5,475 results match your criteria residual damage

Salvage Enbloc Thulium Fiber Laser Enucleation of Prostate for Giant Prostatomegaly after Prostatic Urethral Lift.

Urology 2021 May 7. Epub 2021 May 7.

University of Miami, Miller School of Medicine-1400 NW 12th Ave, Miami, FL 33136. Electronic address:

Objective: Prostatic urethral lift (PUL) is an accepted treatment modality for benign prostatic hyperplasia (BPH) and is currently recommended for surgical management of prostates < 80 grams in size. However, in reality some patients with prostate > 80 gram also receive PUL. A substantial number of these patients may requirement re-treatment for recurrent or persistent lower urinary tract symptoms (LUTS) after PUL. Read More

View Article and Full-Text PDF

The prognostic value of transesophageal echocardiography after transvenous lead extraction: landscape after battle.

Cardiovasc Diagn Ther 2021 Apr;11(2):394-410

Department of Cardiology, Medical University, Lublin, Poland.

Background: In patients undergoing transvenous lead extraction (TLE) transesophageal echocardiography (TEE) provide valuable information after procedure.

Methods: We analyzed data from 936 TEE performed in patients undergoing TLE between 2015 and 2019 (mean follow-up 566.23±224. Read More

View Article and Full-Text PDF

Study on the Strength Performance of Recycled Aggregate Concrete with Different Ages under Direct Shearing.

Materials (Basel) 2021 Apr 29;14(9). Epub 2021 Apr 29.

School of Civil and Architectural Engineering, Guangxi University of Science and Technology, Liuzhou 545006, China.

In order to study the mechanical properties of recycled aggregate concrete (RAC) at different ages, 264 standard cubes were designed to test its direct shear strength and cube compressive strength while considering the parameters of age and recycled aggregate replacement ratio. The failure pattern and load-displacement curve of specimens at direct shearing were obtained; the direct shear strength and residual shear strength were extracted from the load-displacement curves. Experimental results indicate that the influence of the replacement ratio for the front and side cracks of RAC is insignificant, with the former being straight and the latter relatively convoluted. Read More

View Article and Full-Text PDF

Chlorine disinfection facilitates natural transformation through ROS-mediated oxidative stress.

ISME J 2021 May 3. Epub 2021 May 3.

Advanced Water Management Centre (AWMC), The University of Queensland, St Lucia, Brisbane, QLD, Australia.

The bacterial infection that involves antimicrobial resistance is a rising global threat to public health. Chlorine-based water disinfection processes can inactivate antibiotic resistant bacteria. However, at the same time, these processes may cause the release of antibiotic resistance genes into the water as free DNA, and consequently increase the risk to disseminate antibiotic resistance via natural transformation. Read More

View Article and Full-Text PDF

Autism-associated vigilin depletion impairs DNA damage repair.

Mol Cell Biol 2021 May 3. Epub 2021 May 3.

Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir 190006, India.

Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, mRNA stability and is associated with autism-spectrum disorders and cancer, vigilin, for example, can suppress proto-oncogene c-fms expression in breast cancer. Conserved from yeast to humans, vigilin is an RNA-binding protein with 14 tandemly arranged nonidentical hnRNP K type homology (KH) domains. Here we report that vigilin depletion increased cell sensitivity to cisplatin- or ionizing radiation (IR)-induced cell death and genomic instability due to defective DNA repair. Read More

View Article and Full-Text PDF

Current approaches of preservation of cells during (freeze-) drying.

J Pharm Sci 2021 Apr 29. Epub 2021 Apr 29.

Ludwig-Maximilian-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Munich, Germany.

The widespread application of therapeutic cells requires a successful stabilization of cells for the duration of transport and storage. Cryopreservation is currently considered the gold standard for the storage of active cells; however, (freeze-) drying cells could enable higher shelf life stability at ambient temperatures and facilitate easier transport and storage. During (freeze-) drying, freezing, (primary and secondary) drying and also the reconstitution step pose the risk of potential cell damage. Read More

View Article and Full-Text PDF

The in-plane structure domain size of nm-thick MoSe uncovered by low-momentum phonon scattering.

Nanoscale 2021 Apr;13(16):7723-7734

Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA.

