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Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model.

Bipolar Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Epidemiology, University of California Irvine, Irvine, 92697, CA, USA.

Objective: The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. Compared to blood, saliva collection is easier, non-invasive, requires less processing, and can be done without the need for trained personnel. This study investigated the utility of longitudinal salivary lithium level monitoring. Read More

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September 2021

Direct immunofluorescence analysis of oral Tzanck smears for pemphigus vulgaris: A diagnostic test.

J Oral Pathol Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Background: Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune blistering disease. Direct immunofluorescence (DIF) is an important method for PV diagnosis, but oral tissue biopsy for DIF analysis is difficult to perform because of the fragile characteristics of oral mucosa. However, no well-designed diagnostic studies addressing the validity of DIF analysis of oral Tzanck smears for the diagnosis of PV exist. Read More

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September 2021

Acute Kidney Injury is a Common and Significant Complication Following Ileostomy Formation.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.

Aim: To characterize the incidence and short-term prognostic value of an acute kidney injury (AKI) during the admission where an ileostomy is formed.

Methods: Adults with a baseline creatinine discharged alive after ileostomy formation from 2014-2016 were included. All patients had daily basic metabolic panels (BMP) and the Kidney Diseases Improving Global Outcomes criteria were used to determine the presence and severity of any AKI. Read More

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September 2021

Abiraterone acetate plus prednisone in non-metastatic biochemically recurrent castration-naïve prostate cancer.

Eur J Cancer 2021 Sep 15;157:259-267. Epub 2021 Sep 15.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Intermittent androgen deprivation therapy (ADT) in biochemically recurrent castration-naïve prostate cancer is non-inferior to continuous therapy. We hypothesised that finite-duration abiraterone acetate plus prednisone (Abi +P) added to ADT will further reduce the duration of treatment exposure by prolonging time to prostate-specific antigen (PSA) recurrence without impacting eugonad state recovery.

Methods: This phase II, randomised, open-label trial enrolled patients with rising PSA ≥ 0. Read More

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September 2021

Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma.

Eur J Cancer 2021 Sep 15;157:250-258. Epub 2021 Sep 15.

University of Brescia, Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, ASST-Spedali Civili, Brescia, Lombardia, Italy. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) has an overall favourable outcome, except for patients with an advanced stage disease. The programmed death protein-1 (PD-1) inhibitor cemiplimab has been approved for use in advanced cSCC. We report clinical outcomes from the named patient programme-compassionate use of cemiplimab for patients with advanced cSCC in Italy. Read More

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September 2021

Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy.

Eur J Cancer 2021 Sep 15;157:214-224. Epub 2021 Sep 15.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have activity across many tumor types, but activation of the immune system may also lead to significant, often steroid-refractory immune-related adverse events (irAEs). We sought to determine the activity of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in treatment or prevention of auto-immune irAE in ICI-treated patients.

Methods: Institutional databases from 2 melanoma centers were reviewed for patients treated with ICIs and tocilizumab. Read More

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September 2021

Virtual reality surgical planning for endoscopic endonasal approaches to the craniovertebral junction.

Am J Otolaryngol 2021 Sep 11;43(1):103219. Epub 2021 Sep 11.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Otolaryngology Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.

Purpose: To demonstrate the utility of virtual reality (VR) for preoperative surgical planning of endoscopic endonasal craniovertebral junction (CVJ) surgery.

Materials And Methods: Five patients who had undergone endoscopic endonasal surgery of the craniovertebral junction with preoperative virtual reality surgical planning were identified and described.

Results: The anterior approach to the CVJ has been traditionally accomplished transorally. Read More

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September 2021

Defining the microbiome of the head and neck: A contemporary review.

Am J Otolaryngol 2021 Sep 11;43(1):103224. Epub 2021 Sep 11.

University of Connecticut Health Center Department of Otolaryngology-Head and Neck Surgery, United States of America. Electronic address:

Objective: The purpose of this paper is to define the microbiome of the head and neck by characterizing and distinguishing the commensal bacteria from pathogenic species.

