28 results match your criteria ret insulin-like

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c-Met expression in renal cell carcinoma with bone metastases.

J Bone Oncol 2020 Dec 16;25:100315. Epub 2020 Sep 16.

Oncology Division, Hospital de Santa Maria, CHULN, 1649-035 Lisboa, Portugal.

Hepatocyte growth factor (HGF)/c-Met pathway is implicated in embryogenesis and organ development and differentiation. Germline or somatic mutations, chromosomal rearrangements, gene amplification, and transcriptional upregulation in or alterations in autocrine or paracrine c-Met signalling have been associated with cancer cell proliferation and survival, including in renal cell carcinoma (RCC), and associated with disease progression. HGF/c-Met pathway has been shown to be particularly relevant in tumors with bone metastases (BMs). Read More

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December 2020

Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics.

Diabetes Care 2020 09 11;43(9):2183-2189. Epub 2020 Jun 11.

Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA.

Objective: To assess the effects of empagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics.

Research Design And Methods: Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the spectrum of glucose tolerance before and after 4 weeks of empagliflozin 25 mg/day. The biology of the plasma proteins significantly changed by empagliflozin (at false discovery rate-corrected < 0. Read More

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September 2020

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

J Cachexia Sarcopenia Muscle 2019 12 30;10(6):1276-1294. Epub 2019 Sep 30.

MRC-ARUK Centre for Musculoskeletal Ageing Research and Nottingham NIHR BRC, School of Medicine, University of Nottingham, Derby, UK.

Background: The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia), and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RET). Nonetheless, the efficacy and physiological and molecular impacts of T therapy adjuvant to short-term RET remain poorly defined. Read More

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December 2019

Intrauterine programming of the glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis mediates glomerulosclerosis in female adult offspring rats induced by prenatal ethanol exposure.

Toxicol Lett 2019 Sep 27;311:17-26. Epub 2019 Apr 27.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

Prenatal ethanol exposure (PEE) causes intrauterine growth retardation (IUGR), and the occurrence of glomerulosclerosis is closely related to IUGR. This study aimed to confirm the kidney toxic effect of PEE and explore its intrauterine programming mechanism in female offspring. The Wistar female fetuses on gestational day (GD) 20 and the adult offspring at postnatal week 24 were anesthetized and decapitated. Read More

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September 2019

Neurotrophic Factors and Their Receptors Are Altered by the Mere Partial IGF-1 Deficiency.

Neuroscience 2019 04 30;404:445-458. Epub 2019 Jan 30.

Basic Medical Sciences Department, Faculty of Medicine, CEU San Pablo University, Boadilla del Monte, Madrid, Spain.

Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons, playing a role in the maintenance of the synaptic unions, dendrites, and axons and also being crucial for peripheral nervous system development and regulating plasticity in the adult central nervous system. On the other hand, insulin-like growth factor 1 (IGF-1) has been ascertained multiple beneficial actions in the brain: neuro-development, -protection, -genesis and plasticity. To further investigate the possible mechanisms underlying IGF-1 deficiency in the establishment of neurological disease, microarray and reverse transcription polymerase chain reaction gene expression analyses coupled with in silico processing were performed in an experimental model of partial IGF-1 deficiency. Read More

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Muscle Androgen Receptor Content but Not Systemic Hormones Is Associated With Resistance Training-Induced Skeletal Muscle Hypertrophy in Healthy, Young Men.

Front Physiol 2018 9;9:1373. Epub 2018 Oct 9.

Department of Kinesiology, McMaster University, Hamilton, ON, Canada.

The factors that underpin heterogeneity in muscle hypertrophy following resistance exercise training (RET) remain largely unknown. We examined circulating hormones, intramuscular hormones, and intramuscular hormone-related variables in resistance-trained men before and after 12 weeks of RET. Backward elimination and principal component regression evaluated the statistical significance of proposed circulating anabolic hormones (e. Read More

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October 2018

The Role of Different Molecular Markers in Papillary Thyroid Cancer Patients with Acromegaly.

