139,483 results match your criteria resistance type

Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus.

J Pediatr Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan.

Objectives: Bone can act as an endocrine organ through the secretion of bone-specific hormones, i.e., osteokines. Read More

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Cytotoxic effects of alteplase, a recombinant tissue plasminogen activator, on human retinal pigment epithelial cells.

Jpn J Ophthalmol 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kita-ku, Okayama City, 7008558, Japan.

Purpose: To evaluate the cytotoxic effects of alteplase, a recombinant tissue plasminogen activator, and its additives on human retinal pigment epithelial (hRPE) cells.

Study Design: Laboratory study.

Methods: We evaluated the cytotoxic effects of alteplase on human fetal RPE (hfRPE) cells, human induced pluripotent stem cell-derived RPE (hiPS-RPE), and ARPE-19 cells, as well as the cytotoxic effects of L-arginine and polysorbate 80, two additives of alteplase, on hfRPE cells. Read More

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Deletion of Coagulation Factor IX Compromises Bone Mass and Strength: Murine Model of Hemophilia B (Christmas Disease).

Calcif Tissue Int 2021 Jun 12. Epub 2021 Jun 12.

Medical Research Service, Portland Veterans Affairs Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, 97239, USA.

Osteopenia and osteoporosis have increasingly become a recognized morbidity in those persons with hemophilia (PwH) receiving inadequate prophylactic clotting factor replacement. Animal models can control or eliminate genetic and environmental factors and allow for invasive testing not clinically permissible. Here, we describe the skeletal phenotype of juvenile and adult male mice with a genetically engineered deficiency in coagulation factor IX (FIX KO). Read More

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Prescribing Antibiotics in Adults with Respiratory Tract Infections in Lebanon.

Int J Clin Pract 2021 Jun 12:e14514. Epub 2021 Jun 12.

Department of Family Medicine, American University of Beirut Medical Center (AUBMC, Beirut, Lebanon.

Background: Antibiotic resistance is a global concern that has significant health and economic burden. The inappropriate use of antibiotics is a major cause of antibiotic resistance; this includes both unnecessary and incorrect prescriptions. Most antibiotics are prescribed in primary care, mainly for respiratory tract infections. Read More

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Chronobiological evaluation and an intervention study on timing of food intake in the treatment of obesity.

Int J Clin Pract 2021 Jun 12:e14502. Epub 2021 Jun 12.

Department of Family Medicine, Düzce University Medical Faculty, Duzce, Turkey.

Background: The chronotype of patients who cannot reach their ideal weight despite diet and exercise may play a role in this resistance. In this study, the relationship between BMI and chronobiological preferences was examined and a weight loss program was applied to refractory obese patients with evening type (ET).

Method: The study included 50 obese (BMI≥30 kg/m ), 50 overweight (BMI=25-29 kg/m ), and 50 normal normal-weight (BMI<25 kg/m ). Read More

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NK-/T-cell lymphomas.

Leukemia 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, PR China.

Natural killer/T-cell lymphoma (NKTL) is a sub-type of Epstein-Barr virus (EBV)-related non-Hodgkin lymphomas common in Asia and Latin America but rare elsewhere. Its pathogenesis is complex and incompletely understood. Lymphoma cells are transformed from NK- or T-cells, sometimes both. Read More

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Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.

Diabetes Care 2021 Jun 11. Epub 2021 Jun 11.

Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France.

Objective: Gestational diabetes mellitus (GDM) is associated with an increased risk of obesity and insulin resistance in offspring later in life, which might be explained by epigenetic changes in response to maternal hyperglycemic exposure.

Research Design And Methods: We explored the association between GDM exposure and maternal blood and newborn cord blood methylation in 536 mother-offspring pairs from the prospective FinnGeDi cohort using Illumina MethylationEPIC 850K BeadChip arrays. We assessed two hypotheses. Read More

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Downregulation of decidual SKP2 is associated with human recurrent miscarriage.

Reprod Biol Endocrinol 2021 Jun 11;19(1):88. Epub 2021 Jun 11.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China.

Background: Recurrent miscarriage (RM) is a very frustrating problem for both couples and clinicians. To date, the etiology of RM remains poorly understood. Decidualization plays a critical role in implantation and the maintenance of pregnancy, and its deficiency is closely correlated with RM. Read More

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4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors.

Bioorg Chem 2021 May 26;113:105024. Epub 2021 May 26.

Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 34093 Montpellier Cedex 5, France. Electronic address:

In Gram-negative bacteria, the major mechanism of resistance to β-lactam antibiotics is the production of one or several β-lactamases (BLs), including the highly worrying carbapenemases. Whereas inhibitors of these enzymes were recently marketed, they only target serine-carbapenemases (e.g. Read More

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Function and distribution of the conjugative plasmid pLM1686 in foodborne Listeria monocytogenes in China.

Int J Food Microbiol 2021 May 30;352:109261. Epub 2021 May 30.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China. Electronic address:

Listeria monocytogenes, a fatal foodborne pathogen has the extraordinary capacity to survive in harsh conditions and is a potential threat to public health. A novel 91 kb plasmid pLM1686 was found in the prevalent L. monocytogenes sequence type (ST) 87 strain in China. Read More

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Tuberculosis of the spine in children - Does drug resistance affect surgical outcomes?

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Paediatric TB Clinic, Bai Jerbai Wadia Hospital for Children, Mumbai, India. Electronic address:

Background Context: The emergence of drug resistance has complicated the management of spinal tuberculosis (TB). While it is well known that the medical management of drug-resistant spinal TB is more difficult, the surgical outcomes of the same have not been studied sufficiently, particularly in children.

Purpose: To analyze the surgical outcomes in a cohort of children treated for spinal TB, and to thus assess whether drug resistant (DR) disease is associated with poorer surgical outcomes. Read More

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WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the upregulation of IL33 in response to injury.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea. Electronic address:

Background & Aims: WAP four-disulfide core domain protein 2 (WFDC2), also known as human epididymis protein 4 (HE4), is a small secretory protein that is highly expressed in fibrosis and human cancers, particularly in the ovaries, lungs, and stomach. However, the role of WFDC2 in carcinogenesis is not fully understood. The present study aimed to investigate the role of WFDC2 in gastric carcinogenesis using preneoplastic metaplasia models. Read More

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Multidrug-resistant species: underestimated fungal pathogens posing imminent threats in clinical settings.

Crit Rev Microbiol 2021 Jun 11:1-20. Epub 2021 Jun 11.

Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Species of and related genera are widely used in biotechnology and, hence, many species have their genome sequenced. Importantly, yeasts of the genus have been increasingly identified as a cause of life-threatening invasive trichosporonosis (IT) in humans and are associated with an exceptionally high mortality rate. spp. Read More

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The Sw-5b NLR nucleotide-binding domain plays a role in oligomerization and its self-association is important for the activation of cell death signaling.

J Exp Bot 2021 Jun 11. Epub 2021 Jun 11.

Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.

Plant and animal intracellular nucleotide-binding and leucine-rich repeat (NLR) receptors play important roles in sensing pathogens and activating defense signaling. However, the molecular mechanisms underlying the activation of host defense signaling by NLR proteins remain largely unknown. Many previous studies have determined that the coil-coil (CC) or Toll and interleukin-1 receptor/resistance protein (TIR) domain of NLR proteins and their dimerization/oligomerization are critical for activating downstream defense signaling. Read More

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Rapid detection of multidrug-resistant tuberculosis based on allele-specific recombinase polymerase amplification and colorimetric detection.

PLoS One 2021 11;16(6):e0253235. Epub 2021 Jun 11.

Research Unit of Innovative Diagnosis of Antimicrobial Resistance, Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Multidrug-resistant tuberculosis (MDR-TB) poses a serious threat to TB control. Early diagnosis and proper treatment are essential factors to limit the spread of the disease. The existing molecular tests for MDR-TB usually require specific instruments, steady power supply, and routine maintenance, which might be obstacles for low-resource settings. Read More

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Metabolic syndrome and myocardial infarction in women.

Curr Pharm Des 2021 Jun 10. Epub 2021 Jun 10.

University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, University of Skopje, Skopje, Macedonia.

Metabolic syndrome (MetS) represents a cluster of metabolic disorders that arise from insulin resistance (IR) and adipose tissue dysfunction. As a consequence, there is an increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease (CVD). MetS is associated with a 2-fold increase in cardiovascular outcomes. Read More

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Analysis of expression characteristics of soybean leaf and root tissue-specific promoters in Arabidopsis and soybean.

Transgenic Res 2021 Jun 11. Epub 2021 Jun 11.

