61,184 results match your criteria retinal determination


Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F.

J Ethnopharmacol 2021 May 5:114190. Epub 2021 May 5.

Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Ethnopharmacological Relevance: Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear. Read More

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Remnant cholesterol predicts progression of diabetic nephropathy and retinopathy in type 1 diabetes.

J Intern Med 2021 May 8. Epub 2021 May 8.

From the, Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.

Background: We aimed to assess whether remnant cholesterol concentration and variability predict the progression of diabetic nephropathy (DN) and severe diabetic retinopathy (SDR) in type 1 diabetes.

Methods: This observational prospective study covered 5150 FinnDiane Study participants. Remnant cholesterol was calculated as total cholesterol - LDL cholesterol - HDL cholesterol and variability as the coefficient of variation. Read More

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Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina.

Sci Rep 2021 May 7;11(1):9745. Epub 2021 May 7.

Department of Electronic Engineering, Hanyang University, Seoul, Republic of Korea.

Transorbital electrical stimulation (tES) has been studied as a new noninvasive method for treating intractable eye diseases by delivering weak electrical current to the eye through a pair of electrodes attached to the skin around the eye. Studies have reported that the therapeutic effect of tES is determined by the effective stimulation of retinal cells that are densely distributed in the posterior part of the retina. However, in conventional tES with a pair of electrodes, a greater portion of the electric field is delivered to the anterior part of the retina. Read More

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The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication.

Sci Rep 2021 May 7;11(1):9755. Epub 2021 May 7.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China.

Elevated intraocular pressure (IOP) is one of the main risk factors for glaucoma, and pathological changes in the lamina cribrosa (LC) may play a leading role. This study aimed to explore the influence of different IOP on LC parameters and the correlation between parameters and glaucoma severity. A total of 91 eyes were examined by swept-source OCT and divided into IOP ≥ 30 mmHg (group A), 21 mmHg ≤ IOP < 30 mmHg (group B), and normal IOP (control, group C). Read More

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Effect of ECG-gating retinal photographs on retinal vessel caliber measurements in subjects with and without type 2 diabetes.

Curr Eye Res 2021 May 7. Epub 2021 May 7.

Department of Cardiology, Westmead Hospital, Sydney, Australia.

Purpose/Aim of this study:Retinal vessel caliber is an independent risk marker of cardiovascular disease risk. However, variable mechanical delays in capturing retinal photographs and cardiac cycle-induced retinal vascular changes have shown to reduce the accuracy of retinal vessel caliber measurements, but this has only ever been investigated in healthy subjects. This cross-sectional study is the first study to investigate this issue in type 2 diabetes. Read More

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Vascular endothelial growth factor inhibitors for predominantly Caucasian myopic choroidal neovascularization: 2-year treatment outcomes in clinical practice: data from the Fight Retinal Blindness! Registry.

Acta Ophthalmol 2021 May 6. Epub 2021 May 6.

Discipline of Ophthalmology, Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Purpose: To report the 24-month outcomes of vascular endothelial growth factor (VEGF) inhibitors for myopic choroidal neovascularization (mCNV) in predominantly Caucasian eyes in routine clinical practice.

Methods: Retrospective analysis of treatment-naïve eyes starting intravitreal injection of VEGF inhibitors of either bevacizumab (1.25 mg) or ranibizumab (0. Read More

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Complications and visual outcome of sutureless, scleral fixated intraocular lens in cases with traumatic aphakia.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211009095. Epub 2021 Apr 20.

Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education & Research, Gorimedu, India.

Purpose: The aim of this study is to describe the complications and outcome of sutureless scleral fixated intraocular lens (SFIOL) implantation in traumatic aphakia.

Setting: The study was conducted in a tertiary eye care centre in South India.

Design: The study involved a retrospective data analysis. Read More

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Factors associated with reactivation after intravitreal bevacizumab or ranibizumab therapy in infants with retinopathy of prematurity.

