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Waterborne electrospinning of fluorine-free stretchable nanofiber membranes with waterproof and breathable capabilities for protective textiles.

J Colloid Interface Sci 2021 May 30;602:105-114. Epub 2021 May 30.

Innovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China. Electronic address:

Hypothesis: Smart membranes with robust liquid water resistance and water vapor transmission capabilities have attracted growing attentions in personal protective equipment and environmental protection. However, current fluorine-free waterproof and breathable nanofibrous membranes are usually prepared through toxic solvent-based electrospinning, which raises great concerns about their environmental impacts.

Experiments: We develop environmentally friendly fluorine-free polyurethane nanofibrous membranes with robust waterproof and breathable performances via waterborne electrospinning without post-coating treatment. Read More

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2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds.

Malar J 2021 Jun 11;20(1):264. Epub 2021 Jun 11.

Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Background: Emergence of cross-resistance to current anti-malarial drugs has led to an urgent need for identification of potential compounds with novel modes of action and anti-malarial activity against the resistant strains. One of the most promising therapeutic targets of anti-malarial agents related to food vacuole of malaria parasite is haemozoin, a product formed by the parasite through haemoglobin degradation.

Methods: With this in mind, this study developed two-dimensional-quantitative structure-activity relationships (QSAR) models of a series of 21 haemozoin inhibitors to explore the useful physicochemical parameters of the active compounds for estimation of anti-malarial activities. Read More

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A multi-laboratory assessment of congenital thrombophilia assays performed on the ACL Top 50 family for harmonisation of thrombophilia testing in a large laboratory network.

Clin Chem Lab Med 2021 Jun 14. Epub 2021 Jun 14.

Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia.

Objectives: Thrombophilia testing is commonly performed within hemostasis laboratories, and the ACL TOP 50 family of instruments represent a new 'single platform' of hemostasis instrumentation. The study objective was to evaluate these instruments and manufacturer reagents for utility of congenital thrombophilia assays.

Methods: Comparative evaluations of various congenital thrombophilia assays (protein C [PC], protein S [PS], antithrombin [AT], activated protein C resistance [APCR]) using newly installed ACL TOPs 550 and 750 as well as comparative assessments with existing, predominantly STAGO, instrumentation and reagents. Read More

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Ten-Year Follow-up of Lamellar Keratoplasty Treatment With Acellular Porcine Corneal Stroma: A Case Report.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: To report a 10-year follow-up case of the first lamellar keratoplasty treatment with acellular porcine corneal stroma (APCS).

Methods: A 62-year-old woman was diagnosed with a fungal corneal ulcer and received lamellar keratoplasty treatment with APCS in 2010. The 10-year follow-up results were evaluated by slit lamp biomicroscopy, anterior segment optical coherence tomography, in vivo confocal microscopy, and corneal biomechanics analysis. Read More

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Multilevel Resistive Random Access Memory Achieved by MoO3/Hf/MoO3 Stack and its Application in Tunable High-Pass Filter.

Nanotechnology 2021 Jun 11. Epub 2021 Jun 11.

Xi'an Jiaotong University, No.8 Xian Ning West Road, Xi'an City, Xi'an, 710049, CHINA.

In this work, the multilevel resistive random access memories (RRAMs) have been achieved by using the structure of Pt/MoO3/Hf/MoO3/Pt with four stable resistance states. The devices show good retention property of each state (>104s) and large memory window (>104). The simulation and experimental study reveal that the resistive switching mechanism is ascribed to combination of the conductive filament in the stack of MoO3/Hf next to the top electrode and redox reaction at the interface of Hf/MoO3 next to bottom electrode. Read More

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Evaluation of efficacy and safety of oral voriconazole in the management of recalcitrant and recurrent dermatophytosis.

Clin Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Dermatology, CUTIS Academy of cutaneous sciences, Bangalore, Karnataka, India.