Jilin Provincial Key Laboratory of Agricultural Biotechnology, Jilin Academy of Agricultural Sciences, 130033, Changchun, China.

The characterization of tissue-specific promoters is critical for studying the functions of genes in a given tissue/organ. To study tissue-specific promoters in soybean, we screened tissue-specific expressed genes using published soybean RNA-Seq-based transcriptome data coupled with RT-PCR analysis. We cloned the promoters of three genes, GmADR1, GmBTP1, and GmGER1, and constructed their corresponding β-Glucuronidase (GUS) promoter-GUS reporter vectors. Read More

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Effects of physical exercise on memory in type 2 diabetes: a brief review.

Metab Brain Dis 2021 Jun 11. Epub 2021 Jun 11.

Multicenter Post Graduation Program in Physiological Sciences, Brazilian Society of Physiology, Federal University of the Valleys of Jequitinhonha and Mucuri, Diamantina, Minas Gerais, Brazil.

Type 2 diabetes (T2D) is a metabolic disorder that can lead to memory impairment. T2D main features are insulin resistance and hyperglycemia. Physical exercise is a non-pharmacological intervention that can regulate glycemic levels and fight insulin resistance in T2D, but whether it influences memory has been discussed. Read More

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Occlusal Thickness and Cement-Type Effects on Fracture Resistance of Implant-Supported Posterior Monolithic Zirconia Crowns.

Int J Oral Maxillofac Implants 2021 May-Jun;36(3):485-491

Purpose: To evaluate the factors that could influence the fracture resistance of implant-supported posterior monolithic zirconia crowns.

Materials And Methods: Sixty zirconia molar crowns with three different occlusal thicknesses of 0.5, 1. Read More

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A rare case of diabetic ketoacidosis presenting with severe hypertriglyceridemia requiring plasmapheresis in an adult with type-2 diabetes mellitus: Case report.

Medicine (Baltimore) 2021 Jun;100(23):e26237

Internal Medicine Residency Program, UPMC Pinnacle Harrisburg Hospital.

Introduction: Severe hypertriglyceridemia (HTG) is a rare complication of insulin resistance. Its presentation with diabetic ketoacidosis (DKA) has been reported in a few cases, where most patients have type-1 diabetes mellitus (DM). Our case represents a unique presentation of DKA associated with severe HTG above 10,000 mg/dL in an adult with type-2 DM. Read More

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Potential susceptibility of six aquatic plant species to infection by five species of .

Plant Dis 2021 Jun 11. Epub 2021 Jun 11.

Clemson University, Plant & Environmental Sciences, E-143 Poole Agricultural Center, Clemson, South Carolina, United States, 29634-0310;

Investigations of the susceptibility of aquatic plants to species of are limited. Therefore, the objective of this study was to assess the potential susceptibility of six aquatic plant species, frequently used in constructed wetlands or vegetated channels, to infection by five species of commonly found at nurseries in the southeastern United States. In a greenhouse experiment, roots of each plant species (, , 'Rising Sun', , , and ) growing in aqueous solutions were exposed to zoospores of each of the species of (, , , , and ). Read More

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Phenotypic and genotypic characterization of mcr-1-positive multidrug-resistant Escherichia coli ST93, ST117, ST156, ST10, and ST744 isolated from poultry in Poland.

Braz J Microbiol 2021 Jun 10. Epub 2021 Jun 10.

The Faculty of Veterinary Medicine, Department of Epizootiology and Clinic of Birds and Exotic Animals, Wrocław University of Environmental and Life Sciences, Pl. Grunwaldzki 45, 50-366, Wrocław, Poland.

Background: A plasmid-mediated mechanism of bacterial resistance to polymyxin is a serious threat to public health worldwide. The present study aimed to determine the occurrence of plasmid-mediated colistin resistance genes and to conduct the molecular characterization of mcr-positive Escherichia coli strains isolated from Polish poultry.

Methods: In this study, 318 E. Read More

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Perspective: Plant-Based Eating Pattern for Type 2 Diabetes Prevention and Treatment: Efficacy, Mechanisms, and Practical Considerations.

Adv Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of Nutrition, Physicians Committee for Responsible Medicine, Washington, DC, USA.

