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Stringent response processes suppress DNA damage sensitivity caused by deficiency in full-length translation initiation factor 2 or PriA helicase.

Mol Microbiol 2014 Apr 28;92(1):28-46. Epub 2014 Feb 28.

Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Box 571455, 3900 Reservoir Rd. NW, Washington, DC, 20057-1455, USA.

When Escherichia coli grows in the presence of DNA-damaging agents such as methyl methanesulphonate (MMS), absence of the full-length form of Translation Initiation Factor 2 (IF2-1) or deficiency in helicase activity of replication restart protein PriA leads to a considerable loss of viability. MMS sensitivity of these mutants was contingent on the stringent response alarmone (p)ppGpp being at low levels. While zero levels (ppGpp┬░) greatly aggravated sensitivity, high levels promoted resistance. Read More

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