Study Design: Literature review.

Methods: Pubmed and Google scholar databases were queried for relevant articles. Read More

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September 2021

F-FDG-PET/CT interpretation pitfalls in patients with head and neck cancer.

Am J Otolaryngol 2021 Sep 10;43(1):103209. Epub 2021 Sep 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Aim: The aim of the present study is to raise awareness of ENT Surgeons on the limitations of F-FDG PET/CT in head and neck cancer by presenting illustrative cases from our department archives.

Materials And Methods: A retrospective chart review was conducted for all patients with head and neck cancer treated in our ENT department from 2015 to 2020. Cases with various interpretation pitfalls due to false-positive and false-negative PET/CT results that lead to diagnostic dilemmas and treatment delays either in their pre-therapeutic work-up or in their post-therapeutic monitoring were included. Read More

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September 2021

Device failure caused by the dissociation of floating mass transducer in Vibrant SoundBridge®.

Am J Otolaryngol 2021 Sep 11;43(1):103222. Epub 2021 Sep 11.

Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Republic of Korea; Department of Otorhinolaryngology, College of Medicine, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea. Electronic address:

Background: Vibrant SoundBridge® (VSB), a semi-implantable middle ear device, is one of the treatment options for patients with mild-to-severe sensorineural hearing loss or mixed hearing loss. Herein, we report delayed device failure after VSB surgery in two patients.

Case Presentation: In both cases, a revision surgery was performed for the removal of the device; dissociation of the floating mass transducer (FMT) and coupler was noticed in one patient, and dissociation of the FMT-coupler complex from the short process of the incus in the other. Read More

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September 2021

Secular trend in skeletal growth among urban Japanese during the Edo period (1603-1867).

Authors:
Nana Nakayama

Int J Paleopathol 2021 Sep 15;35:29-39. Epub 2021 Sep 15.

Department of Anthropology, National Museum of Nature and Science, 4-1-1, Amakubo, Tsukuba-shi, Ibaraki 305-0005, Japan. Electronic address:

Objective: The present study aims to investigate whether any secular change in growth occurred among the urban populations during the Edo period (1603-1867). During this time, the preconditions for industrialization were established through rapid urbanization, population increase, and economic development.

Materials: Ninety subadult and 189 adult skeletal remains were recovered from eight Edo-period burial sites in Tokyo were examined. Read More

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September 2021

Individual and organizational factors of nurses' job satisfaction in long-term care: A systematic review.

Int J Nurs Stud 2021 Aug 26;123:104073. Epub 2021 Aug 26.

University of Ottawa - School of Nursing, Ottawa Hospital Research Institute, General Campus, 501 Smyth Rd, Box 711, Ottawa, ON K1H 8L6, Canada. Electronic address:

Background: In long-term care facilities, nurses' job satisfaction predicts staff turnover, which adversely affects resident outcomes. Thus, it is important to develop a comprehensive understanding of factors affecting nurses' job satisfaction in long-term care facilities.

Objectives: To analyze factors associated with job satisfaction among nurses in nursing homes from individual and organizational perspectives utilizing a deductive approach. Read More

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Review of prophylactic swallowing interventions for head and neck cancer.

Int J Nurs Stud 2021 Aug 27;123:104074. Epub 2021 Aug 27.

The First Hospital of Jilin University, No.71 Xinmin street, Changchun, Jilin 130021, China. Electronic address:

Background: Head and neck cancer treatment destroys nerves and/or organs associated with swallowing. Previous studies have investigated the efficacy of exercises for muscles used in swallowing before treatment in reducing disuse atrophy and delaying the occurrence of muscle fibrosis. However, the rehabilitation effects of training and the optimal intervention strategy are unknown. Read More

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Clinical Characterization of Epilepsy in Children With Angelman Syndrome.

