1,262 results match your criteria retaining young

Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation.

Acta Biomater 2021 Mar 22. Epub 2021 Mar 22.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 48109, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, 48109, USA; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Synthetic matrices offer a high degree of control and tunability for mimicking extracellular matrix functions of native tissue, allowing the study of disease and development in vitro. In this study, we functionalized degradable poly(ethylene glycol) hydrogels with extracellular matrix (ECM)-sequestering peptides aiming to recapitulate the native ECM composition for culture and maturation of ovarian follicular organoids. We hypothesized that ECM-sequestering peptides would facilitate deposition and retention of cell-secreted ECM molecules, thereby recreating cell-matrix interactions in otherwise bioinert PEG hydrogels. Read More

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Retaining doctors and reducing burnout through a flexible work initiative in a rural South African training hospital.

Afr J Prim Health Care Fam Med 2021 Mar 23;13(1):e1-e5. Epub 2021 Mar 23.

Department of Family and Emergency Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town.

Background: South African doctors work up to 60 h per week to ensure 24-h service delivery. Many doctors are physically and emotionally exhausted, neglecting families, self-care, patient empathy and innovative thinking about complex health issues. Exposure to clinical work hours demonstrated a dose effect with burnout, suggesting cause and effect, affecting up to 80% of doctors. Read More

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Controlling T cells spreading, mechanics and activation by micropatterning.

Sci Rep 2021 Mar 24;11(1):6783. Epub 2021 Mar 24.

Adhesion and Inflammation Lab (LAI), Aix Marseille University, LAI UM 61, 13288, Marseille, France.

We designed a strategy, based on a careful examination of the activation capabilities of proteins and antibodies used as substrates for adhering T cells, coupled to protein microstamping to control at the same time the position, shape, spreading, mechanics and activation state of T cells. Once adhered on patterns, we examined the capacities of T cells to be activated with soluble anti CD3, in comparison to T cells adhered to a continuously decorated substrate with the same density of ligands. We show that, in our hand, adhering onto an anti CD45 antibody decorated surface was not affecting T cell calcium fluxes, even adhered on variable size micro-patterns. Read More

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Recruiting and retaining young adults: What can we learn from behavioural interventions targeting nutrition, physical activity and/or obesity? A systematic review of the literature.

Public Health Nutr 2021 Mar 16:1-46. Epub 2021 Mar 16.

School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan2308, Australia.

Objective: To describe strategies used to recruit and retain young adults in nutrition, physical activity and/or obesity intervention studies, and quantify the success and efficiency of these strategies.

Design: A systematic review was conducted. The search included six electronic databases to identify RCTs published up to 6th December 2019 that evaluated nutrition, physical activity and/or obesity interventions in young adults (17-35 years). Read More

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Role of a bone conserving short stem femoral component in revision total hip arthroplasty: A case report.

J Clin Orthop Trauma 2021 Mar 6;14:29-33. Epub 2020 Oct 6.

Department of Orthopaedic Surgery, Amandeep Hospital, Amritsar, 143001, India.

Choice of the implant during revision total hip arthroplasty (THA) is crucial in younger patients due to the impaired quality of bone and deficient bone stock. The short femoral stem provides an appealing unorthodox alternative implant in young patients undergoing primary total hip arthroplasty. A classic revision total hip arthroplasty predominantly describes the use of conventional or long stem for revision of the femoral component. Read More

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Small things are important: the value of singular point elements for birds in agricultural landscapes.

Biol Rev Camb Philos Soc 2021 Mar 10. Epub 2021 Mar 10.

Department of Biodiversity, Institute of Nature Conservation, Polish Academy of Sciences, Mickiewicza 33, 31-120, Kraków, Poland.

Farmland birds belong to the most endangered group of vertebrates in Europe. They are an important component of farmland biodiversity considering the numerous functions they perform (e.g. Read More

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Coxsackievirus B3 targets TFEB to disrupt lysosomal function.

Autophagy 2021 Mar 10:1-15. Epub 2021 Mar 10.

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.

