10,255 results match your criteria respiratory burst

Impacts of pineapple peel powder on growth performance, innate immunity, disease resistance, and relative immune gene expression of Nile tilapia, Oreochromis niloticus.

Fish Shellfish Immunol 2021 Apr 9. Epub 2021 Apr 9.

Fish Nutrition Research Laboratory, Animal Production Department, Faculty of Agriculture, Cairo University, Cairo, Egypt.

An 8-week growth trial was conducted to examine the efficacy of pineapple peel powder (PAPP) on growth rate and immunity of Nile tilapia, O. niloticus. Three hundred Nile tilapia (20. Read More

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From Flies to Men: ROS and the NADPH Oxidase in Phagocytes.

Front Cell Dev Biol 2021 26;9:628991. Epub 2021 Mar 26.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which are predominantly localized to endosomes, and the electron transport chain in mitochondria are the major sources of ROS. Like any powerful immunological process, ROS formation has costs, in particular collateral tissue damage of the host. Read More

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Mitochondrial Reactive Oxygen Species Regulate Immune Responses of Macrophages to .

Front Immunol 2021 25;12:641495. Epub 2021 Mar 25.

Medical Research Council Centre for Medical Mycology at the University of Exeter, Geoffrey Pope Building, University of Exeter, Exeter, United Kingdom.

Reactive Oxygen Species (ROS) are highly reactive molecules that can induce oxidative stress. For instance, the oxidative burst of immune cells is well known for its ability to inhibit the growth of invading pathogens. However, ROS also mediate redox signalling, which is important for the regulation of antimicrobial immunity. Read More

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Dietary astaxanthin augments disease resistance of Asian seabass, Lates calcarifer (Bloch, 1790) against Vibrio alginolyticus infection.

Fish Shellfish Immunol 2021 Apr 7. Epub 2021 Apr 7.

Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia; International Institute of Aquaculture and Aquatic Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

This investigation describes the impacts of dietary provisioning with astaxanthin on hemato-biochemistry, non-specific immunity, and disease resistance of the Asian seabass, Lates calcarifer against the virulent Vibrio alginolyticus, with specific reference to dose-response associations and variations over different post-infection periods (0-, 7-, and 14-day). Triplicate groups of fish weighing 28 g, on average, were fed various diets (C, the control or astaxanthin-free; AXT50, 50 mg astaxanthin kg diet; AXT100, 100 mg astaxanthin kg diet; and AXT150, 150 mg astaxanthin kg diet) for 90 days and subsequently challenged with V. alginolyticus at the end of the feeding period. Read More

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The Characterization of the Toll of Caring for Coronavirus Disease 2019 on ICU Nursing Staff.

Crit Care Explor 2021 Apr 2;3(4):e0380. Epub 2021 Apr 2.

Jefferson College of Nursing, Thomas Jefferson University, Philadelphia, PA.

Objectives: Coronavirus disease 2019 pandemic exercised a significant demand on healthcare workers. We aimed to characterize the toll of caring for coronavirus disease 2019 patients by registered nurses.

Design: An observational study of two registered nurses cohorts. Read More

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Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress.

Plant Cell 2020 Nov;32(11):3425-3435

Division of Plant Sciences, College of Agriculture Food and Natural Resources, and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65201.

Systemic signaling and systemic acquired acclimation (SAA) are essential for plant survival during episodes of environmental stress. Recent studies highlighted a key role for reactive oxygen species (ROS) signaling in mediating systemic responses and SAA during light stress in Arabidopsis (Arabidopsis thaliana). These studies further identified the RESPIRATORY BURST OXIDASE HOMOLOG D (RBOHD) protein as a key player in mediating rapid systemic ROS responses. Read More

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November 2020

Sulfate import in Typhimurium impacts bacterial aggregation and the respiratory burst in human neutrophils.

Infect Immun 2021 Apr 5. Epub 2021 Apr 5.

Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA

During enteric salmonellosis, neutrophil generated reactive oxygen species alter the gut microenvironment favoring survival of Typhimurium. While the type-3 secretion system-1 (T3SS-1) and flagellar motility are potent Typhimurium agonists of the neutrophil respiratory burst neither of these pathways alone are responsible for stimulation of a maximal respiratory burst. In order to identify Typhimurium genes that impact the magnitude of the neutrophil respiratory burst, we performed a two-step screen of defined mutant libraries in co-culture with human neutrophils. Read More

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Immune Evasion of .

Pathogens 2021 Mar 4;10(3). Epub 2021 Mar 4.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, China.

causes various chronic inflammatory diseases, including mastitis and bronchopneumonia, in dairy and feed cattle. It has been found to suppress the host immune response during infection, leading to the development of chronic conditions. Both in vitro and in vivo studies have confirmed that can induce proinflammatory cytokines and chemokines in the host. Read More

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Crosstalk between Brassinosteroid and Redox Signaling Contributes to the Activation of CBF Expression during Cold Responses in Tomato.

Antioxidants (Basel) 2021 Mar 25;10(4). Epub 2021 Mar 25.

Department of Horticulture, Zijingang Campus, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.

Brassinosteroids (BRs) play a critical role in plant responses to stress. However, the interplay of BRs and reactive oxygen species signaling in cold stress responses remains unclear. Here, we demonstrate that a partial loss of function in the BR biosynthesis gene resulted in lower whilst overexpression of led to increased levels of () transcripts. Read More

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Eco-Environmental Aspects of COVID-19 Pandemic and Potential Control Strategies.

Int J Environ Res Public Health 2021 03 27;18(7). Epub 2021 Mar 27.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A3K7, Canada.

A new coronavirus-strain from a zoonotic reservoir (probably bat)-termed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-has recently claimed more than two million deaths worldwide. Consequently, a burst of scientific reports on epidemiology, symptoms, and diagnosis came out. However, a comprehensive understanding of eco-environmental aspects that may contribute to coronavirus disease 2019 (COVID-19) spread is still missing, and we therefore aim to focus here on these aspects. Read More

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Immuno-stimulatory effect and toxicology studies of salt pan bacteria as probiotics to combat shrimp diseases in aquaculture.

Fish Shellfish Immunol 2021 Mar 31;113:69-78. Epub 2021 Mar 31.

Department of Biotechnology, Goa University, Taleigao Plateau, Goa, 403206, India. Electronic address:

The shrimp aquaculture industry has experienced serious economic losses due to diseases caused by Vibrio species. The application of antibiotics to combat diseases has led to environmental hazards, antibiotic-resistance in pathogens and accumulation of antibiotics in tissues. This study explores the use of probiotics as an alternative to antibiotics. Read More

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C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors .

Front Immunol 2021 15;12:594773. Epub 2021 Mar 15.

Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still unknown. Antibody titers, for example, often do not strictly correlate with clinical outcome. Read More

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Which parameters support disposition decision in suspected COVID-19 cases in the emergency department (ED): a German clinical cohort study.

BMJ Open 2021 03 31;11(3):e044853. Epub 2021 Mar 31.

Emergency and Acute Medicine, Campus Mitte and Virchow, Charite Universitatsmedizin Berlin, Berlin, Germany.

Objectives: One major goal of the emergency department (ED) is to decide, whether patients need to be hospitalised or can be sent home safely. We aim at providing criteria for these decisions without knowing the SARS-CoV-2 test result in suspected cases.

Setting: Tertiary emergency medicine. Read More

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CD38 in the Age of Covid-19: a Medical Perspective.

Physiol Rev 2021 Mar 31. Epub 2021 Mar 31.

Department of Medical Sciences, University of Turin, Italy.

This medical review addresses the hypothesis that CD38/NADase is at the center of a functional axis (i.e., intracellular Ca mobilization/IFNɣ response/ROS burst) driven by SARS-CoV-2 infection, as already verified in Respiratory Syncytial Virus pathology and CD38 activity in other cellular settings. Read More

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Modulation of the innate immune response, antioxidant system and oxidative stress during acute and chronic stress in pacu (Piaractus mesopotamicus).

