10,941 results match your criteria retinal arterial

Combined Central Retinal Arterial and Venous Occlusions due to Leukemic Infiltration.

Retin Cases Brief Rep 2021 Sep 19. Epub 2021 Sep 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium Department of Pathology, Antwerp University Hospital, Edegem, Belgium Department of Radiology, Antwerp University Hospital, Edegem, Belgium Faculty of Health Sciences, University of Antwerp, Edegem, Belgium Name and address for correspondence: Vincent M. De La Porte, M.D. E-mail: Telephone: +32 3 821 4428, Address: Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium.

Purpose: To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Methods: Case report with clinical photography. Read More

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September 2021

Fundus fluorescein angiography in retinopathy of prematurity.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Department of Neonatology, Government Medical College and Hospital, Chandigarh, India.

Background/objectives: Retinopathy of prematurity (ROP) is a potentially blinding disease of immature retinal vasculature. ROP regresses in majority of the cases and very few go on to develop ROP needing treatment. Fundus fluorescein angiography (FFA) is the gold standard technique to study retinal vasculature. Read More

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Ophthalmologic manifestations in patients with antiphospholipid antibodies: Beware of iatrogenic complications.

Lupus 2021 Jul 20:9612033211033988. Epub 2021 Jul 20.

Université de Lorraine, Inserm UMR_S 1116 DCAC and CHRU de Nancy, Vascular Medicine Division And Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases, F-54000 Nancy, France.

Background: Antiphospholipid syndrome (APS) is characterized by several clinical manifestations such as venous and arterial thrombosis associated with persistent antiphospholipid antibodies (aPL). Several studies confirmed that retinal vein occlusion was the most common APS ocular manifestation. The purpose of this study was to identify ophthalmologic manifestations in a homogeneous cohort of well-defined persistently aPL-positive patients and to determine variables associated with these manifestations. Read More

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Peripheral arterial filling time and peripheral retina fluorescence features in ultra-widefield angiography.

Int J Ophthalmol 2021 18;14(7):1034-1040. Epub 2021 Jul 18.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China.

Aim: To evaluate the peripheral arterial filling time (PAFT) and venous filling time (VFT) in eyes without known diseases that may influence filling process using ultra-widefield (UWF) fluorescein angiography (FA), and to review the peripheral retina fluorescence features.

Methods: A total of 30 eyes of 30 patients were retrospectively reviewed in this observational study. UWF-FA was performed using Optos 200Tx. Read More

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Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer's disease mice.

Neurophotonics 2021 Jul 10;8(3):035002. Epub 2021 Jul 10.

University of Illinois at Chicago, Department of Bioengineering, Chicago, Illinois, United States.

: As one part of the central nervous system, the retina manifests neurovascular defects in Alzheimer's disease (AD). Quantitative imaging of retinal neurovascular abnormalities may promise a new method for early diagnosis and treatment assessment of AD. Previous imaging studies of transgenic AD mouse models have been limited to the central part of the retina. Read More

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Correlation of in vivo/ex vivo imaging of the posterior eye segment.

Ophthalmologe 2021 Jul 16;118(Suppl 2):153-159. Epub 2021 Jul 16.

Department of Ophthalmology, University Hospital Würzburg, Würzburg, Germany.

Background: For an understanding of the pathology of retinal diseases, direct comparisons of high-resolution in vivo retinal imaging and ex vivo histological preparations are desirable.

Material And Methods: Multimodal in vivo and ex vivo imaging of a human donor eye with secondary alterations showing atrophic retina due to central retinal arterial occlusion. The subsequent correlation with the histological examination was carried out on identical tissue localizations. Read More

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Retinopathy prematurity: a systematic review and meta-analysis study based on neonatal and maternal risk factors.

J Matern Fetal Neonatal Med 2021 Jul 13:1-19. Epub 2021 Jul 13.

Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: Retinopathy of prematurity is the abnormal development of retinal arteries in preterm neonates less than 32 weeks and weighing 1500 g, and less, which can lead to visual impairment during life and blindness. This study aims to investigate the relationship between some clinical characteristics of neonates and mothers with Retinopathy of prematurity in the world a systematic review and meta-analysis.

Materials And Methods: The present study is a systematic review and meta-analysis on the relationship between maternal and neonatal clinical variables with Retinopathy of prematurity in the world from the beginning of 2000 to the end of 2020. Read More

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Normal-tension glaucomatous optic neuropathy is related to blood pressure variability in the Maracaibo Aging Study.