Coxsackievirus B3 (CVB3) is a prevalent etiological agent for viral myocarditis and neurological disorders, particularly in infants and young children. Virus-encoded proteinases have emerged as cytopathic factors that contribute to disease pathogenesis in part through targeting the cellular recycling machinery of autophagy. Although it is appreciated that CVB3 can usurp cellular macroautophagy/autophagy for pro-viral functions, the precise mechanisms by which viral proteinases disrupt autophagy remain incompletely understood. Read More

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PDX-Derived Ewing's Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures.

Cancers (Basel) 2021 Feb 19;13(4). Epub 2021 Feb 19.

iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal.

Ewing's Sarcoma (ES) is the second most frequent malignant bone tumour in children and young adults and currently only untargeted chemotherapeutic approaches and surgery are available as treatment, although clinical trials are on-going for recently developed ES-targeted therapies. To study ES pathobiology and develop novel drugs, established cell lines and patient-derived xenografts (PDX) are the most employed experimental models. Nevertheless, the establishment of ES cell lines is difficult and the extensive use of PDX raises economic/ethical concerns. Read More

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February 2021

Gut microbiome pattern reflects healthy ageing and predicts survival in humans.

Nat Metab 2021 02 18;3(2):274-286. Epub 2021 Feb 18.

Institute for Systems Biology, Seattle, WA, USA.

The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that compositional uniqueness is strongly associated with microbially produced amino acid derivatives circulating in the bloodstream. Read More

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February 2021

Retaining Adolescent and Young Adult Participants in Research During a Pandemic: Best Practices From Two Large-Scale Developmental Neuroimaging Studies (NCANDA and ABCD).

Front Behav Neurosci 2020 18;14:597902. Epub 2021 Jan 18.

Department of Epidemiology, University of Florida, Gainesville, FL, United States.

The novel coronavirus pandemic that emerged in late 2019 (COVID-19) has created challenges not previously experienced in human research. This paper discusses two large-scale NIH-funded multi-site longitudinal studies of adolescents and young adults - the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD) Study - and valuable approaches to learn about adaptive processes for conducting developmentally sensitive research with neuroimaging and neurocognitive testing across consortia during a global pandemic. We focus on challenges experienced during the pandemic and modifications that may guide other projects, such as implementing adapted protocols that protect the safety of participants and research staff, and addressing assessment challenges through the use of strategies such as remote and mobile assessments. Read More

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January 2021

Shaping Perovskites: Crystallization Mechanism of Rapid Thermally Annealed, Prepatterned Perovskite Films.

ACS Appl Mater Interfaces 2021 Feb 29;13(5):6854-6863. Epub 2021 Jan 29.

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

Understanding and controlling the crystallization of organic-inorganic perovskite materials is important for their function in optoelectronic applications. This control is particularly delicate in scalable single-step thermal annealing methods. In this work, the crystallization mechanisms of flash infrared-annealed perovskite films, grown on substrates with lithographically patterned Au nucleation seeds, are investigated. Read More

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February 2021

Increasing School-Based Mental Health Services with a "Grow Your Own" School Psychology Program.

Contemp Sch Psychol 2021 Jan 21:1-12. Epub 2021 Jan 21.

Green Hills Area Education Agency, Council Bluffs, IA USA.

There is a nationwide shortage of school psychologists, and while NASP has recommended ways to increase recruitment and retention, the research on recruiting and retaining school psychologists, especially in high-need areas, is limited. Teacher education researchers have begun to address teacher shortages through "grow your own" training programs, but the research on these programs is also limited. A team of university school psychology faculty and regional education agency administrators developed a "Grow Your Own" school psychologist re-specialization training program to support recruiting and retaining school psychologists in rural areas. Read More

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January 2021

Environments, processes, and outcomes - using the LEPO framework to examine medical student learning preferences with traditional and electronic resources.

Med Educ Online 2021 Dec;26(1):1876316

Department of Pediatrics, Rutgers New Jersey Medical School , Newark, NJ, USA.

