515 results match your criteria respiratory infection-related

Clinical and Laboratory Predictors of Mortality in COVID-19 Infection: A Retrospective Observational Study in a Tertiary Care Hospital of Eastern India.

Cureus 2021 Sep 2;13(9):e17660. Epub 2021 Sep 2.

Community and Family Medicine, All India Institute of Medical Sciences, Patna, Patna, IND.

Introduction COVID-19 is associated with huge morbidity and mortality in India. Identification of factors associated with mortality would make a difference in the management of COVID-19 infection-related illness. Objective To assess clinical & laboratory parameters associated with adverse outcomes among 984 patients with COVID-19 infection admitted to a tertiary care hospital in eastern India. Read More

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September 2021

O-JMeSH: creating a bilingual English-Japanese controlled vocabulary of MeSH UIDs through machine translation and mutual information.

Genomics Inform 2021 Sep 30;19(3):e26. Epub 2021 Sep 30.

Graduate School of Integrative Science and Engineering, Tokyo City University, Tokyo 158-8557, Japan.

Previous approaches to create a controlled vocabulary for Japanese have resorted to existing bilingual dictionary and transformation rules to allow such mappings. However, given the possible new terms introduced due to coronavirus disease 2019 (COVID-19) and the emphasis on respiratory and infection-related terms, coverage might not be guaranteed. We propose creating a Japanese bilingual controlled vocabulary based on MeSH terms assigned to COVID-19 related publications in this work. Read More

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September 2021

COVID-19 Infection-Related Coagulopathy and Acute Limb Ischemia in a Patient With Pre-existing Diabetes.

Cureus 2021 Aug 29;13(8):e17531. Epub 2021 Aug 29.

Interventional Radiology, Shaheed Mohtarma Benazir Bhutto Medical College, Dow University of Health Sciences, Karachi, PAK.

The pandemic of coronavirus 19 (COVID-19) infection has presented the clinicians with a challenge never experienced on this scale before. Although coagulopathy has been well described in association with COVID-19 infection, some recommendations have emerged so far for the potential role of empiric anticoagulation in specific situations. We describe a case of a middle-aged male with extensive acute lower limb ischemia and severe pneumonia related to COVID-19 infection. Read More

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The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients.

Viruses 2021 09 20;13(9). Epub 2021 Sep 20.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an enormous rise in scientific response with an excess of COVID-19-related studies on the pathogenesis and potential therapeutic approaches. Solid organ transplant (SOT) recipients are a heterogeneous population with long-lasting immunosuppression as a joining element. Immunocompromised patients are a vulnerable population with a high risk of severe infections and an increased infection-related mortality rate. Read More

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September 2021

Associations between gestational age at birth and infection-related hospital admission rates during childhood in England: Population-based record linkage study.

PLoS One 2021 23;16(9):e0257341. Epub 2021 Sep 23.

National Perinatal Epidemiology Unit (NPEU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, United Kingdom.

Background: Children born preterm (<37 completed weeks' gestation) have a higher risk of infection-related morbidity than those born at term. However, few large, population-based studies have investigated the risk of infection in childhood across the full spectrum of gestational age. The objectives of this study were to explore the association between gestational age at birth and infection-related hospital admissions up to the age of 10 years, how infection-related hospital admission rates change throughout childhood, and whether being born small for gestational age (SGA) modifies this relationship. Read More

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September 2021

Influenza vaccination rates and hospitalizations among Medicaid enrollees with and without sickle cell disease, 2009-2015.

Pediatr Blood Cancer 2021 Sep 20:e29351. Epub 2021 Sep 20.

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Personswith sickle cell disease (SCD) face increased risks for pulmonary and infection-related complications. This study examines influenza vaccination coverage and estimates influenza-related morbidity among Medicaid enrollees with and without SCD.

Procedure: Influenza vaccination coverage and hospitalizations related to influenza and pneumonia/acute chest syndrome (ACS) during each influenza season from 2009-2010 to 2014-2015 were assessed among enrollees in the IBM MarketScan® Multi-State Medicaid Database. Read More

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September 2021

FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.

Clin Exp Med 2021 Sep 12. Epub 2021 Sep 12.

Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, 524023, Guangdong, China.

FURIN, as a proprotein convertase, has been found to be expressed in a variety of cancers and plays an important role in cancer. In addition, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires FURIN to enter human cells. However, the role of FURIN in lung adenocarcinoma remains unclear. Read More

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September 2021

Anti-LPS IgA and IgG can inhibit serum killing of in patients with cystic fibrosis.

Infect Immun 2021 Aug 30:IAI0041221. Epub 2021 Aug 30.