Hypertens Res 2021 Jul 12. Epub 2021 Jul 12.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

Hypoperfusion of the optic nerve might be involved in the pathogenesis of normal-tension glaucomatous optic neuropathy (GON). Mean arterial pressure (MAP) drives ocular perfusion, but no previous studies have addressed the risk of GON in relation to blood pressure (BP) variability, independent of BP level. In a cross-sectional study, 93 residents of Maracaibo, Venezuela, underwent optical coherence tomography, visual field assessments and 24-h ambulatory BP monitoring between 2011 and 2016. Read More

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Visualization of three-dimensional microcirculation of rodents' retina and choroid for studies of critical illness using optical coherence tomography angiography.

Sci Rep 2021 Jul 12;11(1):14302. Epub 2021 Jul 12.

Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

We developed a method to measure the relative blood flow speed using optical coherence tomography angiography (OCTA) in retina and choroid, and investigated the feasibility of this method for assessing microcirculatory function in rat models of sepsis and hemorrhagic shock. Two sepsis models, 6-h severe sepsis without treatment and 30-h moderate sepsis maintaining mean arterial pressure, and volume controlled hemorrhagic shock and fluid resuscitation model were used to see the change of microcirculation. The blood flow index (BFI), which was calculated from the OCTA images to represent the average relative blood flow, was decreasing during the 6-h severe sepsis model. Read More

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Developmental Perspectives on Arterial Fate Specification.

Front Cell Dev Biol 2021 25;9:691335. Epub 2021 Jun 25.

Yale Cardiovascular Research Center, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.

Blood vessel acquisition of arterial or venous fate is an adaptive phenomenon in response to increasing blood circulation during vascular morphogenesis. The past two decades of effort in this field led to development of a widely accepted paradigm of molecular regulators centering on VEGF and Notch signaling. More recent findings focused on shear stress-induced cell cycle arrest as a prerequisite for arterial specification substantially modify this traditional understanding. Read More

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Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm.

Sci Rep 2021 Jul 9;11(1):14246. Epub 2021 Jul 9.

Department of Ophthalmology, Kim's Eye Hospital, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, South Korea.

This study aimed to evaluate the long-term visual outcomes of hemorrhagic retinal arterial macroaneurysm (RAM), particularly focusing on the influence of bevacizumab therapy and intraretinal hemorrhage (IRH) on the outcomes. This retrospective study included 49 patients diagnosed with hemorrhagic RAM. Patients were divided into the bevacizumab group and observation group depending on the whether they were administered bevacizumab treatment and the IRH group and the non-IRH group based on the presence of IRH at the fovea. Read More

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Vision loss in giant cell arteritis.

Pract Neurol 2021 Jul 8. Epub 2021 Jul 8.

Department of Ophthalmology and Vision Science, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada

Almost two-thirds of patients with giant cell arteritis (GCA) develop ocular symptoms and up to 30% suffer permanent visual loss. We review the three most common mechanisms for visual loss in GCA, describing the relevant ophthalmic arterial anatomy and emphasising how ophthalmoscopy holds the key to a rapid diagnosis. The short posterior ciliary arteries supply the optic nerve head, while the central retinal artery and its branches supply the inner retina. Read More

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[Malignant hypertension and pheochromocytoma: a case report].

Hipertens Riesgo Vasc 2021 Jul 5. Epub 2021 Jul 5.

Servicio de Nefrología, Hospital Universitario Vall d'Hebron, Barcelona, España.

Malignant arterial hypertension is defined by extremely high levels of pressure associated with organ damage. It is a cause of hypertensive emergency and is defined by the coexistence of high blood pressure and bilateral retinal haemorrhage or exudates (grade III hypertensive retinopathy), with or without papilloedema (grade IV hypertensive retinopathy) currently associated with organ damage such as renal or cardiac failure. Around 1% of malignant arterial hypertension is secondary to endocrinological causes, including the most common: pheochromocytoma, which is classically characterized by the triad: headache, sweating and palpitations. Read More

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Normalized intraplaque hemorrhage signal on MP-RAGE as a marker for acute ischemic neurological events.

Neuroradiol J 2021 Jul 5:19714009211029263. Epub 2021 Jul 5.

Department of Radiology, Mayo Clinic, USA.

Purpose: This study sought to validate whether the signal intensity ratio (SIR) of carotid intraplaque hemorrhage (IPH) was associated with acute ischemic neurologic events.

Methods: A retrospective review was completed of consecutive patients that underwent neck magnetic resonance angiography using magnetization prepared-rapid gradient echo (MP-RAGE) and T1-CUBE sequences between 2017 and 2020. Patients with magnetic resonance evidence of IPH were included. Read More

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Retinal arterial and venous obstruction as the first manifestation of an antiphospholipid antibody syndrome.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Jul 10;96(7):380-383. Epub 2020 Sep 10.

