Methods Mol Biol 2021 ;2275:65-85
Aix Marseille Univ, CNRS, ICR, UMR 7273, Sondes Moléculaires en Biologie et Stress Oxydant, Marseille, France.
The mitochondrion can be considered as the metabolic powerhouse of the cell, having a key impact on energy production, cell respiration, and intrinsic cell death. Mitochondria are also the main source of endogenous reactive oxygen species , including free radicals (FR), which are physiologically involved in signaling pathways but may promote cell damage when unregulated or excessively formed in inappropriate locations. A variety of chronic pathologies have been associated with FR-induced mitochondrial dysfunctions , such as cancer, age-related neurodegenerative diseases, and metabolic syndrome. Read More