The University of Queensland Diamantina Institute, The University of Queensland, Brisbane 4102, QLD, Australia.

is one of the principal pathogens implicated in respiratory infections of patients with cystic fibrosis (CF) and non-CF bronchiectasis. Previously, we demonstrated that impaired serum-mediated killing of was associated with increased severity of respiratory infections in patients with non-CF bronchiectasis. This inhibition was mediated by high titres of O-antigen-specific IgG2 antibodies that cloak the surface of the bacteria, blocking access to the membrane. Read More

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Effect of Obesity on Clinical Failure of Patients Treated With β-Lactams.

Open Forum Infect Dis 2021 Aug 27;8(8):ofab212. Epub 2021 Apr 27.

Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, Mississippi, USA.

Background: Altered pharmacokinetics in obese patients raise concerns over worse clinical outcomes. This study assessed whether obese patients receiving a β-lactam have worse clinical outcomes compared to nonobese patients and to identify if therapeutic drug monitoring may be beneficial.

Methods: This multicenter, retrospective cohort included hospitalized adults admitted from July 2015 to July 2017 treated with a β-lactam as definitive monotherapy against a gram-negative bacilli for ≥72 hours. Read More

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Infectious complications of CAR T-cell therapy: a clinical update.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211036773. Epub 2021 Aug 24.

Department of Haematology and Bone Marrow Transplantation, Royal Brisbane and Women's Hospital, Brisbane, AustraliaQIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.

Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary treatment modality used to treat haematological malignancies. Lymphocytes are engineered to produce CARs directed towards tumour cell antigens. Clinical trials have demonstrated impressive malignancy-related outcomes. Read More

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Thrombosis in COVID-19 infection: Role of platelet activation-mediated immunity.

Thromb J 2021 Aug 23;19(1):59. Epub 2021 Aug 23.

Dezful university of medical sciences, Dezful, Iran.

Background: Thrombosis plays an important role in the Coronavrus Disease 2019 (COVID-19) infection-related complications such as acute respiratory distress syndrome and myocardial infarction. Multiple factors such as oxygen demand injuries, endothelial cells injury related to infection, and plaque formation.

Main Body: Platelets obtained from the patients may have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, showing that the increased activation potential recommends platelet can be hyper-activated in severely ill SARS-CoV-2 cases. Read More

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Mechanism of Fei-Xian Formula in the Treatment of Pulmonary Fibrosis on the Basis of Network Pharmacology Analysis Combined with Molecular Docking Validation.

Evid Based Complement Alternat Med 2021 3;2021:6658395. Epub 2021 Aug 3.

Department of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu Province, China.

Objective: This study aimed to clarify the mechanism of Fei-Xian formula (FXF) in the treatment of pulmonary fibrosis based on network pharmacology analysis combined with molecular docking validation.

Methods: Firstly, ingredients in FXF with pharmacological activities, together with specific targets, were identified based on the BATMA-TCM and TCMSP databases. Then, targets associated with pulmonary fibrosis, which included pathogenic targets as well as those known therapeutic targets, were screened against the CTD, TTD, GeneCards, and DisGeNet databases. Read More

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Efficacy of Brincidofovir in Pediatric Stem Cell Transplant Recipients With Adenovirus Infections.

J Pediatric Infect Dis Soc 2021 Aug 11. Epub 2021 Aug 11.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.

Background: Adenovirus (AdV) infections are of particular concern in pediatric hematopoietic stem cell transplantation (HSCT) recipients as therapeutic options are limited. Brincidofovir (BCV) is the lipid-conjugated pro-drug of cidofovir (CDV) with oral bioavailability and higher intracellular concentrations of the active drug.

Methods: In this retrospective, single-center analysis, we included allogeneic pediatric HSCT recipients with refractory AdV infections because of contraindications or insufficient response to CDV. Read More

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Real-life drug persistence in patients with rheumatic diseases treated with CT-P13: a prospective observational cohort study (PERSIST).

Rheumatol Adv Pract 2021 23;5(2):rkab026. Epub 2021 Apr 23.

Clinical Research Unit in Rheumatology, Institut de rhumatologie de Montréal, Montreal, QC, Canada.

Objective: The aim was to report results from PERSIST, a real-life, observational, prospective cohort study of CT-P13, an infliximab (IFX) biosimilar, for treatment of patients with RA, AS or PsA who were biologic naïve or switched from an IFX reference product (IFX-RP; Remicade).

Methods: Adult patients were recruited during usual care at 38 sites in Europe and Canada and enrolled by their physicians after meeting eligibility criteria according to the country-approved label for CT-P13. Primary outcomes were to determine drug utilization and treatment persistence and to assess safety. Read More

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Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.

