61,635 results match your criteria respiratory distress

Anesthetic Management for Awake Tubeless Suspension Microlaryngoscopy.

Laryngoscope 2021 Apr 21. Epub 2021 Apr 21.

Department of Otorhinolaryngology-Head and Neck Surgery, Rouen University Hospital, Rouen, France.

Objectives/hypothesis: Patients' eligibility for bilateral selective laryngeal reinnervation surgery is evaluated by suspension microlaryngoscopy (SML) examination with laryngeal electromyography (LEMG). Maintaining spontaneous ventilation, with remifentanil sedation/analgesia without endotracheal tube, to allow the patient to phonate with the surgeon during awake, LEMG is a major challenge for the anesthesiologist and the otorhinololaryngologist. The objective of this study was to evaluate the safety and efficacy of a novel anesthesia protocol to manage airway access during awake tubeless SML. Read More

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Acute Severe Mitral Regurgitation Secondary to Ischemic Papillary Muscle Rupture: A Case Report.

Cureus 2021 Mar 19;13(3):e13996. Epub 2021 Mar 19.

Cardiology, Overlook Medical Center, Summit , USA.

Mitral valve rupture secondary to ischemic papillary muscle necrosis is rare in the contemporary era due to improved revascularization techniques. However, when it does occur, prompt diagnosis and urgent surgical intervention can be lifesaving. A 69-year-old male with morbid obesity, hypothyroidism, and a family history of coronary artery disease presented to the hospital with chest pain and dyspnea that began five hours prior. Read More

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Diabetic Ketoacidosis at Onset of Pediatric Type-1 Diabetes Triggered by Covid-19: An Original Case Report.

Cureus 2021 Mar 17;13(3):e13958. Epub 2021 Mar 17.

Department of Diabetology and Endocrinology, Mohammed VI University Hospital, Mohamed I University, Oujda, MAR.

During the course of this year, scientific research has revolved around coronavirus disease 2019 (COVID-19), with much uncertainty surrounding its pathogenesis, complications, and mortality as well as limited pediatric evidence. The exact relationship between COVID-19 and new-onset type 1 diabetes, especially in children, remains an unresolved issue. Our case exhibited a unique presentation of diabetic ketoacidosis (DKA) triggering COVID-19 diagnosis at this age. Read More

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Idiopathic Sclerosing Encapsulating Peritonitis in a Patient with Atypical Symptoms and Imaging Findings.

Case Rep Gastrointest Med 2021 7;2021:6695806. Epub 2021 Apr 7.

Internal Medicine, St Vincent's Medical Center, Bridgeport, CT, USA.

Sclerosing encapsulating peritonitis is a rare condition caused by a fibrotic membrane covering the small bowel which may lead to abdominal pain or obstruction. The cause may be primary and idiopathic or secondary to several diseases, treatments, and/or medications. The condition typically presents with bowel obstruction, and only one previous case has described ascites as the presenting sign. Read More

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Potential Antioxidative, Anti-inflammatory and Immunomodulatory Effects of Ghrelin, an Endogenous Peptide from the Stomach in SARS-CoV2 Infection.

Int J Pept Res Ther 2021 Apr 16:1-9. Epub 2021 Apr 16.

Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, PO Box 5715799313, Urmia, Iran.

The current COVID-19 pandemic is one of the most devastating events in recent history. The respiratory effects of this disease include acute respiratory distress syndrome, systemic inflammation, cytokine storm, and pulmonary fibrosis. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is a peptide hormone secreted mainly by the stomach. Read More

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LXA4 Inhibits Lipopolysaccharide-Induced Inflammatory Cell Accumulation by Resident Macrophages in Mice.

J Inflamm Res 2021 12;14:1375-1385. Epub 2021 Apr 12.

Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.

