77,705 results match your criteria responsible health


A qualitative study exploring the career mindset of a group of early career academic nurses as they deployed 'Habits of Mind' to sustain their career journey.

Nurse Educ Pract 2021 Jul 14;55:103149. Epub 2021 Jul 14.

Vice-Chancellor and Principal, The Vice-Chancellor's Unit, Building 36, University of Wollongong, Australia. Electronic address:

Aim: This study aimed to explore the qualities that sustain a career mindset in a group of early career academics in one Australian university.

Background: Building an academic career is a lengthy, convoluted and complex journey requiring a mindset prepared to make informed and timely decisions. Success is predicated to a large extent on the ability of persons to process information effectively before actions are taken. Read More

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Grandmothers' care practices in areas of high deprivation of Scotland: the potential for health promotion.

Health Promot Int 2021 Jul 22. Epub 2021 Jul 22.

Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, UK.

In many families grandparents play an essential role by providing secondary care for grandchildren. The family is a key setting for promoting children's health; however, studies describing health initiatives with grandparents are rare. Grandparents could play an important role in promoting health for their grandchildren within their families and communities. Read More

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A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles.

J Physiol Biochem 2021 Jul 22. Epub 2021 Jul 22.

INRAE, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Université Clermont Auvergne, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France.

The purpose of this study was to determine whether magnesium L-lactate is responsible for having a beneficial effect on the myocardium and the skeletal muscles and how this substrate acts at the molecular level. Twenty seven young male Wistar rats were supplied with a magnesium L-lactate (L) solution, a magnesium chloride (M) solution and/or water (W) as a vehicle for 10 weeks. The treated animals absorbed the L and M solutions as they wished since they also had free access to water. Read More

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Echocardiographic assessment of the right ventricle in COVID-19: a systematic review.

Int J Cardiovasc Imaging 2021 Jul 22. Epub 2021 Jul 22.

Division of Cardiology, Cardiocentro Ticino Institute, Lugano, Switzerland.

Cardiac involvement has been frequently reported in COVID-19 as responsible of increased morbidity and mortality. Given the importance of right heart function in acute and chronic respiratory diseases, its assessment in SARS-CoV-2 infected patients may add prognostic accuracy. Transthoracic echocardiography has been proposed to early predict myocardial injury and risk of death in hospitalized patients. Read More

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Dengue and the heart.

Cardiovasc J Afr 2021 Jul 20;32:1-8. Epub 2021 Jul 20.

Division of Cardiology, Kingston Health Science Center, Queen's University, Kingston, Ontario, Canada. Email: Adrian.

Dengue is a neglected viral arthropod-borne tropical disease transmitted by the bite of infected spp. mosquitoes. It is responsible for a significant global burden of disease and corresponding socio-economic implications. Read More

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Who holds a shared responsibility view of minimizing gambling harm? Results from a multiwave survey of casino gamblers.

Psychol Addict Behav 2021 Jul 22. Epub 2021 Jul 22.

International Gaming Institute.

Academics, gambling regulators, and the gambling industry increasingly espouse a shared responsibility view of preventing gambling harm, considering individual gamblers and external stakeholders (e.g., gambling industry employees, government regulators, and public health workers) to be jointly responsible for this task. Read More

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Predictors of Vape Shops Going out of Business in Southern California.

Tob Regul Sci 2020 May;6(3):187-195

Artur Galimov, Doctoral Student, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Ellen Galstyan, Doctoral Student, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Sheila Yu, Doctoral Student, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Sabrina Smiley, Assistant Professor, Institute for Health Promotion and Disease Prevention Research , Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Leah Meza, Project Manager, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Lourdes Baezconde-Garbanati, Professor, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Jennifer B. Unger, Professor, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Steve Sussman, Professor, Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Objectives: Vape shops have proliferated in the United States (US) in recent years. As of May 2016, the US Food and Drug Administration (FDA) asserted its authority to regulate electronic nicotine delivery systems. It is critical to understand how these polices have affected the vape shop industry, as the rise and fall of vape shop proliferation has the potential for influencing public health. Read More

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Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy.

Front Public Health 2021 5;9:664748. Epub 2021 Jul 5.

Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Nicotine is the primary pharmacologic component of tobacco, and its highly addictive nature is responsible for its widespread use and significant withdrawal effects that result in challenges to smoking cessation therapeutics. Nicotine addiction often begins in adolescence and this is at least partially attributed to the fact that adolescent brain is most susceptible to the neuro-inflammatory effects of nicotine. There is increasing evidence for the involvement of microglial cells, which are the brain's primary homeostatic sensor, in drug dependence and its associated behavioral manifestations particularly in the adolescent brain. Read More

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AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism.

Oncogene 2021 Jul 21. Epub 2021 Jul 21.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Epidemiologic studies in diabetic patients as well as research in model organisms have indicated the potential of metformin as a drug candidate for the treatment of various types of cancer, including breast cancer. To date most of the anti-cancer properties of metformin have, in large part, been attributed either to the inhibition of mitochondrial NADH oxidase complex (Complex I in the electron transport chain) or the activation of AMP-activated kinase (AMPK). However, it is becoming increasingly clear that AMPK activation may be critical to alleviate metabolic and energetic stresses associated with tumor progression suggesting that it may, in fact, attenuate the toxicity of metformin instead of promoting it. Read More

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Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism.