Although 2D materials have been widely studied for more than a decade, very few studies have been reported on the in-plane structure domain (STD) size even though such a physical property is critical in determining the charge carrier and energy carrier transport. Grazing incidence X-ray diffraction (XRD) can be used for studying the in-plane structure of very thin samples, but it becomes more challenging to study few-layer 2D materials. In this work the nanosecond energy transport state-resolved Raman (nET-Raman) technique is applied to resolve this key problem by directly measuring the thermal reffusivity of 2D materials and determining the residual value at the 0 K-limit. Read More

View Article and Full-Text PDF

Cardiorespiratory Fitness in Volleyball Athletes Following a COVID-19 Infection: A Cross-Sectional Study.

Int J Environ Res Public Health 2021 04 12;18(8). Epub 2021 Apr 12.

Faculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia.

Athletes' lifestyles have been dramatically affected by the coronavirus disease 2019 (COVID-19) pandemic. Since COVID-19 primarily affects the respiratory system and to a lesser degree the cardiovascular system, the goal of this study was to examine the effects of COVID-19-caused detraining on cardiorespiratory fitness (CRF) of recently recovered volleyball athletes. Sixteen experienced volleyball athletes (age 24 ± 4. Read More

View Article and Full-Text PDF

Impact of Drying on Structural Performance of Reinforced Concrete Beam with Slab.

Materials (Basel) 2021 Apr 10;14(8). Epub 2021 Apr 10.

Department of Environmental Engineering and Architecture, Graduate School of Environmental Studies, Nagoya University, Nagoya 464 8603, Japan.

Evaluating the performance of reinforced concrete (RC) structures during earthquakes and the resultant damage in the structures depends on an accurate load-displacement relationship. Several experimental and analytical evaluation methods for load-displacement relationships have been proposed and specified in current design standards. However, there have been few quantitative studies on the impact of drying on the yielding behavior of RC members, including evaluations of the effective stiffness of members. Read More

View Article and Full-Text PDF

Extended Residual-State Creep Test and Its Application for Landslide Stability Assessment.

Materials (Basel) 2021 Apr 14;14(8). Epub 2021 Apr 14.

Department of Building Engineering, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.

This paper contains the results of a newly developed residual-state creep test performed to determine the behavior of a selected geomaterial in the context of reactivated landslides. Soil and rock creep is a time-dependent phenomenon in which a deformation occurs under constant stress. Based on the examination results, it was found that the tested clayey material (from Kobe, Japan) shows tertiary creep behavior only under shear stress higher than the residual strength condition and primary and secondary creep behavior under shear stress lower or equal to the residual strength condition. Read More

View Article and Full-Text PDF

An Acoustic Emission Method for Assessing the Degree of Degradation of Mechanical Properties and Residual Life of Metal Structures under Complex Dynamic Deformation Stresses.

Materials (Basel) 2021 Apr 21;14(9). Epub 2021 Apr 21.

Department of Energetics, Electrical Engineering and Physics, Kherson National Technical University, 73008 Kherson, Ukraine.

An acoustic emission method for assessing the degree of degradation of mechanical properties under conditions of complex dynamic deformation stresses is proposed. It has been shown that changing the operating conditions of metal structures, peak loads, external collisions, and thermally changing loads, which cannot be taken into account, leads to uncertainty and unpredictable structural changes in the material. This in turn makes it difficult to identify the state of the structure material to ensure trouble-free operation of the equipment. Read More

View Article and Full-Text PDF

New Functionalized Macroparticles for Environmentally Sustainable Biofilm Control in Water Systems.

Antibiotics (Basel) 2021 Apr 7;10(4). Epub 2021 Apr 7.

INL, International Iberian Nanotechnology Laboratory, Avenida Mestre José Veiga s/n, 4715-330 Braga, Portugal.

Reverse osmosis (RO) depends on biocidal agents to control the operating costs associated to biofouling, although this implies the discharge of undesired chemicals into the aquatic environment. Therefore, a system providing pre-treated water free of biocides arises as an interesting solution to minimize the discharge of chemicals while enhancing RO filtration performance by inactivating bacteria that could form biofilms on the membrane system. This work proposes a pretreatment approach based on the immobilization of an industrially used antimicrobial agent (benzalkonium chloride-BAC) into millimetric aluminum oxide particles with prior surface activation with DA-dopamine. Read More

View Article and Full-Text PDF

Closing Difficult Laparostomies With the Aid of Botulinum Toxin A: An Audit of 12 Cases.

