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Reducing Time and Patient Radiation of Computed Tomography-guided Thoracic Needle Biopsies With Single-rotation Axial Acquisitions: An Alternative to "CT Fluoroscopy".

J Thorac Imaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, Massachusetts General Hospital, Boston, MA Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin Department of Radiology, Ludwig-Maximilians-University, Munich, Germany.

Purpose: To investigate the effect on procedure time and patient radiation indices of replacing helical acquisitions for needle guidance during thoracic needle biopsy (TNB) with intermittent single-rotation axial acquisitions.

Materials And Methods: This retrospective intervention study included 215 consecutive TNBs performed by a single operator from 2014 to 2018. Characteristics of patients, lesions, and procedures were compared between TNBs guided only by helical acquisitions initiated in the control room (helical group, n=141) and TNBs guided in part by intermittent single-rotation axial computed tomography controlled by foot pedal (single-rotation group, n=74). Read More

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September 2021

Single-level subject-specific finite element model can predict fracture outcomes in three-level spine segments under different loading rates.

Comput Biol Med 2021 Sep 9;137:104833. Epub 2021 Sep 9.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Osteoporosis-related vertebral compression fracture can occur under normal physiological activities. Bone metastasis is another source of vertebral fracture. Different loading rates, either high-energy traumas such as falls or low-energy traumas under normal physiological activities, can result in different fracture outcomes. Read More

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September 2021

Harnessing the potential of nanostructured formulations to mimic the food effect of lurasidone.

Int J Pharm 2021 Sep 14:121098. Epub 2021 Sep 14.

UniSA Clinical and Health Sciences, University of South Australia, Adelaide, South Australia 5000, Australia; ARC Centre for Excellence in Bio-Nano Science and Technology, Adelaide, South Australia 5000, Australia. Electronic address:

Lurasidone is an important antipsychotic drug indicated for the treatment of schizophrenia and bipolar disorder, with an oral bioavailability of 9-19% owing to its poor aqueous solubility. Additionally, lurasidone exhibits a 2-fold positive food effect, such that patients must administer their medication with a meal, leading to significant non-compliance. The aim of this research was to evaluate the in vitro and in vivo performance of lurasidone when engineered as nanostructured systems. Read More

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September 2021

Functional outcomes and physical performance of knee osteoarthritis patients after ultrasound-guided genicular nerve radiofrequency ablation.

Pain Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, Taiwan.

Objective: To elucidate the effectiveness of ultrasound-guided genicular nerve radiofrequency ablation in alleviating pain as well as its effects on functional outcomes, quality of life and physical performance in knee osteoarthritis patients.

Design: Prospective observational study.

Setting: Patients were recruited within one community hospital. Read More

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September 2021

Community-facility linkage models and maternal and infant health outcomes in Malawi's PMTCT/ART program: A cohort study.

PLoS Med 2021 Sep 17;18(9):e1003780. Epub 2021 Sep 17.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Background: In sub-Saharan Africa, 3 community-facility linkage (CFL) models-Expert Clients, Community Health Workers (CHWs), and Mentor Mothers-have been widely implemented to support pregnant and breastfeeding women (PBFW) living with HIV and their infants to access and sustain care for prevention of mother-to-child transmission of HIV (PMTCT), yet their comparative impact under real-world conditions is poorly understood.

Methods And Findings: We sought to estimate the effects of CFL models on a primary outcome of maternal loss to follow-up (LTFU), and secondary outcomes of maternal longitudinal viral suppression and infant "poor outcome" (encompassing documented HIV-positive test result, LTFU, or death), in Malawi's PMTCT/ART program. We sampled 30 of 42 high-volume health facilities ("sites") in 5 Malawi districts for study inclusion. Read More

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September 2021

Surgical Management of Pectoralis Major Tears of the Sternal Origin Because of Seat Belt Trauma: A Report of 2 Cases.

JBJS Case Connect 2021 Sep 17;11(3). Epub 2021 Sep 17.

Northwest Permanente P.C., Portland, Oregon.