Retina 2021 May 3. Epub 2021 May 3.

Department of Ophthalmology, Kindai University Faculty of Medicine, 377-2, Ohonohigashi, Osakasayama, Osaka, 589-8511, Japan Department of Pediatrics, Kindai University Faculty of Medicine, 377-2, Ohonohigashi, Osakasayama, Osaka, 589-8511, Japan.

Purpose: To investigate the efficacy and risk factors of intravitreal anti-vascular endothelial growth factor injection (anti-VEGF therapy) for retinopathy of prematurity (ROP).

Methods: We retrospectively reviewed 80 consecutive eyes of 43 patients with type 1 ROP or worse who received anti-VEGF therapy during January 2012-February 2018. Patients were divided into those who were injected with 0. Read More

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Retinal pigment epithelium melanin distribution estimated by polarisation entropy and its association with retinal sensitivity in patients with high myopia.

Br J Ophthalmol 2021 May 6. Epub 2021 May 6.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Purpose: To investigate retinal sensitivity of highly myopic eyes without choroidal neovascularisation (CNV) or patchy chorioretinal atrophy (PCA) and investigated its association with anatomical characteristics including melanin distribution at the retinal pigment epithelium (RPE), which was evaluated with polarisation-sensitive optical coherence tomography (PS-OCT).

Design: Retrospective consecutive observational cohort study.

Methods: We included highly myopic eyes (refractive error ≤-8. Read More

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Clinical exome sequencing facilitates the understanding of genetic heterogeneity in Leber congenital amaurosis patients with variable phenotype in southern India.

Eye Vis (Lond) 2021 May 6;8(1):20. Epub 2021 May 6.

Department of Molecular Genetics, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, Tamil Nadu, 625020, India.

Background: Leber congenital amaurosis (LCA), primarily characterized by retinal degeneration is the most severe form of inherited retinal dystrophy (IRD) responsible for congenital blindness. The presence of phenotypic heterogeneity makes the diagnosis of LCA challenging, especially in the absence of pronounced disease pathognomonic, yet it can be well comprehended by employing molecular diagnosis. Therefore, the present study aimed to reveal the causative mutations in ten LCA patients with variable phenotypes using clinical exome sequencing (CES). Read More

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Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropathy.

Stem Cell Res Ther 2021 May 6;12(1):275. Epub 2021 May 6.

Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

Background: Glaucomatous optic neuropathy (GON) is an anatomofunctional impairment of the optic nerve triggered by glaucoma. Recently, growth factors (GFs) have been shown to produce retinal neuroenhancement. The suprachoroidal autograft of mesenchymal stem cells (MSCs) by the Limoli retinal restoration technique (LRRT) has proven to achieve retinal neuroenhancement by producing GF directly into the choroidal space. Read More

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Efficacy and Safety of Biosimilar FYB201 Compared With Ranibizumab in Neovascular Age-Related Macular Degeneration.

Ophthalmology 2021 May 3. Epub 2021 May 3.

Department of Ophthalmology, University of Bonn, Bonn, Germany;; Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT, USA.

Purpose: This trial was conducted to investigate the clinical equivalence of the proposed biosimilar FYB201 and reference ranibizumab in patients with treatment-naive, subfoveal choroidal neovascularization caused by neovascular age-related macular degeneration (nAMD).

Design: This was a prospective, multicenter, evaluation-masked, parallel-group, 48-week, phase III randomized study.

Participants: A total of 477 patients were randomly assigned to receive FYB201 (n = 238) or reference ranibizumab (n = 239). Read More

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Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.

PLoS One 2021 6;16(5):e0251098. Epub 2021 May 6.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), Eye Clinic of Genoa, Policlinico San Martino, University of Genova, Genova, Italy.

Purpose: To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coherence tomography angiography (SS-OCTA).

