48,387 results match your criteria responsible production

Impact of CO overpressure on yeast mitochondrial associated proteome during the "prise de mousse" of sparkling wine production.

Int J Food Microbiol 2021 May 4;348:109226. Epub 2021 May 4.

Department of Agricultural Chemistry, Edaphology and Microbiology, Severo Ochoa (C6) building, Agrifood Campus of International Excellence CeiA3, University of Cordoba, Ctra. N-IV-A mm 396, 14014 Cordoba, Spain. Electronic address:

The "prise de mousse" stage during sparkling wine elaboration by the traditional method (Champenoise) involves a second fermentation in a sealed bottle followed by a prolonged aging period, known to contribute significantly to the unique organoleptic properties of these wines. During this stage, CO overpressure, nutrient starvation and high ethanol concentrations are stress factors that affect yeast cells viability and metabolism. Since mitochondria are responsible for energy generation and are required for cell aging and response to numerous stresses, we hypothesized that these organelles may play an essential role during the prise de mousse. Read More

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Residue changes and processing factors of eighteen field-applied pesticides during the production of Chinese Baijiu from rice.

Food Chem 2021 Apr 29;359:129983. Epub 2021 Apr 29.

Longping Branch, Graduate School of Hunan University, Changsha 410125, China; Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, Changsha 410125, China. Electronic address:

The fate of eighteen pesticides in field-collected rice samples during Chinese Baijiu production was systematically studied. The results indicated that steeping decreased flonicamid residue by 73.2% due to its high water-solubility and low octanol/water partition coefficient. Read More

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The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.

Amino Acids 2021 May 8. Epub 2021 May 8.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC6026, Chicago, IL, 60637, USA.

Fibrosis is a pathologic condition resulting from aberrant wound healing responses that lead to excessive accumulation of extracellular matrix components, distortion of organ architecture, and loss of organ function. Fibrotic disease can affect every organ system; moreover, fibrosis is an important microenvironmental component of many cancers, including pancreatic, cervical, and hepatocellular cancers. Fibrosis is also an independent risk factor for cancer. Read More

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Mastering the control of the Rho transcription factor for biotechnological applications.

Appl Microbiol Biotechnol 2021 May 8. Epub 2021 May 8.

Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.

The present review represents an update on the fundamental role played by the Rho factor, which facilitates the process of Rho-dependent transcription termination in the prokaryotic world; it also provides a summary of relevant mutations in the Rho factor and the insights they provide into the functions carried out by this protein. Furthermore, a section is dedicated to the putative future use of Rho (the 'taming' of Rho) to facilitate biotechnological processes and adapt them to different technological contexts. Novel bacterial strains can be designed, containing mutations in the rho gene, that are better suited for different biotechnological applications. Read More

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Evaluation of the performance and gas emissions of a tractor diesel engine using blended fuel diesel and biodiesel to determine the best loading stages.

Sci Rep 2021 May 7;11(1):9811. Epub 2021 May 7.

Agricultural Botany Department, Faculty of Agriculture, (Saba Basha), Alexandria University, P.O. Box 21531, Alexandria, Egypt.

Fossil fuels are the main energy sources responsible for harmful emissions and global warming. Using biodiesel made from waste deep-frying oil as an alternative fuel source in diesel engines has drawn great attention. This biodiesel is produced using the transesterification process and blends with mineral diesel at Faculty of Agriculture Saba Basha, Alexandria University, Egypt. Read More

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from fungus gardens of fungus-growing ants produce antifungals that inhibit the specialized parasite .

Appl Environ Microbiol 2021 May 7. Epub 2021 May 7.

Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA

Within animal associated microbiomes, the functional roles of specific microbial taxa are often uncharacterized. Here, we use the fungus-growing ant system, a model for microbial symbiosis, to determine the potential defensive roles of key bacterial taxa present in the ants' fungus gardens. Fungus gardens serve as an external digestive system for the ants, with mutualistic fungi in the genus spp. Read More

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Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Plateau State Specialist Hospital, Jos, Plateau State, Nigeria.

Objective: To explore repurposing known natural products for managing patients with mild to moderate symptoms of COVID-19.

Case Presentation: We present a case report of a middle aged woman, who was positive to COVID 19, with mild to moderate symptoms; who self -managed at home using well formulated herbal supplement (Combi-5) taken along with vitamin C and Zinc supplements. She recovered within a short time. Read More

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Effects of light spectrum on morpho-physiological traits of grafted tomato seedlings.

PLoS One 2021 7;16(5):e0250210. Epub 2021 May 7.

College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, China.

It is already known that there are many factors responsible for the successful grafting process in plants, including light intensity. However, the influence of the spectrum of light-emitting diodes (LEDs) on this process has almost never been tested. During the pre-grafting process tomato seedlings grew for 30 days under 100 μmol m-2 s-1 of mixed LEDs (red 70%+ blue 30%). Read More

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Role of central kisspeptin and RFRP-3 in energy metabolism in the male Wistar rat.

