43,900 results match your criteria resistance biomarkers

Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report.

Oncol Res Treat 2021 Jul 28:1-7. Epub 2021 Jul 28.

Department of Hematology, Oncology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: The prognosis of pancreatic cancer has improved only modestly in recent years. This is partly due to the lack of development in precision oncology including immune oncology in this entity. Rearrangements of the proto-oncogene tyrosine protein kinase ROS1 gene represent driver alterations found especially in lung cancer. Read More

View Article and Full-Text PDF

Increased nitro-oxidative toxicity in association with metabolic syndrome, atherogenicity and insulin resistance in patients with affective disorders.

J Affect Disord 2021 Jul 18;294:410-419. Epub 2021 Jul 18.

Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. Electronic address:

Background: There is a strong comorbidity between mood disorders and metabolic syndrome (MetS). Increased levels of reactive oxygen and nitrogen species (RONS) and nitro-oxidative stress toxicity (NOSTOX) partially underpin this comorbidity.

Aims: To examine the associations of RONS/NOSTOX biomarkers with MetS after adjusting for the significant effects of mood disorders (major depression, and bipolar type 1 and 2), generalized anxiety disorder (GAD), tobacco use disorder (TUD), and male sex. Read More

View Article and Full-Text PDF

PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer.

J Immunother Cancer 2021 Jul;9(7)

Department of Oncology and Hematology, Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Background: In patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC), immune checkpoint blockade is ineffective, and combinatorial approaches enhancing immunogenicity need exploration.

Methods: We treated 43 patients with predominantly microsatellite stable wild-type mCRC on a phase II trial combining chemotherapy with the epidermal growth factor receptor antibody cetuximab and the programmed cell death ligand 1 (PD-L1) antibody avelumab. We performed next-generation gene panel sequencing for mutational typing of tumors and liquid biopsy monitoring as well as digital droplet PCR to confirm individual mutations. Read More

View Article and Full-Text PDF

Several miRNAs derived from serum extracellular vesicles are potential biomarkers for early diagnosis and progression of Parkinson's disease.

Transl Neurodegener 2021 Jul 28;10(1):25. Epub 2021 Jul 28.

Department of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.

Background: Blood-based test for predicting disease progression and early diagnosis of Parkinson's disease (PD) is an unmet need in the clinic. The profiles of microRNAs (miRNAs) are regarded as potential diagnostic biomarkers for human diseases, whereas miRNAs in the periphery are susceptible to the influence of various components. MiRNAs enriched in serum extracellular vesicles (EVs) have demonstrated disease-specific advantages in diagnosis due to their high abundance, stability and resistance to degradation. Read More

View Article and Full-Text PDF

Heme oxygenase-1 and neopterin plasma/serum levels and their role in diagnosing active and latent TB among HIV/TB co-infected patients: a cross sectional study.

BMC Infect Dis 2021 Jul 27;21(1):711. Epub 2021 Jul 27.

Department of Immunology & Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.

Background: Tuberculosis (TB) diagnosis in the context of HIV co-infection remains challenging. Heme oxygenase 1 (HO-1) and neopterin have been validated as potential biomarkers for TB diagnosis. Latent TB infection (LTBI) is diagnosed using tuberculin skin test (TST) and interferon gamma release assays (T-Spot and QuantiFERON TB gold tests, respectively). Read More

View Article and Full-Text PDF

Exercise training combined with treatment regulates insulin resistance and physical performance in / mice.

Food Funct 2021 Jul 23. Epub 2021 Jul 23.

Graduate Institute of Sports Science, Natioal Taiwan Sport University, Taoyuan City 33301, Taiwan.

Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease characterized by hyperglycemia and insulin resistance. Regular exercise is one of the effective lifestyle interventions for maintaining healthy weight and blood glucose levels in the normal range and lowering risk factors. Probiotics, live microorganisms that are beneficial to health, are involved in the regulation of host metabolism. Read More

View Article and Full-Text PDF

Transcranial magnetic stimulation indices of cortical excitability enhance the prediction of response to pharmacotherapy in late-life depression.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Jul 23. Epub 2021 Jul 23.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, M6J 1H4, Canada;; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, M5T 1R8, Canada;; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, M5T 1R8, Canada;. Electronic address:

Background: Older adults with late-life depression (LLD) often experience incomplete or lack of response to first-line pharmacotherapy. The treatment of LLD could be improved using objective biological measures to predict response. Transcranial magnetic stimulation (TMS) can be used to measure cortical excitability, inhibition, and plasticity, which have been implicated in LLD pathophysiology, and associated with brain stimulation treatment outcomes in younger adults with depression. Read More

View Article and Full-Text PDF

The impact of atezolizumab and bevacizumab in hepatocellular carcinoma with activated ß-catenin signaling.

Cancer Rep (Hoboken) 2021 Jul 26:e1493. Epub 2021 Jul 26.

Department of Internal Medicine I, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: To date, no biomarkers exist to predict response or resistance to immunotherapy in hepatocellular carcinoma (HCC). Recent approaches to classify HCC into different immunological states revealed a negative correlation between Wnt/ß-catenin activation and immunogenicity and T-cell infiltration. If these "cold" tumors with primary resistance to checkpoint inhibition (CPI) may benefit from dual treatment of CPI and anti-angiogenic therapy has not been proved. Read More

View Article and Full-Text PDF

Mycobacterial Infection of Precision-Cut Lung Slices Reveals Type 1 Interferon Pathway Is Locally Induced by but Not in a Cattle Breed.

Front Vet Sci 2021 9;8:696525. Epub 2021 Jul 9.

INRAE, Université de Tours, Nouzilly, France.

Tuberculosis exacts a terrible toll on human and animal health. While (Mtb) is restricted to humans, (Mb) is present in a large range of mammalian hosts. In cattle, bovine TB (bTB) is a noticeable disease responsible for important economic losses in developed countries and underestimated zoonosis in the developing world. Read More

View Article and Full-Text PDF

Metabolic and Immunological Subtypes of Esophageal Cancer Reveal Potential Therapeutic Opportunities.

Front Cell Dev Biol 2021 8;9:667852. Epub 2021 Jul 8.

The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, United States.

Background: Esophageal cancer has the sixth highest rate of cancer-associated deaths worldwide, with many patients displaying metastases and chemotherapy resistance. We sought to find subtypes to see if precision medicine could play a role in finding new potential targets and predicting responses to therapy. Since metabolism not only drives cancers but also serves as a readout, metabolism was examined as a key reporter for differences. Read More

View Article and Full-Text PDF

Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer.

Front Cell Dev Biol 2021 8;9:666515. Epub 2021 Jul 8.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Despite the current progress in the development of new concepts of precision medicine for head and neck squamous cell carcinoma (HNSCC), in particular targeted therapies and immune checkpoint inhibition (CPI), overall survival rates have not improved during the last decades. This is, on the one hand, caused by the fact that a significant number of patients presents with late stage disease at the time of diagnosis, on the other hand HNSCC frequently develop therapeutic resistance. Distinct intratumoral and intertumoral heterogeneity is one of the strongest features in HNSCC and has hindered both the identification of specific biomarkers and the establishment of targeted therapies for this disease so far. Read More

View Article and Full-Text PDF

Targeting Glioblastoma Stem Cells: A Review on Biomarkers, Signal Pathways and Targeted Therapy.

Front Oncol 2021 8;11:701291. Epub 2021 Jul 8.

Department of Neurosurgery, University-Town Hospital of Chongqing Medical University, Chongqing, China.

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation. Although great advances in medical development and improvements in therapeutic methods of GBM have led to a certain extension of the median survival time of patients, prognosis remains poor. The primary cause of its dismal outcomes is the high rate of tumor recurrence, which is closely related to its resistance to standard therapies. Read More

View Article and Full-Text PDF

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis.

Front Oncol 2021 7;11:692142. Epub 2021 Jul 7.