Methods: In this prospective, case-controlled study, patients with NF1 and age-matched control subjects were quantitatively analyzed by using multimodal imaging. All the subjects underwent confocal scanning laser ophthalmoscopy (SLO), SS-OCT and SS-OCTA examinations. Read More

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Visual Acuity, Vitreous Hemorrhage, and Other Ocular Outcomes After Vitrectomy vs Aflibercept for Vitreous Hemorrhage Due to Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Ophthalmol 2021 May 6. Epub 2021 May 6.

Joslin Diabetes Center, Beetham Eye Institute, Harvard Department of Ophthalmology, Boston, Massachusetts.

Importance: Although there were no differences in mean visual acuity (VA) over 24 weeks after vitrectomy with panretinal photocoagulation (PRP) vs aflibercept in a randomized clinical trial among eyes with vitreous hemorrhage due to proliferative diabetic retinopathy (PDR), post hoc analyses may influence treatment choices.

Objective: To compare exploratory outcomes between treatment groups that may affect treatment choices for patients with vitreous hemorrhage due to PDR.

Design, Setting, And Participants: This post hoc analysis of a randomized clinical trial conducted at 39 DRCR Retina Network sites included adults with vision loss due to PDR-related vitreous hemorrhage for whom vitrectomy was considered. Read More

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Two siblings with Heimler syndrome caused by PEX1 variants: follow-up of ophthalmologic findings.

Ophthalmic Genet 2021 May 6:1-6. Epub 2021 May 6.

Department of Ophthalmology, University Hospital Leuven, Leuven, Belgium.

: Heimler syndrome (OMIM number #234580 and #616617) is a rare condition comprising sensorineural hearing loss (SNHL), nail abnormalities and amelogenesis imperfecta. In addition, patients with this syndrome can have retinal dystrophies. Heimler syndrome is caused by bi-allelic pathogenic variants in the or gene. Read More

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Clinical Features, Prognosis, and Long-Term Response to Ranibizumab of Macular CNVs in Pattern Dystrophies Spectrum: A Pilot Study.

J Ophthalmol 2021 16;2021:6698522. Epub 2021 Apr 16.

UOC Ophthalmology, Ospedale A. Fiorini Terracina, Sapienza University of Rome, Terracina 04120, Italy.

Introduction: To analyze the morphological and functional features of choroidal neovascularizations (CNVs) in eyes affected by pattern dystrophies (PD), evaluating their long-term response to intravitreal ranibizumab, and comparing them with CNVs in age-related macular degeneration (AMD). The mean goal is to identify possible disease biomarkers and to evaluate the long-term prognosis of CNVs in PD.

Materials And Methods: A retrospective study of 42 patients with naïve CNV (26 PD and 16 AMD), for a total of 47 eyes (29 eyes in the PD group and 18 eyes in the AMD group). Read More

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Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy.

J Ophthalmol 2021 13;2021:6667755. Epub 2021 Apr 13.

Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital and Henan University People's Hospital, Zhengzhou 450003, Henan, China.

Objective: To evaluate the efficacy of pars plana vitrectomy (PPV) combined with episcleral cryotherapy in treating vasoproliferative tumors of the retina (VPTR) with macular complications.

Methods: In this retrospective noncomparative interventional case-series analysis, we included 11 eyes of ten patients diagnosed with VPTR. All patients underwent comprehensive ophthalmic examinations and were treated with PPV combined with episcleral cryotherapy. Read More

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Intravitreal Dexamethasone Implant for Postoperative Macular Oedema Secondary to Vitrectomy for Epiretinal Membrane and Retinal Detachment: A Systematic Review and Meta-Analysis.

J Ophthalmol 2021 16;2021:6627677. Epub 2021 Apr 16.

Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin 10122, Italy.

Purpose: To evaluate the efficacy of intravitreal dexamethasone implant (DEX) for the treatment of macular oedema secondary to vitrectomy for epiretinal membrane (ERM) and retinal detachment (RD) by conducting a systematic review with meta-analysis of published studies.