Exp Clin Endocrinol Diabetes 2019 Jul 11;127(7):437-444. Epub 2018 Jun 11.

Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Purpose: Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules.

Methods: We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. Read More

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Genomewide DNA Methylation Responses in Patients with β-Thalassemia Treated with Yisui Shengxue Granules ().

Chin J Integr Med 2019 Jul 3;25(7):490-496. Epub 2018 May 3.

Molecular Biology Laboratory of Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.

Objective: To examine the clinical effects of Yisui Shengxue Granules () in the treatment of β-thalassemia and explore its mechanism on DNA methylation levels.

Methods: A randomized placebo-controlled double-blinded trial was conducted. Forty patients with β-thalassemia were recruited and distributed randomly by envelope method into an experimental group and a control group, 20 patients in each group. Read More

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Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1.

Am J Surg Pathol 2017 Jun;41(6):773-780

*ArcherDX Inc., Boulder, CO†Department of Histopathology, King Edward Memorial Hospital, Perth, WA§Sullivan Nicolaides Pathology, Brisbane, Qld, Australia‡Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB#Department of Pathology, British Columbia Cancer Agency and Vancouver General Hospital, Vancouver, BC, Canada∥Department of Pathology, Royal Devon and Exeter Hospital, Exeter**Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK¶Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.

Inflammatory myofibroblastic tumor (IMT) can occur in a number of anatomic sites, including the uterus. Like its soft tissue counterpart, uterine IMT frequently expresses ALK and harbors ALK genetic rearrangements. The aim of this study is to fully characterize the genetic fusions that occur in uterine IMT. Read More

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Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations.

Cancer Res 2014 Dec 27;74(24):7217-7228. Epub 2014 Oct 27.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.

DDR2 mutations occur in approximately 4% of lung squamous cell cancer (SCC) where the tyrosine kinase inhibitor dasatinib has emerged as a new therapeutic option. We found that ERK and AKT phosphorylation was weakly inhibited by dasatinib in DDR2-mutant lung SCC cells, suggesting that dasatinib inhibits survival signals distinct from other oncogenic receptor tyrosine kinases (RTK) and/or compensatory signals exist that dampen dasatinib activity. To gain better insight into dasatinib's action in these cells, we assessed altered global tyrosine phosphorylation (pY) after dasatinib exposure using a mass spectrometry-based quantitative phosphoproteomics approach. Read More

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December 2014

Regulation of hepcidin through GDF-15 in cancer-related anemia.

Clin Chim Acta 2014 Jan 25;428:14-9. Epub 2013 Oct 25.

Department of Hematology Laboratory, the First Affiliated Hospital of Shantou University Medical College, China. Electronic address:

Background: High prevalence and unresponsiveness to erythropoiesis-stimulating agents are 2 major limitations to the treatment of cancer-related anemia (CRA). They are often related to the dis-regulation of iron metabolism regulated by hepcidin, but the regulatory pathway of hepcidin in CRA is poorly understood. Enhanced GDF-15 levels contribute to the cancer progression and metastasis, and also have been found to suppress hepcidin expression in anemia characterized by ineffective erythropoiesis. Read More

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January 2014

Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma.

PLoS One 2013 11;8(12):e82513. Epub 2013 Dec 11.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Warren Albert School of Medicine at Brown University, Providence, Rhode Island, United States of America.

Neuroblastoma is an embryonal tumor of childhood with a heterogenous clinical presentation that reflects differences in activation of complex biological signaling pathways. Protein phosphorylation is a key component of cellular signal transduction and plays a critical role in processes that control cancer cell growth and survival. We used shotgun LC/MS to compare phosphorylation between a human MYCN amplified neuroblastoma cell line (NB10), modeling a resistant tumor, and a human neural precursor cell line (NPC), modeling a normal baseline neural crest cell. Read More

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October 2014

Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.

J Biol Chem 2014 Jan 27;289(3):1639-48. Epub 2013 Nov 27.

From the Section of Molecular Medicine, and.