Introduction: Alveolar macrophages that regulate the inflammatory response in lungs are the main target cell for the treatment of inflammatory pulmonary pathologies, such as acute respiratory distress syndrome (ARDS). Yolk sac derived alveolar resident macrophages play an important role in the pulmonary inflammatory response. With regards to anti-inflammatory actions, lipoxin A4 (LXA4) has been identified as an inflammatory "braking signal". Read More

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A study of red cell distribution width and neonatal sepsis at Soba University Hospital, Khartoum, Sudan.

Sudan J Paediatr 2021 ;21(1):42-47

Soba University Hospital, Khartoum, Sudan.

Neonatal sepsis is one of the most critical illnesses in newborns with significant morbidity and mortality, particularly in developing countries. The present, cross-sectional, hospital-based, study was conducted to evaluate the association of red cell distribution width (RDW) with neonatal sepsis and its role as a predictive marker in the diagnosis of neonatal sepsis at Soba University Hospital, during the period July 2018 to April 2019. The study population was term neonates, aged 1-28 days, who were diagnosed with neonatal sepsis, with positive blood culture. Read More

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January 2021

Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19.

Aging (Albany NY) 2021 Apr 20;13. Epub 2021 Apr 20.

Peking University Shenzhen Hospital, Clinical College of Anhui Medical University, Shenzhen 518036, Guangdong, China.

Coronavirus disease 2019 (COVID-19) experienced an outbreak that expanded worldwide. Lopinavir/ritonavir (LPV/r), which is used effectively for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections, was applied for COVID-19 treatment given similarities in the molecular structures of these viruses. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of lopinavir/ritonavir antiviral treatment in patients with SARS, MERS, and COVID-19. Read More

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Evolution of treatment of femoral shaft fracture in polytrauma: Did damage control orthopaedics improve the outcome? A retrospective study.

Injury 2021 Apr 9. Epub 2021 Apr 9.

Orthopedic Trauma Service, Hadassah University Hospital, Jerusalem, Israel; Orthopedic Department, Hadassah University Hospital, Jerusalem, Israel. Electronic address:

Background: Treatment of polytrauma patients with femoral shaft fracture has changed considerably during the past few decades. A transition from early total care (ETC) to "Damage Control" Orthopaedics (DCO) in selected patients was proposed in order to decrease mortality. The aim of the study was to investigate whether this policy change resulted in improved patient outcome. Read More

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Anxious? Don't Forget... So is Grandpa.

Ankita Adhia

Sr Care Pharm 2021 May;36(5):226-227

Despite the support systems that may be available, the scope of the recent pandemic is debilitating on a multitude of levels including, but not limited to, psychological, social, and financial. Older people already coping with mental distress on the sidelines of chronic illness, may be further compromised. The older person with chronic obstructive pulmonary disease (COPD) often struggles to withstand the anxiety and depression that is intertwined with symptoms of worsening respiratory function. Read More

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Novel criteria to classify ARDS severity using a machine learning approach.

Crit Care 2021 04 20;25(1):150. Epub 2021 Apr 20.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

Background: Usually, arterial oxygenation in patients with the acute respiratory distress syndrome (ARDS) improves substantially by increasing the level of positive end-expiratory pressure (PEEP). Herein, we are proposing a novel variable [PaO/(FiOxPEEP) or P/FP] for PEEP ≥ 5 to address Berlin's definition gap for ARDS severity by using machine learning (ML) approaches.

Methods: We examined P/FP values delimiting the boundaries of mild, moderate, and severe ARDS. Read More

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Transcranial Doppler in Acute COVID-19 Infection: Unexpected Associations.

Stroke 2021 Apr 21:STROKEAHA120032150. Epub 2021 Apr 21.

Dvision of Stroke, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD. (M.C.J., M.N.B.).

Background And Purpose: Stroke may complicate coronavirus disease 2019 (COVID-19) infection based on clinical hypercoagulability. We investigated whether transcranial Doppler ultrasound has utility for identifying microemboli and clinically relevant cerebral blood flow velocities (CBFVs) in COVID-19.

