8,881 results match your criteria retinopathy prematurity


-mediated angiogenesis in retinopathy of prematurity is co-regulated by miR-17-5p and miR-20a-5p.

Biochem Cell Biol 2021 Jul 28:1-10. Epub 2021 Jul 28.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, Central South University, P.R. China.

The microRNAs miR-17-5p and miR-20a-5p play important roles on angiogenesis; however, it is arguable whether they regulate the formation of retinal blood vessels in retinopathy of prematurity (ROP). We used a mouse model of oxygen-induced retinopathy (OIR) to simulate the development of retinas in mice suffering from ROP, and the expression levels of miR-20a-5p, miR-17-5p, hypoxia-inducible factor 1-alpha (HIF-1α), and vascular endothelial growth factor (VEGF) were measured by RT-qPCR and Western blotting. Cell proliferation, apoptosis, and angiogenesis in the OIR model mice were measured using MTT assays, flow cytometry, and Matrigel assays, respectively. Read More

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Study protocol for a multicentre, open-label, single-arm phase I/II trial to evaluate the safety and efficacy of ripasudil 0.4% eye drops for retinopathy of prematurity.

BMJ Open 2021 Jul 27;11(7):e047003. Epub 2021 Jul 27.

Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Retinopathy of prematurity (ROP) is a vascular proliferative disorder that occurs in preterm infants. Existing treatments are only indicated in severe ROP cases due to the high invasiveness and the potential risk of irreversible side effects. We previously elucidated that ripasudil, a selective inhibitor of the Rho-associated protein kinase, has the ability to inhibit abnormal retinal neovascularisation in animal models. Read More

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Strabismus, stereoacuity, accommodation and convergence in young adults born premature and screened for retinopathy of prematurity.

Acta Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.

Purpose: The aim of the study was to evaluate strabismus, stereoacuity, accommodation and convergence in prematurely born young adults; screened for retinopathy of prematurity in the neonatal period and compare with term-born individuals of the same age.

Materials And Methods: The study participants included 59 prematurely born individuals with a birthweight of ≤1,500 grams and 44 term-born controls, all born during 1988-1990 in Stockholm County, Sweden. Ocular alignment was assessed with a cover test, stereoacuity with the TNO stereo test and the amplitude of accommodation and the near point of convergence with the Royal Air Force Rule. Read More

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Atypical Late-Onset Exudative Retinal Detachment in a Treatment-Naïve Infant With Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):403-406. Epub 2021 Jul 1.

A male infant born at 23 weeks gestation with a birthweight of 660 grams presented with retinopathy of prematurity (ROP) that began progressing at 44 weeks. He subsequently developed Zone III, Stage 3, pre-plus disease in both eyes (OU), as well as scattered exudates in the macula, dragged vessels temporally, and an exudative retinal detachment temporally in the left eye after a period of regressing and stable ROP. After bilateral laser photocoagulation, there was regression of the neovascularization, resolution of the exudative detachment, and eventual stabilization of disease OU by 12 months postmenstrual age. Read More

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Correspondence to "Prediction of severe retinopathy of prematurity in 24-30 weeks gestation infants using birth characteristics".

J Perinatol 2021 Jul 24. Epub 2021 Jul 24.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2182-2187

Department of Biostatistics and Medical Informatics, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Purpose: To evaluate the prognostic potential of systemic inflammatory index in the course of retinopathy of prematurity (ROP).

Methods: This is a retrospective case-control study. 303 infants with a gestational age of ≤35 weeks were screened with and without ROP at birth and 1 month after the birth of complete blood counts (CBC) were included in this study. Read More

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Risk of corneal epithelial defects with and without postoperative erythromycin ointment after laser photocoagulation for retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2178-2181

Department of Ophthalmology, Albany Medical College, Albany, NY, USA.

Purpose: We aim to compare the incidence of corneal epithelial defects after laser for retinopathy of prematurity (ROP) with and without the use of postoperative erythromycin ointment.

Methods: In this retrospective observational cohort study, a total of 100 infants (200 eyes) consecutively treated with laser for ROP between 2012 and 2018. The primary outcome was presence or absence of corneal epithelial defect using fluorescein on bedside examination within the first week following laser for ROP. Read More

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Commentary: Are we there yet? Role of anti-vascular endothelial growth factor and laser in the management of retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2176-2177

Vitreo-Retina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Pondicherry, India.

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Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2171-2176

Professor of Ophthalmology, Regional Institute of Ophthalmology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

Purpose: The aim of this study was to report the treatment outcomes of early and deferred laser in infants of aggressive posterior retinopathy of prematurity (APROP) after initial treatment with intravitreal Ranibizumab (IVR).