J Neuroendocrinol 2021 May 7:e12973. Epub 2021 May 7.

Netherlands Institute for Neuroscience (NIN), Amsterdam, The Netherlands.

Kisspeptin (Kp) and (Arg)(Phe) related peptide 3 (RFRP-3) are two RF-amides acting in the hypothalamus to control reproduction. In the past 10 years, it has become clear that, apart from their role in reproductive physiology, both neuropeptides are also involved in the control of food intake, as well as glucose and energy metabolism. To investigate further the neural mechanisms responsible for these metabolic actions, we assessed the effect of acute i. Read More

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Genetic Characterization of Mutations Related to Conidiophore Stalk Length Development in Laboratory Strain N402.

Front Genet 2021 20;12:666684. Epub 2021 Apr 20.

Institute of Biology Leiden, Microbial Sciences, Leiden University, Leiden, Netherlands.

is an important filamentous fungus in industrial biotechnology for the production of citric acid and enzymes. In the late 1980s, the N400/NRRL3 strain was selected for both fundamental and applied studies in relation to several processes including gluconic acid and protein production. To facilitate handling of , the N400 wild-type strain was UV mutagenized in two consecutive rounds to generate N401 and N402. Read More

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A biomimetic peptide has no effect on the isotopic fractionation during in vitro silica precipitation.

Sci Rep 2021 May 6;11(1):9698. Epub 2021 May 6.

University of Bristol, School of Earth Sciences, Wills Memorial Building, Queen's Road, Brsitol, BS8 1RJ, UK.

The stable isotopic composition of diatom silica is used as a proxy for nutrient utilisation in natural waters. This approach provides essential insight into the current and historic links between biological production, carbon cycling and climate. However, estimates of isotopic fractionation during diatom silica production from both laboratory and field studies are variable, and the biochemical pathways responsible remain unknown. Read More

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The effect of extractive lacto-fermentation on the bioactivity and natural products content of Pittosporum angustifolium (gumbi gumbi) extracts.

J Chromatogr A 2021 Apr 20;1647:462153. Epub 2021 Apr 20.

Department of Pharmaceutical and Toxicological Chemistry named after Arzamastsev of the Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia; School of Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Sciences, La Trobe University, Edwards Rd, Bendigo 3550, Australia.

Pittosporum angustifolium, known as gumbi gumbi, is a native Australian plant, which has traditionally been used as an Aboriginal medicine. This study investigates the effect of different solvents and extractive fermentation on the content and natural products composition of Pittosporum angustifolium extracts, and compares their antioxidant activity, in vitro α-amylase inhibition, and anti-inflammatory properties. Anti-inflammatory activity of the extracts was determined by measuring the inhibition of nitric oxide (NO) production. Read More

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Selectivity Control of Cu Nanocrystals in a Gas-Fed Flow Cell through CO Pulsed Electroreduction.

J Am Chem Soc 2021 May 6. Epub 2021 May 6.

Department of Interface Science, Fritz-Haber Institute of the Max-Planck Society, 14195 Berlin, Germany.

In this study, we have taken advantage of a pulsed CO electroreduction reaction (CORR) approach to tune the product distribution at industrially relevant current densities in a gas-fed flow cell. We compared the CORR selectivity of Cu catalysts subjected to either potentiostatic conditions (fixed applied potential of -0.7 V) or pulsed electrolysis conditions (1 s pulses at oxidative potentials ranging from = 0. Read More

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Perturbation of the peptidoglycan network and utilization of the signal recognition particle-dependent pathway enhances the extracellular production of a truncational mutant of CelA in Escherichia coli.

J Ind Microbiol Biotechnol 2021 May 6. Epub 2021 May 6.

Department of Food Science and Technology, Chung-Ang University, Anseong, Gyeonggi 17546, Republic of Korea.

Caldicellulosiruptor bescii is the most thermophilic, cellulolytic bacterium known and has the native ability to utilize unpretreated plant biomass. Cellulase A (CelA) is the most abundant enzyme in the exoproteome of C. bescii and is primarily responsible for its cellulolytic ability. Read More

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The seven ways eukaryotes produce repeated colour motifs on external tissues.

Biol Rev Camb Philos Soc 2021 May 6. Epub 2021 May 6.

Institut de Systématique, Evolution, Biodiversité (ISYEB), Muséum national d'Histoire naturelle, CNRS, Sorbonne Université, EPHE, Université des Antilles, 57 rue Cuvier, CP39, Paris, 75005, France.

