138,962 results match your criteria response rates

Hypomethylating agents and FLT3 inhibitors as maintenance treatment for acute myeloid leukemia and myelodysplastic syndrome following allogeneic hematopoietic stem cell transplant - a systematic review and meta-analysis.

Transplant Cell Ther 2021 Sep 19. Epub 2021 Sep 19.

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medical Oncology, Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA.

Background: Disease relapse remains the major cause of death among patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who receive an allogeneic hematopoietic cell transplant (allo-HCT). Maintenance treatment with FLT3 inhibitors and hypomethylating agents (HMA) has been studied in various clinical trials with mixed results.

Objective: To synthesize the current evidence on the efficacy and safety of FLT3 inhibitors and HMA for maintenance therapy following allo-HCT in AML and MDS. Read More

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September 2021

Negative immune responses to two-dose mRNA COVID-19 vaccines in renal allograft recipients assessed with simple antibody and interferon gamma release assay cellular monitoring.

Am J Transplant 2021 Sep 22. Epub 2021 Sep 22.

Department of Nephrology, Hospital del Mar, Barcelona, Spain.

Studies are urgently needed to characterize immunogenicity, efficacy, and safety of SARS-CoV-2 mRNA vaccines in kidney transplant (KT) recipients, excluded from major clinical trials. Complex ELISPOT and other cellular response techniques have been applied, but simpler tools are needed. An easy-to-use real-world monitoring of SARS-CoV-2 IgG antibodies against the Spike protein and QuantiFERON SARS-CoV-2 IFNγ release assay (IGRA) were performed at baseline and 28 days after the second dose in KT recipients and controls (dialysis patients and healthy ones). Read More

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September 2021

The role of water in the confinement of ibuprofen in SBA-15.

J Mater Chem B 2021 Sep 22;9(36):7482-7491. Epub 2021 Sep 22.

Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, Poland.

The introduction of ibuprofen into mesopores of SBA-15 has been accomplished using the melting method. Samples exhibit from 9 to 33% of the hydrophobic drug. They are not toxic to mouse monocyte-macrophage cells and do not stimulate a pro-inflammatory response. Read More

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September 2021

[email protected] NPs synergy PD-L1 immune checkpoint nanoinhibitor to reshape immunosuppressive tumor microenvironment for enhancing chemo-immunotherapy.

J Mater Chem B 2021 Sep 22;9(36):7544-7556. Epub 2021 Sep 22.

Center of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.

Immunosuppressed tumor microenvironment (TME) is a major cause of the low response rate in solid tumor patients during PD-1/PD-L1 checkpoint blockade therapy. In this study, a series of small molecule nanomedicines with a 100% drug loading rate were prepared the nanoprecipitation method. They were used in synergistic chemo-immunotherapy for 4T1 tumors. Read More

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September 2021

Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children's Pilot Study.

PLoS One 2021 22;16(9):e0257721. Epub 2021 Sep 22.

Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.

Background: The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population.

Methods: The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. Read More

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September 2021

Finding Kinematics-Driven Latent Neural States from Neuronal Population Activity for Motor Decoding.

IEEE Trans Neural Syst Rehabil Eng 2021 Sep 22;PP. Epub 2021 Sep 22.

While intracortical brain-machine interfaces (BMIs) demonstrate feasibility to restore mobility to people with paralysis, it is still challenging to maintain high-performance decoding in clinical BMIs. One of the main obstacles for high-performance BMI is the noise-prone nature of traditional decoding methods that connect neural response explicitly with physical quantity, such as velocity. In contrast, the recent development of latent neural state model enables a robust readout of large-scale neuronal population activity contents. Read More

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September 2021

Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy - a systematic review and meta-analysis.

Disabil Rehabil 2021 Sep 22:1-12. Epub 2021 Sep 22.

Faculty of Medicine, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

Background: Urinary incontinence is one of the most clinically relevant side effects in the treatment of prostate cancer patients. The aim of this systematic review and meta-analysis was to analyze the specific exercise effects of supervised versus unsupervised pelvic floor muscle exercise (PFME) and exercise volume on urinary incontinence status after radical prostatectomy.

Methods: A systematic data search was performed for studies published from January 2000 to December 2020 using the following databases: PubMed, Embase, SciSearch, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews and Effects. Read More

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September 2021

Genomic and phenotypic analysis of heat and sanitizer resistance in from beef in relation to the locus of heat resistance.