Changes in medical student learning preferences help drive innovation in teaching and require schools and commercial resources to quickly adapt. However, few studies have detailed the relationship of learner preferences to the environment and teaching modalities used in the pre-clerkship years, nor do they incorporate third-party resources. Our study attempts to analyze learner preferences by comparing the use of traditional and third-party resources. Read More

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December 2021

Pluripotential Risk and Clinical Staging: Theoretical Considerations and Preliminary Data From a Transdiagnostic Risk Identification Approach.

Front Psychiatry 2020 8;11:553578. Epub 2021 Jan 8.

Orygen, Parkville, VIC, Australia.

Most psychiatric disorders develop during adolescence and young adulthood and are preceded by a phase during which attenuated or episodic symptoms and functional decline are apparent. The introduction of the ultra-high risk (UHR) criteria two decades ago created a new framework for identification of risk and for pre-emptive psychiatry, focusing on first episode psychosis as an outcome. Research in this paradigm demonstrated the comorbid, diffuse nature of emerging psychopathology and a high degree of developmental heterotopy, suggesting the need to adopt a broader, more agnostic approach to risk identification. Read More

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January 2021

Outcomes of a Total Joint Arthroplasty Enhanced Recovery Program in a Community Hospital Setting.

J Arthroplasty 2021 Jan 19. Epub 2021 Jan 19.

Department of Orthopaedic Surgery, St. Peter's Healthcare Partners, Albany, NY.

Background: Same-day discharge (SDD) total joint arthroplasty (TJA) is increasingly popular, yet there remain concerns regarding patient safety, complication rates, and unforeseen overnight admission (failure to launch; FTL). The aim of this study is to retrospectively examine the outcomes of a large consecutive SDD-TJA series in the community hospital setting.

Methods: We retrospectively reviewed 1200 consecutive SDD-TJA candidates between March 2017 and December 2019 by 5 surgeons at a community hospital. Read More

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January 2021

Teamwork and Coaching for Successful Manuscript Development by Nurse Faculty: A Novel Approach.

Nurs Educ Perspect 2021 Jan 19. Epub 2021 Jan 19.

About the Authors Susan D. Moch, PhD, RN, is professor emerita, College of Nursing and Health Sciences, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin. Veronica G. Parker, PhD, is director, Center for Research on Health Disparities, and professor/biostatistician, School of Nursing, Clemson University, Clemson, South Carolina. Linda K. Young, PhD, RN, is dean and professor, College of Nursing and Health Sciences, University of Wisconsin-Eau Claire. Kathleen L. Valentine, PhD, RN, is chief nursing academic officer and director, School of Nursing, Clemson University. For more information, contact Dr. Moch at

Abstract: The current nurse faculty shortage warrants new models for both retaining faculty effectively and coaching new faculty efficiently. An approach for retaining faculty members through meeting publication review criteria while conserving senior faculty mentoring time is proposed. This article describes a successful manuscript development process using teamwork and coaching among faculty. Read More

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January 2021

Developing a health communication campaign for disposal of unused opioid medications.

Addict Behav Rep 2020 Dec 18;12:100291. Epub 2020 Jun 18.

Department of Communication, University of Kentucky, Lexington, KY, United States.

Introduction: Communities throughout the United States have implemented medicine disposal programs to prevent diversion of unused opioid analgesics from homes but a general lack of awareness may contribute to low rates of utilization. The objective of this study was to develop and test community-based campaign messages promoting appropriate disposal of unused opioids at disposal programs.

Methods: In Fall 2019, 491 residents (79% female, 97% White, mean age: 40 years) of five rural, Appalachian counties (3 in Kentucky and 2 in North Carolina) completed a web-based, experimental survey. Read More

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December 2020

The Soft Skills Inventory: Developmental procedures and psychometric analysis.

Psychol Rep 2020 Dec 20:33294120979933. Epub 2020 Dec 20.

Instituto Politécnico de Santarém, Portugal.

