29,709 results match your criteria retinal fundus


At the Pulse of Time: Machine Vision in Retinal Videos.

Acta Neurochir Suppl 2022 ;134:303-311

Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Spontaneous venous pulsations (SVP) are a common finding in healthy people. The absence of SVP is associated with rapid progression in glaucoma and increased intracranial pressure. Traditionally, SVP has been documented qualitatively by clinicians during biomicroscopy. Read More

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January 2022

Lessons of the month 2: Retinal vasculitis: a first presentation of Takayasu's arteritis.

Clin Med (Lond) 2021 Nov;21(6):e673-e676

Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.

Takayasu's arteritis is a chronic, systemic, large-vessel vasculitis affecting the aorta and its primary branches. However, coronary, renal and pulmonary arteries and small vessel involvement has been documented. We describe a rare case of Takayasu's arteritis with extensive supra-aortic arch disease, manifesting with bilateral occlusive retinal vasculitis as a first presentation. Read More

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November 2021

Monocular retinopathy of prematurity-like retinal vasculopathy in a dog.

Vet Ophthalmol 2021 Dec 3. Epub 2021 Dec 3.

Section of Ophthalmology and Division of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose: To describe a case of monocular retinopathy of prematurity (ROP)-like vasculopathy without oxygen supplementation in the dog.

Methods: Fundus photographs (RetCam), spectral-domain optical coherence tomography (sdOCT), confocal scanning laser ophthalmoscopy (cSLO), and fluorescein angiography (FA), as well as postmortem histology and immunohistochemistry (Collagen IV and anti-vWF antibodies), were carried out to characterize the vascular abnormalities.

Results: Ophthalmic examination showed peripheral and mid-temporal avascular areas in the tapetal region, neovascularization and abnormally dilated and tortuous retinal vessels in the left eye. Read More

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December 2021

RFARN: Retinal vessel segmentation based on reverse fusion attention residual network.

PLoS One 2021 3;16(12):e0257256. Epub 2021 Dec 3.

College of Computer Science and Engineering, Northwest Normal University, Lanzhou Gansu, China.

Accurate segmentation of retinal vessels is critical to the mechanism, diagnosis, and treatment of many ocular pathologies. Due to the poor contrast and inhomogeneous background of fundus imaging and the complex structure of retinal fundus images, this makes accurate segmentation of blood vessels from retinal images still challenging. In this paper, we propose an effective framework for retinal vascular segmentation, which is innovative mainly in the retinal image pre-processing stage and segmentation stage. Read More

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December 2021

Review on diabetic retinopathy with deep learning methods.

J Med Imaging (Bellingham) 2021 Nov 29;8(6):060901. Epub 2021 Nov 29.

College of Engineering Pune, Department of Electronics and Telecommunication Engineering, Pune, Maharashtra, India.

The purpose of our review paper is to examine many existing works of literature presenting the different methods utilized for diabetic retinopathy (DR) recognition employing deep learning (DL) and machine learning (ML) techniques, and also to address the difficulties faced in various datasets used by DR. DR is a progressive illness and may become a reason for vision loss. Early identification of DR lesions is, therefore, helpful and prevents damage to the retina. Read More

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November 2021

Factors for Visual Acuity Improvement After Anti-VEGF Treatment of Wet Age-Related Macular Degeneration in China: 12 Months Follow up.

Front Med (Lausanne) 2021 11;8:735318. Epub 2021 Nov 11.

Department of Ophthalmology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.

To evaluate the treatment solutions and effectiveness of intravitreal ranibizumab (RBZ) or conbercept in patients with wet age-related macular degeneration (wAMD) in a real-life setting in China. The medical records of 368 patients with wAMD who started RBZ or conbercept treatment between 1 May 2014 and 30 April 2018 were evaluated. All patients were defined on fundus angiography at baseline to determine the subtype of AMD (PCV or CNV). Read More

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November 2021

Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure.

