126,331 results match your criteria respiration rate


A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).

Int Immunopharmacol 2021 Sep 14;100:108137. Epub 2021 Sep 14.

Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

A growing body of evidence indicates that neutrophil elastase (NE) is involved in the pathogenesis of respiratory infectious diseases, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to analyze the dynamic changes in serum levels of NE associated with inflammation, disease activity, and mortality rate in patients with COVID-19. We measured the serum concentrations of NE, C-Reactive protein (CRP), interleukin (IL)- 4, IL-6, IL-8, IL-10, and vitamin D levels in 83 ICU and 69 non-ICU patients compared with 82 healthy subjects (HS) in three-time points (T1-T3). Read More

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September 2021

A prospective, phase II trial of monotherapy with low-dose afatinib for patients with EGFR, mutation-positive, non-small cell lung cancer: Thoracic oncology research group 1632.

Lung Cancer 2021 Aug 31;161:49-54. Epub 2021 Aug 31.

Department of Pulmonary Medicine and Oncology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan. Electronic address:

Objectives: Afatinib is an effective treatment for patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). However, the toxicity associated with this agent often leads to dose modifications. The aim of this study was to assess the efficacy, safety and plasma concentrations of low dose afatinib monotherapy in patients with EGFR mutation-positive NSCLC. Read More

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Blood cell respiration rates and mtDNA copy number: a promising tool for the diagnosis of mitochondrial disease.

Mitochondrion 2021 Sep 15. Epub 2021 Sep 15.

Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Uruguay. Electronic address:

Human mitochondrial diseases are a group of heterogeneous diseases caused by defects in oxidative phosphorylation, due to mutations in mitochondrial (mtDNA) or nuclear DNA. The diagnosis of mitochondrial disease is challenging since mutations in multiple genes can affect mitochondrial function, there is considerable clinical variability and a poor correlation between genotype and phenotype. Herein we assessed mitochondrial function in peripheral blood mononuclear cells (PBMCs) and platelets from volunteers without known metabolic pathology and patients with mitochondrial disease. Read More

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September 2021

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet Neurol 2021 Oct;20(10):821-831

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, and Department of Neurology, King's College Hospital, King's College London, London, UK.

Background: There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile function of the human diaphragm. We aimed to evaluate the safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis, with a focus on respiratory function. Read More

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October 2021

Genetic diversity of bat coronaviruses and comparative genetic analysis of MERS-related coronaviruses in South Korea.

Transbound Emerg Dis 2021 Sep 18. Epub 2021 Sep 18.

Laboratory of Veterinary Infectious Disease, College of Veterinary Medicine, Jeonbuk National University, Iksan, Jeonbuk, Republic of Korea.

Bats have been identified as a natural reservoir of several potentially zoonotic viruses, including Lyssavirus, Ebola virus, Marburg virus, Hendra virus, Nipah virus, as well as SARS and MERS-coronavirus. Here, we performed a molecular epidemiological investigation of South Korean bat viruses. Genetic comparative analysis was performed on the spike glycoprotein gene of the detected MERS-related coronaviruses. Read More

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September 2021

Rural Adolescent Immunization: Delivery Practices and Barriers to Uptake.

J Am Board Fam Med 2021 Sep-Oct;34(5):937-949

From the ACCORDS, University of Colorado Anschutz Medical Campus, Aurora, CO (JRC, SEB, CP, AF, AN, KS, STO, AFD); Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO (JRC, STO, AFD); Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (SEB, AN); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO (KS); Immunization Services Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA (CW).

Background: Rural adolescent vaccination rates lag behind urban. We sought to assess rural-urban differences in barriers to adolescent vaccination, perceived parental vaccine attitudes, and immunization delivery practices among public health nursing (PHN), pediatric (Peds), and family medicine (FM) clinicians.

Methods: Internet and mail survey of Colorado PHN, Peds, and FM clinicians from June-August 2019. Read More

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Hemodynamic Effects of Ketamine Versus Etomidate for Prehospital Rapid Sequence Intubation.

Air Med J 2021 Sep-Oct;40(5):312-316. Epub 2021 Jul 2.

Department of Surgery, New Hanover Regional Medical Center, Wilmington, NC.

Objective: Rapid sequence intubation (RSI) is often required in managing critically ill patients in the prehospital setting. Although etomidate is a commonly used induction agent for RSI, ketamine has gained new interest in prehospital management with reported neutral hemodynamic effects. Limited data exist to support ketamine as an alternative to etomidate, particularly in the prehospital setting. Read More

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Effect of animal protein diet on the prognosis of children with Henoch-Schönlein purpura.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):927-932

Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University/National Children's Medical Center, Beijing 100045, China (Hu Y, Email: com).