Methods: We performed transcranial Doppler for a consecutive series of patients with confirmed or suspected COVID-19 infection admitted to 2 intensive care units at a large academic center including evaluation for microembolic signals. Read More

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General anaesthesia in end-of-life care: extending the indications for anaesthesia beyond surgery.

Anaesthesia 2021 Apr 20. Epub 2021 Apr 20.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

In this article, we describe an extension of general anaesthesia - beyond facilitating surgery - to the relief of suffering during dying. Some refractory symptoms at the end of life (pain, delirium, distress, dyspnoea) might be managed by analgesia, but in high doses, adverse effects (e.g. Read More

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Epidemiological and Clinical Presentations of Hospitalized COVID-19 patients in Libya: an initial report from Africa.

Travel Med Infect Dis 2021 Apr 17:102064. Epub 2021 Apr 17.

Faculty of Medicine, University of Tripoli, Tripoli, Libya. Electronic address:

Background: The first case of the novel coronavirus disease 2019 (COVID-19) in Libya was diagnosed in March 2020. We aimed to determine the epidemiological, clinical, and laboratory characteristics of COVID-19 in Libya.

Method: In this retrospective descriptive study, we analyzed the demographics, initial clinical presentation, history, comorbidities, laboratory findings, complications, and outcomes of hospitalized patients with COVID-19 at several centers in the Western part of Libya between March 24, 2020, and December 3, 2020. Read More

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Development of a Prone Team and Exploration of Staff Perceptions During COVID-19.

AACN Adv Crit Care 2021 Apr 22:e1-e10. Epub 2021 Apr 22.

Xianghong Sean Wang is Senior Data Analyst, Patient Care Services Quality, Safety & Practice, Massachusetts General Hospital, Boston, Massachusetts.

Objective: As intensive care unit bed capacity doubled due to COVID-19 cases, nursing leaders created a prone team to support labor-intensive prone positioning of patients with COVID-related acute respiratory distress syndrome. The goal of the prone team was to reduce workload on intensive care teams, standardize the proning process, mitigate pressure injuries and turning-related adverse events, and ensure prone team safety.

Methods: Staff were trained using a hybrid learning model focused on prone-positioning techniques, pressure injury prevention, and turning-related adverse events. Read More

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7q35q36.3 deletion and concomitant 20q13.2q13.33 duplication in a newborn: familiar case.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):2949-2957

Unit of Medical Genetics, "Madonna delle Grazie" Hospital, Matera, Italy.

Objective: Array-CGH is a powerful tool in identifying and characterizing complex genomic rearrangements smaller than 5-10 megabase (Mb), for which classical cytogenetic approaches are not sensitive enough. The use of Array-CGH has increased of 10-20% the detection rate of unbalanced cryptic rearrangements, such as deletions and/or duplications.

Patients And Methods: We present here the first report of a patient with 7q35q36. Read More

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The potential role of miR-124-3p in tumorigenesis and other related diseases.

Mol Biol Rep 2021 Apr 20. Epub 2021 Apr 20.

Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, 01610, USA.

MicroRNAs (miRNAs) are a class of single-stranded noncoding and endogenous RNA molecules with a length of 18-25 nucleotides. Previous work has shown that miR-124-3p leads to malignant progression of cancer including cell apoptosis, migration, invasion, drug resistance, and also recovers neural function, affects adipogenic differentiation, facilitates wound healing through control of various target genes. miR-124-3p has been mainly previously characterized as a tumor suppressor regulating tumorigenesis and progression in several cancers, such as hepatocellular carcinoma (HCC), gastric cancer (GC), bladder cancer, ovarian cancer (OC), and leukemia, as a tumor promotor in breast cancer (BC), and it has been also widely studied in a variety of neurological diseases, like Parkinson's disease (PD), dementia and Alzheimer's disease (AD), and cardiovascular diseases, ulcerative colitis (UC), acute respiratory distress syndrome (ARDS). Read More

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Characteristics of the 24-hour ambulatory blood pressure monitoring in a COVID-19 survivor.

