2,970 results match your criteria responsive aqueous

Structural changes in pH-responsive gelatin/hydroxypropyl methylcellulose phthalate blends aimed at drug-release systems.

Int J Biol Macromol 2021 Sep 16. Epub 2021 Sep 16.

Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address:

The present study aimed to investigate the thermal- and pH-dependent gelation behavior of gelatin/HPMCP blends using ultraviolet (UV) spectrophotometry, viscoelasticity, and dynamic light scattering (DLS). We found that the release of lisinopril from gelatin/HPMCP gels can be inhibited at low pH. UV spectrophotometric analysis showed that pH had a significant effect on the transparency of aqueous HPMCP systems and gelatin/HPMCP gels. Read More

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September 2021

Temperature-responsive spin column for sample preparation using an all-aqueous eluent.

Anal Chim Acta 2021 Sep 28;1179:338806. Epub 2021 Jun 28.

Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato, Tokyo, 105-8512, Japan.

We present a temperature-responsive spin column using an all-aqueous eluent. The method is intended as a simple sample preparation method for protein removal from serum, which is required for serum drug analysis. As packing materials for the spin column, we prepared two types of silica beads via surface-initiated radical polymerization. Read More

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September 2021

Stimuli-responsive supramolecular polymers from amphiphilic phosphodiester-linked azobenzene trimers.

Angew Chem Int Ed Engl 2021 Sep 16. Epub 2021 Sep 16.

University of Bern: Universitat Bern, Department of Chemistry and Biochemistry, SWITZERLAND.

An amphiphilic phosphodiester-linked azobenzene trimer has been exploited in the development of stimuli-responsive water-soluble supramolecular polymers. It can reversibly undergo thermal and photoisomerization between Z and E isomers in EtOH solution. Its self-assembly properties in aqueous medium have been investigated by spectroscopic and microscopic techniques, demonstrating that E - and Z -azobenzene trimers form supramolecular nanosheets and toroidal nanostructures, respectively. Read More

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September 2021

Enantioselective liquid-liquid extraction of tryptophan enantiomers by a recyclable aqueous biphasic system based on stimuli-responsive polymers.

J Chromatogr A 2021 Sep 4;1656:462532. Epub 2021 Sep 4.

Institute of Bast Fiber Crops and Center of Southern Economic Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China. Electronic address:

The hydrophobic organic solvents/water biphasic system had been always used in the traditional enantioselective liquid-liquid extraction (ELLE). In recent years, aqueous biphasic systems (ABSs) are considered as a promising method used in the ELLE. In the present work, a recyclable ABS composed of a temperature-responsive polymer poly(MAH-β-CD-co-NIPAAm) (P) and a pH-responsive polymer poly(AA-DMAEMA-BMA) (P) was employed in the enantioseparation of tryptophan enantiomers. Read More

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September 2021

Multiresponsive Microgels: Toward an Independent Tuning of Swelling and Surface Properties.

Langmuir 2021 Sep 15. Epub 2021 Sep 15.

Faculty of Pharmacy, Université de Montréal, C. P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

Dual-responsive poly-(-isopropylacrylamide) (PNIPAM) microgels surface-functionalized with polyethylene glycol (PEG) or poly-2-dimethylaminoethyl methacrylate (PDMAEMA) were developed to enable the swelling behavior and surface properties of the microgels to be tuned independently. The thermo-triggered swelling and pH-triggered surface properties of the microgels were investigated in aqueous suspensions using dynamic light scattering and on substrates using the surface forces apparatus. Grafting polymer chains on the microgel surface did not impede the thermo-triggered swelling behavior of the microgels in suspensions and immobilized on substrates. Read More

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September 2021

Fluorescent, electrically responsive and ultratough self-healing hydrogels bioinspired all-in-one hierarchical micelles.

Mater Horiz 2021 Sep 13. Epub 2021 Sep 13.

Key Laboratory of Functional Polymer Materials of Ministry of Education and College of Chemistry, and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.

Intelligent hydrogels that simultaneously exhibit excellent toughness, self-healing ability and photoelectronic responsiveness are in high demand but are greatly challenging to prepare. Inspired by the hierarchical structure of fluorescent proteins in jellyfish and biomembranes in nature, herein, a facile and universal all-in-one strategy is demonstrated to construct fluorescent, electrically responsive and ultratough self-healing hydrogels aqueous self-assembly of polyelectrolyte-surfactant micelles with hierarchical structures and functionality. The self-assembled 2-ureido-4-[1]-pyrimidone (UPy) hydrophobic core containing reversible physical crosslinks embedded in micelles leads to a durable network structure with excellent toughness and self-healing ability. Read More

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September 2021

Radical-Doped Crystalline Lanthanide-Based Photochromic Complexes: Self-Assembly Driven by Multiple Interactions and Photoswitchable Luminescence.

