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Manipulating feedback on schizophrenia: Evidence from a Posner task.

J Psychiatr Res 2021 Jul 22;142:25-32. Epub 2021 Jul 22.

Department of Personality, Evaluation and Psychological Treatment, University of Valencia, Valencia, Spain; Neonatal Research Unit, La Fe Health Research Institute, Valencia, Spain; Department of Psychiatry and Clinical Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain. Electronic address:

Individuals with schizophrenia show difficulties in achieving vital objectives. Abnormal behavioral and emotional responses to environmental feedback may be some of the psychological mechanisms underlying this lack of goal attainment in schizophrenia. The present study aims to assess how different types of feedback may affect performance in a computerized affective Posner task (non-monetary vs. Read More

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Assessment of Biochemical, Hematological and Behavioral Biomarkers of Cyprinus carpio on exposure to a type-II Pyrethroid insecticide Alpha-cypermethrin.

Environ Toxicol Pharmacol 2021 Jul 24:103717. Epub 2021 Jul 24.

Fishery and Ecotoxicology Research Laboratory, Department of Zoology, The University of Burdwan, Purba Barddhaman, West Bengal, India. Electronic address:

This study assessed some important physiological biomarkers of freshwater edible fish Cyprinus carpio following exposure to 10% (T1) and 20% (T2) sublethal concentrations of Alpha-cypermethrin (A-cyp) over a total period of 45 days. Behavioral responses were noticed and Kaplan-Meier survival curves were prepared during acute toxicity study. Total serum protein concentration, total erythrocyte count, hemoglobin, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and total leukocytes count were decreased significantly (p < 0. Read More

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A proteomics investigation of 'immune priming' in Penaeus vannamei as shown by isobaric tags for relative and absolute quantification.

Fish Shellfish Immunol 2021 Jul 24. Epub 2021 Jul 24.

College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, 201306, China. Electronic address:

Invertebrates are considered completely dependent on their innate immunity to defend themselves against pathogens as they lack an adaptive immunity. However, a growing body of evidence has indicated a specific acquired immunity called 'immune priming' may exist. The Pacific white shrimp, Penaeus vannamei is one of the most economically important shrimp species in the world. Read More

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Evaluation of a Chronic Pain Screening Program Implemented in Primary Care.

JAMA Netw Open 2021 Jul 1;4(7):e2118495. Epub 2021 Jul 1.

National Committee for Quality Assurance, Washington, DC.

Importance: Although pain is among the most common symptoms reported by patients, primary care practitioners (PCPs) face substantial challenges identifying and assessing pain.

Objective: To evaluate a 2-step process for chronic pain screening and follow-up in primary care.

Design, Setting, And Participants: A cross-sectional study of patients with a primary care visit between July 2, 2018, and June 1, 2019, was conducted at a statewide, multisite federally qualified health center. Read More

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Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models.

MAbs 2021 Jan-Dec;13(1):1954136

External Innovations, IPSEN, Cambridge, MA, USA.

Inhibitors of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the treatment landscape for patients with cancer. Clinical activity of anti-PD-(L)1 antibodies has resulted in increased median overall survival and durable responses in patients across selected tumor types. To date, 6 PD-1 and PD-L1, here collectively referred to as PD-(L)1, pathway inhibitors are approved by the US Food and Drug Administration for clinical use. Read More

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Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.

Sci Rep 2021 Jul 26;11(1):15149. Epub 2021 Jul 26.

Laboratory of Toxinology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, 21040-900, Brazil.

Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or hypoimmune states. Monocytes are central regulators of the inflammatory response, but our understanding of their role in the genesis and resolution of sepsis is still limited. Here, we report a comprehensive exploration of monocyte molecular responses in a cohort of patients with septic shock via proteomic profiling. Read More

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Preventing Childhood Toxic Stress: Partnering With Families and Communities to Promote Relational Health.

Pediatrics 2021 Jul 26. Epub 2021 Jul 26.

Partners in Pediatrics, Westlake, Ohio.