Cases: Two patients presented with medial chest pain and deformity after high-speed motor vehicle accidents (MVAs) in which they were restrained drivers. Physical examination revealed retraction of the pectoralis major from the sternum on resisted adduction and internal rotation of the arm. MRI confirmed tears of the pectoralis major from the sternal origin. Read More

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September 2021

[Unstable RAMP Lesions of the Medial Meniscus in ACL-Deficient Knee: Comparing the Outcomes of Outside-in versus All-inside Surgical Repair - a Retrospective Study].

Acta Chir Orthop Traumatol Cech 2021 ;88(4):273-283

Klinika dětské a dospělé ortopedie a traumatologie, 2. lékařská fakulta Univerzity Karlovy a Fakultní nemocnice v Motole, Praha.

PURPOSE OF THE STUDY We present the results of the retrospective study comparing the clinical outcomes of outside-in versus all-inside suture techniques of unstable RAMP lesions (RL) of the medial meniscus in patients with simultaneous ACL lesion with a minimum two-year follow-up. MATERIAL AND METHODS The retrospective evaluation covered two groups of patients who underwent the arthroscopic repair of unstable RL in combination with anterior cruciate ligament reconstruction (ACLR). Group 1 included 42 patients (28 men/24 women). Read More

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January 2021

Population-based return on investment of deploying transient elastography.

Am J Manag Care 2021 Sep;27(9):376-381

Santa Barbara Actuaries, 3221 Calle Mariposa, Santa Barbara, CA 93105. Email:

Objectives: To evaluate the cost savings outcomes, from the payer's perspective, of deploying vibration-controlled transient elastography/controlled attenuation parameter (VCTE/CAP) machines for detecting and monitoring fatty liver disease (FLD).

Study Design: We modeled disease transitions and costs under the current observed pathway and under an alternative pathway in which VCTE/CAP devices are adopted. Marginal savings (or costs) due to implementing the device are derived by comparing the aggregate costs between the 2 pathways. Read More

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September 2021

Age-related prescription medication utilization for the -management of sickle cell disease among Texas Medicaid patients.

J Opioid Manag 2021 Jul-Aug;17(4):301-310

College of Pharmacy, The University of Texas at Austin, Austin, Texas.

Introduction: Sickle cell disease (SCD) is associated with recurrent complications and healthcare burden. Although SCD management guidelines differ based on age groups, little is known regarding actual utilization of preventative (hydroxyurea) and palliative therapies (opioid and nonopioid analgesics) to manage complications. This study assessed whether there were agerelated differences in SCD index therapy type and SCD-related medication utilization. Read More

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September 2021

The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases.

Cardiovasc Drugs Ther 2021 Sep 17. Epub 2021 Sep 17.

Department of Hypertension and Diabetology, Faculty of Medicine, Medical University of Gdansk, Debinki 7c, 80-952, Gdansk, Poland.

Cardiovascular disease is the leading cause of mortality worldwide, affecting a wide range of patients at different stages across the cardiovascular continuum. Hypertension is one of the earliest risk factors in this continuum and can be controlled in most patients with currently available antihypertensive agents. However, goals are often not met because treatments are not optimized in terms of tailoring therapy to individual patients based on their hypertension subclass and cardiovascular risk profile and initiating early use of adapted-dose, single-pill combinations. Read More

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September 2021

The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression.

Mol Cell Biochem 2021 Sep 17. Epub 2021 Sep 17.

Department of Cytobiology and Proteomics, Medical University of Lodz, 6/8 Mazowiecka St., 92-215, Lodz, Poland.

The F11 Receptor (F11R), also called Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A), is a transmembrane glycoprotein of the immunoglobulin superfamily, which is mainly located in epithelial and endothelial cell tight junctions and also expressed on circulating platelets and leukocytes. It participates in the regulation of various biological processes, as diverse as paracellular permeability, tight junction formation and maintenance, leukocyte transendothelial migration, epithelial-to-mesenchymal transition, angiogenesis, reovirus binding, and platelet activation. Dysregulation of F11R/JAM-A may result in pathological consequences and disorders in normal cell function. Read More

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September 2021

Anterior suprascapular nerve block versus interscalene brachial plexus block for arthroscopic shoulder surgery: a systematic review and meta-analysis of randomized controlled trials.