Translational Immunology and Nanotechnology Research Program, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor microenvironment promotes the secretion of diverse cytokines, in different types and stages of cancers. These cytokines may inhibit tumor development but alternatively may contribute to chronic inflammation that supports tumor growth in both autocrine and paracrine manners and have been linked to poor cancer outcomes. Read More

View Article and Full-Text PDF

Establishment of an Immune Cell Infiltration Score to Help Predict the Prognosis and Chemotherapy Responsiveness of Gastric Cancer Patients.

Front Oncol 2021 9;11:650673. Epub 2021 Jul 9.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

The immune microenvironment plays a critical role in tumor biology. The molecular profiles of immune components and related genes are of tremendous value for the study of primary resistance to immune checkpoint blockers (ICBs) for gastric cancer (GC) and serve as prognostic biomarkers to predict GC survival. Recent studies have revealed that tumor immune cell infiltration (ICI) is an indicator of the survival and responsiveness to chemotherapy in GC patients. Read More

View Article and Full-Text PDF

Role of insulin, insulin sensitivity, and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates.

Open Vet J 2021 Apr-Jun;11(2):228-237. Epub 2021 Apr 30.

Division of Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.

Background: Ketosis is one of the most critical metabolic disorders that occur in dairy cows after parturition due to negative energy balance around calving.

Aim: The study evaluated a specific therapeutic regimen of ketosis in Holstein dairy cattle by using the combination therapy including hormones, corticosteroids, propylene glycol, and vitamin B12 as well as the use of milk yield rates, insulin, insulin sensitivity, and abomasal functions monitors as diagnostic biomarkers for the recovery of ketotic cows either pre-therapy (0 days) or post-therapy (7 and 14 days).

Methods: This study was conducted on ketotic cattle ( = 20) belonged to different dairy farms in Cairo and Giza governorates, Egypt. Read More

View Article and Full-Text PDF

[Relationships between decreased LAMC3 and poor prognosis in ovarian cancer].

Zhonghua Fu Chan Ke Za Zhi 2021 Jul;56(7):489-497

Life Science Institute, Key Laboratory of Early Prevention and Treatment of Regional High-incidence Tumors, Ministry of Education, Guangxi Medical University,Nanning 530021, China.

To investigate the correlations of laminin subunit gamma 3 (LAMC3) expression with prognosis of ovarian cancer (OC). LAMC3 protein expression was measured using immunohistochemical streptavidin-peroxidase-biotin connection method (IHC). Gene expression and related clinical data in the cancer genome atlas (TCGA) cohort and clinical proteomic tumor analysis consortium (CPTAC) were applied to analyse the correlation between gene and protein expressions and clinical outcomes. Read More

View Article and Full-Text PDF

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors.

Support Care Cancer 2021 Jul 25. Epub 2021 Jul 25.

Department of Kinesiology, University of Wisconsin-Madison, 1300 University Ave, Bardeen 253A, Madison, WI, 53706, USA.

Purpose: Endometrial cancer is strongly linked to obesity and inactivity; however, increased physical activity has important benefits even in the absence of weight loss. Resistance (strength) training can deliver these benefits; yet few women participate in resistance exercise. The purpose of this study was to describe both physiological and functional changes following a home-based strength training intervention. Read More

View Article and Full-Text PDF

Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia.

NPJ Precis Oncol 2021 Jul 23;5(1):71. Epub 2021 Jul 23.

Computational Oncology, Sage Bionetworks, Seattle, WA, USA.

The FDA recently approved eight targeted therapies for acute myeloid leukemia (AML), including the BCL-2 inhibitor venetoclax. Maximizing efficacy of these treatments requires refining patient selection. To this end, we analyzed two recent AML studies profiling the gene expression and ex vivo drug response of primary patient samples. Read More

View Article and Full-Text PDF

Effects of high-load and low-load resistance training in patients with coronary artery disease: rationale and design of a randomised controlled clinical trial.