Future Cardiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.

COVID-19 infection primarily causes severe pneumonia complicated by acute respiratory distress syndrome and multiorgan failure requiring a ventilator support. We present a case of a 55-year-old male, admitted with COVID-19. He was obese but had no other medical conditions. Read More

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Assessment of morbidity and mortality in newborns with late prematurity: experience of a reference maternity in the northeast of Brazil.

Minerva Obstet Gynecol 2021 Apr 20. Epub 2021 Apr 20.

Department of Maternal and Child Health, Federal University of Ceará (UFC), Fortaleza-CE, Brazil.

Background: Late preterm infants show high rates of adverse perinatal outcomes. The aim of this study is to assess the morbidity and mortality of newborns (NBs) with late preterm birth in a reference maternity hospital in northeastern Brazil.

Methods: Retrospective cohort study from March 1 to July 15, 2017. Read More

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Comparative Efficacy of Fentanyl and Morphine in Patients with or At Risk for Acute Respiratory Distress Syndrome: A Propensity Score-Matched Cohort Study.

Drugs R D 2021 Apr 19. Epub 2021 Apr 19.

Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital, No. 1017 Dongmen North Road, Shenzhen, 518020, Guangdong, China.

Introduction: Opioids are potent painkillers but can have severe adverse effects in the intensive care unit (ICU). The aim of this study was to compare the outcomes of fentanyl and morphine use among patients at risk for and with acute respiratory distress syndrome (ARDS).

Methods: We developed a dataset of real-world data to enable the comparison of the effectiveness and safety of opioids and the associated outcomes from the Multiparameter Intelligent Monitoring in Intensive Care (MIMIC)-III database and the eICU Collaborative Research Database. Read More

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Neonatal listeriosis presentation and outcome: a prospective study of 189 cases.

Clin Infect Dis 2021 Apr 20. Epub 2021 Apr 20.

Institut Pasteur, Biology of Infection Unit, Paris, France.

Context: Listeriosis is caused by the foodborne pathogen Listeria monocytogenes. It can present as a maternal-neonatal infection. We implemented the nationwide prospective cohort MONALISA and analyzed the features of neonatal listeriosis. Read More

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Identifying clinical and biochemical phenotypes in acute respiratory distress syndrome secondary to coronavirus disease-2019.

EClinicalMedicine 2021 Apr 15:100829. Epub 2021 Apr 15.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114, USA.

Background: Acute respiratory distress syndrome (ARDS) secondary to coronavirus disease-2019 (COVID-19) is characterized by substantial heterogeneity in clinical, biochemical, and physiological characteristics. However, the pathophysiology of severe COVID-19 infection is poorly understood. Previous studies established clinical and biological phenotypes among classical ARDS cohorts, with important therapeutic implications. Read More

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Therapeutic effects and outcomes of rescue high-frequency oscillatory ventilation for premature infants with severe refractory respiratory failure.

Sci Rep 2021 Apr 19;11(1):8471. Epub 2021 Apr 19.

Division of Neonatology and Pediatric Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, No.707, Gongye Rd., Sansheng, Mailiao Township, Yunlin, Taiwan, ROC.

Despite wide application of high frequency oscillatory ventilation (HFOV) in neonates with respiratory distress, little has been reported about its rescue use in preterm infants. We aimed to evaluate the therapeutic effects of HFOV in preterm neonates with refractory respiratory failure and investigate the independent risk factors of in-hospital mortality. We retrospectively analyzed data collected prospectively (January 2011-December 2018) in four neonatal intensive care units of two tertiary-level medical centers in Taiwan. Read More

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Severe metabolic ketoacidosis as a primary manifestation of SARS-CoV-2 infection in non-diabetic pregnancy.