Cureus 2021 Mar 23;13(3):e14066. Epub 2021 Mar 23.

General Surgery, Fiona Stanley and Fremantle Hospital Group, Perth, AUS.

Background Obtaining primary fascial closure following laparostomy can be difficult; especially with fascial retraction or large pre-existing fascial defects. Various techniques have been described in the literature which attempt to improve reapproximation rates. Most techniques described comprise the use of adjuncts including Bogota Bags, negative pressure dressings, anchor devices and various types of mesh. Read More

View Article and Full-Text PDF

A novel technology for reversible fallopian tubal occlusion using a reverse thermo-responsive polymer-Preliminary results from a rabbit animal study.

Contraception 2021 Apr 21. Epub 2021 Apr 21.

Department of Medical Imaging, Interventional Radiology Unit, Hadassah Medical Center - Hebrew University of Jerusalem, Jerusalem, Israel.

Objectives: To determine if PF-88, a reverse thermo-responsive polymer designed to create a gel at body temperature and liquefy at a lower temperature (21°C) can reversibly occlude the fallopian tubes in rabbits.

Study Design: Mature female New Zealand White rabbits underwent laparotomy and placement of 22-gage catheter into the lumen of the distil uterine horns for evaluation of tubal patency by fluoroscopy using radio opaque contrast and treatment with PF-88. In the Acute Phase group (n = 5) after PF-88 treatment we immediately cooled the serosal surface of the tube with ice for 90 seconds to liquify the gel then reassessed patency. Read More

View Article and Full-Text PDF

Incorporation of residual attention modules into two neural networks for low-dose CT denoising.

Med Phys 2021 Apr 23. Epub 2021 Apr 23.

Department of Medical Imaging, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.

Purpose: The low-dose computed tomography (CT) imaging can reduce the damage caused by x-ray radiation to the human body. However, low-dose CT images have a different degree of artifacts than conventional CT images, and their resolution is lower than that of conventional CT images, which can affect disease diagnosis by clinicians. Therefore, methods for noise-level reduction and resolution improvement in low-dose CT images have inevitably become a research hotspot in the field of low-dose CT imaging. Read More

View Article and Full-Text PDF

Impact of Pathogenic Germline DNA Damage Repair alterations on Response to Intense Neoadjuvant Androgen Deprivation Therapy in High-risk Localized Prostate Cancer.

Eur Urol 2021 Apr 19. Epub 2021 Apr 19.

Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Background: Intense neoadjuvant androgen deprivation therapy (ADT) before radical prostatectomy (RP) is an investigational approach to reduce recurrence rates in men with high-risk localized prostate cancer (PCa). The impact of germline DNA damage repair (gDDR) gene alterations on response to intense neoadjuvant ADT is not known.

Objective: To evaluate the prevalence of gDDR alterations among men with localized PCa at high risk of recurrence and evaluate their impact on response to intense neoadjuvant ADT. Read More

View Article and Full-Text PDF

Electrophysiological and histomorphological changes of cochlea in miniature pigs after abrasion of round window niches.

Acta Otolaryngol 2021 Apr 21:1-10. Epub 2021 Apr 21.

Department of Otolaryngology, Head and Neck Surgery, Institute of Otolaryngology of PLA, Chinese PLA General Hospital, Beijing, P.R. China.

In operations of cochlea implantation (CI), many surgeons choose to drill a window on the bone wall of cochlea basic rotation, when more and more patients receive CI with residual hearing, what damage this step would result in is unclear. To study the effect to inner ear hair cells which is caused by drilling during CI. 6 miniature pigs are equally divided into two groups, Round window niche of each pig in the experimental group was milled, while the pigs in control group wasn't. Read More

View Article and Full-Text PDF

Perioperative Complications in 255 Patients Who Underwent Lateral Anterior Lumbar Interbody Fusion (LaLIF) Surgery.

Eur Spine J 2021 Apr 19. Epub 2021 Apr 19.

Department of Spine Surgery, the First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan, 2nd Road, Guangzhou, 510080, Guangdong, China.

Purpose: To investigate the perioperative complications of lateral anterior lumbar interbody fusion (LaLIF) surgery.