Appl Environ Microbiol 2021 Sep 22:AEM0157421. Epub 2021 Sep 22.

Agriculture and Agri-Food Canada, 6000 C&E Trail, Lacombe, Alberta, Canada T4L 1W1.

The locus of heat resistance (LHR) can confer heat resistance to to various extents. This study investigated the phylogenetic relationships, and genomic and phenotypic characteristics of with or without LHR recovered from beef by direct plating or from enrichment broth at 42°C. LHR-positive isolates (n=24) were whole genome-sequenced by short- and long-reads. Read More

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September 2021

Surgeon, patient, and caregiver perspective of pediatric surgical telemedicine in the COVID-19 pandemic era.

Pediatr Surg Int 2021 Sep 22. Epub 2021 Sep 22.

Division of Pediatric Surgery, Children's Hospital Colorado, University of Colorado, 13123 E 16th Ave, B323, Aurora, CO, 80045, USA.

Purpose: Adoption of telemedicine (TME) in surgical specialties, prior to the COVID-19 pandemic, has previously been slow. The purpose of this prospective, observational, single institution study is to evaluate surgeon and caregiver perspectives of TMEs during the pandemic.

Methods: Surveys were distributed to surgical faculty regarding perceptions of TME early during the pandemic and 2 months later. Read More

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September 2021

Assessing couples' preferences for fresh or frozen embryo transfer: a discrete choice experiment.

Hum Reprod 2021 Sep 22. Epub 2021 Sep 22.

Aberdeen Fertility Centre, NHS Grampian, Aberdeen, UK.

Study Question: What are couples' preferences for fresh embryo transfer versus freezing of all embryos followed by frozen embryo transfer and the associated clinical outcomes that may differentiate them?

Summary Answer: Couples' preferences are driven by anticipated chances of live birth, miscarriage, neonatal complications, and costs but not by the differences in the treatment process (including delay of embryo transfer linked to frozen embryo transfer and risk of ovarian hyperstimulation syndrome (OHSS) associated with fresh embryo transfer).

What Is Known Already: A policy of freezing all embryos followed by transfer of frozen embryos results in livebirth rates which are similar to or higher than those following the transfer of fresh embryos while reducing the risk of OHSS and small for gestational age babies: it can, however, increase the risk of pre-eclampsia and large for gestational age offspring. Hence, the controversy continues over whether to do fresh embryo transfer or freeze all embryos followed by frozen embryo transfer. Read More

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September 2021

Ganglion cells in larval zebrafish retina integrate inputs from multiple cone types.

J Neurophysiol 2021 Sep 22. Epub 2021 Sep 22.

Unit on Neural Circuits, National Institute of Neurological Disorders and Stroke, Rockville, MD, United States.

We recently showed the presence of 7 physiological cone opsins - R1 (575nm), R2 (556nm), G1 (460nm), G3 (480nm), B1 (415nm), B2 (440nm), UV (358nm) - in ERG recordings of larval zebrafish (Danio rerio) retina. Larval ganglion cells (GCs) are generally thought to integrate only 4 cone opsin signals (red, green blue and UV). We address the question as to whether they may integrate 7 cone spectral signals. Read More

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September 2021

Monoclonal Antibodies in Myeloma: Optimizing Targeted Therapy.

Cancer J 2021 May-Jun 01;27(3):222-230

From the Monter Cancer Center, Division of Hematology/Medical Oncology, Department of Medicine, Northwell Health Cancer Institute, New Hyde Park, NY.

Abstract: In the past several years, there have been significant advances in the therapeutic arsenal of agents used to treat multiple myeloma (MM). Despite these advances, MM remains incurable. One of the most recent therapeutic advances is the development of targeted monoclonal antibodies (MoAbs). Read More

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September 2021

Inhibition of O-glycosylation aggravates GalN/LPS-induced liver injury through activation of ER stress.

Immunopharmacol Immunotoxicol 2021 Sep 22:1-8. Epub 2021 Sep 22.

Department of Oncology, First Hospital of Qinhuangdao, Qinhuangdao, China.

Objective: O-glycosylation is the most common post-translational modification of proteins, which is involved in many pathophysiological processes including inflammation. Acute liver injury is characterized by an excessive, uncontrolled inflammatory response, but the effects of aberrant O-glycosylation on acute liver injury are yet to explore. Here we aimed to investigate the role of defective O-glycosylation in D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced acute liver damage in mice. Read More

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September 2021

Debulking Followed by Intralesional 5-Fluorouracil for the Treatment of Cutaneous Squamous Cell Carcinoma and Keratoacanthoma: A Retrospective Analysis.