Inorg Chem 2021 Sep 9;60(18):14286-14293. Epub 2021 Sep 9.

College of Materials and Chemical Engineering, Pingxiang University, Pingxiang, Jiangxi 337055, P. R. China.

Stimuli-responsive functional materials, especially the light stimulation color change and tunable fluorescent materials, have received considerable attention because of their broad applications in smart materials. Herein, a series of lanthanide-based [Ln = Nd(III) (), Sm(III) (), Eu(III) (), Gd(III) (), Tb(III) (), Yb(III) (), and Lu(III) ()] crystalline complexes were attained by simply adding the aqueous lanthanide nitrate solution to the water-soluble naphthalenediimide derivative. The obtained lanthanide-based crystalline materials not only show significant photochromism but also possess reactive organic radicals under ambient conditions. Read More

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September 2021

Photo-Responsive Self-Assembly of Plasmonic Magnetic Janus Nanoparticles.

Langmuir 2021 Sep 9. Epub 2021 Sep 9.

Organic Chemistry Institute, Westfälische Wilhelms-Universität Münster, Corrensstraße 36, D-48149 Münster, Germany.

Stimuli-responsive self-assembly of nanoparticles is a versatile approach for the bottom-up fabrication of adaptive and functional nanomaterials. For this purpose, anisotropic building blocks are of particular importance due to the unique shapes and structures that can be obtained upon self-assembly. Here, we demonstrate the photo-responsive self-assembly of plasmonic magnetic "dumbbell" Janus nanoparticles (Au-FeO) the host-guest interaction of the supramolecular host cyclodextrin and the molecular photoswitch arylazopyrazole. Read More

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September 2021

Asymmetric polymersomes, from the formation of asymmetric membranes to the application on drug delivery.

J Control Release 2021 Sep 5;338:422-445. Epub 2021 Sep 5.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, Liaoning, PR China. Electronic address:

Nano drug delivery systems have attracted researchers' growing attention and are gradually emerging into the public views. More and more nano-formulations are being approved for marketing or clinical use, representing the field's booming development. Copolymer self-assembly systems such as micelles, nanoparticles, polymersomes occupy a prominent position in the field of nano-drug delivery carriers. Read More

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September 2021

Visible-light-responsive Z-scheme system for photocatalytic lignocellulose-to-H conversion.

Chem Commun (Camb) 2021 Sep 8. Epub 2021 Sep 8.

National Laboratory of Solid State Microstructures and Collaborative Innovation Center of Advanced Microstructures, Jiangsu Key Laboratory for Nano Technology, College of Engineering and Applied Science, Nanjing University, Nanjing 210093, People's Republic of China.

A -scheme system was successfully constructed for visible-light-driven photocatalytic H production from lignocelluloses, the highest H evolution rate of this Z-scheme system is 5.3 and 1.6 μmol h in α-cellulose and poplar wood chip aqueous solutions, respectively, under visible light irradiation. Read More

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September 2021

Glycopeptide-Conjugated Aggregation-Induced Emission Luminogen: A pH-Responsive Fluorescence Probe with Tunable Self-Assembly Morphologies for Cell Imaging.

J Phys Chem B 2021 Sep 8;125(36):10224-10231. Epub 2021 Sep 8.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), University of Chinese Academy of Sciences, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China.

pH values play an important role in various cell biological processes. Abnormal pH values in living systems are frequently associated with the development of diseases such as cancers, infection, and other diseases. Real-time monitoring of the changes of pH values will give us the significant indication for these diseases' progression. Read More

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September 2021

Tuning the Cloud-Point and Flocculation Temperature of Poly(2-(diethylamino)ethyl methacrylate)-Based Nanoparticles via a Postpolymerization Betainization Approach.

ACS Polym Au 2021 Aug 8;1(1):47-58. Epub 2021 Jul 8.

School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

The ability to tune the behavior of temperature-responsive polymers and self-assembled nanostructures has attracted significant interest in recent years, particularly in regard to their use in biotechnological applications. Herein, well-defined poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA)-based core-shell particles were prepared by RAFT-mediated emulsion polymerization, which displayed a lower-critical solution temperature (LCST) phase transition in aqueous media. The tertiary amine groups of PDEAEMA units were then utilized as functional handles to modify the core-forming block chemistry via a postpolymerization betainization approach for tuning both the cloud-point temperature ( ) and flocculation temperature ( ) of these particles. Read More

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Reduced Fractional Absorption of Zinc in Children With Environmental Enteropathy in Zambia.