Methods: In a prospective, randomized, interventional study, infants with APROP received IVR (0.25 mg) and were randomized into two groups prior to laser. Read More

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Combined intravitreal ranibizumab and zone I sparing laser ablation in infants with posterior zone I retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2164-2170

Consultant, Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India.

Purpose: To evaluate the efficacy of combined intravitreal ranibizumab (IVR) and zone I sparing laser ablation in infants with posterior zone I Retinopathy of Prematurity (ROP).

Methods: This was a retrospective, interventional case series including premature infants diagnosed with posterior zone I ROP (n = 24) on ROP screening. Charts and RetCam images of preterm infants with posterior zone I ROP treated with immediate IVR and zone I sparing laser ablation at 4 weeks between April 2016 and September 2019 were reviewed. Read More

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Anti-vascular endothelial growth factor in the management of retinopathy of prematurity: A survey among the members of Indian Retinopathy of Prematurity Society.

Indian J Ophthalmol 2021 Aug;69(8):2158-2163

Director, MGM Eye Institute, Raipur, Chhattisgarh, India.

Purpose: To report the results of the survey for the role of anti-VEGF in the management of retinopathy of prematurity (ROP) among the members of Indian ROP (iROP) society.

Methods: A questionnaire was designed in English using Google forms and its link was circulated to the members of the iROP society on their mobile numbers. The survey included questions pertaining to demographics, anti-VEGF agents, injection technique, post-injection follow-up, and documentation pertaining to their ROP practice. Read More

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A comparison of posterior segment optical coherence tomography findings in full-term and preterm children without retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2151-2156

Ophthalmology and Optometry Department - Hospital Militar Central, Bogotá, Colombia.

Purpose: Structural differences have been described in the retina of prematurely born children, including increased macular thickness caused by failed migration of the inner retina during development and retinal nerve fiber layer (RNFL) thinning related to low birth weight. The present study aimed to evaluate the differences in macular and RNFL optical coherence tomography (OCT) findings between full-term and preterm children without retinopathy of prematurity (ROP).

Methods: Thirty-four premature (study group) and 43 full-term patients (control group)-aged 3 to 8 years-were studied. Read More

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Retinopathy of prematurity screening and retinal hemorrhages - Our experience among Indian babies.

Indian J Ophthalmol 2021 Aug;69(8):2147-2150

Minto Regional Institute of Ophthalmology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.

Purpose: To evaluate the clinical characteristics of intraocular hemorrhages among babies screened for retinopathy of prematurity (ROP) and thereby their additional risk to the progression of ROP.

Methods: A descriptive study was conducted at a tertiary referral hospital, which included 108 eyes of 60 neonates who were discovered to have retinal hemorrhages on retinal screening of 540 babies at risk for ROP. Maternal, obstetric, and neonatal risk factors were assessed in neonates with retinal hemorrhages. Read More

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Commentary: Wide-field imaging vs binocular indirect ophthalmoscopy in retinopathy of prematurity screening: Real-world advantages.

Authors:
Anand Vinekar

Indian J Ophthalmol 2021 Aug;69(8):2146

Department of Pediatric Retina, Program Director, KIDROP, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India.

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Analysis of the parental satisfaction for retinopathy of prematurity screening using binocular indirect ophthalmoscopy versus wide field retinal imaging.

Indian J Ophthalmol 2021 Aug;69(8):2142-2145

Medical Director, Dhami Eye Care Hospital, Ludhiana, Punjab, India.

Purpose: Analysis of the parental satisfaction for retinopathy of prematurity screening using binocular indirect ophthalmoscopy versus wide field retinal imaging.

Methods: This was an observational, questionnaire survey-based study. The study cohort comprised of parents/legal guardians of consecutive Asian Indian premature infants enrolled for retinopathy of prematurity screening (for infants less than 2000 gms and/or 34-weeks gestational age) using binocular indirect ophthalmoscopy (BIO) with scleral depression and b) wide field retinal imaging using the 3Nethra Neo Camera (Forus Health, India). Read More

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Commentary: Parental involvement in retinopathy of prematurity care: An individualized approach.

Indian J Ophthalmol 2021 Aug;69(8):2141

Associate Professor, Department of Psychiatry, Grant Government Medical College, Mumbai, Maharashtra, India.

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Should parents be present during screening examinations for retinopathy of prematurity?

Indian J Ophthalmol 2021 Aug;69(8):2134-2140

Department of Ophthalmology, Bilkent City Hospital, Ankara, Turkey.

Purpose: To investigate whether parents should be present during screening examinations for retinopathy of prematurity (ROP) by investigating the anxiety levels of parents using two different approaches.

Methods: This cross-sectional and two-center study was carried out with the parents at the time of the first ROP screening examination of their premature infants. At one center, the parents accompanied the infants during the ROP examination (Group 1), and in the other center, they did not (Group 2). Read More

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Commentary: Retinopathy of prematurity: Where do we stand?