J Anesth 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthetics, Princess Alexandra Hospital, Brisbane, QLD, Australia.

This systematic review aimed to compare the analgesic effectiveness and complications rates for anterior suprascapular nerve blocks (ASSB) compared to interscalene brachial plexus blocks (ISB) for arthroscopic and outpatient shoulder surgery. Only randomized controlled trials (RCTs) comparing the ASSB versus ISB in the context of arthroscopic shoulder surgery were eligible for inclusion. The primary outcomes included pain scores (Numeric Rating Scale of 0 to 10) up to 24 h postoperatively and analgesic consumption. Read More

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September 2021

Big Data for Treatment Planning: Pathways and Possibilities for Smart Healthcare Systems.

Curr Med Imaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Computer Science, Jamia Millia Islamia, India.

Background: Treatment planning is one of the crucial stages of healthcare assessment and delivery. Moreover, it also has a significant impact on patient outcomes and system efficiency. With the evolution of transformative healthcare technologies, most areas of healthcare have started collecting data at different levels, as a result of which there is a splurge in the size and complexity of health data being generated every minute. Read More

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September 2021

Superior Mesenteric Artery and Vein Injuries: Operative Strategies and Outcomes.

Vasc Endovascular Surg 2021 Sep 17:15385744211042491. Epub 2021 Sep 17.

Emory University School of Medicine, Marcus Trauma Center, 71741Grady Memorial Hospital, Atlanta, GA, USA.

Traumatic injuries to the mesenteric vessels are rare and often lethal. Visceral vessels, such as the superior mesenteric artery (SMA) and vein (SMV), supply blood to the small and large bowel by a rich system of collaterals. Because fewer than 100 such injuries have been described in the literature, they pose challenges in both diagnosis and management and can unfortunately result in high mortality rates. Read More

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September 2021

Occupational therapy intervention for cancer patients following hospital discharge: How and when should we intervene? A systematic review.

Aust Occup Ther J 2021 Sep 17. Epub 2021 Sep 17.

Occupational Therapy Department, Sir Charles Gairdner Hospital, North Metropolitan Health Service, Perth, Western Australia, Australia.

Introduction: Advances in cancer treatment over the last decade have led to increased survival rates. As a result, survivors are living longer with and beyond cancer, often with greater levels of morbidity. Occupational therapists, with their focus on remedial and compensatory strategies to improve function and participation, are well suited to assess and intervene with this population. Read More

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September 2021

Hospital admissions and place of death of residents of care homes receiving specialist healthcare services: A systematic review without meta-analysis.

J Adv Nurs 2021 Sep 17. Epub 2021 Sep 17.

Institute of Mental Health, University of Nottingham, Nottingham, UK.

Aim: To synthesize evidence on the ability of specialist care home support services to prevent hospital admission of older care home residents, including at end of life.

Design: Systematic review, without meta-analysis, with vote counting based on direction of effect.

Data Sources: Fourteen electronic databases were searched from January 2010 to January 2019. Read More

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September 2021

Efficacy of Naoxueshu in acute spontaneous intracerebral hemorrhage: a multicenter observational study.

Neurol Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Objective: To evaluate the efficacy and safety outcome and related risk factors of Naoxueshu in the treatment of acute SICH.

Methods: Two hundred twenty patients were enrolled in this study. Diagnosis of SICH was based on neuroimaging. Read More

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September 2021

Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis.

Transl Androl Urol 2021 Aug;10(8):3255-3266

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, China.

Background: Whether the histologic subtype (type 1 and type 2) of papillary renal cell carcinoma (pRCC) is a tool to predict the prognosis is of great debate. This study is aimed to evaluate the prognostic significance of histologic subtype in patients with pRCC after surgery through a systematic review and meta-analysis.

