Toxicol Lett 2021 Apr 16. Epub 2021 Apr 16.
State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou medical university, No. 151 Yanjiang Road, Yuexiu District, Guangzhou 510120, China; The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China. Electronic address:
Tobacco exposure is well known to induce genetic and epigenetic changes that contribute to the pathogenesis of lung cancer. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a significant tobacco-specific carcinogen, but the oncogenic mechanisms of NNK have not been thoroughly elucidated. In this study we found that DNA methyltransferase 1(DNMT1) was overexpressed in malignantly transformed human bronchial epithelial Beas-2B cells induced by NNK (2B-NNK cells), by treatment with NNK (400 μg/ml) for 7 days. Read More