Dermatol Ther 2021 Sep 21:e15139. Epub 2021 Sep 21.

Department of Dermatology, University of North Carolina at Chapel Hill; Chapel Hill, North Carolina.

Background: Debulking followed by intralesional 5-fluorouracil (deb-IL5FU) is a non-surgical modality which has been used to treat skin cancer anecdotally for many years. There are few in depth studies examining this technique and success rate of intralesional 5-fluorouracil (IL5FU) for the treatment of cutaneous squamous cell carcinoma (cSCC).

Objective: To evaluate the response rate of deb-IL5FU for the treatment of cSCC and to determine which patient factors were associated with tumor clearance or treatment failure. Read More

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September 2021

Impact of rituximab on COVID-19 outcomes.

Ann Hematol 2021 Sep 22. Epub 2021 Sep 22.

Tisch Cancer Institute, New York, NY, USA.

Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clinical outcomes from SARS-CoV-2 infection and development of COVID-19 antibodies, we conducted a retrospective study of adults across the Mount Sinai Health System diagnosed with COVID-19 who received rituximab for any indication from February 2019 to October 2020. Patients' baseline characteristics, markers of disease severity, clinical outcomes, and antibody development were examined. Read More

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September 2021

Risk of SARS-CoV-2 Transmission among Air Passengers in China.

Clin Infect Dis 2021 Sep 21. Epub 2021 Sep 21.

WorldPop, School of Geography and Environmental Science, University of Southampton, Southampton, UK.

Background: Modern transportation plays a key role in the spread of SARS-CoV-2 and new variants. However, little is known about the exact transmission risk of the virus on airplanes.

Methods: Using the itinerary and epidemiological data of COVID-19 cases and close contacts on domestic airplanes departing from Wuhan city in China before the lockdown on January 23, 2020, we estimated the upper and lower bounds of overall transmission risk of COVID-19 among travellers. Read More

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September 2021

Tumor volumes as a predictor of response to the anti-EGFR antibody drug conjugate depatuxizumab mafadotin.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab102. Epub 2021 Aug 3.

Tumour Targeting Program, Olivia Newton-John Cancer Research Institute, Austin Health, Heidelberg, Melbourne, Australia.

Background: The adverse impact of increasing brain tumor size on the efficacy of antibody-drug conjugates (ADCs) was investigated preclinically then validated with clinical data.

Methods—preclinical Study: The impact of tumor size on ADC tumor delivery and treatment response was evaluated in an -amplified patient-derived glioblastoma (GBM) model following treatment with Depatuxizumab mafadotin (Depatux-M). Biodistribution and imaging studies correlated drug distribution with starting treatment volume and anti-tumor activity. Read More

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Unexpected Effects of Oral Isotretinoin in Adolescents With Acne Vulgaris.

Demet Akpolat

Cureus 2021 Aug 11;13(8):e17115. Epub 2021 Aug 11.

Dermatology, Demet Akpolat Clinic, Istanbul, TUR.

Background This study aimed to assess the effects of isotretinoin treatment on hirsutism, menstrual cycle and hormonal response in adolescents with acne vulgaris (AV). Methods In the study, 76 participants with nodulocystic acne were included. Free testosterone (fT), total testosterone (tT), dehydroepiandrosterone sulfate (DHEAS), luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17-OH progesterone (17-OH PG), and sex hormone-binding globulin (SHBG) levels of the participants were measured before and at the third and sixth months of treatment. Read More

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Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity.

Biomicrofluidics 2021 Sep 14;15(5):054102. Epub 2021 Sep 14.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27599, USA.

Extravasation of circulating cells is an essential process that governs tissue inflammation and the body's response to pathogenic infection. To initiate anti-inflammatory and phagocytic functions within tissues, immune cells must cross the vascular endothelial barrier from the vessel lumen to the subluminal extracellular matrix. In this work, we present a microfluidic approach that enables the recreation of a three-dimensional, perfused endothelial vessel formed by human endothelial cells embedded within a collagen-rich matrix. Read More

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September 2021

Enhancement of COVID-19 detection time by means of electrothermal force.

Microfluid Nanofluidics 2021 17;25(10):86. Epub 2021 Sep 17.

Laboratory of Electronics and Microelectronics, Faculty of Science of Monastir, University of Monastir, Environment Boulevard, 5019 Monastir, Tunisia.