Pediatr Neurol 2021 Aug 31;124:42-50. Epub 2021 Aug 31.

Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. Electronic address:

Background: Epilepsy is highly prevalent in children with Angelman syndrome (AS), and its detailed characterization and relationship to the genotype (deletion vs nondeletion) is important both for medical practice and for clinical trial design.

Methods And Materials: We retrospectively analyzed the main clinical features of epilepsy in 265 children with AS who were enrolled in the AS Natural History Study, a multicenter, observational study conducted at six centers in the United States. Participants were prospectively followed up and classified by genotype. Read More

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Psychiatric disorders, depression and quality of life in patients with psychogenic non-epileptic seizures and drug resistant epilepsy living in Argentina.

Seizure 2021 Sep 10;92:174-181. Epub 2021 Sep 10.

Universidad de Buenos Aires (UBA), Facultad de Medicina, IBCN (Instituto de Biología Celular y Neurociencias) - Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (CONICET), Argentina; Universidad de Buenos Aires (UBA), Facultad de Medicina, Centro de Epilepsia del Hospital Ramos Mejía, Buenos Aires, Argentina. Electronic address:

Objectives: Psychiatric disorders are frequently found in both patients with PNES and DRE, making the differential diagnosis even more complex. The aim of this study was to analyze and compare psychiatric aspects and the quality of life in patients with psychogenic non-epileptic seizures (PNES) and drug resistant epilepsy (DRE).

Methods: Patients admitted to video-electroencephalograpy (VEEG) unit with confirmed PNES and DRE were included. Read More

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September 2021

Meta-empirical support for eliminative reasoning.

Authors:
C D McCoy

Stud Hist Philos Sci 2021 Sep 15;90:15-29. Epub 2021 Sep 15.

Underwood International College, Yonsei University, 50 Yonsei-ro, Seodaemun-gu 03722, Seoul, Republic of Korea. Electronic address:

Eliminative reasoning is a method that has been employed in many significant episodes in the history of science. It has also been advocated by some philosophers as an important means for justifying well-established scientific theories. Arguments for how eliminative reasoning is able to do so, however, have generally relied on a too narrow conception of evidence, and have therefore tended to lapse into merely heuristic or pragmatic justifications for their conclusions. Read More

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September 2021

Benzyl isothiocyanate-modified α-lactalbumin - Two-dimensional high-performance thin-layer chromatography for analyzing modified peptides.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Sep 15;1181:122937. Epub 2021 Sep 15.

University of Hamburg, Hamburg School of Food Science, Institute of Food Chemistry, Grindelallee 117, D-20146 Hamburg, Germany; Technische Universität Berlin, Institute of Food Technology and Food Chemistry, Department of Food Chemistry and Analysis, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany. Electronic address:

In complex food matrices, non-directed reactions between food proteins and secondary plant metabolites (SPM) are conceivable. In this study, the interaction between the bioactive metabolite from garden cress (Lepidium sativum) and selected Brassicaceae - benzyl isothiocyanate (BITC) - and the dairy protein α-lactalbumin (α-LA) was investigated. It was focused on monitoring the proteolytic degradation behaviour of unmodified and BITC-modified α-LA with two-dimensional high-performance thin-layer chromatography (2D-HPTLC). Read More

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September 2021

Arthroscopic debridement of osteochondral lesions of the talus: A systematic review.

Foot (Edinb) 2021 Jul 12;49:101852. Epub 2021 Jul 12.

Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.

Background: Arthroscopic debridement (AD) for the osteochondral lesions of the talar dome (OLT) was widely documented in the nineties with satisfactory results. However, in modern treatment algorithms, its role is not described. The present systematic review aims to evaluate the current evidence on the clinical outcomes of AD in the management of OLT. Read More

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Primary total ankle replacement surgery is a cost-effective intervention.

Foot (Edinb) 2021 Sep 15;49:101830. Epub 2021 Sep 15.