Introduction: Dermatophytosis is a worldwide public health problem affecting more than 20-25% of the world's population. There is a rampant increase in the resistant, recurrent dermatophytosis in the past few years, especially in India. Azole resistance in dermatophytes has been reported as high as 19% worldwide. Read More

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A Robust Incubator to Improve Access to Microbiological Culture in Low Resource Environments.

J Med Device 2019 Mar 22;13(1):0110071-110077. Epub 2019 Jan 22.

Intellectual Ventures Global Good Fund, Bellevue, WA 98007.

To help address the limitations of operating conventional microbiological culture incubators in low resource environments, a new incubator design was developed and tested to meet the requirements of operation in laboratories without reliable power (power outages up to 12 contiguous hours) or climate control (ambient indoor temperatures from 5 °C to 45 °C). The device is designed to enable adherence to incubation temperatures recommended for growth detection, identification, and drug susceptibility testing (DST) of human pathogenic bacteria. During power outages, stable temperatures are maintained in the device's internal sample compartment by employing phase change material (PCM) as a bi-directional thermal battery to maintain incubation temperature. Read More

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Characterization of a Novel Bacteriophage swi2 Harboring Two Lysins Can Naturally Lyse .

Front Microbiol 2021 25;12:670799. Epub 2021 May 25.

College of Veterinary Medicine, Qingdao Agricultural University, Shandong, China.

The novel virulent bacteriophage swi2 was isolated from a pig farm, and its biological characteristics, genome architecture, and infection-related properties were characterized. Phage swi2 has a high titer of 1.01 × 10 PFU/mL with good tolerance to UV rays and remains stable in the pH range of 6-10 and at temperatures less than 50°C. Read More

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Prevalence, knowledge and perception of self-medication practice among undergraduate healthcare students.

J Pharm Policy Pract 2021 Jun 10;14(1):49. Epub 2021 Jun 10.

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Background: Globally, self-medication is a common practice, and an increasingly perceived necessity to relieve burdens on health services. However, inappropriate self-medication may result to reduced health outcomes, increased antimicrobial resistance and economic waste. Healthcare students are the future health professionals who will be consistently responsible for educating the public on rational use of medication. Read More

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Enhanced dewatering of activated sludge by acid assisted Heat-CaO treatment: Simultaneously removing heavy metals and mitigating antibiotic resistance genes.

J Hazard Mater 2021 May 27;418:126248. Epub 2021 May 27.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

High water content and accumulation of heavy metals and antibiotic resistance genes (ARGs) in sewage sludge limit its application. Fenton process has been widely used in sludge dewatering, but the use of hydrogen peroxide (HO) and generation of acid sludge are the main drawbacks. Here, a novel method of heat-CaO treatment was proposed to enhance sludge dewatering. Read More

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BCL-2 Inhibition as Treatment for Chronic Lymphocytic Leukemia.

Curr Treat Options Oncol 2021 Jun 10;22(8):66. Epub 2021 Jun 10.

Bone Marrow Transplantation Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein (SP), São Paulo, 627/520, Brazil.

Opinion Statement: At the end of the 1990s, with the advent of imatinib for chronic myeloid leukemia and rituximab for B cell lymphoproliferative diseases with CD20 expression, there was a great conceptual evolution in the treatment of onco-hematological diseases. Researchers from around the world and the pharmaceutical industry began to focus their efforts on the so-called target therapy used alone or associated with classic chemotherapeutic drugs. In chronic lymphocytic leukemia, the development of second-generation anti-CD20 antibodies, biosimilars, PI3K (phosphatidylinositol 3-kinases) inhibitors, BTK (Bruton's tyrosine kinase) inhibitors, and anti-bcl 2 drugs represented mainly by venetoclax brought new, broader, and more effective opportunities in the treatment of this disease. Read More

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Associations between the severity of medical and surgical complications and perception of surgeon empathy in esophageal and gastric cancer patients.

Support Care Cancer 2021 Jun 10. Epub 2021 Jun 10.

SCALab UMR CNRS 9193, University of Lille, Villeneuve D'AscqCedex, Rue du Barreau BP 60149, Lille, France.