Mol Psychiatry 2021 Jul 21. Epub 2021 Jul 21.

Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1249, Institut de Neurobiologie de la Méditerranée (INMED), Institut Marseille Maladies Rares (MarMaRa), Aix-Marseille Université, Marseille, France.

Oxytocin is an important regulator of the social brain. In some animal models of autism, notably in Magel2-deficient mice, peripheral administration of oxytocin in infancy improves social behaviors until adulthood. However, neither the mechanisms responsible for social deficits nor the mechanisms by which such oxytocin administration has long-term effects are known. Read More

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Delaying sexual onset: outcome of a comprehensive sexuality education initiative for adolescents in public schools.

BMC Public Health 2021 Jul 21;21(1):1439. Epub 2021 Jul 21.

Center for Health Systems Research, National Institute of Public Health, Avenida Universidad 655, Colonia Santa María de Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico.

Background: A common risk behavior in adolescence is the early initiation of unprotected sex that exposes adolescents to an unplanned pregnancy or sexually transmitted infections. Schools are an ideal place to strengthen adolescents' sexual knowledge and modify their behavior, guiding them to exercise responsible sexuality. The purpose of this article was to evaluate the knowledge of public secondary school teachers who received training in comprehensive education in sexuality (CES) and estimate the counseling's effect on students' sexual behavior. Read More

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Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress.

EMBO Mol Med 2021 Jul 20:e13901. Epub 2021 Jul 20.

Department of Infectious Diseases, Italian Institute of Health, Rome, Italy.

HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV-1 infection, but its role in the development and maintenance of HIV-1 latency has not been elucidated. By combining transcriptomic, proteomic, and metabolomic analyses, we here show that transition to latent HIV-1 infection downregulates glycolysis, while viral reactivation by conventional stimuli reverts this effect. Read More

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Electronic Structure of Tetrahedral, = 2, [Fe{(EPPr)N}], E = S, Se, Complexes: Investigation by High-Frequency and -Field Electron Paramagnetic Resonance, Fe Mössbauer Spectroscopy, and Quantum Chemical Studies.

Inorg Chem 2021 Jul 21. Epub 2021 Jul 21.

Inorganic Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.

In this work, we assessed the electronic structures of two pseudotetrahedral complexes of Fe, [Fe{(SPPr)N}] ) and [Fe{(SePPr)N}] (), using high-frequency and -field EPR (HFEPR) and field-dependent Fe Mössbauer spectroscopies. This investigation revealed = 2 ground states characterized by moderate, negative zero-field splitting (zfs) parameters . The crystal-field (CF) theory analysis of the spin Hamiltonian (sH) and hyperfine structure parameters revealed that the orbital ground states of and have a predominant d character, which is admixed with d (∼10%). Read More

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Acute-care hospitalizations among First Nations people, Inuit and Métis: Results from the 2006 and 2011 Canadian Census Health and Environment Cohorts.

Authors:
Evelyne Bougie

Health Rep 2021 Jul;32(7):11-26

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: The objective of this study was to describe sex-specific hospitalization rates among Indigenous people in Canada (excluding Quebec), separately for First Nations people living on and off reserve, Inuit living in Inuit Nunangat (excluding Nunavik), Métis, and the non-Indigenous population.

Data And Methods: The 2006 and 2011 Canadian Census Health and Environment Cohorts (CanCHECs) were used, allowing hospital records to be examined by Indigenous identity as reported on the census. Five years of hospitalization data were used for each CanCHEC. Read More

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Acquisition of microbiota according to the type of birth: an integrative review.

Rev Lat Am Enfermagem 2021 19;29:e3446. Epub 2021 Jul 19.

Universidade Federal de Viçosa, Departamento de Medicina e Enfermagem, Viçosa, MG, Brasil.

Objective: to analyze scientific evidence regarding the relationship between the type of birth and the microbiota acquired by newborns.

Method: this integrative review addresses the role of the type of delivery on newborns' microbial colonization. A search was conducted in the Medical Literature Analysis and Retrieval System Online/PubMed and Virtual Health Library databases using the descriptors provided by Medical Subject Headings (MeSH) and Health Science Descriptors (DeCS). Read More

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Using the Multi-Theory Model (MTM) of Health Behavior Change to Explain the Correlates of Mammography Screening among Asian American Women.

Pharmacy (Basel) 2021 Jul 15;9(3). Epub 2021 Jul 15.

School of Health and Applied Human Sciences, University of North Carolina Wilmington, Wilmington, NC 28403, USA.

Globally, breast cancer is the most common malignancy affecting women. The incidence of breast cancer has been growing among Asian American women. Mammography is a screening procedure that provides early diagnosis for the timely treatment to reduce premature mortality due to breast cancer. Read More

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Acute cellular rejection in lung transplantation.

Afr J Thorac Crit Care Med 2019 31;25(2). Epub 2019 Jul 31.