Department of Orthopaedics - Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, United Kingdom.

Aims: The primary aim was to assess the cost-effectiveness of primary total ankle replacements (PTAR) in the UK. Secondary aim was to identify predictors associated with increased cost-effectiveness of PTAR.

Methods: Pre-operative and six-month post-operative data was obtained over a 90-month period across the two centres receiving adult referrals in the UK. Read More

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September 2021

Hemicraniectomy for Dominant vs Nondominant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis.

J Stroke Cerebrovasc Dis 2021 Sep 15;30(11):106102. Epub 2021 Sep 15.

Department of Neurology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki 00290, Finland.

Objectives: Decompressive hemicraniectomy decreases mortality and severe disability from space-occupying middle cerebral artery infarction in selected patients. However, attitudes towards hemicraniectomy for dominant-hemispheric stroke have been hesitant. This systematic review and meta-analysis examines the association of stroke laterality with outcome after hemicraniectomy. Read More

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September 2021

Predictors of Infarction in Tuberculous Meningitis in Indian Patients.

J Stroke Cerebrovasc Dis 2021 Sep 15;30(11):106088. Epub 2021 Sep 15.

Department OF Neurology, AIIMS, New Delhi. Electronic address:

Background: Stroke is a devastating complication of tuberculous meningitis (TBM) and is an important determinant of its outcome. We propose a model which would help to predict development of infarction or cerebrovascular events in patients of TBM.

Methods: A prospective study with n=129 patients of TBM were evaluated for predictors and outcomes of stroke. Read More

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September 2021

Hydrothermal aging affects the three-dimensional fit and fatigue lifetime of zirconia abutments.

J Mech Behav Biomed Mater 2021 Sep 8;124:104832. Epub 2021 Sep 8.

Department of Prosthodontics and Periodontology, Bauru School of Dentistry - University of Sao Paulo, 9-75 Octavio Pinheiro Brizolla, 17012-901, Bauru, SP, Brazil.

Objective: Evaluate the effect of aging using two different methods on the three-dimensional fit of zirconia abutments at the implant-abutment connection and estimate the probability of survival of anterior crowns supported by straight and 17-degree angled abutments.

Materials And Methods: Two different zirconia abutment designs, straight and 17-degree angled abutments (n = 63/group), were evaluated in the current study. The abutments were randomly allocated into three experimental groups according to laboratory aging condition (134°C, 2. Read More

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September 2021

Considering the type and timing of breast reconstruction after mastectomy: Qualitative insights into women's decision-making.

Eur J Oncol Nurs 2021 Aug 28;54:102024. Epub 2021 Aug 28.

The University of Sydney, Faculty of Science, School of Psychology, NSW, Australia; Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), School of Psychology, The University of Sydney, NSW, Australia; Psycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Faculty of Science, The University of Sydney, NSW, Australia. Electronic address:

Purpose: The information women receive about the type and timing of breast reconstruction (BR) from healthcare providers is crucial to help them make an informed decision, and this is particularly important in complex cases and/or high-risk cases. This study sought to provide qualitative insights into Australian women's BR decision-making experiences.

Method: Twenty-nine women who had received a mastectomy and made decisions about BR, including the type (expander, implant and/or autologous) and timing (immediate, delayed or immediate-delayed), participated in semi-structured telephone interviews. Read More

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Using a station within an objective structured clinical examination to assess interprofessional competence performance among undergraduate nursing students.

Nurse Educ Pract 2021 Sep 4;56:103190. Epub 2021 Sep 4.

Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Department of Nursing, Spain.

Aim/objective: To describe and analyse the use of a station within an OSCE to assess interprofessional competence performance in undergraduate nursing students. The specific objectives were: - To measure the students' level of competence performance in relation to the interprofessional competences Roles and Responsibilities, Communication and Teamwork. - To determine inter-observer concordance in the assessment of the interprofessional competences. Read More

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September 2021

Exploring the effect of two different teaching strategies on first-year nursing students' understanding of nutritional concepts: A mixed-method approach.