The external tissues of numerous eukaryote species show repeated colour patterns, usually characterized by units that are present at least twice on the body. These dotted, striped or more complex phenotypes carry out crucial biological functions, such as partner recognition, aposematism or camouflage. Very diverse mechanisms explaining the formation of repeated colour patterns in eukaryotes have been identified and described, and it is timely to review this field from an evolutionary and developmental biology perspective. Read More

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Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2 driven parkinson's disease.

Dis Model Mech 2021 May 6. Epub 2021 May 6.

Immuno-Oncology Therapeutic Research Area, Sanofi Strasbourg R&D Center, 16 rue d'Ankara, 67000 Strasbourg, France.

Parkinson's disease (PD) is a fatal neurodegenerative disorder which is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of late-onset PD identified to date, with G2019S being the most frequent LRRK2 mutation, which is responsible for up to 1-2% of sporadic PD and up to 6% of familial PD cases. As no treatment is available for this devastating disease, developing new therapeutic strategies is of foremost importance. Read More

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J Appl Physiol (1985) 2021 May 6. Epub 2021 May 6.

Department of Clinical and Experimental Sciences, University of Brescia, Italy.

Modulation of movement velocity is necessary during daily life tasks, work, and sports activities. However, assessing motor unit behavior during muscle shortening and lengthening at different velocities is challenging. High-density surface electromyography (HD-sEMG) is an established method to identify and track motor unit behavior in isometric contractions. Read More

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Exploring the role of finance, natural resources, and governance on the environment and economic growth in South Asian countries.

Environ Sci Pollut Res Int 2021 May 6. Epub 2021 May 6.

Southwestern University of Finance and Economics, Chengdu, China.

We studied the influence of finance, natural resources, and governance on environmental degradation and economic growth for seven countries of the South Asian Association for Regional Cooperation (SAARC) using the latest panel data over 1996-2018. Panel cointegration tests and the long-run algorithms capable of addressing endogeneity and cross-sectional dependence have been applied to analyze the variables' linkages. To explore the short-run causalities, we further utilized a panel heterogeneous causality test. Read More

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Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster.

Genetics 2019 Dec;213(4):1447-1464

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.

Correct scaling of body and organ size is crucial for proper development, and the survival of all organisms. Perturbations in circulating hormones, including insulins and steroids, are largely responsible for changing body size in response to both genetic and environmental factors. Such perturbations typically produce adults whose organs and appendages scale proportionately with final size. Read More

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December 2019

Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster.

Genetics 2019 Dec;213(4):1447-1464

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.

Correct scaling of body and organ size is crucial for proper development, and the survival of all organisms. Perturbations in circulating hormones, including insulins and steroids, are largely responsible for changing body size in response to both genetic and environmental factors. Such perturbations typically produce adults whose organs and appendages scale proportionately with final size. Read More

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December 2019

Invariant Natural Killer T Cells as Key Players in Host Resistance against .

J Immunol Res 2021 16;2021:6673722. Epub 2021 Apr 16.

Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.

Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to infection remains unknown. Using splenocytes from CD1d (CD1d) and iNKT-deficient (J18) mice, we found that iNKT cells are the innate source of IFN- after infection and are required to potentiate macrophage oxidative burst and control fungal growth. To determine whether iNKT cells contribute to host resistance against infection, we infected intratracheally wild-type and J18 C57BL/6 mouse strains with the virulent Pb18 isolate. Read More

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Piperlongumine promotes death of retinoblastoma cancer cells.

Oncotarget 2021 Apr 27;12(9):907-916. Epub 2021 Apr 27.

Institute for Research in Ophthalmology, Sion, Switzerland.

Retinoblastoma is the most common pediatric intraocular malignant tumor. While retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene () in the developing retina, tumor progression requires additional epigenetic changes, retinoblastoma genomes being quite stable. Although the management of RB has recently improved, new therapeutic agents are necessary to improve the treatment of advanced forms of retinoblastoma. Read More

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Application of Four Genotyping Methods to Isolates Derived from Western Canadian Feedlot Cattle.

J Clin Microbiol 2021 May 5. Epub 2021 May 5.

Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada

is a significant pathogen of feedlot cattle, responsible for chronic pneumonia and polyarthritis syndrome (CPPS). isolates ( = 129) were used to compare four methods of phylogenetic analysis, and to determine if the isolates' genotypes were associated to phenotypes. Metadata included the health status of the animal from which an isolate was derived (healthy, diseased, dead); anatomical location (nasopharynx, lung, joint); feedlot; and production year (2006 to 2018). Read More

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OsCOP1 regulates embryo development and flavonoid biosynthesis in rice (Oryza sativa L.).

Theor Appl Genet 2021 May 5. Epub 2021 May 5.

Department of Agriculture, Forestry and Bioresources, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul, 08826, Republic of Korea.