Methods: We searched PubMed, the Web of Science, Cochrane library and EMBASE databases to identify studies published until January 20, 2021 according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

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Asymptomatic parasitaemia among pregnant women: a health facility based survey in Nassarawa-Eggon, Nigeria.

Malariaworld J 2017 1;8. Epub 2017 Jun 1.

Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.

Background: Asymptomatic malaria parasitaemia remains an effective transmission pool for malaria during pregnancy, which can result in placenta parasitaemia and adverse pregnancy outcomes. This study examined asymptomatic malaria parasitaemia among pregnant women in the antenatal clinic in General Hospital, Nassarawa-Eggon, Nasarawa State, Nigeria.

Materials And Methods: A cross-sectional hospital based survey was carried out among 242 apparently healthy pregnant women presenting for booking in an antenatal clinic between June and August 2014. Read More

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Clinicoradiological Profile and Functional Outcome of Acute Cerebral Venous Thrombosis: A Hospital-Based Cohort Study.

Cureus 2021 Sep 12;13(9):e17898. Epub 2021 Sep 12.

Neurology Unit, S.Orsola-Malpighi University Hospital of Bologna, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Bologna, ITA.

Introduction Acute cerebral venous thrombosis (CVT) may result in a variety of clinical presentations, with headache being the most common. The relationship between clinical and neuroradiological characteristics in acute CVT patients is still not univocally characterized. Materials and methods We enrolled 32 consecutive acute CVT patients admitted to our emergency department from January 1, 2012, to June 30, 2019. Read More

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September 2021

Returning the Favor? Feeling Obliged and Reported Participation in Discretionary Safety Activities.

Front Psychol 2021 31;12:674110. Epub 2021 Aug 31.

Human Resources Development Unit, University of Liège, Liège, Belgium.

Recent research has shown that the reported participation of employees in voluntary safety activities is related to the prevention of accidents and injuries. Encouraging such participation, then, is beneficial to organizations. A key question, therefore, is why employees should choose to report that they engage in such activities: what is their motivation given such activities are not compulsory? We used social exchange theory (SET) and organizational support theory (OST) to develop a model linking perceived organizational support to reports of safety participation. Read More

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Advancing Rights-Based Family Planning from 2020 to 2030.

Open Access J Contracept 2021 9;12:157-171. Epub 2021 Sep 9.

Public Health Consulting, Bethesda, MD, USA.

Introduction: An assessment in 2019 by Family Planning 2020 of progress on rights-based family planning since 2012 highlighted the development of tools and guidelines that identify and explain rights in relation to family planning, promotion of rights-based approaches to programing, strengthened accountability, and measurement of rights-focused outcomes. The assessment was also forward-looking, asking what aspects of rights-based family planning still need attention moving from 2020 to 2030.

Methods: This paper draws on interviews with 23 key informants from governments, civil society, and youth focused organizations, implementing partners, and bi-lateral and multilateral organizations from Africa, Asia and the Pacific, Europe and North America, all working on family planning and engaged in various roles with the FP2020 partnership at global and national levels, along with documentation of FP2030 partnership plans. Read More

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September 2021

Analysis of Brush Cutter-Related Accidents: Describing an Extraordinary Kind of Agricultural Injury.

J Emerg Med 2021 Sep 13. Epub 2021 Sep 13.

Department of Emergency Medicine, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkey. Electronic address:

Background: Brush cutter (BC)-related penetrating trauma, similar to other types of power saws, can cause serious injuries, especially to the extremities. Studies of this particular injury are limited.

Objective: The objective of this study was to characterize injury patterns and patient demographic characteristics for BC-related injuries. Read More

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September 2021

Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy.

Clin Epigenetics 2021 Sep 16;13(1):172. Epub 2021 Sep 16.

Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.