When attending and participating in Higher Education, students face a multitude of personal, social, and work-related challenges, which may increase the risk of developing psychopathological symptomatology. To date, there is no instrument that grasps the non-technical skills that may help prepare students to respond to these challenges. This paper presents the development and psychometric properties of the Soft Skills Inventory (SSI). Read More

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December 2020

"Like a huge weight lifted off my shoulders": Exploring young peoples' experiences of treatment in a pilot trial of trauma-focused cognitive behavioral therapy.

Psychother Res 2020 Dec 6:1-15. Epub 2020 Dec 6.

Orygen, Parkville, Victoria, Australia.

The efficacy of trauma-focused cognitive behavioral therapy (TF-CBT) is well-established, yet little work has been done to understand how young people experience this intervention. Semi-structured interviews were conducted with 13 young people aged 17-25 years (= 20.0, = 2. Read More

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December 2020

Study on Seed Emergence and Seedling Growth of with Superabsorbent Polymers.

Polymers (Basel) 2020 Nov 30;12(12). Epub 2020 Nov 30.

Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Northwest Normal University, Lanzhou 730070, China.

In this study, the emergence rate, emergence potential, root length, stem length, water consumption, and biomass around a root system were used as evaluation indexes, and we used the laboratory-prepared super absorbent resin watermelon rind (WMR)-p (AA--DAAM) (superabsorbent polymer 1-SAP), WMR-p (AA--DAAM)/palygorskite (PGS) (SAP) in a laboratory and commercially available water-retaining agents (SAP and SAP) to assist the emergence of seeds and seedling growth; then, their water absorption and thermal stability were discussed. The results showed that the thermal stability of an SAP prepared in the laboratory and the water consumption during seed emergence, root length, and stem length after emergence were better than those of an SAP purchased on the market, and this information could help to promote the emergence and seedling growth of . While enhancing the drought resistance of plants, using a laboratory-produced SAP can effectively reduce the number of artificial irrigations. Read More

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November 2020

The state of memory-matched distractor in working memory influence the visual attention.

PLoS One 2020 1;15(12):e0242721. Epub 2020 Dec 1.

Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China.

Information in working memory (WM) can guide visual attention towards matched features. While recent work has suggested that cognitive control can act upon WM guidance of visual attention, little is known about how the state of memorized items retaining in WM contribute to its influence over attention. Here, we disentangle the role of inhibition and maintenance on WM-guided attention with a novel delayed match-to-sample dual-task. Read More

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January 2021

Long-Term Survival (up to 34 Years) of Retained Cementless Anatomic Femoral Stem in Patients <50 Years Old.

J Arthroplasty 2021 Apr 1;36(4):1388-1392. Epub 2020 Nov 1.

The Joint Replacement Center of Seoul Metropolitan SeoNam Hospital, Seoul, Republic of Korea.

Background: There is a paucity of studies longer than 30 years to determine clinical and radiographic results of retained cementless anatomic stem. The purpose of this study is to determine the long-term (up to 34 years) survival rate of the retained cementless anatomic femoral stem in patients <50 years of age.

Methods: Isolated cup revision was performed with retaining primary cementless anatomic femoral stem in 206 patients (149 men and 57 women). Read More

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Yu V Burdastova

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2020 Oct;28(Special Issue):1162-1167

State Budgetary Institution "Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department", 115088 Moscow, Russian Federation,

This article is devoted to current issues of human resources development in healthcare. The article emphasizes that the effectiveness of the healthcare system and the quality of medical care delivery deeply depend on the results of the work of medical workers, which are determined by their knowledge, skills and motivation. Considering the necessity of providing the healthcare sector with highly qualified personnel, as well as replenishing the staff with young specialists, we can say that public health is directly dependent on their competence. Read More

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October 2020

A comparison of penalised regression methods for informing the selection of predictive markers.

PLoS One 2020 20;15(11):e0242730. Epub 2020 Nov 20.

Faculty of Health, School of Psychology, Centre for Social and Early Emotional Development, Deakin University, Geelong, Australia.

Background: Penalised regression methods are a useful atheoretical approach for both developing predictive models and selecting key indicators within an often substantially larger pool of available indicators. In comparison to traditional methods, penalised regression models improve prediction in new data by shrinking the size of coefficients and retaining those with coefficients greater than zero. However, the performance and selection of indicators depends on the specific algorithm implemented. Read More

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January 2021

Compositional Fluctuations Locked by Athermal Transformation Yielding High Thermoelectric Performance in GeTe.