Methods: Studies reporting clinical outcomes of DEX use for the treatment of macular oedema secondary to ERM and RD vitrectomy were searched on PubMed and Embase databases. The primary outcome was best-corrected visual acuity (BCVA) change between baseline and post-DEX treatment, reported as mean difference (MD) with 95% confidence interval (CI). Read More

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Differences in activation of intracellular signaling in primary human retinal endothelial cells between isoforms of VEGFA 165.

Mol Vis 2021 28;27:191-205. Epub 2021 Apr 28.

Eye Research Institute, Oakland University, Rochester, MI.

Purpose: There are reports that a b-isoform of vascular endothelial growth factor-A 165 (VEGFAb) is predominant in normal human vitreous, switching to the a-isoform (VEGFAa) in the vitreous of some diseased eyes. Although these isoforms appear to have a different ability to activate the VEGF receptor 2 (VEGFR2) in various endothelial cells, the nature of their ability to activate intracellular signaling pathways is not fully characterized, especially in retinal endothelial cells. We determined their activation potential for two key intracellular signaling pathways (MAPK, AKT) over complete dose-response curves and compared potential effects on the expression of several VEGFA target genes in primary human retinal microvascular endothelial cells (HRMECs). Read More

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Quantification of the early pupillary dilation kinetic to assess rod and cone activity.

Sci Rep 2021 May 5;11(1):9549. Epub 2021 May 5.

Neuro-Ophtalmology, Department of Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland.

Rods, cones and melanopsin contribute in various proportions, depending on the stimulus light, to the pupil light response. This study used a first derivative analysis to focus on the quantification of the dynamics of pupillary dilation that immediately follows light-induced pupilloconstriction in order to identify novel parameters that reflect rod and cone activity. In 18 healthy adults, the pupil response to a 1 s blue light stimulus ranging from - 6. Read More

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Association of meteorological factors with the frequency of primary rhegmatogenous retinal detachment in Japan.

Sci Rep 2021 May 5;11(1):9559. Epub 2021 May 5.

Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

This 5-year ecological study assessed the association between meteorological factors and rhegmatogenous retinal detachment (RRD) frequency in 571 eyes of 543 cases of primary RRD at the Jikei University Kashiwa Hospital, Japan. We examined the monthly and seasonal distributions of RRD frequency using one-way analysis of variance. We then evaluated the relationship between monthly RRD frequency and 36 meteorological parameters using Poisson regression analysis. Read More

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Determinants of peripapillary retinal nerve fiber layer's grayscale value in normal eyes by spectral domain optical coherence tomography.

Sci Rep 2021 May 5;11(1):9577. Epub 2021 May 5.

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou University Medical College, Shantou, 515000, Guangdong, China.

To determine and evaluate the distribution, variation, and determinants of peripapillary retinal nerve fiber layer (pRNFL) grayscale value with spectral-domain optical coherence tomography (SD-OCT) in normal eyes. In this cross-sectional study, three hundred ninety-seven normal eyes from 397 healthy Chinese adults aged 18-80 were consecutively recruited from a tertiary eye care center. An SD-OCT instrument took pRNFL imaging. Read More

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Target 5000: a standardized all-Ireland pathway for the diagnosis and management of inherited retinal degenerations.

Orphanet J Rare Dis 2021 May 5;16(1):200. Epub 2021 May 5.

Mater Clinical Ophthalmic Genetics Unit, Mater Misericordiae University Hospital, Dublin, Ireland.

Introduction: Inherited retinal degenerations (IRD) are rare genetic disorders with > 300 known genetic loci, manifesting variably progressive visual dysfunction. IRDs were historically underserved due to lack of effective interventions. Many novel therapies will require accurate diagnosis (phenotype and genotype), thus an efficient and effective pathway for assessment and management is required. Read More

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Frequency and phenotypic characteristics of RPE65 mutations in the Chinese population.