Acta Ophthalmol 2021 Dec 1. Epub 2021 Dec 1.

Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Purpose: To assess the impact of neurodegenerative morphologic alterations due to macular telangiectasia type 2 (MacTel) on microperimetry (MP) and multifocal electroretinography (mfERG).

Methods: Thirty-five eyes of 18 patients with MacTel were examined using spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), mfERG and MP. Software was used to match SD-OCT B-scans with the corresponding retinal sensitivity map and multifocal electroretinograms (mfERGs), thus enabling direct structure/function correlation. Read More

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December 2021

Acute Multifocal Placoid Pigment Epitheliopathy-like Presentation following the First Dose of BNT162B2 COVID-19 Vaccination.

Ocul Immunol Inflamm 2021 Dec 1:1-4. Epub 2021 Dec 1.

Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.

Purpose: To report a case with acute posterior multifocal placoid pigment epitheliopathy (APMPPE)-like presentation following the first dose of BNT162b2 COVID-19 vaccination.

Case Report: An otherwise healthy 45-year-old woman presented with a headache and blurred vision in her right eye 7 days after the administration of first dose of mRNA (BNT162b2) COVID-19 vaccine. Fundus examination of the right eye revealed multiple discrete yellow-white placoid lesions at the level of deep retinal layers throughout the posterior pole, while left fundus was unremarkable at that time. Read More

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December 2021

Inter-eye comparison of retinal vascular growth rate and angiographic findings following unilateral bevacizumab treatment.

Eur J Ophthalmol 2021 Dec 1:11206721211064019. Epub 2021 Dec 1.

Departmant of Health Science University Kanuni Sultan Suleyman Training and Research Hospital, Tertiary ROP Center, Istanbul, Turkey.

Purpose: To compare retinal vascularization progression rate, final retinal vascularization, and fluorescein angiography (FA) findings in infants who received intravitreal bevacizumab (IVB) treatment in one eye and with spontaneous regression in the other eye.

Methods: Thirty eyes of 15 infants who underwent IVB in one eye due to asymmetric retinopathy of prematurity, and who had pre-treatment fundus photographs and fluorescein angiography images were included in the study. Horizontal disc diameter (DD), optic disc-to-fovea distance (FD), and the length of temporal retinal vascularization (LTRV) distance were measured by evaluating pre-treatment and FA images. Read More

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December 2021

Spectral fundus autofluorescence peak emission wavelength in ageing and AMD.

Acta Ophthalmol 2021 Dec 1. Epub 2021 Dec 1.

Department of Ophthalmology, University Hospital Jena, Jena, Germany.

Purpose: To investigate the spectral characteristics of fundus autofluorescence (FAF) in AMD patients and controls.

Methods: Fundus autofluorescence spectral characteristics was described by the peak emission wavelength (PEW) of the spectra. Peak emission wavelength (PEW) was derived from the ratio of FAF recordings in two spectral channels at 500-560 nm and 560-720 nm by fluorescence lifetime imaging ophthalmoscopy. Read More

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December 2021

In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope.

J Clin Invest 2021 Nov 30. Epub 2021 Nov 30.

Physical Chemistry of Biological Systems, Polish Academy of Sciences, Warsaw, Poland.

Background: Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases. Fluorescent vitamin A derivatives, which are the chemical intermediates of these processes, are highly sensitive to UV light; thus, safe analyses of these processes in humans are currently beyond the reach of even the most modern ocular imaging modalities.

Methods: We present a compact fluorescence scanning laser ophthalmoscope (TPEF-SLO) and spectrally resolved images of the human retina based on two-photon excitation (TPE) with near-infrared (IR) light. Read More

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November 2021

Choriocapillaris Flow Signal Impairment in Sorsby Fundus Dystrophy.

Ophthalmologica 2021 Nov 29. Epub 2021 Nov 29.