J Am Geriatr Soc 2021 Aug 10. Epub 2021 Aug 10.

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.

The burden of senescent cells (SnCs), which do not divide but are metabolically active and resistant to death by apoptosis, is increased in older adults and those with chronic diseases. These individuals are also at the greatest risk for morbidity and mortality from SARS-CoV-2 infection. SARS-CoV-2 complications include cytokine storm and multiorgan failure mediated by the same factors as often produced by SnCs through their senescence-associated secretory phenotype (SASP). Read More

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Anti-GAD associated post-infectious cerebellitis after COVID-19 infection.

Neurol Sci 2021 Oct 30;42(10):3995-4002. Epub 2021 Jul 30.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

The coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread rapidly all over the world. Besides severe pneumonia, it causes multisystemic disease, including neurological findings. Here, we present a patient with anti-glutamic acid decarboxylase (anti-GAD) antibody-associated cerebellitis developed after COVID-19 infection. Read More

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October 2021

First finding of Streptococcus phocae infections in mink (Neovison vison).

Res Vet Sci 2021 Oct 16;139:145-151. Epub 2021 Jul 16.

National Veterinary Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

Streptococcus phocae infection has been described in salmon, sea otters, and several families of pinnipeds. The pathology of the infected animals has mainly been located in the respiratory tract and reproductive system, and with indications of septicemia. In this study, we report the finding of S. Read More

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October 2021

Associations between the indoor microbiome, environmental characteristics and respiratory infections in junior high school students of Johor Bahru, Malaysia.

Environ Sci Process Impacts 2021 Aug 19;23(8):1171-1181. Epub 2021 Jul 19.

Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, PR China.

Pathogens are commonly present in the human respiratory tract, but symptoms are varied among individuals. The interactions between pathogens, commensal microorganisms and host immune systems are important in shaping the susceptibility, development and severity of respiratory diseases. Compared to the extensive studies on the human microbiota, few studies reported the association between indoor microbiome exposure and respiratory infections. Read More

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Availability of facility resources and services and infection-related maternal outcomes in the WHO Global Maternal Sepsis Study: a cross-sectional study.

Lancet Glob Health 2021 09 21;9(9):e1252-e1261. Epub 2021 Jul 21.

Centro Rosarino de Estudios Perinatales (CREP), Rosario, Argentina.

Background: Infections are among the leading causes of maternal mortality and morbidity. The Global Maternal Sepsis and Neonatal Initiative, launched in 2016 by WHO and partners, sought to reduce the burden of maternal infections and sepsis and was the basis upon which the Global Maternal Sepsis Study (GLOSS) was implemented in 2017. In this Article, we aimed to describe the availability of facility resources and services and to analyse their association with maternal outcomes. Read More

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September 2021

Long-Residence Pneumonia Vaccine Developed Using PEG-Grafted Hybrid Nanovesicles from Cell Membrane Fusion of Mycoplasma and IFN-γ-Primed Macrophages.

Small 2021 08 16;17(34):e2101183. Epub 2021 Jul 16.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.

CD8 T cell responses play a critical regulatory role in protection against mycoplasma infection-related respiratory diseases. Nanovesicles derived from cell membranes have been shown to induce CD8 T cell responses. Moreover, the short residence time of mycoplasma membrane-related vaccines in local lymph nodes limits the efficacy of current mycoplasma vaccines. Read More

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Complex movement disorders in SARS-CoV-2 infection induced acute disseminated encephalomyelitis.

J Neuroimmunol 2021 09 30;358:577655. Epub 2021 Jun 30.

Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain. Electronic address:

Movement disorders are extremely rare in acute disseminated encephalomyelitis (ADEM) and in the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. We herein report a 34-years-old previously healthy woman who presented with a febrile illness and a constellation of movement disorders (predominantly myoclonus) followed by encephalopathy. After exclusion of common infectious, autoimmune and paraneoplastic etiologies, she was diagnosed to have COVID-19 induced ADEM, which responded to intravenous methylprednisolone and intravenous immunoglobulin. Read More

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September 2021

Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.

Crit Care Med 2021 Jul 12. Epub 2021 Jul 12.

4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen, The Netherlands. Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany. Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Objective: Coronavirus disease 2019 is a heterogeneous disease most frequently causing respiratory tract infection, which can induce respiratory failure and multiple organ dysfunction syndrome in its severe forms. The prevalence of coronavirus disease 2019-related sepsis is still unclear; we aimed to describe this in a systematic review.

Data Sources: MEDLINE (PubMed), Cochrane, and Google Scholar databases were searched based on a prespecified protocol (International Prospective Register for Systematic Reviews: CRD42020202018). Read More

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Neuropilin-1: A feasible link between liver pathologies and COVID-19.