Orphanet J Rare Dis 2021 Apr 13;16(1):174. Epub 2021 Apr 13.

Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, 200032, China.

Background: The retinoid isomerohydrolase RPE65 has received considerable attention worldwide since a successful clinical gene therapy was approved in 2017 as the first treatment for vision loss associated with RPE65-mediated inherited retinal disease. Identifying patients with RPE65 mutations is a prerequisite to assessing the patients' eligibility to receive RPE65-targeted gene therapies, and it is necessary to identify individuals who are most likely to benefit from gene therapies. This study aimed to investigate the RPE65 mutations frequency in the Chinese population and to determine the genetic and clinical characteristics of these patients. Read More

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Correlation of Ocular Biometric Parameters and Macular Ganglion Cell Layer in Normal Eyes.

Semin Ophthalmol 2021 May 6:1-6. Epub 2021 May 6.

Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey.

Purpose: To determine the association between ocular biometric parameters and macular ganglion cell layer (MGCL) thickness in normal eyes.

Methods: This observational cohort study was conducted with 76 eyes of 76 healthy subjects. Keratometry, pachymetry, corneal volume, iridocorneal angle were measured with Sirius (CSO, Florence, Italy); axial length, anterior chamber depth, anterior chamber volume, corneal diameter were measured with IOL Master (Carl Zeiss Meditec, Dublin, California). Read More

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Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Department of Ophthalmology, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasizes its protective behavior in retinal cells that help to provide new information about the development of treatment for retinal complications.

Objectives: This study analyzes the effect of in vitro changes associated with the cell survival and rescue mechanism in IGF2 inhibition and activation using chromeceptin and IGF2 peptides in ARPE-19 cells cultured in high glucose conditions. Read More

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Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the gene.

Ophthalmic Genet 2021 May 5:1-12. Epub 2021 May 5.

Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium.

: Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy related to gene variants.: Twenty-six patients (21-81 years) with L-ORD due to c.562C>A p. Read More

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Strehl Ratio and Myopia in Chinese Adolescents: The Tuyou County Pediatric Eye (TYPE) Study.

Int J Gen Med 2021 27;14:1541-1546. Epub 2021 Apr 27.

Department of Ophthalmology, Changzhi People's Hospital, Changzhi, 046000, People's Republic of China.

Aim: To investigate the relationships between property of the visual quality, Strehl ratio (SR) and the degree of myopia.

Methods: A total of 444 anatomically normal eyes of 222 adolescents were enrolled in the TYPE study. Based on spherical equivalent (SE), subjects were divided into four groups: emmetropia/control (SE: +0. Read More

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Perceived facilitators and barriers to chronic disease management in primary care networks of Singapore: a qualitative study.

BMJ Open 2021 May 4;11(5):e046010. Epub 2021 May 4.

Health Systems and Behavioural Sciences Domain, Saw Swee Hock School of Public Health, National University Singapore, Singapore.

Objective: The increasing chronic disease burden has placed tremendous strain on tertiary healthcare resources in most countries, necessitating a shift in chronic disease management from tertiary to primary care providers. The Primary Care Network (PCN) policy was promulgated as a model of care to organise private general practitioners (GPs) into groups to provide GPs with resources to anchor patients with chronic conditions with them in the community. As PCN is still in its embryonic stages, there is a void in research regarding its ability to empower GPs to manage patients with chronic conditions effectively. Read More

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Correlation of sectoral choroidal vascularity with angiographic leakage in central serous chorioretinopathy.

Eur J Ophthalmol 2021 May 4:11206721211013653. Epub 2021 May 4.

UPMC Eye Centre, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: To correlate sectoral choroidal vascularity with angiographic leakage in eyes with central serous chorioretinopathy (CSCR).

Methods: This was a retrospective, cross-sectional study including patients with active CSCR. Multimodal imaging including fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) were performed to identify leakage site and obtain choroidal measurements, respectively. Read More

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