Transplantation 2021 Feb 11. Epub 2021 Feb 11.
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA Arch Oncology, Inc., St. Louis, MO, USA.
Background: Towards the goal of utilizing more livers for transplantation, transplant centers are looking to increase the use of organs from "marginal" donors. Livers from these donors, however, have been shown to be more susceptible to preservation and reperfusion injury.
Methods: Using a porcine model of donation after circulatory death (DCD), we studied the use of antibody-mediated CD47 blockade to further improve liver graft function undergoing normothermic machine perfusion. Read More