Adv Mater 2021 Jan 20;33(1):e2005612. Epub 2020 Nov 20.

Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 30010, Taiwan.

Phase transition in thermoelectric (TE) material is a double-edged sword-it is undesired for device operation in applications, but the fluctuations near an electronic instability are favorable. Here, Sb doping is used to elicit a spontaneous composition fluctuation showing uphill diffusion in GeTe that is otherwise suspended by diffusionless athermal cubic-to-rhombohedral phase transition at around 700 K. The interplay between these two phase transitions yields exquisite composition fluctuations and a coexistence of cubic and rhombohedral phases in favor of exceptional figures-of-merit zT. Read More

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January 2021

Opportunities for improving the safety of dairy parlor workers.

J Dairy Sci 2021 Jan 12;104(1):419-430. Epub 2020 Nov 12.

DairyNZ Ltd., Private Bag 3221, Hamilton 3240, New Zealand.

One aspect of a successful dairy business is attracting and retaining skilled staff. The ability to do this is influenced by workplace attractiveness, one aspect of which is worker comfort and safety. Working with heavy machinery and animals makes dairy farming a dangerous occupation relative to many other sectors. Read More

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January 2021

Adaptive spatial working memory assessments for aging pet dogs.

Anim Cogn 2020 Nov 13. Epub 2020 Nov 13.

Department of Psychology, Arizona State University, Tempe, AZ, USA.

Assessments for spatial working memory (SWM) in pet dogs that can detect age-related cognitive deficits in a single session may aid in diagnosing canine dementia and may facilitate translational research on Alzheimer's disease in humans. Adaptive testing procedures are widely used in single-session assessments for humans with diverse cognitive abilities. In this study, we designed and deployed two up-down staircase assessments for SWM in which 26 pet dogs were required to recall the location of a treat hidden behind one of two identical boxes following delays of variable length. Read More

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November 2020

Prediction of enhancer-promoter interactions using the cross-cell type information and domain adversarial neural network.

BMC Bioinformatics 2020 Nov 7;21(1):507. Epub 2020 Nov 7.

NCMIS, CEMS, RCSDS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, 55 Zhongguancun East Road, Beijing, 10090, China.

Background: Enhancer-promoter interactions (EPIs) play key roles in transcriptional regulation and disease progression. Although several computational methods have been developed to predict such interactions, their performances are not satisfactory when training and testing data from different cell lines. Currently, it is still unclear what extent a across cell line prediction can be made based on sequence-level information. Read More

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November 2020

Time-course of the visual Impact on presbyopes of a low dose miotic.

Ophthalmic Physiol Opt 2021 Jan 4;41(1):73-83. Epub 2020 Nov 4.

School of Optometry, Indiana University, Bloomington, USA.

Purpose: To examine the pupil and visual impact of a single early morning drop of a low concentration miotic.

Methods: Pupil size, refraction, visual acuity (VA), near reading performance and intraocular pressure were monitored for 8 h at a wide range of light levels following bilateral instillation of single drops of 0.1% brimonidine tartate in 19 early presbyopes (40-50 years) and 11 mature presbyopes (>50 years). Read More

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January 2021

Post-Orthodontic Lower Incisors Recessions: Combined Periodontic and Orthodontic Approach.

Int J Environ Res Public Health 2020 11 2;17(21). Epub 2020 Nov 2.

Department of Orthodontics, The Maurice and Gabriela Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

The bonded lingual retainer (BLR) is considered a favorable choice for retaining lower incisors' alignment post-orthodontic treatment; however, it may cause some unwanted effects such as inadvertent tooth movement and torque changes. These often result in gingival recession (Miller class III-type) with exposure of the root surface, which compromises the esthetics and hinders the comfort of the patient. Fifteen post-orthodontic patients presenting Miller class III-type recessions with BLR were examined. Read More

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November 2020