BMJ Open 2021 Jul 22;11(7):e051325. Epub 2021 Jul 22.

Division of Cardiology, General Hospital Murska Sobota, Murska Sobota, Slovenia

Introduction: Resistance training (RT) combined with aerobic training (AT) enhances the effects of cardiac rehabilitation (CR) in patients with coronary artery disease (CAD). However, it remains to be investigated which type of RT (high loads (HLs) vs low loads (LLs)) is more efficacious in improving exercise performance, cardio-metabolic health and quality of life.

Methods And Analysis: A randomised, controlled, clinical trial will enrol 20 patients with CAD into each of three study arms (total 60 patients): HL-RT (70%-80% of one repetition maximum (1-RM)) combined with AT; LL-RT (30%-40% of 1-RM) combined with AT and AT alone as standard care. Read More

View Article and Full-Text PDF

Risk of non-typhoidal Salmonella vascular infections is increased with degree of atherosclerosis and inflammation: A multicenter study in southern Taiwan.

J Microbiol Immunol Infect 2021 Jun 21. Epub 2021 Jun 21.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Infection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Diagnostic Microbiology and Antimicrobial Resistance Laboratory, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Background: Atherosclerosis and vascular inflammatory response have been considered as risk factors for non-typhoidal Salmonella (NTS) vascular infection. The study aims to assess the risk of vascular infection by measuring atherosclerosis severity, NTS vascular infection (NTSVI) score, and serum levels of inflammatory markers in people with NTS bacteremia.

Methods: A prospective observational study was conducted in two medical centers and two regional hospitals. Read More

View Article and Full-Text PDF

VOCs Are Relevant Biomarkers of Elicitor-Induced Defences in Grapevine.

Molecules 2021 Jul 13;26(14). Epub 2021 Jul 13.

Agroécologie, AgroSup Dijon, CNRS, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, 21000 Dijon, France.

Grapevine is susceptible to fungal diseases generally controlled by numerous chemical fungicides. Elicitors of plant defence are a way of reducing the use of these chemicals, but still provide inconsistent efficiency. Easy-to-analyse markers of grapevine responses to elicitors are needed to determine the best conditions for their efficiency and position them in protection strategies. Read More

View Article and Full-Text PDF

The Role of microRNAs in Cholangiocarcinoma.

Int J Mol Sci 2021 Jul 16;22(14). Epub 2021 Jul 16.

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.

Cholangiocarcinoma (CCA), an aggressive malignancy, is typically diagnosed at an advanced stage. It is associated with dismal 5-year postoperative survival rates, generating an urgent need for prognostic and diagnostic biomarkers. MicroRNAs (miRNAs) are a class of non-coding RNAs that are associated with cancer regulation, including modulation of cell cycle progression, apoptosis, metastasis, angiogenesis, autophagy, therapy resistance, and epithelial-mesenchymal transition. Read More

View Article and Full-Text PDF

PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1.

Cancers (Basel) 2021 Jul 20;13(14). Epub 2021 Jul 20.

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, ICM, F-34298 Montpellier, France.

Resistance to castration is a crucial issue in the treatment of metastatic prostate cancer. Kinase inhibitors (KIs) have been tested as potential alternatives, but none of them are approved yet. KIs are subject of extensive metabolism at both the hepatic and the tumor level. Read More

View Article and Full-Text PDF

Target Heterogeneity in Oncology: The Best Predictor for Differential Response to Radioligand Therapy in Neuroendocrine Tumors and Prostate Cancer.

Cancers (Basel) 2021 Jul 19;13(14). Epub 2021 Jul 19.

Department of Nuclear Medicine, University Hospital Ulm, 89081 Ulm, Germany.

Tumor or target heterogeneity (TH) implies presence of variable cellular populations having different genomic characteristics within the same tumor, or in different tumor sites of the same patient. The challenge is to identify this heterogeneity, as it has emerged as the most common cause of 'treatment resistance', to current therapeutic agents. We have focused our discussion on 'Prostate Cancer' and 'Neuroendocrine Tumors', and looked at the established methods for demonstrating heterogeneity, each with its advantages and drawbacks. Read More

View Article and Full-Text PDF

DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model.