Purpose To quantify choriocapillaris flow alterations in early Sorsby Fundus Dystrophy (SFD) and to investigate the relationship of the choriocapillaris flow deficits with the choroidal and outer retinal microstructure. Methods In this prospective case-control study, 18 eyes of 11 patients with early SFD and 31 eyes of 31 controls without ocular pathology underwent multimodal imaging, including spectral-domain optical coherence tomography (OCT), followed by deep-learning-based layer segmentation. OCT Angiography (OCTA) was performed to quantify choriocapillaris flow signal deficits (FDs). Read More

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November 2021

Efficacy of Large Optic Intraocular Lenses in Myopic Eyes with Posterior Segment Pathology.

Ophthalmol Ther 2021 Nov 27. Epub 2021 Nov 27.

Borkenstein & Borkenstein, Private Practice at Privatklinik der Kreuzschwestern Graz, Kreuzgasse 35, 8010, Graz, Austria.

We report a case series of patients with high myopia (axial length 25.04-27.59 mm) diagnosed with cataract and maculopathy who underwent a combined procedure of phacoemulsification with implantation of a large optic intraocular lens (IOL) and intravitreal injection. Read More

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November 2021

SCORE2 Report 17: Macular thickness fluctuations in anti-VEGF-treated patients with central or hemiretinal vein occlusion.

Graefes Arch Clin Exp Ophthalmol 2021 Nov 29. Epub 2021 Nov 29.

University of Wisconsin Fundus Photograph Reading Center, Madison, WI, USA.

Purpose: To evaluate macular thickness fluctuations and their association with visual acuity outcome in eyes with macular edema (ME) secondary to central (CRVO) or hemiretinal vein occlusion (HRVO) treated initially with intravitreal aflibercept or bevacizumab.

Methods: Post hoc analysis of 362 patients with ME secondary to CRVO or HRVO initially randomized to six monthly intravitreal injections of aflibercept or bevacizumab. Three spectral domain optical coherence tomography (SD-OCT) central subfield thickness (CST) fluctuation measures were investigated over Months 1-12: standard deviation (SD), number of turning points (T) for each participant, and a measure denoted as Zigzag reflecting the magnitude of alternating ups and downs in a participant's CST. Read More

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November 2021

Wide-field swept source optical coherence tomography evaluation of posterior segment changes in highly myopic eyes.

Eur J Ophthalmol 2021 Nov 29:11206721211062362. Epub 2021 Nov 29.

Department of Ophthalmology, 34732Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: To investigate the features in the posterior pole of highly myopic (HM) eyes using a wide-field high-resolution swept source optical coherence tomography (SS OCT).

Methods: This observational cross-sectional study involved 262 eyes of 139 patients, who were diagnosed as HM and had consecutively been examined by SS OCT in the Ophthalmology Department of the Peking Union Medical College Hospital between March 2019 and December 2019. The characteristics of OCT images were documented and analyzed. Read More

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November 2021

[Evaluation of papilledema and visual improvement in patients with idiopathic intracranial hypertension after venous sinus stenting].

Zhonghua Wai Ke Za Zhi 2021 Dec 1;59(12):1020-1025. Epub 2021 Dec 1.

Department of Neurosurgery,Tianjin Huanhu Hospital,Tianjin 300350,China.

To evaluate the improvement of papilledema and visual acuities in patients with idiopathic intracranial hypertension (IIH) after venous sinus stenting. The clinical data of 8 IIH patients who met the inclusion criteria underwent venous sinus stenting between January 2013 and December 2016 at Department of Neurosurgery, Tianjin Huanhu Hospital were analyzed retrospectively. There were 6 females and 3 males,aged (32. Read More

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December 2021

Retinal autofluorescence findings after COVID-19.

Int J Retina Vitreous 2021 Nov 27;7(1):71. Epub 2021 Nov 27.

São Paulo Hospital, Paulista School of Medicine, Federal University of São Paulo, Rua Botucatu 816 Vila Clementino, São Paulo, Brazil.