A plant-based eating pattern is associated with a reduced risk of developing type 2 diabetes and is highly effective in its treatment. Diets that emphasize whole grains, vegetables, fruits, and legumes and exclude animal products improve blood glucose concentrations, body weight, plasma lipid concentrations, and blood pressure and play an important role in reducing the risk of cardiovascular and microvascular complications. This article reviews scientific evidence on the effects of plant-based diets for the prevention and treatment of type 2 diabetes. Read More

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Role of LncRNAs in the Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.

Front Oncol 2021 25;11:690800. Epub 2021 May 25.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Hepatocellular carcinoma (HCC) is a type of primary liver cancer with a high incidence and mortality rate. HCC develops insidiously, and most newly diagnosed cases are in the middle and advanced stages. The epithelial-mesenchymal transition (EMT) is a vital mechanism underlying metastasis in patients with advanced HCC. Read More

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Whole genome sequence analysis of multi drug resistant community associated methicillin resistant from food fish: detection of clonal lineage ST 28 and its antimicrobial resistance and virulence genes.

PeerJ 2021 24;9:e11224. Epub 2021 May 24.

Microbiology, Fermentation & Biotechnology, ICAR- Central Institute of Fisheries Technology, Cochin, Kerala, India.

Methicillin-resistant staphylococcus (MRSA) sequence type 28 (ST 28) and spa type t021 is a CC30, prototype of ST-30, Community Associated-MRSA (CA-MRSA) (S-F +). It is a multi-drug resistant strain harbouring staphylococcal endotoxins, haemolysins, ureolysin, serine protease, and antimicrobial resistance genes. In this study, we report the draft genome sequence of this MRSA isolated from the most commonly used food fish, ribbon fish (). Read More

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Prevalence of 16S rRNA Methylation Enzyme Gene in From Outpatients and Food.

Front Microbiol 2021 25;12:663210. Epub 2021 May 25.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

is the primary cause of community-acquired foodborne infections, so its resistance to antimicrobials, such as aminoglycosides, is a public health issue. Of concern, aminoglycoside resistance in is increasing rapidly. Here, we performed a retrospective study evaluating the prevalence of harboring -mediated aminoglycoside resistance in community-acquired infections and in food or environmental sources. Read More

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Mining of Gram-Negative Surface-Active Enzybiotic Candidates by Sequence-Based Calculation of Physicochemical Properties.

Front Microbiol 2021 25;12:660403. Epub 2021 May 25.

Departamento de Biotecnología Microbiana y de Plantas, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain.

Phage (endo)lysins are nowadays one of the most promising ways out of the current antibiotic resistance crisis. Either as sole therapeutics or as a complement to common antibiotic chemotherapy, lysins are already entering late clinical phases to get regulatory agencies' authorization. Even the old paradigm of the inability of lysins to attack Gram-negative bacteria from without has already been overcome in a variety of ways: either by engineering approaches or investigating the natural mechanisms by which some wild-type lysins are able to interact with the bacterial surface. Read More

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Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder.

Front Psychiatry 2021 25;12:636174. Epub 2021 May 25.

Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.

Bipolar disorder (BD) often progresses to a more chronic and treatment resistant (neuroprogressive) course. Identifying which patients are at risk could allow for early intervention and prevention. Bipolar disorder is highly comorbid with metabolic disorders including type II diabetes mellitus (T2DM), hypertension, obesity, and dyslipidemia. Read More

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Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway.

Diabetes Metab Syndr Obes 2021 4;14:2525-2537. Epub 2021 Jun 4.

Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

Objective: Hepatic insulin resistance is a major initiating factor for type 2 diabetes mellitus. In previous study, Gegen Qinlian Decoction containing berberine could enhance hepatic insulin sensitivity by SIRT1-dependent deacetylation of FOXO1. However, it is not clear whether berberine also can improve hepatic insulin sensitivity by SIRT1/FOXO1 pathway. Read More

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Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes.

Diabetes Metab Syndr Obes 2021 3;14:2489-2494. Epub 2021 Jun 3.

Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue City, Vietnam.

Introduction: Clarifying the prevalence of vitamin D deficiency in diabetic patients, and the relationship between vitamin D concentration and insulin resistance, fasting plasma glucose, and HbA1C in patients in Hue City, Vietnam.

Methods: A cross-sectional study on 110 diabetic patients examined at Hue Central Hospital and Hue University of Medicine and Pharmacy Hospital. These patients were collected venous blood sampling, and the 25(OH)D test, fasting plasma glucose test, fasting insulin test, HOMA-IR and QUICKI calculation. Read More

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