Aberrant receptor tyrosine kinase phosphorylation (pRTK) has been associated with diverse pathological conditions, including human neoplasms. In lung cancer, frequent liver kinase B1 (LKB1) mutations correlate with tumor progression, but potential links with pRTK remain unknown. Heightened and sustained receptor activation was demonstrated by LKB1-deficient A549 (lung) and HeLaS3 (cervical) cancer cell lines. Read More

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January 2014

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats.

Exp Gerontol 2013 Apr 16;48(4):427-36. Epub 2013 Feb 16.

School of Physical Education and Sports Science, Soochow University, Suzhou 215021, China.

Resistance exercise training (RET) remains the most effective treatment for the loss of muscle mass and strength in elderly people. However, the underlying cellular and molecular mechanisms are not well understood. Recent evidence suggests that autophagic signaling is altered in aged skeletal muscles. Read More

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Integrative analysis of neuroblastoma and pheochromocytoma genomics data.

BMC Med Genomics 2012 Oct 29;5:48. Epub 2012 Oct 29.

2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str, 46, Budapest, H-1088, Hungary.

Background: Pheochromocytoma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. We have performed a large-scale in silico analysis of altogether 1784 neuroblastoma and 531 pheochromocytoma samples to establish similarities and differences using analysis of mRNA and microRNA expression, chromosome aberrations and a novel bioinformatics analysis based on cooperative game theory.

Methods: Datasets obtained from Gene Expression Omnibus and ArrayExpress have been subjected to a complex bioinformatics analysis using GeneSpring, Gene Set Enrichment Analysis, Ingenuity Pathway Analysis and own software. Read More

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October 2012

STAT3 negatively regulates thyroid tumorigenesis.

Proc Natl Acad Sci U S A 2012 Aug 13;109(35):E2361-70. Epub 2012 Aug 13.

Department of Cancer Biology, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal.

Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, preferentially in association with the tumor stroma. An inverse relationship between pY-STAT3 expression with tumor size and the presence of distant metastases was observed. Read More

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Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays.

Hum Pathol 2009 Sep 14;40(9):1244-51. Epub 2009 Apr 14.

Vancouver Coastal Health Research Institute and University of British Columbia, Canada.

Myxoid liposarcoma displays variably aggressive behavior and responds poorly to available systemic therapies. Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers. We applied these techniques to independent series of primary myxoid liposarcomas in an effort to assess markers of adipose differentiation in myxoid liposarcoma and to identify prognostic markers that can be efficiently assessed by immunohistochemistry. Read More

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September 2009

17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice.

Glia 2009 Jun;57(8):807-14

Department of Neurology, Faculty of Medicine, University of Pécs, Rét u. 2, Pécs, Hungary.

Sex hormones, for example, estrogen and progesterone, are thought to affect and delay progression of multiple sclerosis (MS) in pregnant women. Although both steroid hormones are neuroprotective in the brain and elevated during pregnancy, only estrogen was tested in clinical trials. To evaluate the role of 17beta-estradiol (E) and progesterone (P) in prevention demyelination, young adult male mice were fed with cuprizone for a defined time interval and simultaneously treated with steroids by repeated injections into the neck region. Read More

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The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors.

Cell Cycle 2008 Oct 7;7(19):2949-55. Epub 2008 Oct 7.

Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

The majority of gastrointestinal stromal tumors (GISTs) are characterized by oncogenic gain-of-function mutations in the receptor tyrosine kinase (RTK) c-KIT with a minority in PDGFRalpha. Therapy for GISTs has been revolutionized by the use of the selective tyrosine kinase inhibitor imatinib mesylate (IM). For the subset (approximately 10-15%) of GISTs that lack oncogenic mutations in these receptors, the genetic changes driving tumorigenesis are unknown. Read More

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October 2008

Trophic factors in the carotid body.

Int Rev Cell Mol Biol 2008 ;269:1-58

Department of Human Anatomy and Physiology, University of Padova, Padova 35127, Italy.