The main purpose of this study was to investigate the presence of retinal autofluorescence findings in COVID-19 patients. Observational study conducted in São Paulo in 2020. Demographic, medical history, and concomitant events, as well as medications used, hospitalization details, and laboratory test results, were obtained. Read More

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November 2021

Clinical features and genetic spectrum of NMNAT1-associated retinal degeneration.

Eye (Lond) 2021 Nov 26. Epub 2021 Nov 26.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, China.

Objectives: To systematically analyse the NMNAT1 variant spectrum and frequency, the associated phenotypic characteristics, and potential genotype-phenotype correlations based on our data and literature review.

Methods: Biallelic potential pathogenic variants (PPV) in NMNAT1 were collected from our in-house exome sequencing data. Whole-genome sequencing was conducted subsequently for patients with only one heterozygous PPV detected in NMNAT1. Read More

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November 2021

High myopia and macular vascular density: an optical coherence tomography angiography study.

BMC Ophthalmol 2021 Nov 27;21(1):407. Epub 2021 Nov 27.

School of Medicine, University of New South Wales, Kensington, NSW, 2052, Australia.

Objective: To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA).

Method: OCTA was performed on 35 eyes with HM with spherical equivalence (SE) > - 6.00D and 35 eyes with NHM with SE ≤ -6. Read More

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November 2021

Optimized Prediction Models from Fundus Imaging and Genetics for Late Age-Related Macular Degeneration.

J Pers Med 2021 Nov 1;11(11). Epub 2021 Nov 1.

iHealthscreen Inc., New York, NY 11418, USA.

Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. In this study, we compare the performance of retinal fundus images and genetic-information-based machine learning models for the prediction of late AMD. Using data from the Age-related Eye Disease Study, we built machine learning models with various combinations of genetic, socio-demographic/clinical, and retinal image data to predict late AMD using its severity and category in a single visit, in 2, 5, and 10 years. Read More

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November 2021

Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up.

Medicina (Kaunas) 2021 Nov 20;57(11). Epub 2021 Nov 20.

Department of Opthalmology and Ocular Oncology, University Hospital, 31-501 Kraków, Poland.

We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. Read More

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November 2021

Macular Morpho-Functional and Visual Pathways Functional Assessment in Patients with Spinocerebellar Type 1 Ataxia with or without Neurological Signs.

J Clin Med 2021 Nov 12;10(22). Epub 2021 Nov 12.

IRCCS-Fondazione Bietti, Via Livenza 1, 00198 Rome, Italy.

Spinocerebellar ataxia type 1 (SCA-ATXN1) is an autosomal dominant, neurodegenerative disease, caused by CAG repeat expansion in the ataxin-1 gene (). In isolated reports of patients with neurological signs [symptomatic patients (SP)], macular abnormalities have been described. However, no reports exist about macular anomalies in SCA1 subjects carrying the mutation without neurological signs [not symptomatic carriers (NSC)]. Read More

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November 2021

Rare Case of Bilateral Diffuse Uveal Melanocytic Proliferation with Dermal and Mucosal Hyperpigmentations.

Diagnostics (Basel) 2021 Nov 5;11(11). Epub 2021 Nov 5.

Department of Ophthalmology, University of Lübeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 Lübeck, Germany.

Purpose: The demonstration of a rare case of bilateral diffuse uveal melanocytic proliferation (BDUMP) due to a lung carcinoma with unusual dermal lesions.

Case Description: A 76-year-old man with painless bilateral vision loss revealed leopard or giraffe spot chorioretinopathy and bilateral serous retinal detachment. Ultrasound biomicroscopy revealed uveal swelling expanding into the anterior chamber angle. Read More

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November 2021

Identifying Peripheral Neuropathy in Colour Fundus Photographs Based on Deep Learning.

Diagnostics (Basel) 2021 Oct 20;11(11). Epub 2021 Oct 20.