Objectives: To study the association of animal protein diet with the recurrence of Henoch-Schönlein purpura (HSP)/skin rash and the risk factors for recurrence of HSP.

Methods: A prospective analysis was performed for 121 children with HSP who were admitted to the Beijing Children's Hospital from October to December 2020. The children were given the doctor's advice of the same diet (animal protein diet could be added after 1 week without new-onset skin rash). Read More

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September 2021

Clinical features and prognosis of severe meconium aspiration syndrome with acute respiratory distress syndrome.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):903-908

Department of Neonatology, Dongguan Children's Hospital Affiliated to Guangdong Medical University, Dongguan, Guangdong 523325, China (Email: com).

Objectives: To study the clinical features and prognosis of neonates with severe meconium aspiration syndrome (MAS) and acute respiratory distress syndrome (ARDS).

Methods: A retrospective analysis was performed on the medical data of 60 neonates with severe MAS who were admitted from January 2017 to December 2019. According to the presence or absence of ARDS, they were divided into two groups: ARDS (=45) and non-ARDS (=15). Read More

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September 2021

Risk factors for treatment failure of heated humidified high-flow nasal cannula as initial respiratory support for preterm infants.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):896-902

Department of Neonatology, Mindong Hospital Affiliated to Fujian Medical University, Ningde, Fujian 355000, China (Xiao C-X, Email: com).

Objectives: To study the risk factors for treatment failure of heated humidified high-flow nasal cannula (HHHFNC) as initial respiratory support for preterm infants.

Methods: A retrospective analysis was performed on the medical data of the preterm infants who were admitted from January 2018 to April 2021 and received HHHFNC for initial respiratory support after birth. According to whether it was necessary to upgrade to noninvasive continuous positive airway pressure or invasive mechanical ventilation within 72 hours after treatment, they were divided into a failure group and a success group. Read More

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September 2021

Early versus late awake prone positioning in non-intubated patients with COVID-19.

Crit Care 2021 09 17;25(1):340. Epub 2021 Sep 17.

Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, 600 S Paulina St, Suite 765, Chicago, IL, USA.

Background: Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective of this study was to compare the outcome of COVID-19 patients who received early versus late APP.

Methods: Post hoc analysis of data collected for a randomized controlled trial (ClinicalTrials. Read More

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September 2021

Prevention of SARS-CoV-2 (COVID-19) transmission in residential aged care using ultraviolet light (PETRA): a two-arm crossover randomised controlled trial protocol.

BMC Infect Dis 2021 Sep 17;21(1):967. Epub 2021 Sep 17.

The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

Background: SARS-CoV-2 poses a considerable threat to those living in residential aged care facilities (RACF). RACF COVID-19 outbreaks have been characterised by the rapid spread of infection and high rates of severe disease and associated mortality. Despite a growing body of evidence supporting airborne transmission of SARS-CoV-2, current infection control measures in RACF including hand hygiene, social distancing, and sterilisation of surfaces, focus on contact and droplet transmission. Read More

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September 2021

Efficacy of bedaquiline in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis.

BMC Infect Dis 2021 Sep 17;21(1):970. Epub 2021 Sep 17.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Alley, Chengdu, Sichuan, People's Republic of China.

Background: Drug-resistant tuberculosis (DR-TB) remains a major public health concern worldwide. Bedaquiline, a novel diarylquinoline, was added to the WHO-recommended all-oral regimen for patients with multidrug-resistant tuberculosis. We performed a systematic review and meta-analysis to determine the effect of bedaquiline on tuberculosis treatment outcomes. Read More

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September 2021

COVID-19 and miscarriage: From immunopathological mechanisms to actual clinical evidence.

J Reprod Immunol 2021 Sep 10;148:103382. Epub 2021 Sep 10.

Reproductive Medicine and Immunology, Obstetrics and Gynecology, Clinical Sciences Department, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA.

The association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the first half of pregnancy and pregnancy loss is still unknown. Infections by other coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), appear to increase the risk of miscarriage. The purpose of this study is to assess whether SARS-CoV-2 infection increases the risk of miscarriage. Read More

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September 2021

Exposure to black carbon is associated with symptoms of depression: A retrospective cohort study in college students.

Environ Int 2021 Sep 14;157:106870. Epub 2021 Sep 14.

Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: Previous studies have revealed a significant association of fine particulate matter (PM) with emotional disorders. However, as a crucial component of PM, little is known about the potential effect of exposure to black carbon (BC) on the symptoms of depression and anxiety.

Objectives: To explore the associations of long-term exposure to BC during the past six years with the current symptoms of depression and anxiety in a group of incoming college students. Read More

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September 2021

Cardiovascular mechanisms of interoceptive awareness: Effects of resonance breathing.