Fish Physiol Biochem 2021 Mar 31. Epub 2021 Mar 31.

Universidade Estadual Paulista, UNESP, Centro de Aquicultura, Via de Acesso Paulo Donato Castellane, 14.884-900, Jaboticabal, SP, Brazil.

Stress is an energy-demanding process, as well as the responses of the innate immune system, that impose a metabolic overload on cellular energy production, which can affect the cellular redox balance, causing oxidative damage. We evaluated the role of stress in the modulation of innate immune and oxidative/antioxidant mechanisms in juvenile pacu exposed to acute and chronic stressors. The experimental period lasted 30 days, and fish (113. Read More

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Interactions Between Neutrophils and Periodontal Pathogens in Late-Onset Periodontitis.

Front Cell Infect Microbiol 2021 12;11:627328. Epub 2021 Mar 12.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Late-onset periodontitis is associated with a series of inflammatory reactions induced by periodontal pathogens, such as , a keystone pathogen involved in periodontitis. Neutrophils are the most abundant leukocytes in the periodontal pocket/gingival crevice and inflamed periodontal tissues. They form a "wall" between the dental plaque and the junctional epithelium, preventing microbial invasion. Read More

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Characteristics of patients with frequent systemic corticosteroid bursts for asthma in real clinical practice: are there frequent "short bursts?"

J Asthma 2021 Apr 1:1-8. Epub 2021 Apr 1.

Department of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.

Objective: The data on intermittent systemic corticosteroid therapy for asthma exacerbation, clinically called a "short burst," is limited. This study aimed to investigate the characteristics of patients with frequent systemic corticosteroid bursts for asthma in real clinical practice.

Methods: Consecutive patients who regularly visited our hospital for asthma treatment between January 2019 and December 2020 were reviewed. Read More

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Regulation of dual oxidase hydrogen peroxide synthesis results in an epithelial respiratory burst.

Gregory E Conner

Redox Biol 2021 Mar 5;41:101931. Epub 2021 Mar 5.

Department of Cell Biology, University of Miami Miller School of Medicine, 1600 NW 10(th) Avenue, Miami, Fl, 33136, USA. Electronic address:

Redox status is a central determinant of cellular activities and redox imbalance is correlated with numerous diseases. NADPH oxidase activity results in formation of HO, that, in turn, sets cellular redox status, a key regulator of cellular homeostasis and responses to external stimuli. Hydrogen peroxide metabolism regulates cell redox status by driving changes in protein cysteine oxidation often via cycling of thioredoxin/peroxiredoxin and glutathione; however, regulation of enzymes controlling synthesis and utilization of HO is not understood beyond broad outlines. Read More

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Treatment of air leakage using the VIO soft coagulation system: a mouse pulmonary air leak model.

Surg Today 2021 Mar 20. Epub 2021 Mar 20.

Department of Thoracic Surgery, School of Medicine and Hospital, Sapporo Medical University, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

Purpose: We aimed to compare the efficacy of the VIO soft coagulation system (VSCS) for the treatment of air leaks by sealing with fibrin glue, and also assess the histological alterations that occur after soft coagulation.

Methods: A mouse pulmonary air leak model was designed. The pulmonary fistula was subsequently coagulated with the VSCS or sealed with fibrin glue with polyglycolic acid (PGA) sheets. Read More

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Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India.

Front Immunol 2021 25;12:625320. Epub 2021 Feb 25.

Allergy Immunology Unit, Advanced Pediatrics Centre, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Chronic granulomatous disease (CGD) is an inherited defect in phagocytic respiratory burst that results in severe and life-threatening infections in affected children. Single center studies from India have shown that proportion of autosomal recessive (AR) CGD is more than that reported from the West. Further, affected patients have high mortality rates due to late referrals and difficulties in accessing appropriate treatment. Read More

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February 2021

Baseline Arterial CO Pressure Regulates Acute Intermittent Hypoxia-Induced Phrenic Long-Term Facilitation in Rats.