Methods: The participants were patients who underwent LaLIF surgery for degenerative lumbar diseases between April 2016 and November 2020. The collected data were classified into intraoperative and early-stage postoperative (1 month) complications. Read More

View Article and Full-Text PDF

Formation of pancreatic β-cells from precursor cells contributes to the reversal of established type 1 diabetes.

Cell Immunol 2021 Jun 9;364:104360. Epub 2021 Apr 9.

Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA; Department of Child Health, University of Missouri School of Medicine, Columbia, MO 65212, USA; Department of Neurology, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address:

Ig-GAD2, an antigen-specific immune modulator, requires bone marrow (BM) cell transfer in order to restore beta (β)-cell formation and induce recovery from established type 1 diabetes (T1D). The BM cells provide endothelial precursor cells (EPCs) that give rise to islet resident endothelial cells (ECs). This study shows that, during development of T1D, the immune attack causes collateral damage to the islet vascular network. Read More

View Article and Full-Text PDF

[Stereotactic irradiation in the complex treatment of patients with intracranial pilocytic astrocytoma].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):34-46

Burdenko Neurosurgical Center, Moscow, Russia.

Complex management of patients with intracranial pilocytic astrocytoma (PA) consists of surgical treatment, drug therapy (mainly in young children) and radiotherapy. For many years, radiotherapy (RT) has been a standard for residual tumors, recurrence or continued growth of PA. Currently, stereotactic radiosurgery and radiotherapy are preferred for PA, because these procedures are characterized by high conformity and selectivity, precise irradiation of tumor with minimal damage to surrounding intact tissues. Read More

View Article and Full-Text PDF

A rare complication of an Arteriovenous shunt after bimaxillary surgery.

JPRAS Open 2021 Jun 11;28:90-96. Epub 2021 Mar 11.

Department of Oral and Maxillofacial Surgery, Erasmus MC, University Medical Center Rotterdam, Netherlands.

The most common complications following bimaxillary surgery are inferior alveolar nerve damage, hemorrhage, and relapse. Severe complications are rare, but few cases of vascular arteriovenous malformation, cavernous sinus thrombosis, formation of an aneurysm or arteriovenous shunting are reported in literature. We present a case of a 20-year-old male patient who developed a right sided tinnitus and visible pulsations close to the mandibular angle on the right side after bimaxillary surgery. Read More

View Article and Full-Text PDF

ROS‑associated mechanism of different concentrations of pinacidil postconditioning in the rat cardiac Nrf2‑ARE signaling pathway.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.

Previous studies have confirmed that 50 mol/l pinacidil postconditioning (PPC) activates the nuclear factor‑E2 related factor 2 (Nrf2)‑antioxidant responsive element (ARE) pathway, which protects the myocardium from ischemia‑reperfusion (IR) injury; however, whether this is associated with reactive oxygen species (ROS) generation remains unclear. In the present study, a Langendorff rat model of isolated myocardial IR was established to investigate the mechanism of PPC at different concentrations, as well as the association between the rat myocardial Nrf2‑ARE signaling pathway and ROS. A total of 48 rats were randomly divided into the following six groups (n=8 per group): i) Normal; ii) IR iii) 10 mol/l PPC (P10); iv) 30 mol/l PPC (P30); v) 50 mol/l PPC (P50); and vi) N‑(2‑mercaptopropionyl)‑glycine (MPG; a ROS scavenger) + 50 mol/l pinacidil (P50 + MPG). Read More

View Article and Full-Text PDF

Evaluation of renal tubulointerstitial damage as a residual renal risk factor for adverse cardiac events in patients with myocardial infarction.

J Cardiol 2021 Apr 5. Epub 2021 Apr 5.

Department of Internal Medicine II, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo 409-3898, Yamanashi, Japan.

Background: Renal dysfunction, defined as a lower estimated glomerular filtration rate (eGFR), has been shown to be related to cardiovascular events in patients with myocardial infarction (MI). However, the contribution of renal tubulointerstitial damage to the predictive value for cardiovascular events has not been established. The aim of this study was to elucidate whether renal tubulointerstitial damage is associated with the occurrence of cardiac death and recurrence of MI in patients who have had MI. Read More

View Article and Full-Text PDF


Handb Clin Neurol 2021 ;178:297-310

Trajectoires, Centre de Recherche en Neurosciences de Lyon, Inserm, CNRS, Université Lyon 1, Bron, France; Plateforme "Mouvement et Handicap", Hôpital Henry-Gabrielle, Hospices Civils de Lyon, Saint-Genis-Laval, France.