Int J Psychophysiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Kinesiology and Health, Rutgers University, New Brunswick, United States of America; Cardiac Neuroscience Laboratory, Center of Alcohol Studies, Rutgers University, New Brunswick, United States of America.

Interoception, the ability to perceive internal bodily sensations, and heart rate variability (HRV) share common physiological pathways, including the baroreflex feedback loop. The baroreflex can be activated by resonance breathing, wherein respiration is paced at 6 times per minute (0.1 Hz), eliciting immediate physiological changes and longer-term therapeutic responses. Read More

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September 2021

Adverse Events Following One Dose of mRNA COVID-19 Vaccination Among US Nursing Home Residents With and Without a Previous SARS-CoV-2 Infection.

J Am Med Dir Assoc 2021 Aug 28. Epub 2021 Aug 28.

Brown University School of Public Health, Providence, RI, USA.

Objectives: To compare rates of adverse events following Coronavirus Disease 2019 (COVID-19) vaccination among nursing home residents with and without previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design: Prospective cohort.

Setting And Participants: A total of 20,918 nursing home residents who received the first dose of messenger RNA COVID-19 vaccine from December 18, 2020, through February 14, 2021, in 284 facilities within Genesis Healthcare, a large nursing home provider spanning 24 US states. Read More

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Diaphragm Activity Pre and Post Extubation in Ventilated Critically Ill Infants and Children Measured With Transcutaneous Electromyography.

Pediatr Crit Care Med 2021 Aug 23. Epub 2021 Aug 23.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. Faculty of Science and Technology, University of Twente, Enschede, The Netherlands. Pediatric Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.

Objectives: Swift extubation is important to prevent detrimental effects of invasive mechanical ventilation but carries the risk of extubation failure. Accurate tools to assess extubation readiness are lacking. This study aimed to describe the effect of extubation on diaphragm activity in ventilated infants and children. Read More

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Feasibility of remote home monitoring with a T-shirt wearable device in post-recovery COVID-19 patients.

J Cardiovasc Med (Hagerstown) 2021 Sep 14. Epub 2021 Sep 14.

Centro Cardiologico Monzino, IRCCS Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan L.I.F.E. Italia S.R.L., Milan, Italy.

Background And Aim Of The Study: During the last months, a pandemic by a novel coronavirus (Sars-Cov-2) has spread worldwide, putting hospitals under enormous pressure. Although follow-up data in this setting are scarce, early reports suggested that more than 80% of patients who had recovered from COronaVIrus Disease 19 (COVID-19) reported persistence of at least one symptom during follow-up. Therefore, a prolonged post-discharge monitoring for long-lasting effects is advisable. Read More

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September 2021

Synthetic Neutralizing Peptides Inhibit the Host Cell Binding of Spike Protein and Block Infection of SARS-CoV-2.

J Med Chem 2021 Sep 17. Epub 2021 Sep 17.

Department of Biomedical Engineering, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.

Antiviral treatments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been extensively pursued to conquer the pandemic. To inhibit the viral entry to the host cell, we designed and obtained three peptide sequences via quartz crystal microbalance measurement screening, which showed high affinity at nanomole to the S1 subunit of the spike protein and wild-type SARS-CoV-2 pseudovirus. Circular dichroism spectroscopy measurements revealed significant conformation changes of the S1 protein upon encounter with the three peptides. Read More

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September 2021

Does affiliation to a cross-sectorial lung team impact well-being, health-related quality of life, symptoms of anxiety and depression and patient involvement in patients with COPD? A randomised controlled trial.

Scand J Caring Sci 2021 Sep 17. Epub 2021 Sep 17.

ResCenPI - Research Centre for Patient Involvement, Aarhus University & Central Denmark Region, Aarhus, Denmark.

Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease causing limitations in daily life. A cross-sectorial lung team was established for COPD patients at risk of hospitalisation due to exacerbation of COPD.

Aims: To investigate the impact of affiliation to a cross-sectorial lung team on well-being, health-related quality of life, symptoms of anxiety and depression and patient involvement in patients with severe COPD. Read More

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September 2021

Non-invasive neurally adjusted ventilatory assist in preterm infants with RDS: effect of changing NAVA levels.

Eur J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Neonatology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

We aimed to examine the effect of changing levels of support (NAVA level) during non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants with respiratory distress syndrome (RDS) on electrical diaphragm activity. This is a prospective, single-centre, interventional, exploratory study in a convenience sample. Clinically stable preterm infants supported with NIV-NAVA for RDS were eligible. Read More

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September 2021

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI.