The rapid spread and quick transmission of the new ongoing pandemic coronavirus disease 2019 (COVID-19) has urged the scientific community to looking for strong technology to understand its pathogenicity, transmission, and infectivity, which helps in the development of effective vaccines and therapies. Furthermore, there was a great effort to improve the performance of biosensors so that they can detect the pathogenic virus quickly, in reliable and precise way. In this context, we propose a numerical simulation to highlight the important role of the design parameters that can significantly improve the performance of the biosensor, in particular the sensitivity as well as the detection limit. Read More

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September 2021

Low Dose of Lenvatinib Treatment for Patients of Radioiodine-Refractory Differentiated Thyroid Carcinoma - A Real-World Experience.

Cancer Manag Res 2021 14;13:7139-7148. Epub 2021 Sep 14.

Division of Endocrinology and Metabolism, Department of Internal Medicine, E-DA Hospital; Thyroid Center, E-DA Cancer Hospital; College of Medicine, I-Shou University, Kaohsiung, Taiwan.

Background: Lenvatinib treatment of 24 mg/day for radioiodine-refractory differentiated thyroid carcinoma (RRDTC) patients was almost intolerable, with high rates of dose reduction, interruption and discontinuation. Balancing treatment safety with disease risks remains challenging, and the appropriate dosage remains unclear in Asia.

Patients And Methods: A total of 65 RRDTC patients treated with lenvatinib were retrospectively collected from Oct. Read More

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September 2021

A cross-sectional survey on buprenorphine-naloxone practice and attitudes in 22 Canadian emergency physician groups: a cross-sectional survey.

CMAJ Open 2021 Jul-Sep;9(3):E864-E873. Epub 2021 Sep 21.

Department of Emergency Medicine (Kestler, Moe, Scheueremeyer), University of British Columbia, Vancouver, BC; Département de médecine de famille et de médecine d'urgence ( Kaczorowski), Université de Montréal, Montréal, Que.; Department of Emergency Medicine (Dong), University of Alberta, Edmonton, Alta.; Department of Family & Community Medicine (Orkin), University of Toronto, Toronto, Ont.; Centre de recherche de l'Hôpital Sacré-Coeur de Montréal (Daoust), Montréal, Que.; British Columbia Centre on Substance Use (Van Pelt), Vancouver, BC; Department of Emergency Medicine (Andolfatto), University of British Columbia, North Vancouver, BC; Department of Medicine (Klaiman), University of Toronto, Toronto, Ont.; Division of Emergency Medicine (Yan), Schulich School of Medicine & Dentistry, Western University, London, Ont.; Department of Emergency Medicine (Koh, Stempien), University of Saskatchewan, Saskatoon, Sask.; Department of Emergency Medicine (Crowder), University of Calgary, Calgary, Alta.; Department of Emergency Medicine (Webster, Atkinson), Dalhousie University, St. John, NB; Division of Clinical Sciences (Savage), Northern Ontario School of Medicine, Thunder Bay, Ont.; Department of Emergency Medicine (Besserer), University of British Columbia, Prince George, BC; Department of Emergency Medicine (Wale), University of British Columbia, Victoria, BC; Centre de recherche du Centre hospitalier de l'Université de Montréal (Lam), Montréal, Que.; Canadian Research Initiative in Substance Misuse (Lam), Montréal, Que.

Background: Buprenorphine-naloxone (BUP) initiation in emergency departments improves follow-up and survival among patients with opioid use disorder. We aimed to assess self-reported BUP-related practices and attitudes among emergency physicians.

Methods: We designed a cross-sectional physician survey by adapting a validated questionnaire on opioid harm reduction practices, attitudes and barriers. Read More

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September 2021

Risk factors associated with durable progression-free survival in relapsed or refractory multiple myeloma patients treated with anti-BCMA CAR-T cell therapy.

Clin Cancer Res 2021 Sep 21. Epub 2021 Sep 21.

Bone Marrow Transplantation Center, the first Affiliated Hospital, School of Medicine, Zhejiang University

Purpose: B-cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy results in high remission rates in patients with relapsed/refractory (R/R) multiple myeloma (MM). However, the factors associated with prognosis following CAR-T cell therapy are unknown.

Experimental Design: Between July 1, 2018, and July 31, 2020, 61 patients with R/R MM received anti-BCMA CAR-T cell therapy (Chictr. Read More

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September 2021

[Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells].