Nurse Educ Pract 2021 Sep 4;56:103193. Epub 2021 Sep 4.

Basque Nurse Education Research Group, Department of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bº Sarriena s/n, 48940 Leioa, Spain; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903 Barakaldo, Spain. Electronic address:

Aim: The aim of the study was twofold. First, to explore understanding difficulties in nutritional concepts among nursing students and second, to analyse the effect of two teaching strategies on the level of understanding.

Background: Previous studies have pointed out the need to improve the nutritional care education offered to undergraduates in health sciences. Read More

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September 2021

NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.

Leuk Res 2021 Sep 11;111:106708. Epub 2021 Sep 11.

Department of Ophthalmology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, PR China. Electronic address:

Background: The aberrant expression of serine/threonine kinase 33 (STK33) has been implicated in cancers. However, its clinical significance and biological functions in diffuse large B cell lymphoma (DLBCL) remain largely unknown. In the present investigation, we delineated the expression of STK33 in DLBCL and its function in cisplatin resistance. Read More

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September 2021

Preoperative rotational assessment of the distal femur with CT may cause femoral component malrotation in TKA.

Knee 2021 Sep 15;33:24-30. Epub 2021 Sep 15.

Department of Orthopaedic Surgery, Hallym University Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea. Electronic address:

Background: Before total knee arthroplasty (TKA), rotational assessment of the distal femur can be performed using either magnetic resonance imaging (MRI) or computed tomography (CT). Until now, there has been no study comparing the two modalities regarding rotational assessment of the distal femur in the same patients.

Methods: We retrospectively reviewed the preoperative CT and MRI images of 110 knees in 110 patients who underwent TKA. Read More

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September 2021

The ACS-NSQIP surgical risk calculator is a poor predictor of postoperative complications in patients undergoing oncologic distal femoral replacement.

Knee 2021 Sep 15;33:17-23. Epub 2021 Sep 15.

Mayo Clinic, Department of Orthopedic Surgery, Rochester, MN, United States. Electronic address:

Background: Distal femur replacement (DFR) has become a preferred reconstruction for tumors involving the femur but is associated with known complications. The ACS-NSQIP surgical risk calculator is an online tool developed to estimate postoperative complications in the first 30-days, however, has not been used in patients undergoing DFR. The purpose of this study was determining the utility of the ACS-NSQIP calculator to predict postoperative complications. Read More

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September 2021

Effect of ultrasound-guided selective sensory nerve blockade of the knee on pain management compared with periarticular injection for patients undergoing total knee arthroplasty: A prospective randomized controlled trial.

Knee 2021 Sep 15;33:1-10. Epub 2021 Sep 15.

Department of Anesthesiology, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society and Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Ultrasound-guided selective sensory nerve blockade (SSNB) of the knee, including an adductor canal block (ACB), anterior femoral cutaneous nerve block, and infiltration between the popliteal artery and posterior capsule of the knee may provide effective motor-sparing knee analgesia for total knee arthroplasty (TKA). We hypothesized that the SSNB would manage pain better on ambulation 24 hours postoperatively compared to periarticular infiltration (PAI), when combined with postoperative continuous ACB.

Methods: Seventy-two patients undergoing elective TKA under spinal anesthesia were randomly assigned to either SSNB (SSNB group) or intraoperative PAI (PAI group). Read More

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September 2021

Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19.

Int Immunopharmacol 2021 Sep 9;100:108127. Epub 2021 Sep 9.

Department of Biochemistry, Faculty of Medicine, Van Yuzuncu Yıl University, 65080-Van, Turkey. Electronic address:

Background: Early detection of oxidant-antioxidant levels and special care in severe patients are important in combating the COVID-19 epidemic. However, this process is costly and time consuming. Therefore, there is a need for faster, reliable and economical methods. Read More

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September 2021