Front Physiol 2021 24;12:573385. Epub 2021 Feb 24.

Department of Physical Therapy, McKnight Brain Institute, Center for Respiratory Research and Rehabilitation, University of Florida, Gainesville, FL, United States.

Moderate acute intermittent hypoxia (mAIH) elicits a progressive increase in phrenic motor output lasting hours post-mAIH, a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). mAIH-induced pLTF is initiated by activation of spinally-projecting raphe serotonergic neurons during hypoxia and subsequent serotonin release near phrenic motor neurons. Since raphe serotonergic neurons are also sensitive to pH and CO, the prevailing arterial CO pressure (PaCO) may modulate their activity (and serotonin release) during hypoxic episodes. Read More

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February 2021

Dietary Supplementation of Bacillus sp. SJ-10 and Lactobacillus plantarum KCCM 11322 Combinations Enhance Growth and Cellular and Humoral Immunity in Olive Flounder (Paralichthys olivaceus).

Probiotics Antimicrob Proteins 2021 Mar 13. Epub 2021 Mar 13.

Department of Biotechnology, Pukyong National University, Busan, 608-737, Republic of Korea.

Experiments were conducted to identify different ratios of Bacillus sp. SJ-10 and Lactobacillus plantarum KCCM 11322 mixtures at a concentration of 1 × 10 CFU/g diet; the effects on growth and cellular and humoral immune responses and the characteristics of disease protection in olive flounder (Paralichthys olivaceus). Flounder were divided into six groups and fed control diet D-1 (without Bacillus sp. Read More

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Characterization of innate immune response to Brucella melitensis infection in goats with permissive or restrictive phenotype for Brucella intramacrophagic growth.

Vet Immunol Immunopathol 2021 Apr 8;234:110223. Epub 2021 Mar 8.

Instituto de Patobiología Veterinaria, Instituto Nacional de Tecnología Agropecuaria (INTA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), N. Repetto y De los Reseros, 1686 Hurlingham, Buenos Aires, Argentina. Electronic address:

Caprine brucellosis is a chronic, world-wide distributed disease which causes reproductive failure in goats and Brucella melitensis, its causative agent, bears a great zoonotic potential. There is evidence suggesting that some cattle and pigs have an innate ability to resist Brucella infection, but this has not yet been investigated in goats. In this study, we compared caprine macrophages that exhibit extreme restriction and permissiveness to B. Read More

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Ascorbate-glutathione pathways mediated by cytokinin regulate H2O2 levels in light-controlled rose bud burst.

Plant Physiol 2021 Mar 12. Epub 2021 Mar 12.

Univ Angers, Institut Agro, INRAE, IRHS, SFR QUASAV, F-49000 Angers, France.

Rosebush (Rosa 'Radrazz') plants are an excellent model to study light control of bud outgrowth since bud outgrowth only arises in the presence of light and never occurs in darkness. Recently, we demonstrated high levels of H2O2 present in the quiescent axillary buds strongly repress the outgrowth process. In light, the outgrowing process occurred after H2O2 scavenging through the promotion of Ascorbic acid-Glutathione (AsA-GSH) dependent pathways and the continuous decrease in H2O2 production. Read More

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Reactive Oxygen Species and Their Involvement in Red Blood Cell Damage in Chronic Kidney Disease.

Oxid Med Cell Longev 2021 25;2021:6639199. Epub 2021 Feb 25.

Department of Pharmacology and Toxicology, Medical University of Lodz, Lodz, Poland.

Reactive oxygen species (ROS) released in cells are signaling molecules but can also modify signaling proteins. Red blood cells perform a major role in maintaining the balance of the redox in the blood. The main cytosolic protein of RBC is hemoglobin (Hb), which accounts for 95-97%. Read More

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February 2021