Zhonghua Xue Ye Xue Za Zhi 2021 Aug;42(8):660-665

Institute of Hematology, Henan Provincial People's Hospital; Henan Key Laboratory of Hematopathology; Henan Key Laboratory of Stem Cell Differentiation and Modification, People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou 450003, China.

To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. Read More

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Driver behavior and performances on in-vehicle display based speed compliance.

Accid Anal Prev 2021 Sep 18;162:106390. Epub 2021 Sep 18.

University of Massachusetts, Amherst 160 Governors Drive, Amherst, MA 01003, USA. Electronic address:

Traffic safety, and the inherent risks associated with speeding, continue to remain a national priority. Advances in both roadway and vehicle technology have created potential mechanisms to mitigate speeding behaviors. This driving simulator study evaluated the effects of alternative ways to increase driver safety by investigating the characteristics of specific driving cues and drivers' response rates to those cues. Read More

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September 2021

Impact of systemic inflammatory response syndrome on acute ischemic stroke patients treated with mechanical thrombectomy.

J Neurol Sci 2021 Sep 15;430:119988. Epub 2021 Sep 15.

Department of Neurology, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Aim: Systemic inflammatory response syndrome (SIRS) has been associated with poor outcomes after acute ischemic stroke (AIS). The primary goal of this study was to determine whether SIRS status on admission correlated with functional outcomes in AIS treated with mechanical thrombectomy (MT).

Methods: Consecutive patients from September 2015 to April 2019 were retrospectively reviewed for SIRS on admission. Read More

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September 2021

Engineering a 3D Human Intracranial Aneurysm Model using Liquid-Assisted Injection Molding and Tuned Hydrogels.

Acta Biomater 2021 Sep 18. Epub 2021 Sep 18.

Pharmaceutical Production Research Facility, Department of Chemical and Petroleum Engineering, Schulich School of Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada.; Center of Bioengineering Research and Education, Schulich School of Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada.. Electronic address:

Physiologically relevant intracranial aneurysm (IA) models are crucially required to facilitate testing treatment options for IA. Herein, we report the development of a new in vitro tissue-engineered platform, which recapitulates the microenvironment, structure, and cellular complexity of native human IA. A new modified liquid-assisted injection molding technique was developed to fabricate a three-dimensional hollow IA model with clinically relevant IA dimensions within a mechanically tuned Gelatin Methacryloyl (GelMA) hydrogel. Read More

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September 2021

Obstructive sleep apnea screening, diagnosis, and treatment in the transportation industry.

J Clin Sleep Med 2021 Sep 21. Epub 2021 Sep 21.

Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Obstructive sleep apnea (OSA) is a common, identifiable, and treatable disorder with serious health, safety, and financial implications - including sleepiness-related crashes and incidents - in workers who perform safety-sensitive functions in the transportation industry. Up to one third of crashes of large trucks are attributable to sleepiness, and large truck crashes result in more than 4,000 deaths annually. For each occupant of a truck who is killed, 6 to 7 occupants of other vehicles are killed. Read More

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September 2021

Therapy outcome related to adalimumab trough levels in pediatric patients with inflammatory bowel disease.

Scand J Gastroenterol 2021 Sep 21:1-6. Epub 2021 Sep 21.

University of Helsinki, Children's Hospital, Helsinki, Finland.

Objectives: We evaluated the relationship between serum concentration and efficacy of adalimumab (ADA), an anti-tumor necrosis factor-alpha agent, in pediatric patients with inflammatory bowel disease (PIBD).

Materials And Methods: This retrospective cross-sectional study traced 75 patients with PIBD (Crohn's disease,  = 57) treated with ADA at two tertiary centers in Finland in 2012-2018. Drug levels and drug antibody titers were chart-reviewed, and the treatment continuation rate of ADA therapy was evaluated. Read More

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September 2021

Clinical Outcomes and Adverse Events after First-Line Treatment in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis.

J Urol 2021 Sep 21:101097JU0000000000002252. Epub 2021 Sep 21.

Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada.

Background: Four recent first-line clinical trials leveraging immune-oncology agents demonstrated an overall survival (OS) benefit relative to sunitinib. We aimed to provide formal comparisons among immune-oncology combinations in term of OS, progression-free survival (PFS), objective response rates (ORR) and treatment-related adverse events (AEs).

Methods: Pubmed database was searched for studies indexed from January 1, 2016 through March 6, 2021. Read More

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September 2021