Indian J Ophthalmol 2021 Aug;69(8):2132-2133

Director, MGM Eye Institute, Raipur, Chhattisgarh, India.

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Five-year demographic profile of retinopathy of prematurity at a tertiary care institute in North India.

Indian J Ophthalmol 2021 Aug;69(8):2127-2131

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: The purpose of this study is to study the demographic profile and pattern of retinopathy of prematurity (ROP) at a tertiary care institute in India.

Methods: An ambispective study from January 2013 to December 2017. Infants with birth weights (BWs) <1750 g and gestational ages <34 weeks were screened for ROP. Read More

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Commentary: Knowledge gap among nurses related to retinopathy of prematurity and its prevention and management.

Indian J Ophthalmol 2021 Aug;69(8):2125-2126

Department of Vitreo-Retina, Senior Vitreoretina Consultant, Aditya Jyot Eye Hospital, Mumbai, Maharashtra, India.

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A descriptive survey on knowledge gap related to retinopathy of prematurity and its prevention and management among nurses in a tertiary care hospital.

Indian J Ophthalmol 2021 Aug;69(8):2122-2125

College of Nursing, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Retinopathy of prematurity (ROP) is a leading cause of severe visual impairment of childhood affecting preterm babies. The disease is sensitive to the quality of neonatal nursing care provided to preterm neonates in any neonatal intensive care unit. (NICU). Read More

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Timing of laser following intravitreal anti-vascular endothelial growth factor injections for aggressive posterior zone 1 retinopathy of prematurity.

Authors:
Anand Vinekar

Indian J Ophthalmol 2021 Aug;69(8):1988-1989

Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India.

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Small Leucine-Rich Proteoglycans (SLRPs) in the Retina.

Int J Mol Sci 2021 Jul 7;22(14). Epub 2021 Jul 7.

Ocular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Retinal diseases such as age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual impairment worldwide. There is a critical need to understand the structural and cellular components that play a vital role in the pathophysiology of retinal diseases. One potential component is the family of structural proteins called small leucine-rich proteoglycans (SLRPs). Read More

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Retinopathy of Prematurity: Advances in the Screening and Treatment of Retinopathy of Prematurity Using a Single Center Approach.

Am J Ophthalmol 2021 Jul 20. Epub 2021 Jul 20.

Murray Oncology and Retina, 6705 Red Road, Suite 412, South Miami, FL, 33143.

Purpose: To focus on the longitudinal evaluation of high-risk infants for the development of retinopathy of prematurity (ROP) at a single tertiary neonatal intensive care unit (NICU) and to evaluate evolving demographics of ROP and the transition of treatment-warranted disease.

Methods: Consecutive retrospective review was performed of all infants screened for ROP between 1990 and 2019 at the Jackson Memorial Hospital neonatal intensive care unit. All inborn infants meeting a birth criteria of <32 weeks gestational age (GA) or a birthweight (BW) of 1500 grams were included. Read More

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Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts.

Neonatology 2021 Jul 22:1-8. Epub 2021 Jul 22.

Wilhelmina Children's Hospital, Utrecht, The Netherlands.

Introduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP.

Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Read More

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Fundus fluorescein angiography in retinopathy of prematurity.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Department of Neonatology, Government Medical College and Hospital, Chandigarh, India.

Background/objectives: Retinopathy of prematurity (ROP) is a potentially blinding disease of immature retinal vasculature. ROP regresses in majority of the cases and very few go on to develop ROP needing treatment. Fundus fluorescein angiography (FFA) is the gold standard technique to study retinal vasculature. Read More

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Evolving outcomes of surgery for retinal detachment in retinopathy of prematurity: the need for a national service in the United Kingdom : An audit of surgery for acute tractional retinal detachment complicating ROP in the UK.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

Objectives: To audit the structural and functional outcomes of surgery for acute tractional retinal detachment due to retinopathy or prematurity between 2004 and 2014 in Oxford UK.

Methods: Consecutive operations were identified from a surgical log. Clinical data including demography, perioperative data, and retinal outcomes were extracted into a spreadsheet and compared against two international data sets referenced in the method section. Read More

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The Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Insulin-Like Growth Factor-1 in Preterms with Retinopathy of Prematurity.

Fetal Pediatr Pathol 2021 Jul 22:1-6. Epub 2021 Jul 22.

Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.

Objective: To determine the serum levels of asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF-1) in preterms with retinopathy of prematurity (ROP). We included 37 preterm infants. The first blood samples were obtained within the first 5 days of life and repeated at the time of the first ophthalmologic examination for ROP. Read More

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Combating the Third Epidemic of Retinopathy of Prematurity.

Authors:
Rudolph S Wagner

J Pediatr Ophthalmol Strabismus 2021 Jul-Aug;58(4):208. Epub 2021 Jul 1.

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