Bioorg Med Chem Lett 2018 02 19;28(3):360-364. Epub 2017 Dec 19.
Research Institute of Pesticidal Design & Synthesis, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjing 300071, China; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, China. Electronic address:
In continuation of our program aimed at the development of natural product-based pesticidal agents, a series of andrographolide-related esters, such as 3,19-dialkyl(aryl)carbonyloxy andrographolide (3a-g), 3-alkyl(aryl)carbonyloxyandrographolide (4a-g), and 19-alkyl(aryl)carbonyloxyandrographolide (5a-g), were prepared. Their structures were well characterized by H NMR, IR, optical rotation, HRMS and mp. Especially three-dimensional structures of compounds 3a, 4g, and 5g were unambiguously confirmed by single-crystal X-ray diffraction. Read More