NIHR Moorfields Biomedical Research Centre, 162 City Road, London EC1V 2PD, UK.

The aim of this study was to develop and validate a deep learning-based system to detect peripheral neuropathy (DN) from retinal colour images in people with diabetes. Retinal images from 1561 people with diabetes were used to predictDN diagnosed on vibration perception threshold. A total of 189 had diabetic retinopathy (DR), 276 had DN, and 43 had both DR and DN. Read More

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October 2021

Ultra-wide-field fundus autofluorescence and asteroid hyalosis.

Natl Med J India 2021 May-Jun;34(3):186

Department of Vitreo-Retinal Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

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November 2021

A case series from a single family of familial retinal arteriolar tortuosity with common history of sudden visual loss.

Am J Ophthalmol Case Rep 2021 Dec 9;24:101230. Epub 2021 Nov 9.

Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Purpose: To report family members with familial retinal arteriolar tortuosity (FRAT) identified after sudden visual loss.

Observations: A 15-year-old boy had sudden visual loss in his left eye while playing on a horizontal bar. He was referred to Nagoya City University Hospital from an eye clinic. Read More

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December 2021

X-linked Retinoschisis: Deep Phenotyping and Genetic Characterization.

Ophthalmology 2021 Nov 22. Epub 2021 Nov 22.

Moorfields Eye Hospital, London, United Kingdom; UCL Institute of Ophthalmology, University College London, London, United Kingdom. Electronic address:

Objective: To examine the genetic and clinical features in children and adults with XLRS.

Design: Single-center consecutive, retrospective, observational study.

Setting: Single tertiary referral center. Read More

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November 2021

2D alpha-shapes to quantify retinal microvasculature morphology and their application to proliferative diabetic retinopathy characterisation in fundus photographs.

Sci Rep 2021 Nov 24;11(1):22814. Epub 2021 Nov 24.

VAMPIRE Project, Scottish Collaborative Optometry-Ophthalmology Network e-Research (SCONe), Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.

The use of 2D alpha-shapes (α-shapes) to quantify morphological features of the retinal microvasculature could lead to imaging biomarkers for proliferative diabetic retinopathy (PDR). We tested our approach using the MESSIDOR dataset that consists of colour fundus photographs from 547 healthy individuals, 149 with mild diabetic retinopathy (DR), 239 with moderate DR, 199 pre-PDR and 53 PDR. The skeleton (centrelines) of the automatically segmented retinal vasculature was represented as an α-shape and the proposed parameters, complexity ([Formula: see text]), spread (OpA), global shape (VS) and presence of abnormal angiogenesis (Grad) were computed. Read More

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November 2021

Central Serous Chorioretinopathy Following Oral Use of Adulterated Honey Mixed with Tadalafil: A Case Report.

Int Med Case Rep J 2021 15;14:773-776. Epub 2021 Nov 15.

Ophthalmology Division, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.

Background: Central serous chorioretinopathy (CSCR) is an idiopathic condition characterized by serous retinal detachment and/or retinal pigment epithelial (RPE) detachment, the condition associated with a fluid leak through the RPE into subretinal space. This article reports on an unusual case of CSCR following taking adulterated honey mixed with tadalafil powder.

Case Presentation: A 38-year-old male, not known to have any medical illnesses, came to our ophthalmology clinic complaining of sudden onset of blurred central vision in the left eye for five days after taking an adulterated honey which was claimed to improve sexual performance. Read More

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November 2021

Single-Examination Risk Prediction of Severe Retinopathy of Prematurity.

Pediatrics 2021 Dec;148(6)

Departments of Ophthalmology.

Background And Objectives: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. Screening and treatment reduces this risk, but requires multiple examinations of infants, most of whom will not develop severe disease. Previous work has suggested that artificial intelligence may be able to detect incident severe disease (treatment-requiring retinopathy of prematurity [TR-ROP]) before clinical diagnosis. Read More

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December 2021