Doctora en Medicina y Cirugía. Hospital Príncipe de Asturias, Servicio de Oftalmología, Alcalá de Henares, Madrid, Spain. Electronic address:

Case Report: A 34 year-old woman presented with decrease in visual acuity in her right eye (RE). Her past medical history was unremarkable. Dilated fundus examination revealed a central venous occlusion and an obstruction of the cilioretinal artery. Read More

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Colour Doppler imaging of retrobulbar circulation in different severity of glaucoma optic neuropathy.

Med Ultrason 2021 Jun 14. Epub 2021 Jun 14.

Department of Ophthalmology Military Institute of Medicine, Warsaw, Poland.

Aims: To compare retrobulbar hemodynamic measured by colour Doppler imaging (CDI) in patients with a different severity of glaucoma and to correlate variables CDI with the structural parameters of the retina and optic disc.

Material And Methods: Of 89 eyes studied, 31 had preperimetric, 29 early, 12 moderate and 17 advanced glaucoma. Peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI) in ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCAs) were evaluated by CDI and compared between study groups. Read More

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Remifentanil target-controlled infusion with intranasal dexmedetomidine for vitreoretinal procedures: a randomized controlled trial.

Croat Med J 2021 Jun;62(3):233-240

Iztok Potočnik, Department of Anesthesiology and Intensive Care, Institute of Oncology, Zaloška cesta 2, 1000 Ljubljana, Slovenia,

Aim: To evaluate the consumption of remifentanil (as a primary end-point), analgesia, sedation, hemodynamics, respiratory effects, and surgeon and patient satisfaction (as a secondary end-point) with dexmedetomidine sedation compared with those of remifentanil sedation in patients undergoing vitreoretinal surgery.

Methods: Patients subjected to retinal ophthalmic surgical procedures were randomized to one of two intraoperative sedation groups: one group (n=21) received intranasal dexmedetomidine plus intravenous remifentanil (DEX-REMI group), and the other group (n=19) received intravenous remifentanil only (REM group). The treatment was placebo-controlled. Read More

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Novel Insights Into Monogenic Obesity Syndrome Due to Gene Variant: A Case Report of a Female Patient.

Front Endocrinol (Lausanne) 2021 15;12:581134. Epub 2021 Jun 15.

University Children's Hospital, Department of Endocrinology, Diabetes and Metabolism, Ljubljana University Medical Centre, Ljubljana, Slovenia.

A Caucasian girl with consanguineous parents presented with early severe obesity and retinal dystrophy. A novel, homozygous gene truncating variant (c.1897C>T) in the gene confirmed the diagnosis of MORMS (OMIM #610156). Read More

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Recent advancements in the management of retinoblastoma and uveal melanoma.

Fac Rev 2021 28;10:51. Epub 2021 May 28.

Retina Consultants of Texas, Houston, Texas, USA.

Retinoblastoma in children and uveal melanoma in adults can pose a serious threat to both vision and life. For many decades, enucleation was often the only option to treat these intraocular malignancies. For retinoblastoma, intra-arterial chemotherapy is often utilized as the primary treatment at advanced academic centers and has dramatically improved local tumor control and eye salvage rates. Read More

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Non-invasive Assessment of Neurovascular Coupling After Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Trial Using Retinal Vessel Analysis.

Front Neurol 2021 14;12:690183. Epub 2021 Jun 14.

Department of Neurosurgery, RWTH Aachen University, Aachen, Germany.

Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Read More

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Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES).

BMC Cardiovasc Disord 2021 Jun 30;21(1):322. Epub 2021 Jun 30.

Physiology Division, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Neue Stiftingtalstrasse 6, 8036, Graz, Austria.

Background: The risk of cardiovascular diseases (CVDs) is becoming more prevalent in pregnant women though not much data is available for pregnant women with human immunodeficiency virus (HIV). Foetoplacental vascular endothelial dysfunction is thought to be at the origin of chronic diseases such as diabetes and obesity later on in life. Because HIV and anti-retroviral treatment (ARTs) are associated with endothelial dysfunction, children exposed in utero to these conditions may be at greater risk of developing CVDs. Read More

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Venous thrombotic events in psoriasis patients: a systematic review with meta-analysis.

Ann Med 2021 12;53(1):1074-1081

Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.

Background: Psoriasis is a chronic inflammatory skin disease associated with numerous comorbidities. Psoriasis has been linked to an increased risk of metabolic syndrome and atherosclerotic arterial disease. Inflammatory conditions are known to increase the risk of venous thromboembolism (VTE), a frequent cause of morbidity and mortality. Read More

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December 2021

Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia.