Cochrane Database Syst Rev 2021 Sep 17;9:CD009806. Epub 2021 Sep 17.

Emergency Medicine and Evidence Based Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Mucopolysaccharidosis type VI (MPS VI) or Maroteaux-Lamy syndrome is a rare genetic disorder caused by the deficiency of arylsulphatase B. The resultant accumulation of dermatan sulphate causes lysosomal damage. The clinical symptoms are related to skeletal dysplasia (i. Read More

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September 2021

Similar mortality risk in incident cognitive impairment and dementia: Evidence from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.

J Am Geriatr Soc 2021 Sep 17. Epub 2021 Sep 17.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: This study examined the risk of mortality in older adults with newly detected cognitive impairment or dementia.

Methods: Data from the Australian cohort of the ASPirin in Reducing Events in the Elderly (ASPREE) trial were examined. The ASPREE clinical trial compared daily low-dose aspirin to a placebo and involved 16,703 individuals aged 70 years and over, who were without major cognitive impairment, physical disability, or cardiovascular disease at recruitment. Read More

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September 2021

Effectiveness and safety of bevacizumab in extensive-disease small cell lung cancer: a systemic review and meta-analysis.

Ann Transl Med 2021 Aug;9(16):1285

Department of Thoracic Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Small cell lung cancer (SCLC) is highly invasive and poorly prognostic. The effects of chemotherapy with bevacizumab are promising on other tumors but unclear in extensive-disease SCLC (ED-SCLC). A systemic review and meta-analysis were performed to investigate the efficacy and toxicity in ED-SCLC patients. Read More

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High BTBD7 expression positive is correlated with SLUG-predicted poor prognosis in hormone receptor-negative breast cancer.

Ann Transl Med 2021 Aug;9(15):1252

Department of Rheumatology, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.

Background: Hormone receptor-negative breast cancer (HRNBC), which includes triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer, is prone to metastasis and has a poor prognosis. BTB/POZ domain-containing protein 7 (Btbd7) is thought to regulate SLUG and the epithelial-mesenchymal transition (EMT) process. However, the role of Btbd7 in HRNBC is unclear. Read More

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Shock in China 2018 (SIC-study): a cross-sectional survey.

Ann Transl Med 2021 Aug;9(15):1219

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Background: Shock is a critical illness that seriously threatens the lives of patients. This study explains the epidemiology of shock, mortality of shock, and identify factors that related to hospital death.

Methods: This is a multi-centre cross-sectional survey, which included 1,064 tertiary hospitals in 31 provinces, municipalities, and autonomous regions across China mainland. Read More

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The Risk Factors for Weaning Failure of Mechanically Ventilated Patients With COVID-19: A Retrospective Study in National Medical Team Work.

Front Med (Lausanne) 2021 31;8:678157. Epub 2021 Aug 31.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

This study aimed to describe the clinical and laboratory characteristics and the parameters of the respiratory mechanics of mechanically ventilated patients with confirmed COVID-19 pneumonia and to clarify the risk or protective factors for weaning failure. Patients diagnosed with COVID-19 pneumonia were selected from the special intensive care unit (ICU) of the Sino-French New City Branch of Tong Ji Hospital, Wuhan, and treated by the National Medical Team Work. They were divided into successful weaning (SW) group ( = 15) and unsuccessful weaning (USW) group ( = 18) according to the prognosis. Read More

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Case selection and implementation of tubeless percutaneous nephrolithotomy.

Transl Androl Urol 2021 Aug;10(8):3415-3422

Department of Urology, Lingnan Hospital, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: The tubeless percutaneous nephrolithotomy (PCNL) was proposed to eliminate the side effects of the nephrostomy tube in recent years, such as pain, channel infection, postoperative bleeding, and longer hospital stay. But there is neither clinical guidelines nor consensus about tubeless PCNL in clinical practice. The study is aimed to how to implement the tubeless PCNL step by step, including case selection preoperatively, improving the technique of the surgeon, making the correct decisions at the end of the procedure, which had not been previously examined. Read More

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Safety assessment of HEA-enriched mycelia on the central nervous system (CNS), cardiovascular system, and respiratory system in ICR male mice.

Food Sci Nutr 2021 Sep 16;9(9):4905-4915. Epub 2021 Jul 16.

Biotech Research Institute Grape King Bio Ltd Taoyuan City Taiwan.

, an entomopathogenic fungus, is a source of traditional Chinese medicine in China. Due to the low yield of wild , artificial cultivation approaches will be needed to meet the increasing market demand. Using bioreactor culture can increase mass production and the abundance of the active component, N6-(2-hydroxyethyl)-adenosine (HEA). Read More

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September 2021