J Pediatr Gastroenterol Nutr 2021 Aug 30. Epub 2021 Aug 30.

Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London Section of Pediatric Nutrition, University of Colorado School of Medicine, Aurora, Colorado, USA.

Objectives: We measured fractional absorption of zinc (FAZ) in children with environmental enteropathy (EE) and carried out transcriptomic analysis of biopsies from these children in order to compare FAZ to histology of intestinal biopsies, expression of zinc transporter genes, and biomarkers of enteropathy.

Methods: Fractional absorption of a standardized aqueous dose of zinc was measured by a dual isotope ratio technique in a cohort of children aged between 9 and 24 months in Lusaka, Zambia, who all had non-responsive stunting. Gene expression analysis was carried out on biopsies through RNA sequencing using an Illumina HiSeq2000 platform. Read More

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Construction of Enhanced Photostability Anthraquinone-Type Nanovesicles Based on a Novel Two-Step Supramolecular Assembly Strategy and Their Application on Multiband Laser-Responsive Composites.

ACS Appl Mater Interfaces 2021 Sep 31;13(36):43458-43472. Epub 2021 Aug 31.

Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.

The photostability and dispersity under aggregation states always become an obstacle for the development of small-molecular organic dye (SMOD) composites. Herein, a novel supramolecular assembly strategy with a two-step assembly method is implemented to encapsulate SMODs for improving their photostability and acquiring uniformly dispersed nanoaggregates in aqueous solution. By the novel assembly strategy, photodegradation rates of the anthraquinone-type dyes can decrease significantly, and the stability of dispersed nanoassembly bodies can be improved in solution. Read More

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September 2021

3D-printed smartphone-based device for fluorimetric diagnosis of ketosis by acetone-responsive dye marker and red emissive carbon dots.

Mikrochim Acta 2021 Aug 27;188(9):306. Epub 2021 Aug 27.

Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, China.

A portable smartphone device is reported that uses 3D printing technology for the primary diagnosis of diseases by detecting acetone. The key part of the device consists of red carbon dots (RCDs), which are used as internal standards, and a sensing reagent (3-N,N-(diacethydrazide)-9-ethylcarbazole (2-HCA)) for acetone. With an excitation wavelength of 360 nm, the emission wavelengths of 2-HCA and RCDs are 443 nm and 619 nm, respectively. Read More

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Liquid-Liquid Phase Separation of Single Optically Levitated Water-Ionic Liquid Droplets in Air.

J Phys Chem A 2021 Sep 25;125(35):7716-7722. Epub 2021 Aug 25.

Graduate School of Advanced Science and Engineering, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.

In this study, to investigate the equilibrium morphology of liquid-liquid phase-separated droplets in air, a temperature-responsive ionic liquid (IL) showing lower critical solution temperature behavior was employed. ILs have negligible vapor pressure and do not evaporate from aerosol droplets during dehumidifying processes. We demonstrated that the liquid-liquid phase separation of single optically levitated aqueous droplets containing the temperature-responsive IL can be induced by controlling the air relative humidity. Read More

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September 2021

Adenosine triphosphate (ATP) and zinc(II) ions responsive pyrene based turn-on fluorescent probe and its application in live cell imaging.

J Photochem Photobiol B 2021 Aug 4;223:112279. Epub 2021 Aug 4.

Technology Center, China Tobacco Henan Industrial Co., Ltd., Zhengzhou 450016, Henan, China. Electronic address:

A novel highly selective and sensitive turn-on fluorescent chemosensor PCE to recognize Zn has been developed. The sensor PCE displays a remarkable fluorescent enhancement at 456 nm (λ = 340 nm) with Zn without the interference of other biologically important relevant metal ions in aqueous acetonitrile solution. Job's plot and mass spectral studies divulge such the interaction of PCE by Zn was 1:1 binding stoichiometry. Read More

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Implementations of temperature gradients in temperature-responsive liquid chromatography.

J Chromatogr A 2021 Sep 22;1654:462425. Epub 2021 Jul 22.

Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4bis, Ghent B-9000, Belgium. Electronic address:

Temperature Responsive Liquid Chromatography (TRLC) offers an alternative and environmentally friendly way to perform reversed-phase like separations. Its use of temperature responsive polymers to control retention based on column temperature, instead of the fraction of organic modifier in the mobile phase mobile, eliminates the need for solvent composition gradients and allows, for example, for purely aqueous separations. In principle this temperature induced retention should allow for gradient elutions to be performed using downward temperature gradients to control retention and refocus the analyte peaks. Read More

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September 2021

Indocyanine green-carrying polymeric nanoparticles with acid-triggered detachable PEG coating and drug release for boosting cancer photothermal therapy.

Colloids Surf B Biointerfaces 2021 Aug 16;208:112048. Epub 2021 Aug 16.

Department of Chemical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. Electronic address:

In order to boost anticancer efficacy of indocyanine green (ICG)-mediated photothermal therapy (PTT) by promoting intracellular ICG delivery, the ICG-carrying hybrid polymeric nanoparticles were fabricated in this study by co-assembly of hydrophobic poly(lactic-co-glycolic acid) (PLGA) segments, ICG molecules, amphiphilic tocopheryl polyethylene glycol succinate (TPGS) and pH-responsive methoxy poly(ethylene glycol)-benzoic imine-1-octadecanamine (mPEG-b-C18) segments in aqueous solution. The ICG-loaded nanoparticles were characterized to have ICG-containing PLGA core stabilized by hydrophilic PEG-rich surface coating and a well-dispersed spherical shape. Moreover, the ICG-loaded nanoparticles in pH 7. Read More

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Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon.

Mol Nutr Food Res 2021 Aug 18:e2100539. Epub 2021 Aug 18.

Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843, USA.

Scope: This study investigates the mechanism of action and functional effects of coffee extracts in colonic cells, on intestinal stem cell growth, and inhibition of dextran sodium sulfate (DSS)-induced intestinal barrier damage in mice.

Methods And Results: Aqueous coffee extracts induced Ah receptor (AhR) -responsive CYP1A1, CYP1B1, and UGT1A1 gene expression in colon-derived Caco2 and YAMC cells. Tissue-specific AhR knockout (AhR x Lgr5-GFP-CreERT2 x Villin-Cre), wild-type (Lgr5-CreERT2 x Villin-Cre) mice are sources of stem cell enriched organoids and both coffee extracts and norharman, an AhR-active component of these extracts inhibited stem cell growth. Read More

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Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment.

Drug Deliv 2021 Dec;28(1):1695-1708

Department of Pharmacy, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Read More

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December 2021

A novel chemosensor for sensitive and facile detection of strontium ions based on ion-imprinted hydrogels modified with guanosine derivatives.

J Hazard Mater 2021 Aug 4;421:126801. Epub 2021 Aug 4.

School of Chemical Engineering, Sichuan University, Chengdu 610065, People's Republic of China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.

A novel chemosensor is developed for the sensitive and facile detection of trace strontium ions (Sr) based on the ion-imprinted hydrogels. With Sr as the templates, the ion-imprinted hydrogels are synthesized by copolymerizing the ion-responsive units 5'-O-acryloyl-2',3'-O-isopropylidene guanosine (APG) and the thermo-responsive units N-isopropylacrylamide (NIPAM). In the presence of Sr, APG units can self-assemble to form planar G-quartets via the complexation with Sr, which are introduced into the gel network during polymerization. Read More

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Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.

Biomacromolecules 2021 Sep 13;22(9):3827-3838. Epub 2021 Aug 13.

Department of Mechanical Engineering & Materials Science, Duke University, Durham, North Carolina 27708, United States.

Diblock copolymers are valued for their ability to form thin films with nanoscale features that typically reflect those of their microphase-separated structures in concentrated solution. Here, we show that such self-assembled structures can be easily formed with diblock copolymers composed of thermally responsive polypeptides, such as resilin-like polypeptides (RLP) and elastin-like polypeptides (ELP), by exploiting the inverse temperature transition behavior of ELPs in aqueous media. Specifically, we examine the self-assembly of a series of RLP--ELP diblock copolypeptides in concentrated aqueous solution (30 and 50 wt %) by small-angle X-ray scattering (SAXS). Read More

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September 2021

Pure redox-sensitive paclitaxel-maleimide prodrug nanoparticles: Endogenous albumin-induced size switching and improved antitumor efficiency.

Acta Pharm Sin B 2021 Jul 5;11(7):2048-2058. Epub 2020 Dec 5.