By focusing on the safe, stable, and nurturing relationships (SSNRs) that buffer adversity and build resilience, pediatric care is on the cusp of a paradigm shift that could reprioritize clinical activities, rewrite research agendas, and realign our collective advocacy. Driving this transformation are advances in developmental sciences as they inform a deeper understanding of how early life experiences, both nurturing and adverse, are biologically embedded and influence outcomes in health, education, and economic stability across the life span. This revised policy statement on childhood toxic stress acknowledges a spectrum of potential adversities and reaffirms the benefits of an ecobiodevelopmental model for understanding the childhood origins of adult-manifested disease and wellness. Read More

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Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish.

Genes Chromosomes Cancer 2021 Jul 23. Epub 2021 Jul 23.

Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA.

Malignant peripheral nerve sheath tumors (MPNSTs) are a type of sarcoma that generally originates from Schwann cells. The prognosis for this type of malignancy is relatively poor due to complicated genetic alterations and the lack of specific targeted therapy. Chromosome fragment 4q22-23 is frequently deleted in MPNSTs and other human tumors, suggesting tumor suppressor genes may reside in this region. Read More

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Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes.

J Neurosci Res 2021 Jul 23. Epub 2021 Jul 23.

Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.

Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is typically transmitted upon tick bite and can cause meningitis and encephalitis in humans. In TBEV-infected mice, mitochondrial antiviral-signaling protein (MAVS), the downstream adaptor of retinoic acid-inducible gene-I (RIG-I)-like receptor (RLR) signaling, is needed to induce early type I interferon (IFN) responses and to confer protection. To characterize the brain-resident cell subset that produces protective IFN-β in TBEV-infected mice, we isolated neurons, astrocytes, and microglia from mice and exposed these cell types to TBEV in vitro. Read More

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miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.

Mol Med Rep 2021 Sep 23;24(3). Epub 2021 Jul 23.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Ischemia/reperfusion (I/R)‑induced liver injury remains a primary concern in liver transplantation and hepatectomy. Previous studies have indicated that microRNAs (miRs) are involved in multiple pathophysiological processes, including liver I/R. miR‑140‑5p reportedly inhibits inflammatory responses and apoptosis in several diseases; however, the role of miR‑140‑5p in liver I/R remains unknown. Read More

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September 2021

Weighting of Prosodic and Lexical-Semantic Cues for Emotion Identification in Spectrally Degraded Speech and With Cochlear Implants.

Ear Hear 2021 Jul 21. Epub 2021 Jul 21.

Division of Speech and Hearing Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Center for Hearing Research, Boys Town National Research Hospital, Omaha, Nebraska, USA.

Objectives: Normally-hearing (NH) listeners rely more on prosodic cues than on lexical-semantic cues for emotion perception in speech. In everyday spoken communication, the ability to decipher conflicting information between prosodic and lexical-semantic cues to emotion can be important: for example, in identifying sarcasm or irony. Speech degradation in cochlear implants (CIs) can be sufficiently overcome to identify lexical-semantic cues, but the distortion of voice pitch cues makes it particularly challenging to hear prosody with CIs. Read More

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Dynamics of cellular immune responses in recipients of renal allografts positive for hepatitis B surface antigen.

J Formos Med Assoc 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan; Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu City, Taiwan. Electronic address:

Background/purpose: Hepatitis B surface antigen (HBsAg)-positive renal transplantation recipients must take lifelong immunosuppressants and nucleotide analogues (NAs). We investigated the cellular immune responses of HBsAg-positive renal transplantation recipients taking immunosuppressants and NAs.

Methods: Blood samples were collected from HBsAg-positive individuals with end-stage renal disease on the transplant waiting list (Group 1) and renal transplantation recipients taking immunosuppressants and NAs (Group 2) or immunosuppressants without NAs (Group 3). Read More

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Alumni survey of a combined doctor of pharmacy/graduate certificate in aging studies program.

Curr Pharm Teach Learn 2021 Aug 16;13(8):964-967. Epub 2021 Jun 16.

Virginia Commonwealth University School of Pharmacy, 410 N 12th Street, P.O. Box 980533, Richmond, VA 23298-0533, United States. Electronic address:

Introduction: The Certificate in Aging Studies at Virginia Commonwealth University allows students to study gerontology while completing their doctor of pharmacy (PharmD) or graduate pharmaceutical sciences degree concurrently. The objective of the study was to evaluate alumni satisfaction with the Certificate in Aging Studies program, its application, and its perceived usefulness.

