinese traditional medicine Longchai Jiangxue formula (LCJX) has showed the powerful effects on PV. However, the active ingredients and mechanisms of this formula have not been elucidated. Read More

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Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Dec 26;111:110366. Epub 2021 May 26.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The biological cascade of second messenger-cyclic adenosine monophosphate (cAMP) -as a molecular mechanism implicated in memory and learning regulation has captured the attention of neuroscientists worldwide. cAMP triggers its foremost effector, protein kinase A (PKA), resulting in the activation of innumerable downstream targets. Roflumilast (ROF), a phosphodiesterase 4 inhibitor, has demonstrated a greater efficiency in enhancing cAMP signaling in various neurological disorders. Read More

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December 2021

Insight into the Formation and Stability of Solid Electrolyte Interphase for Nanostructured Silicon-Based Anode Electrodes Used in Li-Ion Batteries.

ACS Appl Mater Interfaces 2021 Jun 21;13(21):24734-24746. Epub 2021 May 21.

LPICM, CNRS, Ecole polytechnique, IP Paris, Palaiseau 91228 Cedex, France.

Silicon-based anode fabrication with nanoscale structuration improves the energy density and life cycle of Li-ion batteries. As-synthesized silicon (Si) nanowires (NWs) or nanoparticles (NPs) directly on the current collector represent a credible alternative to conventional graphite anodes. However, the operating potentials of these electrodes are below the electrochemical stability window of all electrolytes used in commercial Li-ion systems. Read More

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The Key Target and Molecular Mechanism of the Volatile Component of Georgi in Acute Lung Injury Based on Network Pharmacology.

Front Pharmacol 2021 26;12:650780. Epub 2021 Apr 26.

Clinical Bioinformatics Experimental Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

georgi is one of the most widely studied TCMs; its effects in ALI have been studied in a large number of experiments, and the efficacy of volatile oil from TCM remains to be studied. The volatile component of georgi was selected to act on the key target of acute lung injury and was preliminarily studied for its specific molecular mechanism. The volatile active substances of georgi were extracted by GC-MS, and the active ingredients related with the occurrence and development of acute lung injury were searched and matched by the TCMSP database. Read More

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Study on antidepressant mechanism of Radix Bupleuri-Radix Paeoniae Alba herb pair by metabonomics combined with 1H nuclear magnetic resonance and ultra-high-performance liquid chromatography-tandem mass spectrometry detection technology.

J Pharm Pharmacol 2021 Aug;73(9):1262-1273

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.

Objectives: Radix Bupleuri-Radix Paeoniae Alba (BP), a traditional Chinese medicine herb pair, has treated depression by coordinating the liver in Chinese classical medicine books and modern research. This study aims to verify the antidepressant effect of BP by behavioural examination, and reveal the underlying antidepressant mechanisms of BP.

Methods: The antidepressant effects in chronic unpredictable mild stress (CUMS) of BP were observed by behavioural indicators and 1H nuclear magnetic resonance (1H-NMR) and ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) metabonomics techniques combined with the related analysis platforms. Read More

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Does age affect perception of the Speech-to-Song Illusion?

PLoS One 2021 19;16(4):e0250042. Epub 2021 Apr 19.

University at Buffalo, Buffalo, NY, United States of America.

The Speech-to-Song Illusion is an auditory illusion that occurs when a spoken phrase is repeatedly presented. After several presentations, listeners report that the phrase seems to be sung rather than spoken. Previous work [1] indicates that the mechanisms-priming, activation, and satiation-found in the language processing model, Node Structure Theory (NST), may account for the Speech-to-Song Illusion. Read More

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October 2021