For over a century, research has demonstrated that damage to primary visual cortex does not eliminate all capacity for visual processing in the brain. From Riddoch's (1917) early demonstration of intact motion processing for blind field stimuli, to the iconic work of Weiskrantz et al. (1974) showing reliable spatial localization, it is clear that secondary visual pathways that bypass V1 carry information to the visual brain that in turn influences behavior. Read More

View Article and Full-Text PDF
January 2021

Detection of residual subclinical myocardial damage by speckle-tracking echocardiography in previous autoimmune myocarditis.

Eur Heart J Cardiovasc Imaging 2021 Apr 8. Epub 2021 Apr 8.

Department of Medicine, University of Padova, Via Nicolò Giustiniani 3, 35128 Padova, Italy.

View Article and Full-Text PDF

Effect of the interface on femtosecond laser damage of a metal-dielectric low dispersion mirror.

Opt Express 2021 Mar;29(6):8171-8180

Metal-dielectric low dispersion mirrors (MLDM) have a promising application prospect in petawatt (PW) laser systems. We studied the damage characteristics of MLDM and found that the damage source of MLDM (Ag + AlO+SiO) is located at the metal-dielectric interface. We present the effect of the interface on the femtosecond laser damage of MLDM. Read More

View Article and Full-Text PDF

Updates in the outcomes of radiation therapy for Cushing's disease.

Best Pract Res Clin Endocrinol Metab 2021 Mar 10:101514. Epub 2021 Mar 10.

University of Medicine and Pharmacy Carol Davila, Bucharest, Romania; National Institute of Endocrinology C.I. Parhon, Bucharest, Romania. Electronic address:

External radiation therapy (RT) directed to the pituitary gland is generally recommended in patients with Cushing's disease (CD) as adjuvant to transsphenoidal surgery, among other second-line therapies offered to patients with residual or recurrent hypercortisolism (i.e., medical treatment, repeat surgery or bilateral adrenalectomy). Read More

View Article and Full-Text PDF

[Evaluation of the Clinical Efficacy and Prognosis of Long-Term Maintenance Lenalidomide Therapy in Patients with Multiple Myeloma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):540-546

Department of Oncology, Shunde Hospital, Guangzhou University of Chinese Medicine, Shunde 528333, Guangdong Province,

Objective: To investigate the clinical efficacy and prognosis of patients with multiple myeloma (MM) treated by long-term maintenance lenalidomide treatment.

Methods: A total of 97 patients diagnosed as MM in the Department of Hematology of First Affiliated Hospital of Guangzhou University of Chinese Medicine from 2012 to 2019 were selected, and the basic clinical characteristics and laboratory indicators of the patients were tested and evaluated. After long-term maintenance lenalidomide treatment for patients with MM, the short-term and long-term clinical efficacy and the incidence of adverse reactions were evaluated, and factors affecting the prognosis of the patients were analyzed. Read More

View Article and Full-Text PDF

Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation.

DNA Repair (Amst) 2021 Jun 16;102:103100. Epub 2021 Mar 16.

Department of Radiotherapy and Radiooncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Tumor Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt; Mildred-Scheel Cancer Career Center HATRICs4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Analysis and quantification of residual, unrepaired DNA double-strand breaks by detecting damage-associated γH2AX or 53BP1 foci is a promising approach to evaluate radiosensitivity or radiosensitization in tumor cells. Manual foci quantification by eye is well-established but unsatisfactory due to inconsistent foci numbers between different observers, lack of information about foci size and intensity and the time-consuming scoring process. Therefore, automated foci counting is an important goal. Read More

View Article and Full-Text PDF

Simulating lesion-dependent functional recovery mechanisms.

Sci Rep 2021 Apr 2;11(1):7475. Epub 2021 Apr 2.

Wellcome Centre for Human Neuroimaging, University College London, UCL Queen Square Institute of Neurology, 12 Queen Square, London, WC1N 3AR, UK.

Functional recovery after brain damage varies widely and depends on many factors, including lesion site and extent. When a neuronal system is damaged, recovery may occur by engaging residual (e.g. Read More

View Article and Full-Text PDF