Methods: Alumni of the program (n = 49) were emailed an anonymous electronic survey about their perceptions of the program. Read More

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A Retrospective Examination of Home PCA Use and Parental Satisfaction With Pediatric Palliative Care Patients.

Am J Hosp Palliat Care 2021 Jul 23:10499091211034421. Epub 2021 Jul 23.

Haslinger Family Pediatric Palliative Care Center, 1079Akron Children's Hospital, Akron, OH, USA.

Introduction: Home Patient-Controlled Analgesia (PCA) is an effective and often preferred therapy for the treatment of chronic pain symptoms in the pediatric palliative care patient. There is little previous research of patient experience with Home PCA. The purpose of this study was to investigate use of home PCA devices in pediatric patients to inform palliative care providers considering an alternative management option for the treatment of end-of-life or chronic pain. Read More

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Transcriptome profiling reveals CD73 and age-driven changes in neutrophil responses against .

Infect Immun 2021 Jul 26:IAI0025821. Epub 2021 Jul 26.

Department of Microbiology Immunology, State University of New York at Buffalo School of Medicine, 14203, Buffalo, NY, USA.

Neutrophils are required for host resistance against but their function declines with age. We previously found that CD73, an enzyme required for antimicrobial activity, is down-regulated in neutrophils from aged mice. This study explored transcriptional changes in neutrophils induced by to identify pathways controlled by CD73 and dysregulated with age. Read More

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Immunogenicity and safety of a recombinant fusion protein vaccine (V-01) against coronavirus disease 2019 in healthy adults: a randomized, double-blind, placebo-controlled, phase II trial.

Chin Med J (Engl) 2021 Jul 22. Epub 2021 Jul 22.

Guangdong Provincial Institute of Biological Products and Materia Medica, Guangzhou, Guangdong 510440, China Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong 511430, China Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China National Institutes for Food and Drug Control, Beijing 100050, China Gaozhou Center for Disease Control and Prevention, Maoming, Guangdong 525000, China Livzon Bio Inc., Zhuhai, Guangdong 519045, China Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong 518112, China.

Background: Innovative coronavirus disease 2019 (COVID-19) vaccines, with elevated global manufacturing capacity, enhanced safety and efficacy, simplified dosing regimens, and distribution that is less cold chain-dependent, are still global imperatives for tackling the ongoing pandemic. A previous phase I trial indicated that the recombinant COVID-19 vaccine (V-01), which contains a fusion protein (IFN-PADRE-RBD-Fc dimer) as its antigen, is safe and well tolerated, capable of inducing rapid and robust immune responses, and warranted further testing in additional clinical trials. Herein, we aimed to assess the immunogenicity and safety of V-01, providing rationales of appropriate dose regimen for further efficacy study. Read More

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The optimization of pepsin processing time to balance the mechanical and biological properties of xenogeneic bone.

J Biomed Mater Res B Appl Biomater 2021 Jul 26. Epub 2021 Jul 26.

Department of Orthopeadic Surgery, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital Central South University.

Xenogeneic bone showed great prospects to treat large bone defects due to its bionic composition and structure, but the immunogenicity limited its wide applications. Previously, we developed a pepsin treating method to eliminate the immunogenicity of xenogeneic bone. In this study, we further investigated the effect of pepsin processing time on the biological and mechanical properties. Read More

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Key Components Related to Pressure Injury Formation: An Initial Investigation Into Pressure Distribution and Blood Perfusion Responses in Wheelchair Users.

J Biomech Eng 2021 Jul 26. Epub 2021 Jul 26.

Department of Mechanical Engineering, Michigan State University, 428 S Shaw Lane, Rm. 2555 Engineering Building, East Lansing, MI 48824-1226, USA.

Soft tissue around bony prominences in the buttocks and back are high risk areas prone to the development of pressure injuries. From a clinical perspective, prevention of pressure injuries all together is the ideal situation. Unfortunately, prevalence rates still reach 47% with recurrence rates even higher. Read More

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Adapting to the challenges of the global pandemic on genetic counselor education: Evaluating students' satisfaction with virtual clinical experiences.