World J Gastroenterol 2021 Jun;27(24):3516-3529

Department of Cellular Biology and Histology, School of Medicine and Nursing, University of the Basque Country, Leioa 48940, Bizkaia, Spain.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has a tremendous impact on the health of millions of people worldwide. Unfortunately, those suffering from previous pathological conditions are more vulnerable and tend to develop more severe disease upon infection with the new SARS-CoV-2. This coronavirus interacts with the angiotensin-converting enzyme 2 receptor to invade the cells. Read More

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Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids.

Respir Res 2021 Jul 7;22(1):200. Epub 2021 Jul 7.

Department of Genetic Medicine, Weill Cornell Medical College, 1300 York Avenue, Box 164, New York, NY, 10065, USA.

Background: The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter SARS-CoV-2. Epidemiologic data suggests that asthmatics who get infected may be at increased risk of more severe disease. Read More

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Sudden unexpected death in infancy: Severe pulmonary anatomopathological findings in spite of inconsistent clinical features.

Med Leg J 2021 Sep 4;89(3):173-177. Epub 2021 Jul 4.

Section of Legal Medicine, S. Chiara Hospital, University of Pisa, Pisa, Italy.

Respiratory tract infections play a considerable pathogenetic role in many cases of sudden infant death (SID). Frequently, clinicians encounter difficulties in diagnosing the disease because of its often unspecific clinical and radiological presentation. We report three cases of sudden unexpected death in infancy (SUDI), involving two males and one female admitted to hospital due to mild respiratory distress. Read More

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September 2021

Analysis of Nosocomial Infection and Risk Factors in Patients with ECMO Treatment.

Infect Drug Resist 2021 25;14:2403-2410. Epub 2021 Jun 25.

Office of the Dean, Jiangsu Shengze Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu, 215228, People's Republic of China.

Objective: To investigate the drug resistance of nosocomial infection-related pathogens in patients who underwent extracorporeal membrane oxygenation (ECMO), analyzing the nosocomial infection-related risk factors.

Methods: The medical records of 56 patients who received ECMO support treatment in the First Affiliated Hospital with Nanjing Medical University from January 2013 to December 2019 were selected. The nosocomial infection, pathogen distribution and drug resistance, and the influencing factors of nosocomial infection were analyzed. Read More

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Timing and causes of death in severe COVID-19 patients.

Crit Care 2021 06 30;25(1):224. Epub 2021 Jun 30.

Intensive Care Unit, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

Background: Previous studies reporting the causes of death in patients with severe COVID-19 have provided conflicting results. The objective of this study was to describe the causes and timing of death in patients with severe COVID-19 admitted to the intensive care unit (ICU).

Methods: We performed a retrospective study in eight ICUs across seven French hospitals. Read More

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The Reasons for Higher Mortality Rate in Opium Addicted Patients with COVID-19: A Narrative Review.

Iran J Public Health 2021 Mar;50(3):470-479

Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused COVID-19 has developed into an unexampled worldwide pandemic. The most important cause of death in patients with COVID-19 is Acute Respiratory Distress Syndrome (ARDS). Opium is widely used for its analgesic features in control of acute and chronic pain related to different diseases. Read More

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Bloodstream Infections in Preterm Neonates and Mortality-Associated Risk Factors.

J Pediatr 2021 Oct 22;237:206-212.e1. Epub 2021 Jun 22.

Department of pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To investigate the association of early (±4 hours after onset of bloodstream infection) clinical and laboratory variables with episode-related mortality (<7 days).

Study Design: This 2-site retrospective study included 142 neonates born at <35 weeks of gestational age with positive blood/cerebrospinal fluid (CSF) culture at >72 hours of age from organisms other than coagulase-negative Staphylococcus. Early variables were compared between those with bloodstream infection-related mortality and survivors. Read More

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October 2021

Male pituitary-gonadal axis dysfunction in post-acute COVID-19 syndrome-Prevalence and associated factors: A Mediterranean case series.

Clin Endocrinol (Oxf) 2021 Jun 23. Epub 2021 Jun 23.

Endocrinology and Nutrition Department, Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.

Objective: Severe acute respiratory syndrome coronavirus 2 through angiotensin-converting enzyme 2 receptor can harm testes function. The objectives were to analyse the prevalence of low serum testosterone (LT) and impaired fertility potential (Leydig and Sertoli cells dysfunction, respectively) in coronavirus disease 2019 (COVID-19) male survivors and to evaluate acute infection-related associated factors. Also, we explore its association with post-acute COVID-19 syndrome (PCS) and quality of life (QOL). Read More

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