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

A commercial albumin-bound paclitaxel nano-formulation has been considered a gold standard against breast cancer. However, its application still restricted unfavorable pharmacokinetics and the immunogenicity of exogenous albumin carrier. Herein, we report an albumin-bound tumor redox-responsive paclitaxel prodrugs nano-delivery strategy. Read More

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Dual-Stimuli Responsive Single-Chain Polymer Folding via Intrachain Complexation of Tetramethoxyazobenzene and β-Cyclodextrin.

Langmuir 2021 08 9;37(33):10126-10134. Epub 2021 Aug 9.

Molecular Engineering & Sciences Institute, University of Washington, Seattle, Washington 98195, United States.

We synthesize and characterize a triblock polymer with asymmetric tetramethoxyazobenzene (TMAB) and β-cyclodextrin functionalization, taking advantage of the well-characterized azobenzene derivative-cyclodextrin inclusion complex to promote photoresponsive, self-contained folding of the polymer in an aqueous system. We use H NMR to show the reversibility of ()-to-() and ()-to-() TMAB photoisomerization, and evaluate the thermal stability of ()-TMAB and the comparatively rapid acid-catalyzed thermal ()-to-() isomerization. Important for its potential use as a functional material, we show the photoisomerization cyclability of the polymeric TMAB chromophore and calculate isomerization quantum yields by extinction spectroscopy. Read More

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Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks.

Macromol Rapid Commun 2021 Sep 6;42(17):e2100312. Epub 2021 Aug 6.

Rubber Technology Centre, Indian Institute of Technology Kharagpur, 721302, India.

Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe ) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. Read More

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September 2021

Water compatible supramolecular polymers: recent progress.

Chem Soc Rev 2021 Sep 20;50(18):10025-10043. Epub 2021 Sep 20.

Department of Chemistry, The University of Texas at Austin, 105 E. 24th Street A5300, Austin, TX 78712, USA.

Water compatible supramolecular polymers (WCSPs) combine aqueous compatibility with the reversibility and environmental responsiveness of supramolecular polymers. WCSPs have seen application across a number of fields, including stimuli-responsive materials, healable materials, and drug delivery, and are attracting increasing attention from the design, synthesis, and materials perspectives. In this review, we summarize the chemistry of WCSPs from 2016 to mid-2021. Read More

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September 2021

Temperature-Responsive Hydrogel Carrier for Reducing Adsorption Loss of Petroleum Sulfonates.

Langmuir 2021 Aug 3. Epub 2021 Aug 3.

Beijing Key Laboratory for Greenhouse Gas Storage and CO2-EOR, Unconventional Petroleum Research Institute, China University of Petroleum-Beijing, Beijing 102249, China.

As an effective anionic surfactant for chemical flooding, petroleum sulfonate (PS) is often used in conjunction with alkalis to reduce the adsorption loss of PS onto rock and clay surfaces. However, alkali injection can lead to scaling, aggravate the water-sensitive effect of clays, and accelerate polymer hydrolysis. Here, a temperature-responsive biohydrogel-based carrier (XLK) was designed to protect PS from adsorption onto geological features. Read More

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Magnetically-stimulated transformations in the nanostructure of PEGylated phytantriol-based nanoparticles for on-demand drug release.

Colloids Surf B Biointerfaces 2021 Jul 26;207:112005. Epub 2021 Jul 26.

Drug Delivery, Disposition and Dynamics and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC, 3052, Australia. Electronic address:

Lipid-based liquid crystalline (LLC) systems are formed by the self-assembly of lipid materials in aqueous environments. The internal nanostructures of LLC systems can be manipulated using remote stimuli and have the potential to serve as 'on-demand' drug delivery systems. In this study, a magnetically-responsive system that displayed a transition in nanostructure from liposomes to cubosomes/hexasomes under external alternating magnetic field (AMF) was established by the incorporation of iron oxide nanoparticles (IONPs) into a PEGylated phytantriol (PHYT)-based LLC system. Read More

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Guanidinium-Responsive Crown Ether-Based Macrocyclic Amphiphile in Aqueous Medium.

J Phys Chem Lett 2021 Aug 30;12(31):7418-7422. Epub 2021 Jul 30.

School of Life Sciences, Sino-German Joint Research Lab for Space Biomaterials and Translational Technology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China.

Supramolecular assemblies based on oligo(ethylene glycol) (OEG) building blocks are well-known for their neutral chemical property and thermal-responsive behavior. Here, the cyclic "CLOSED" and linear "OPEN" typologies of OEGs led to dramatic difference in the sensitivity to guanidinium-containing species. From thermodynamic studies, the association constant () between the "CLOSED" form amphiphile and guanidinium salt was determined to be 28. Read More

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