Circulation 2021 Jun 29. Epub 2021 Jun 29.

Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven CT; Yale University School of Medicine, Department of Molecular and Cellular Physiology, New Haven, CT; Université de Paris, PARCC, INSERM, F-75006 Paris, France.

Activin receptor-like kinase 1 (ALK1) is an endothelial transmembrane serine threonine kinase receptor for BMP family ligands that plays a critical role in cardiovascular development and pathology. Loss-of-function mutations in the gene cause type 2 hereditary hemorrhagic telangiectasia (HHT), a devastating disorder that leads to arteriovenous malformations (AVMs). Here we show that ALK1 controls endothelial cell polarization against the direction of blood flow and flow-induced endothelial migration from veins through capillaries into arterioles. Read More

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Severe visual loss by inhalation of methanol.

Rom J Ophthalmol 2021 Apr-Jun;65(2):176-179

Department of Ophthalmology, Virgen de las Nieves University Hospital, Granada, Spain.

To describe a clinical case of toxic optic neuropathy with severe visual loss caused by inhalation abuse of methanol products. A 25-year-old male student was admitted to the emergency department with an acute bilateral visual loss and headaches, nausea, and cold sweats. A complete clinical and ophthalmologic examination was performed. Read More

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Automatic Artery/Vein Classification Using a Vessel-Constraint Network for Multicenter Fundus Images.

Front Cell Dev Biol 2021 11;9:659941. Epub 2021 Jun 11.

School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Retinal blood vessel morphological abnormalities are generally associated with cardiovascular, cerebrovascular, and systemic diseases, automatic artery/vein (A/V) classification is particularly important for medical image analysis and clinical decision making. However, the current method still has some limitations in A/V classification, especially the blood vessel edge and end error problems caused by the single scale and the blurred boundary of the A/V. To alleviate these problems, in this work, we propose a vessel-constraint network (VC-Net) that utilizes the information of vessel distribution and edge to enhance A/V classification, which is a high-precision A/V classification model based on data fusion. Read More

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A case of retinal vascular involvement in a 6-year-old patient with Covid-19.

Eur J Ophthalmol 2021 Jun 26:11206721211027069. Epub 2021 Jun 26.

Department of Medicine and Surgery, University of Salerno, Salerno, Italy.

Purpose: This study evaluated fundus changes in a 6-year-old child who contracted Sars-CoV-2 without developing symptoms of the disease.

Materials And Methods: The patient underwent a complete ophthalmic evaluation, which included assessment of visual acuity with and without correction, extensive ophthalmological examination, cicloplegic refraction by retinoscopy and funduscopic examination, OCT, and angio-OCT examination.

Results: Fundoscopic examination in a young patient with previous Sars-CoV-2 infection showed marked vascular tortuosity, evident both at the posterior pole and retinal periphery, especially on the arterial vasculature, and cotton wool spots along the retinal vessels, highlightable also at OCT and angio-OCT examination. Read More

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Diurnal Variation of Retinal Vessel Density in Healthy Human Eyes.

J Glaucoma 2021 Jun 24. Epub 2021 Jun 24.

Hamilton Glaucoma Center, Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA.

Precis: A small increase in optic nerve head vessel density (VD), but not macular VD, in the evening compared to the morning is observed in healthy subjects.

Purpose: To evaluate the diurnal variation of the macular and optic nerve head (ONH) vessel density (VD) in healthy eyes as measured with optical coherence tomography angiography (OCT-A).

Methods: In this prospective study of healthy individuals older than 18 years old, VD parameters, including macular whole image vessel density (wiVD), parafoveal vessel density (pfVD), ONH whole image vessel density (ONH-wiVD), ONH whole image capillary density (ONH-wiCD), circumpapillary vessel density (cpVD), and circumpapillary capillary density (cpCD), were measured with OCT-A at four time points throughout the day (8 AM, 12 PM, 4 PM, and 8 PM). Read More

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New evidence on the protector effect of weight gain in retinopathy of prematurity.

An Pediatr (Engl Ed) 2021 Jun 22. Epub 2021 Jun 22.

Servicio de Oftalmología, Hospital Universitario San Cecilio, Granada, Spain.

Introduction: Retinopathy of prematurity (ROP) is characterised by insufficient vascular development in the retina, and requires early treatment to avoid visual disability in severe cases. ROP is currently the second leading cause of preventable child blindness in the world.

Patients And Methods: This was an observational, retrospective, case-control study including 233 preterm infants examined between 1999 and 2019. Read More

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Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 24. Epub 2021 Jun 24.

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged.

Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012-2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Read More

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