Key Message: Novel mutations of OsCOP1 were identified to be responsible for yellowish pericarp and embryo lethal phenotype, which revealed that OsCOP1 plays a crucial role in flavonoid biosynthesis and embryogenesis in rice seed. Successful production of viable seeds is a major component of plant life cycles, and seed development is a complex, highly regulated process that affects characteristics such as seed viability and color. In this study, three yellowish-pericarp embryo lethal (yel) mutants, yel-hc, yel-sk, and yel-cc, were produced from three different japonica cultivars of rice (Oryza sativa L). Read More

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An oxygen-coordinated molybdenum single atom catalyst for efficient electrosynthesis of ammonia.

Chem Commun (Camb) 2021 May 4. Epub 2021 May 4.

Key Laboratory of Materials Physics, Centre for Environmental and Energy Nanomaterials, Anhui Key Laboratory of Nanomaterials and Nanotechnology, CAS Center for Excellence in Nanoscience, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China.

Electrochemical nitrogen (N2) reduction has been regarded as a promising strategy for artificial ammonia (NH3) production under ambient conditions. Herein, we report the fabrication of molybdenum (Mo) single atoms anchored on activated carbon (Mo-SAs/AC) for the electrochemical N2 reduction to NH3. The surface-rich oxygen functional groups of activated carbon can effectively capture the Mo precursor, and concurrently act as the coordination sites to anchor Mo single atoms by forming Mo-Ox bonds. Read More

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(r)HDL in theranostics: how do we apply HDL's biology for precision medicine in atherosclerosis management?

Biomater Sci 2021 May;9(9):3185-3208

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain and Institut de Recerca de l'Hospital Santa Creu i Sant Pau-Institut d'Investigacions Biomèdiques (IIB) Sant Pau, 08025 Barcelona, Spain.

High-density lipoproteins (HDL) are key players in cholesterol metabolism homeostasis since they are responsible for transporting excess cholesterol from peripheral tissues to the liver. Imbalance in this process, due to either excessive accumulation or impaired clearance, results in net cholesterol accumulation and increases the risk of cardiovascular disease (CVD). Therefore, significant effort has been focused on the development of therapeutic tools capable of either directly or indirectly enhancing HDL-guided reverse cholesterol transport (RCT). Read More

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The Role of Health Care Quality in Hypertension Self-Management: A Qualitative Study of the Experience of Patients in a Public Hospital, North-West Ethiopia.

Integr Blood Press Control 2021 27;14:55-68. Epub 2021 Apr 27.

School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Purpose: Hypertension is becoming a global epidemic in all population groups. For its effective management and control, patients should have enhanced self-management skills and get adequate support from care providers. Although the quality of health care is critical in enhancing self-management behaviors of patients with hypertension, the issue has not been fully explored in the Ethiopian context. Read More

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Human, Animal and Planet Health for Complete Sustainability.

Giuseppe Bertoni

Animals (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Emeritus, Department of Animal Sciences, Food and Nutrition, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy.

In order to discuss the concepts of animal health and sustainability, we must remind ourselves that ASF (animal source foods) can play a large role in human health, but that animals are assumed to have a negative role in the environment. Indeed, ASF can compromise human health, both in excess and in deficiency, so a proper amount of them is important. In addition, the environmental impact of farmed animals: land occupation, greenhouse gas (GHG) emissions, energy use and water utilization, acidification and eutrophication, must be minimized by reducing ASF consumption, as well as by increasing productivity. Read More

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AP Collagen Peptides Prevent Cortisol-Induced Decrease of Collagen Type I in Human Dermal Fibroblasts.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Amorepacific Research and Development 1, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do, Korea.

Cortisol is an endogenous glucocorticoid (GC) and primary stress hormone that regulates a wide range of stress responses in humans. The adverse effects of cortisol on the skin have been extensively documented but the underlying mechanism of cortisol-induced signaling is still unclear. In the present study, we investigate the effect of cortisol on collagen type I expression and the effect of AP collagen peptides, collagen tripeptide-rich hydrolysates containing 3% glycine-proline- hydroxyproline (Gly-Pro-Hyp, GPH) from the fish skin, on the cortisol-mediated inhibition of collagen type I and the cortisol-induced signaling that regulates collagen type I production in human dermal fibroblasts (HDFs). Read More

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A Real-Time Fluorescent Reverse Transcription Quantitative PCR Assay for Rapid Detection of Genetic Markers' Expression Associated with Fusarium Wilt of Banana Biocontrol Activities in .

J Fungi (Basel) 2021 Apr 30;7(5). Epub 2021 Apr 30.

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Ministry of Education Key Laboratory of Agriculture Biodiversity for Plant Disease Management, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China.

Fusarium wilt of banana, caused by f. sp. (), especially Tropical Race 4 (TR4), seriously threatens banana production worldwide. Read More

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