Prion 2021 Dec;15(1):112-120
Department of Pathology and Experimental Therapeutics, University of Barcelona; Biomedical Research Centre of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, Ministry of Economy, Innovation and Competitiveness, Hospitalet De Llobregat; Bellvitge Institute of Biomedical Research (IDIBELL); Institute of Neurosciences, University of Barcelona, Barcelona; Spain.
Glial vulnerability to prions is assessed in murine Creutzfeldt-Jakob disease (CJD) using the tg340 mouse line expressing four-fold human PrP M129 levels on a mouse PrP null background at different days following intracerebral inoculation of sCJD MM1 brain tissues homogenates. The mRNA expression of several astrocyte markers, including glial fibrillary acidic protein (), aquaporin-4 (), solute carrier family 16, member 4 (), mitochondrial pyruvate carrier 1 () and solute carrier family 1, member 2 (glial high-affinity glutamate transporter, ) increases at 120 and 180 dpi. In contrast, the mRNA expression of oligodendrocyte and myelin markers oligodendrocyte transcription factor 1 (, neural/glial antigen 2 (), solute carrier family 16, member 1 (), myelin basic protein (), myelin oligodendrocyte glycoprotein () and proteolipid protein 1 () is preserved. Read More