Division of Pulmonology, University of Cape Town Lung Institute and Groote Schuur Hospital, Cape Town, South Africa.

Lung transplantation is an important therapy for end-stage respiratory failure in patients who have exhausted other therapeutic options. The lung is unique among solid-organ transplants in that it is exposed to the outside environment, and undergoes continuous stimulation from infectious and non-infectious agents, which may play a part in upregulating the immune response to the allograft. Despite induction immunosuppression and the use of aggressive maintenance regimens, acute allograft rejection is still a major problem, especially in the first year after transplant, with important diagnostic and therapeutic challenges. Read More

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Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes.

iScience 2021 Jul 24;24(7):102766. Epub 2021 Jun 24.

Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China.

Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly. However, the underlying mechanisms remain largely unknown. Read More

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Erectile dysfunction among testicular cancer survivors: A systematic review and meta-analysis.

Heliyon 2021 Jul 3;7(7):e07479. Epub 2021 Jul 3.

Department of Psychiatry, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Erectile dysfunction is one of the common complications of testicular cancer with a prevalence of 11.3%-84%. It has devastating effects on men and their partner's quality of life, sexual satisfaction, and sexual experience. Read More

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The Current Situation and Influencing Factors of the Alarm Fatigue of Nurses' Medical Equipment in the Intensive Care Unit Based on Intelligent Medical Care.

J Healthc Eng 2021 3;2021:9994303. Epub 2021 Jul 3.

Intensive Care Unit, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China.

After rapid development and reform, the health level and medical diagnosis and treatment capabilities of Chinese residents have been significantly improved, and high-quality medical resources have significantly improved the life safety and health of the masses. As the most concentrated area of medical equipment in the hospital, the intensive care unit produces the most alarms during the operation of the equipment. The intensive care unit nurses are responsible for heavier nursing work, and the problem of alarming in other departments is more prominent. Read More

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Multimorbidity of chronic diseases of lifestyle among South African adults.

Pan Afr Med J 2021 6;38:332. Epub 2021 Apr 6.

Diseases of Lifestyle Niche Area, Faculty of Health Sciences, North West University, Mafikeng Campus, Mahikeng, South Africa.

Introduction: the prevalence of non-communicable and chronic diseases has been on the increase globally and has been a major factor responsible for high morbidity and mortality. Multimorbidity of the chronic diseases in low/medium income countries should be a major concern for public health practitioners because of the communicable diseases they also battle with. This study was carried out to determine the prevalence of multi-morbidity of chronic diseases of lifestyle (CDL) among adult South Africans. Read More

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Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.

Exp Mol Med 2021 Jul 20. Epub 2021 Jul 20.

Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.

In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12), the major acyl-CoA thioesterase, induced the accumulation of acetyl-CoA and resulted in the stimulation of de novo lipogenesis (DNL) and cholesterol biosynthesis in the liver. KEGG pathway analysis suggested PPARα signaling as the most significantly enriched pathway in Acot12 livers. Read More

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T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes.

Diabetes 2021 Mar 18. Epub 2021 Mar 18.

Mater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.

Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown. We postulated that early in diabetes, glucose variations contribute to kidney injury molecule-1 (KIM-1) release from circulating T cells, elevating uACR and DKD risk. Read More

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Community implementation of the 3 Wishes Project: an observational study of a compassionate end-of-life care initiative for critically ill patients.

CMAJ Open 2021 Jul-Sep;9(3):E757-E764. Epub 2021 Jul 20.

Department of Critical Care (Reeve, Dechert, Longo, Scholes, Arthur), Brantford General Hospital, Brantford, Ont.; Department of Medicine (Dennis, Cook), McMaster University, Hamilton, Ont.; Department of Health Research Methods, Evaluation, and Impact (Dennis, Heels-Ansdell, Clarke, Cook), McMaster University, Hamilton, Ont.; Department of Critical Care (Dechert, Clarke, Cook), St. Joseph's Healthcare Hamilton, Ont.

Background: The 3 Wishes Project (3WP) promotes a personalized dying experience by eliciting and facilitating individualized terminal wishes for patients, families and the clinicians caring for them. We aimed to evaluate the adaptability of the 3WP to a community intensive care unit (ICU), and to describe the patients cared for with this palliative approach, as well as local implementation strategies.

Methods: The 3WP was implemented in a 15-bed community hospital ICU in southern Ontario from 2017 to 2019. Read More

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Polysubstance Use Is Positively Associated with Gaming Disorder Symptom Severity: A Latent Class Analytical Study.

Eur Addict Res 2021 Jul 20:1-11. Epub 2021 Jul 20.

Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

Introduction: The link between gaming disorder (GD) and substance use amongst adolescents is not clear. Some studies reported positive associations, whereas others suggested that alcohol and illicit drug use are not related to GD severity.

Objectives: The present study aimed to identify empirically based latent classes of alcohol and illicit drug use amongst adolescents and explore their associations with GD symptom severity and whether endorsement of specific criteria of GD is linked to the membership of latent classes of alcohol and illicit drug use. Read More

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