Objective: To assess the impact of global physician empathy and its three subdimensions (establishing rapport, emotional and cognitive processes) on the severity of postoperative complications in a sample of cancer patients.

Methods: We retrospectively analyzed data on 256 patients with esogastric cancer from the French national FREGAT database. Empathy and its subdimensions were assessed using the patient-reported CARE scale and the severity of medical and surgical complications was reported with the Clavien-Dindo classification system. Read More

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Design and Construction of Photochromic and Antileakage Reinforced Wood-Based Cellulose Microframework/Hexadecanol-Coconut Oil Composite Phase Change Material.

Langmuir 2021 Jun 10. Epub 2021 Jun 10.

School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China.

The development of high-performance shape-stable phase change material composites (SPCMs) with high phase change enthalpy and high conversion efficiency, especially with good photochromic properties, is essential for thermal energy storage. Here, we report that one type of SPCMs with both photochromic and phase change energy storage is obtained by incorporating organic binary composite PCMs (hexadecanol/coconut oil, H/C) and photochromic phosphotungstic acid (PA) into Ochroma pyramidale wood-based cellulose microframe (DOW) through simple vacuum impregnation. When the ratio of hexadecanol to coconut oil is 3:7 and the ratio of phosphotungstic acid to ,-dimethylacetamide is 4:13. Read More

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Additives in pet food: are they safe?

Authors:
J M Craig

J Small Anim Pract 2021 Jun 9. Epub 2021 Jun 9.

Re-Fur-All Referrals, Newbury, Berkshire, RG14 7QH, UK.

A good, nutritious diet is essential for the health and well-being of our domestic pets. Today, most pet dogs and cats are fed highly processed food bearing little resemblance to canine and feline ancestral diets. Additives are included in processed pet food to provide nutritional benefits, ensure food safety, and maintain the desirable features of colour, flavour, texture, stability and resistance to spoilage. Read More

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Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal.

Front Med (Lausanne) 2021 24;8:641646. Epub 2021 May 24.

Departamento de Química Inorgánica y Orgánica, Universitat Jaume I, Castellón, Spain.

New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has prepared and described two new readily available materials based on the combination of Rose Bengal (singlet oxygen photosensitizer) and commercially available cationic polystyrene (macroporous resin Amberlite® IRA 900 or gel-type resin IRA 400). These materials showed high efficacy in the antimicrobial photodynamic inactivation (aPDI) of . Read More

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Improved Contact Resistance by a Single Atomic Layer Tunneling Effect in WS /MoTe Heterostructures.

Adv Sci (Weinh) 2021 Jun 15;8(11):e2100102. Epub 2021 Mar 15.

School of Electronic and Electrical Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

Manipulation of Ohmic contacts in 2D transition metal dichalcogenides for enhancing the transport properties and enabling its application as a practical device has been a long-sought goal. In this study, n-type tungsten disulfide (WS ) single atomic layer to improve the Ohmic contacts of the p-type molybdenum ditelluride (MoTe ) material is covered. The Ohmic properties, based on the lowering of Schottky barrier height (SBH) owing to the tunneling barrier effect of the WS monolayer, are found to be unexpectedly excellent at room temperature and even at 100 K. Read More

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Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR : In silico, in vitro and in vivo Studies.

Int J Nanomedicine 2021 1;16:3755-3773. Epub 2021 Jun 1.

Department of Microbiology, Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi, Pakistan.

Purpose: antibiotic resistant infections in high-risk patients are a great challenge for researchers and clinicians worldwide. In an effort to achieve potent bactericidal outcomes, a novel chitosan-mastoparan nanoconstruct (Mast-Cs NC) was designed and assessed for its therapeutic potential through in silico, in vitro and in vivo experimentation against clinical multidrug-resistant (MDR) .

Methods: Optimized 3D structures of mastoparan and chitosan were coupled computationally through an ionic cross-linker to generate a circular ring of chitosan encasing mastoparan. Read More

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Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights.

Drug Des Devel Ther 2021 31;15:2325-2337. Epub 2021 May 31.

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.