BMJ Case Rep 2021 Apr 19;14(4). Epub 2021 Apr 19.

Obstetrics & Gynaecology, Amsterdam UMC Location AMC, Amsterdam, North Holland, The Netherlands.

We present a case of a metabolic acidosis in a term-pregnant woman with SARS-CoV-2 infection.Our patient presented with dyspnoea, tachypnoea, thoracic pain and a 2-day history of vomiting, initially attributed to COVID-19 pneumonia. Differential diagnosis was expanded when arterial blood gas showed a high anion gap metabolic non-lactate acidosis without hypoxaemia. Read More

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Dyspnea and respiratory muscles ultrasound to predict extubation failure.

Eur Respir J 2021 Apr 19. Epub 2021 Apr 19.

AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service de Pneumologie, Médecine intensive Réanimation (Département R3S), Paris, France.

This study investigated dyspnea intensity and respiratory muscles ultrasound early after extubation to predict extubation failure.It was conducted prospectively in two intensive care units in France and Canada. Patients intubated for at least 48 h were studied within 2 h after an extubation following a successful spontaneous breathing trial. Read More

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Interferon Regulatory Factor 5 siRNA-Loaded Folate-Modified Cationic Liposomes for Acute Lung Injury Therapy.

J Biomed Nanotechnol 2021 Mar;17(3):466-476

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an overwhelming pulmonary inflammation with limited clinical treatment strategies. Interferon regulatory factor 5 (IRF5) is a crucial regulator of inflammation factors, which can be upregulated under an inflammatory state and related to the efferocytosis of macrophages. Herein, IRF5 was knockdown by small interfering RNA (siIRF5) to promote the anti-inflammatory effect of macrophages. Read More

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A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial.

Trials 2021 Apr 19;22(1):288. Epub 2021 Apr 19.

Royal College of Surgeons in Ireland, Dublin, Ireland.

Objectives: The primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin®(plasma-purified alpha-1 antitrypsin) reduces circulating plasma levels of interleukin-6 (IL-6). Secondary objectives are to determine the effects of intravenous Prolastin® on important clinical outcomes including the incidence of adverse events (AEs) and serious adverse events (SAEs).

Trial Design: Phase 2, randomised, double-blind, placebo-controlled, pilot trial. Read More

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Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study.

Crit Care 2021 04 19;25(1):148. Epub 2021 Apr 19.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.

Background: Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19.

Methods: We prospectively enrolled 171 ICU patients, including 78 (46%) patients positive and 93 (54%) negative for SARS-CoV-2 infection from April to September, 2020. Read More

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[Effects of positive end-expiratory pressure setting of mechanical ventilation guided by esophageal pressure in the treatment of patients with traumatic craniocerebral injury and acute respiratory distress syndrome].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-7. Epub 2021 Mar 24.

Department of Intensive Care Unit, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 453000, China.

To investigate the effects of positive end-expiratory pressure (PEEP) setting of mechanical ventilation guided by esophageal pressure in the treatment of patients with traumatic craniocerebral injury and acute respiratory distress syndrome (ARDS). The retrospective cohort study was conducted. From June 2016 to June 2018, 55 patients with traumatic craniocerebral injury and ARDS who met the inclusion criteria were admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University. Read More

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Management of COVID-19: Current Status and Future Prospects.

Microbes Infect 2021 Apr 16:104832. Epub 2021 Apr 16.

Department of Computer & Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL 33431; Asghar-Lab, Micro and Nanotechnology in Medicine, College of Engineering and Computer Science, Boca Raton, FL 33431; Department of Biological Sciences (Courtesy Appointment), Florida Atlantic University, Boca Raton, FL 33431. Electronic address:

COVID-19, a highly transmissible pandemic disease, affecting millions of lives around the world. Severely infected patients show acute respiratory distress symptoms. Sustainable management strategies are required to save the lives of the infected people and further preventing spread of the virus. Read More

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