Cancers (Basel) 2021 Jul 17;13(14). Epub 2021 Jul 17.

Hématologie Biologique, CHU Clermont-Ferrand, Hôpital Estaing, 1 Place Lucie et Raymond Aubrac, CEDEX 1, 63003 Clermont-Ferrand, France.

Chronic Myeloid Leukemia (CML) is a model to investigate the impact of tumor intra-clonal heterogeneity in personalized medicine. Indeed, tyrosine kinase inhibitors (TKIs) target the BCR-ABL fusion protein, which is considered the major CML driver. TKI use has highlighted the existence of intra-clonal heterogeneity, as indicated by the persistence of a minority subclone for several years despite the presence of the target fusion protein in all cells. Read More

View Article and Full-Text PDF

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma.

Cancers (Basel) 2021 Jul 12;13(14). Epub 2021 Jul 12.

Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy that shows a remarkable ethnic and geographical distribution. It is one of the major public health problems in some countries, especially Southern China and Southeast Asia, but rare in most Western countries. Multifactorial interactions such as Epstein-Barr virus infection, individual's genetic susceptibility, as well as environmental and dietary factors may facilitate the pathogenesis of this malignancy. Read More

View Article and Full-Text PDF

Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer.

Cancers (Basel) 2021 Jul 6;13(14). Epub 2021 Jul 6.

Clinic of Medical Oncology, Hospital Nadezhda, 1000 Sofia, Bulgaria.

Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. Read More

View Article and Full-Text PDF

Gamma oscillations predict treatment response to aripiprazole in bipolar disorder.

J Affect Disord 2021 Jul 16;294:159-162. Epub 2021 Jul 16.

Uskudar University, NPIstanbul Brain Hospital, Department of Neurology, Istanbul, Turkey.

Objective: Treatment of Bipolar Disorder (BD) is a challenging issue. Aripiprazole monotherapy is a recommended option for the treatment of mania in BD. The electrophysiological markers of treatment response to aripiprazole could be potentially identified by quantitative Electroencephalography (qEEG). Read More

View Article and Full-Text PDF

An Immunogenomic Phenotype Predicting Behavioral Treatment Response: Toward Precision Psychiatry for Mothers and Children with Trauma Exposure.

Brain Behav Immun 2021 Jul 20. Epub 2021 Jul 20.

Department of Psychiatry, Weill Institute for Neurosciences, University of California San Francisco; Center for Health and Community, University of California San Francisco; Department of Pediatrics, Division of Developmental Medicine, University of California San Francisco. Electronic address:

Inflammatory pathways predict antidepressant treatment non-response among individuals with major depression; yet, this phenomenon may have broader transdiagnostic and transtherapeutic relevance. Among trauma-exposed mothers (M=32 years) and their young children (M=4 years), we tested whether genomic and proteomic biomarkers of pro-inflammatory imbalance prospectively predicted treatment response (PTSD and depression) to an empirically-supported behavioral treatment. Forty-three mother-child dyads without chronic disease completed Child Parent Psychotherapy (CPP) for roughly 9 months. Read More

View Article and Full-Text PDF

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives.

Front Oncol 2021 6;11:664290. Epub 2021 Jul 6.

Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.

Globally, lung cancer is the most commonly diagnosed cancer and carries with it the greatest mortality rate, with 5-year survival rates varying from 4-17% depending on stage and geographical differences. For decades, researchers have studied disease mechanisms, occurrence rates and disease development, however, the mechanisms underlying disease progression are not yet fully elucidated, thus an increased understanding of disease pathogenesis is key to developing new strategies towards specific disease diagnoses and targeted treatments. Circular RNAs (circRNAs) are a class of non-coding RNA widely expressed in eukaryotic cells, and participate in various biological processes implicated in human disease. Read More

View Article and Full-Text PDF