Background: Pancreatic cancer is one of the lethal cancers among solid malignancies. Pathological diagnosis of surgical margins is sometimes unreliable due to tissue shrinkage, invisible field cancerization and skipped lesions like tumor budding. As a result, tumor recurrences sometimes occur even from the pathologically negative surgical margins. Read More

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September 2021

Therapeutic Approaches for the Management of Autoimmune Disorders via Gene Therapy: Prospects, Challenges, and Opportunities.

Curr Gene Ther 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmacy, Southeast University, Banani, Dhaka-1213. Bangladesh.

Background: Autoimmune diseases are the diseases that result due to the overactive immune response, and comprise systemic autoimmune diseases like rheumatoid arthritis (RA), sjӧgren's syndrome (SS), and organ-specific autoimmune diseases like type-1 diabetes mellitus (T1DM), myasthenia gravis (MG), and inflammatory bowel disease (IBD). Currently, there is no long-term cure; but, several treatments exist which retard the evolution of the disease, embracing gene therapy, which has been scrutinized to hold immense aptitude for the management of autoimmune diseases.

Objective: The review highlights the pathogenic mechanisms and genes liable for the development of autoimmune diseases, namely T1DM, type-2 diabetes mellitus (T2DM), RA, SS, IBD, and MG. Read More

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September 2021

Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum.

Hum Reprod 2021 Sep 16. Epub 2021 Sep 16.

Assistance Publique-Hôpitaux de Paris (AP-HP), Centre-Université de Paris, Hôpital Cochin, Service d'Histologie-Embryologie-Biologie de la Reproduction, Paris, France.

Study Question: Are ICSI outcomes impaired in cases of severe asthenozoospermia with multiple morphological abnormalities of the flagellum (MMAF phenotype)?

Summary Answer: Despite occasional technical difficulties, ICSI outcomes for couples with MMAF do not differ from those of other couples requiring ICSI, irrespective of the genetic defect.

What Is Known Already: Severe asthenozoospermia, especially when associated with the MMAF phenotype, results in male infertility. Recent findings have confirmed that a genetic aetiology is frequently responsible for this phenotype. Read More

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September 2021

Biomedical graduate student experiences during the COVID-19 university closure.

PLoS One 2021 16;16(9):e0256687. Epub 2021 Sep 16.

The Office of Biomedical Research Education and Training, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

COVID-19-associated university closures moved classes online and interrupted ongoing research in universities throughout the US. In Vanderbilt University, first year biomedical sciences PhD students were in the middle of their spring semester coursework and in the process of identifying a thesis research lab, while senior students who had already completed the first year were at various stages of their graduate training and were working on their thesis research projects. To learn how the university closure and resulting interruptions impacted our students' learning and well-being, we administered two surveys, one to the first year students and the other to the senior students. Read More

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September 2021

Risk factors for the development of DJK in AIS patients undergoing posterior spinal instrumentation and fusion.

Spine Deform 2021 Sep 16. Epub 2021 Sep 16.

Department of Orthopaedic Surgery, Columbia Universityl, New York, NY, USA.

Purpose: Typically, selection of lowest instrumented vertebra (LIV) in Adolescent Idiopathic Scoliosis (AIS) is based on the coronal radiograph; however, increasing evidence suggests that fusions proximal to the stable sagittal vertebrae (SSV) on the lateral radiograph can result in distal junctional kyphosis (DJK). The purpose of this study is to compare rates of DJK in patients with AIS that have a discordance between the Lowest Touched Vertebra (LTV) and the SSV and to identify risk factors for developing DJK.

Methods: Patients with AIS Lenke type 1, 2 and 3 curves treated with a posterior spinal fusion were separated into two groups. Read More

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September 2021

Optimizing integrated imaging service delivery by tier in low-resource health systems.

Insights Imaging 2021 Sep 16;12(1):129. Epub 2021 Sep 16.

Department of Pediatric Radiology, The Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Access to imaging diagnostics has been shown to result in accurate treatment, management, and optimal outcomes. Particularly in low-income and low-middle-income countries (LICs, LMICs), access is limited due to a lack of adequate resources. To achieve Sustainable Development Goal (SDG) 3, access to imaging services is critical at every tier of the health system. Read More

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September 2021