J Genet Couns 2021 Jul 26. Epub 2021 Jul 26.

Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.

Travel restrictions, physical distancing, and limits to clinical placements due to the global pandemic raised enormous challenges for genetic counseling education in 2020. In response, we created authentic virtual clinical experiences in our Master of Genetic Counseling program, mimicking clinical practice: virtual simulation with standardized clients, and virtual clinical placements, including intake calls, triage, consultations, teamwork and time management, and genetic counseling with standardized clients. The virtual clinical experiences involved online pre-brief, simulation, and debrief. Read More

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In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses.

Mol Biotechnol 2021 Jul 25. Epub 2021 Jul 25.

Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Human papillomaviruses (HPV)-16 and 18 are the most prevalent types associated with cervical cancer. HPV L1 and L2 capsid proteins and E7 oncoprotein play crucial roles in HPV-related diseases. Hence, these proteins were proposed as target antigens for preventive and therapeutic vaccines. Read More

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Understanding COVID-19 dynamics and the effects of interventions in the Philippines: A mathematical modelling study.

Lancet Reg Health West Pac 2021 Sep 14;14:100211. Epub 2021 Jul 14.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: COVID-19 initially caused less severe outbreaks in many low- and middle-income countries (LMIC) compared with many high-income countries, possibly because of differing demographics, socioeconomics, surveillance, and policy responses. Here, we investigate the role of multiple factors on COVID-19 dynamics in the Philippines, a LMIC that has had a relatively severe COVID-19 outbreak.

Methods: We applied an age-structured compartmental model that incorporated time-varying mobility, testing, and personal protective behaviors (through a "Minimum Health Standards" policy, MHS) to represent the first wave of the Philippines COVID-19 epidemic nationally and for three highly affected regions (Calabarzon, Central Visayas, and the National Capital Region). Read More

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September 2021

The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF-B Pathway in Created Temporomandibular Osteoarthritis.

Biomed Res Int 2021 9;2021:9978651. Epub 2021 Jul 9.

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China.

Temporomandibular joint osteoarthritis (TMJOA) is characterized by chronic inflammatory degradation of mandibular condylar cartilage (MCC). Studies have found a positive correlation between inflammation and cyclooxygenase- (COX-) 2 in OA pathology. NF-B is a crucial transcription factor of inflammatory and immune responses in the cause of TMJOA pathology. Read More

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Phenotypic and Functional Analyses of B7S1 in Ovarian Cancer.

Front Mol Biosci 2021 9;8:686803. Epub 2021 Jul 9.

Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine,Tongji University, Shanghai, China.

Although programmed death (PD) ligand 1 (PD-L1)/PD-1 inhibitors show potent and durable antitumor effects in a variety of tumors, their efficacy in patients with OvCa is modest. Thus, additional immunosuppressive mechanisms beyond PD-L1/PD-1 need to be identified. The mRNA expression profiles of OvCa patients were obtained from The Cancer Genome Atlas (TCGA) database. Read More

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Profiling of Sexually Dimorphic Genes in Neural Cells to Identify , Whose Overexpression Causes Autism-Like Behaviors in Male Mice.

Front Cell Dev Biol 2021 6;9:669798. Epub 2021 Jul 6.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute for Neuroscience, School of Medicine, Xiamen University, Xiamen, China.

Many neurological disorders exhibit sex differences and sex-specific therapeutic responses. Unfortunately, significant amounts of studies investigating molecular and cellular mechanisms underlying these neurological disorders use primary cell cultures with undetermined sexes; and this may be a source for contradictory results among different studies and impair the validity of study conclusion. Herein, we comprehensively compared sexual dimorphism of gene expression in primary neurons, astrocytes, and microglia derived from neonatal mouse brains. Read More

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Responses of two dominant desert plant species to the changes in groundwater depth in hinterland natural oasis, Tarim Basin.

Ecol Evol 2021 Jul 16;11(14):9460-9471. Epub 2021 Jun 16.