Introduction: Epidermal growth factor receptor (EGFR) inhibition is an imperative therapeutic approach targeting various types of cancer including colorectal, lung, breast, and pancreatic cancer types. Moreover, cyclooxygenase-2 (COX-2) is frequently overexpressed in different types of cancers and has a role in the promotion of malignancy, apoptosis inhibition, and metastasis of tumor cells. Combination therapy has been emerged to improve the therapeutic benefit against cancer and curb intrinsic and acquired resistance. Read More

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[The clinical effect and imaging features of accordion maneuver in promoting bone healing at the docking site after tibial transport under ultrasonic monitoring].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):477-483

Department of Orthopaedics,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China.

To explore the imaging features and clinical effect of accordion maneuver in promoting the bone healing at the docking site after tibial transport under ultrasonic monitoring. Retrospective analysis was conducted on the clinical data of 16 patients with tibial bone transport who were admitted to the Department of Orthopedics, the second Hospital of Shanxi Medical University from May 2018 to October 2019. All the patients were treated with accordion maneuver to promote bone healing at the docking site under ultrasound monitoring. Read More

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Resistance to Eating in People with Dementia Living in Long-term Care Facilities: Gaps between Common and Good Practices.

Clin Gerontol 2021 Jun 8:1-11. Epub 2021 Jun 8.

Department of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain.

: The present study aims to explore the perception of common and best practices for dealing with resistance to eating of persons with dementia living in long-term care facilities.: Forty-two staff members working in long-term care facilities were interviewed. They worked in four Spanish long-term care facilities; 21 were nursing assistants and 21 technical staff. Read More

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An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile.

Biomacromolecules 2021 Jun 8. Epub 2021 Jun 8.

Functional Polymer Materials, Chair for Advanced Materials Synthesis, Institute for Functional Materials and Biofabrication, Department of Chemistry and Pharmacy, Julius-Maximilians-University Würzburg, Röntgenring 11, Würzburg 97070, Germany.

Hydrogels are key components in several biomedical research areas such as drug delivery, tissue engineering, and biofabrication. Here, a novel ABA-type triblock copolymer comprising poly(2-methyl-2-oxazoline) as the hydrophilic A blocks and poly(2-phenethyl-2-oxazoline) as the aromatic and hydrophobic B block is introduced. Above the critical micelle concentration, the polymer self-assembles into small spherical polymer micelles with a hydrodynamic radius of approx 8-8. Read More

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The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio.

Diabetol Metab Syndr 2021 Jun 7;13(1):61. Epub 2021 Jun 7.

Clinical Analysis Department, College of Pharmacy, Hawler Medical University, Roya Towers C21, Erbil, Iraq.

Background: Prediabetes is characterized by a hemoglobin A1c of 5.7-6.4% and fasting blood glucose of 100-125 mg/dl. Read More

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Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties.

ACS Appl Mater Interfaces 2021 Jun 7. Epub 2021 Jun 7.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

Diabetic foot ulcers (DFUs) are hard-healing chronic wounds and susceptible to bacterial infection. Conventional hydrogel dressings easily lose water at high temperature or freeze at low temperature, making them unsuitable for long-term use or in extreme environments. Herein, a temperature-tolerant (-20 to 60 °C) antibacterial hydrogel dressing is fabricated by the assembly of polyacrylamide, gelatin, and ε-polylysine. Read More

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Delving into possible missing links for attainment of food security in Central Malawi: farmers' perceptions and long term dynamics in maize ( L.) production.

Heliyon 2021 May 24;7(5):e07130. Epub 2021 May 24.

Ministry of Agriculture, Salima Agricultural Development Division, Private Bag 1, Salima, Malawi.

Globally, maize is one of the major cereal crops contributing 30% of food calories to about 4.6 billion people. The crop is considered staple in 125 developing countries where majority of producers are smallholder farmers. Read More

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Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications.

Heliyon 2021 May 21;7(5):e07058. Epub 2021 May 21.