The aim of the present study is to provide a review of the expression and action of trophic factors in the carotid body. In glomic type I cells, the following factors have been identified: brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, artemin, ciliary neurotrophic factor, insulin-like growth factors-I and -II, basic fibroblast growth factor, epidermal growth factor, transforming growth factor-alpha and -beta1, interleukin-1beta and -6, tumour necrosis factor-alpha, vascular endothelial growth factor, and endothelin-1 (ET-1). Growth factor receptors in the above cells include p75LNGFR, TrkA, TrkB, RET, GDNF family receptors alpha1-3, gp130, IL-6Ralpha, EGFR, FGFR1, IL1-RI, TNF-RI, VEGFR-1 and -2, ETA and ETB receptors, and PDGFR-alpha. Read More

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February 2009

Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults.

Int J Sport Nutr Exerc Metab 2008 Aug;18(4):389-98

Department of Human Kinetics, St. Francis Xavier University, Antigonish, NS, Canada.

The purpose of this study was to compare changes in muscle insulin-like growth factor-I (IGF-I) content resulting from resistance-exercise training (RET) and creatine supplementation (CR). Male (n=24) and female (n=18) participants with minimal resistance-exercise-training experience (=1 year) who were participating in at least 30 min of structured physical activity (i.e. Read More

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Immunohistochemical characterization of the rat carotid body.

Respir Physiol Neurobiol 2008 Mar 8;161(1):95-9. Epub 2008 Jan 8.

Department of Neuroscience, Centre for Applied Medical Research-University of Navarra, Avda. Pío XII 55, 31008 Pamplona, Navarra, Spain.

We studied the histochemical phenotype of carotid body (CB) cells in the adult rat. In addition to tyrosine hydroxylase (TH), type I cells expressed numerous growth factors such as glial cell line-derived neurotrophic factor (GDNF), basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), insulin-like growth factor-I (IGF-I), epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha), as well as the receptors p75, Ret, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor-alpha (PDGFR-alpha). Type II cells expressed the glial fibrillary acid protein (GFAP), vimentin, the trophic factor bFGF and receptors p75, EGFR and PDGFR-alpha. Read More

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Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases.

Mol Cancer Ther 2006 Jul;5(7):1883-94

University of Colorado Cancer Center, 12801 East 17th Avenue, Aurora, CO 80010, USA.

To date, clinical studies combining the new generation of targeted therapies and chemotherapy have had mixed results. Preclinical studies can be used to identify potential antagonism/synergy between certain agents, with the potential to predict the most efficacious combinations for further investigation in the clinical setting. In this study, we investigated the sequence-dependent interactions of ZD6474 with oxaliplatin in two human colon cell lines in vitro. Read More

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[Mechanism of abnormal thyroid cell proliferation in normal and tumor tissues].

Osamu Isozaki

Nihon Rinsho 2005 Oct;63 Suppl 10:153-8

Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University.

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October 2005

Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells.

J Cell Physiol 2004 Dec;201(3):459-69

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

PC12 cells serve as a model for exploring nerve growth factor (NGF)-stimulated signal pathways that mediate neural differentiation. We previously demonstrated that neurofilament light chain (NFLC) gene induction by NGF requires collaborative extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling. Herein, we investigate the broader requirement for integrated ERK and JNK signaling in NGF-stimulated gene expression. Read More

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December 2004

Differential gene expression in nasopharyngeal carcinoma cells.

Life Sci 2000 Jul;67(8):923-36

Dept of Anatomy, Faculty of Medicine, University of Hong Kong, SAR, People's Republic of China.

Nasopharyngeal carcinoma (NPC) is a common cancer among southern Chinese. The profile of gene expression in NPC cells is largely unknown. In this study, we have examined differential gene expression in non-malignant and malignant nasopharyngeal epithelial (NPE) cells using a cDNA array hybridization method. Read More

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Comparative role of phosphotyrosine kinase domains of c-ros and c-ret protooncogenes in metanephric development with respect to growth factors and matrix morphogens.

Dev Biol 1996 Aug;178(1):133-48

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

Receptor-like protooncogenes, with tyrosine kinase catalytic domains, are expressed in neoplastic and fetal tissues and potentially have a role in embryonic development. Which protooncogene may have the dominant role in embryonic renal development during the "postinductive" period, i.e. Read More

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