Key Laboratory of Oasis Ecology College of Resources and Environmental Science Xinjiang University Urumqi China.

Groundwater is increasingly becoming a permanent and steady water source for the growth and reproduction of desert plant species due to the frequent channel cutoff events in arid inland river basins. Although it is widely acknowledged that the accessibility of groundwater has a significant impact on plant species maintaining their ecological function, little is known about the water use strategies of desert plant species to the groundwater availability in Daryaboyi Oasis, Central Tarim Basin. This study initially determined the desirable and stressing groundwater depths based on ecological and morphological parameters including UAV-based fractional vegetation cover (FVC) images and plant growth status. Read More

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miR-122 and miR-197 expressions in hepatic carcinoma patients before and after chemotherapy and their effect on patient prognosis.

Am J Transl Res 2021 15;13(6):6731-6737. Epub 2021 Jun 15.

Department of General Surgery, Central Theater General Hospital (Hankou Hospital) Wuhan 430010, Hubei, China.

Objective: To quantify the miR-122 and miR-197 expression levels in liver cancer (LC) patients before and after chemotherapy and to determine their prognostic implications.

Methods: The present study included 169 patients with LC who were admitted to our hospital from January 2005 to December 2010. The miR-122 and miR-197 expression levels in the patients' cancerous and adjacent tissues were quantified, and their peripheral blood levels before and after chemotherapy were analyzed, as well as their prognostic implications. Read More

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Intranasal Ketamine for Acute Pain: Behavioral and Neurophysiological Safety Analysis in Mice.

Curr Ther Res Clin Exp 2021 11;94:100627. Epub 2021 Mar 11.

Division of Behavioral Neuroscience, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.

Background: Subanesthetic ketamine has been used for treatment-resistant depression and is popular as an opioid-sparing agent.

Objective: The present study aimed to investigate the dose-dependent antinociceptive effect of intranasal ketamine (INK) along with behavioral and neurophysiological safety in mice.

Methods: Antinociceptive efficacy was evaluated in the terms of thermal nociceptive response and formalin test. Read More

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Leaf and Community Photosynthetic Carbon Assimilation of Alpine Plants Under Warming.

Front Plant Sci 2021 8;12:690077. Epub 2021 Jul 8.

Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China.

The Tibetan Plateau is highly sensitive to elevated temperatures and has experienced significant climate warming in the last decades. While climate warming is known to greatly impact alpine ecosystems, the gas exchange responses at the leaf and community levels to climate warming in alpine meadow ecosystems remain unclear. In this study, the alpine grass, , and forb, , were grown in open-top chambers (OTCs) for 3 consecutive years to evaluate their response to warming. Read More

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Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice.

Front Microbiol 2021 8;12:671466. Epub 2021 Jul 8.

Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Hepatitis D Virus (HDV) is classified into eight genotypes with distinct clinical outcomes. Despite the maintenance of highly conserved functional motifs, it is unknown whether sequence divergence between genotypes, such as HDV-1 and HDV-3, or viral interference mechanisms may affect co-infection in the same host and cell, thus hindering the development of HDV inter-genotypic recombinants. We aimed to investigate virological differences of HDV-1 and HDV-3 and assessed their capacity to infect and replicate within the same liver and human hepatocyte . Read More

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The Impact of Naturalistic Age Stereotype Activation.

Front Psychol 2021 9;12:685448. Epub 2021 Jul 9.

Department of Psychology, University of Florida, Gainesville, FL, United States.

Almost self-fulfilling, commonly held negative stereotypes about old age and memory can impair older adults' episodic memory performance, due to age-based stereotype threat or self-stereotyping effects. Research studies demonstrating detrimental impacts of age stereotypes on memory performance are generally conducted in research laboratories or medical settings, which often underestimate memory abilities of older adults. To better understand the "real world" impact of negative age and memory stereotypes on episodic memory, the present research tested story recall performance of late middle-aged and older adults ( = 51) following a naturalistic age stereotype manipulation, wherein every day, newspaper-style materials (comics and puzzles) were either embedded with negative age and memory stereotype stimuli (stereotype group) or neutral stimuli (control group). Read More

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