Grupo de Investigación de Fotoquímica y Fotobiología, Universidad del Atlántico, Carrera 30 Número 8-49, Puerto Colombia 081008, Colombia.

Graphene oxide (GO) has recently gained attention as a scaffold reinforcing agent for tissue engineering. Biomechanical and biological properties through a synergistic effect can be strengthened when combined with other materials such as chitosan (CS). For that reason, chitosan was used for Graphene Oxide (GO) functionalization through an amide group whose formation was evident by bands around 1600 cm in the FTIR analysis. Read More

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Implementation of Automated Blood Culture With Quality Assurance in a Resource-Limited Setting.

Front Med (Lausanne) 2021 21;8:627513. Epub 2021 May 21.

Laboratoire Central, Centre Hospitalier et Universitaire de Bouaké, Bouaké, Côte d'Ivoire.

Blood cultures (BC) have a high clinical relevance and are a priority specimen for surveillance of antimicrobial resistance. Manual BC are still most frequently used in resource-limited settings. Data on automated BC performance in Africa are scarce. Read More

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Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1.

Front Oncol 2021 20;11:664689. Epub 2021 May 20.

Department of Medicine, Queen Mary School, Medical College of Nanchang University, Nanchang, China.

Estrogen receptor α (ERα) is the major driver for breast tumor carcinogenesis and progression, while ERα positive breast cancer is the major subtype in breast malignancies, which account for 70% breast cancers in patients. The success of endocrine therapy such as tamoxifen is one of the biggest breakthroughs in breast cancer treatments. However, the endocrine therapy resistance is a headache problem in breast cancer. Read More

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The Outcome and Safety of Re-challenge Lutetium-177 PSMA (Lu-PSMA) Therapy with Low-Dose Docetaxel as a Radiosensitizer-a Promising Combination in Metastatic Castrate-Resistant Prostate Cancer (mCRPC): a Case Report.

Nucl Med Mol Imaging 2021 Jun 13;55(3):136-140. Epub 2021 Apr 13.

Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.

Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (PSMA-RLT) with lutetium-177 (Lu-PSMA) has been used in metastatic castrate-resistant prostate cancer (mCRPC), and retrospective data have shown this therapy to be favourably safe with attractive clinical responses. Re-challenge Lu-PSMA therapy in early responders has been shown to be safe and effective. We report the use of low-dose Taxol-based chemotherapy (modified dose 25 mg/m weekly × 6 weeks) as a radiosensitizer with re-challenge Lu-PSMA therapy (4 cycles). Read More

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Chemical constituents from coconut waste and their evaluation as potential antiviral agents against SARS-CoV-2.

S Afr J Bot 2021 Sep 28;141:278-289. Epub 2021 May 28.

Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, 33516, Egypt.

Eleven compounds were isolated from the ethyl acetate extract of L endocarp, jezonofol , scirpusin A , cassigarol G , maackin A , threoguiacyl glycerol-8'-vanillic acid ether , erythroguiacyl glycerol-8'-vanillic acid ether , apigenin-7---D-glucoside , piceatannol , -hydroxy-benzoic acid , protocatechuic acid and vanillic acid . Compounds - were isolated for the first time from the plant. The isolated compounds were virtually screened against four critical components of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the main protease (M), papain-like protease (PL), nonstructural protein 13 (nsp13) and RNA dependent RNA polymerase (RdRp). Read More

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September 2021

Enterococcus faecium CMUL1216 an Immunobiotic Strain with a Potential Application in Animal Sector.

Biocontrol Sci 2021 ;26(2):75-84

Laboratoire de Microbiologie Santé et Environnement (LMSE), Doctoral School of Sciences and Technology, Faculty of Public Health, Lebanese University.

Antibiotic misuse in the animal sector is the first cause of the emergence and spreading of MDR bacteria. Prevention of infectious diseases and enhancement of animal growth are the main effects of antibiotics that push farmers and veterinarians to use this molecule in animal farms. Thus, the use of alternative solutions such as natural antimicrobial substances as well as probiotic strains is a crucial need in this sector. Read More

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January 2021