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Combination of transurethral resection of the prostate and flexible and rigid ureteroscopy for benign prostatic hyperplasia and ureteral calculus.

Transl Androl Urol 2021 Aug;10(8):3395-3401

Department of Urology Surgery, Hengshui People's Hospital, Hengshui, China.

Background: Combination of transurethral resection of the prostate (TURP) and flexible and rigid ureteroscopy (URS/RIRS) is a successful approach for patients with benign prostatic hyperplasia (BPH) and ureteral calculus (UC), and the sequence is URS/RIRS followed by TURP. This research aims to compare TURP followed by URS/RIRS with URS/RIRS followed by TURP in terms of clinical efficiency and safety.

Methods: From June 2009 to June 2021, 173 patients with BPH and upper urinary tract stones were recruited through the Harrison International Peace Hospital and were divided into intervention (TURP followed by URS/RIRS) and control groups (URS/RIRS followed by TURP). Read More

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Peritumoral Delivery of Docetaxel-TIPS Microparticles for Prostate Cancer Adjuvant Therapy.

Adv Ther (Weinh) 2021 Feb 19;4(2):2000179. Epub 2020 Oct 19.

Centre for Precision Healthcare UCL Division of Medicine University College London Gower Street London WC1E 6BT UK.

Recurrence of prostate cancer after radical prostatectomy is a consequence of incomplete tumor resection. Systemic chemotherapy after surgery is associated with significant toxicity. Improved delivery methods for toxic drugs capable of targeting positive resection margins can reduce tumor recurrence and avoid their known toxicity. Read More

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February 2021

Associations Between Kidney Dysfunction and Risk Factors in Patients with Transurethral Resection of the Prostate.

Res Rep Urol 2021 7;13:665-672. Epub 2021 Sep 7.

Medical Faculty of Riau University, Pekanbaru, Riau, Indonesia.

Purpose: Benign prostate hyperplasia (BPH) with urinary retention can result in kidney dysfunction. Several risk factors might influence deterioration in kidney function. The aims of this study were to assess the association between kidney dysfunction and risk factors in patients with transurethral resection of the prostate (TURP). Read More

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September 2021

Median Duration of Hospital Stay after Early Removal of Foley's Catheter among Patients Undergoing Transurethral Resection of Prostate: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Jul 30;59(239):688-691. Epub 2021 Jul 30.

Department of Surgery, National Medical College, Birgunj, Nepal.

Introduction: Transurethral resection of the prostate requires a catheter in situ post-surgery. Early removal of catheter can reduce the length of hospital stay reducing the healthcare cost. It can also reduce the risk of infection due to prolonged catheterization. Read More

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Multi-Institutional Study of Dorsal Onlay Urethroplasty of the Membranous Urethra after Endoscopic Prostate Procedures: Operative Results, Continence, Erectile Function and Patient Reported Outcomes.

J Clin Med 2021 Sep 2;10(17). Epub 2021 Sep 2.

Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

(1) Background: To critically evaluate dorsal onlay buccal mucosal graft urethroplasty (DOBMGU) for posterior urethral stenosis repair following transurethral resection and other endoscopic prostate procedures. (2) Methods: A retrospective multi-institutional review of patients with membranous or bulbomembranous urethral stenosis for whom treatment with DOBMGU was conducted after receipt of prostate endoscopic procedures. Baseline data, peri-operative care, post-operative care and patient-reported outcomes were analyzed. Read More

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September 2021

Two cases of pelvic schwannomas simultaneously resected with the prostate by robot-assisted surgery.

IJU Case Rep 2021 Sep 7;4(5):277-281. Epub 2021 Jun 7.

Department of Urology Higashinagoya National Hospital Nagoya Aichi Japan.

Introduction: Schwannoma is a rare benign tumor of peripheral nerves arising from Schwann cells of the ubiquitous nerve sheath. The operative steps and technical aspects of robotic resection of pelvic schwannoma are described herein.

Case Presentation: We describe two patients with pelvic tumors simultaneously resected with the prostate by robot-assisted surgery: a 69-year-old man with schwannoma of the right side of the pelvic floor and a 68-year-old man with schwannoma in the left pelvis. Read More

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September 2021

Patients with renal transplant and moderate-to-severe LUTS benefit from urodynamic evaluation and early transurethral resection of the prostate.

World J Urol 2021 Sep 4. Epub 2021 Sep 4.

Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.

Purpose: To assess long-term renal function and micturition pattern of males submitted to transurethral resection of the prostate (TURP) for moderate-to-severe lower urinary tract symptoms (LUTS) after renal transplantation (RT). To investigate the role of clinical and urodynamic (UD) parameters for bladder outlet obstruction (BOO) diagnosis in these patients.

Methods: Retrospective data analysis of ≥ 50 years old patients who underwent RT between 01/2005 and 12/2016. Read More

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September 2021

Genomic analysis of circulating tumor cells in adenosquamous carcinoma of the prostate: a case report.

BMC Med Genomics 2021 Sep 3;14(1):217. Epub 2021 Sep 3.

Department of Urology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Background: Adenosquamous carcinoma of the prostate (ASCP) is an extremely rare and aggressive prostate cancer variant, whose genomic characteristics have not been elucidated. Although liquid biopsy of circulating tumor cells (CTCs) is an emerging topic in oncology, no study has assessed CTCs in patients with ASCP.

Case Presentation: A 76-year-old man presented with discomfort in his urethra. Read More

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September 2021

Thermal effects of thulium: YAG laser treatment of the prostate-an in vitro study.

World J Urol 2021 Sep 2. Epub 2021 Sep 2.

Department of Urology, Division of Urotechnology, Medical Centre, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, D-79106, Freiburg, Germany.

Purpose: To objectively determine whether there is potential thermal tissue damage during Tm:YAG laser-based LUTS treatment.

Methods: Our experimental model was comprised of a prostatic resection trainer placed in a 37 °C water bath. In a hollowed-out central area simulating the urethral lumen, we placed a RigiFib 800 fibre, irrigation inflow regulated with a digital pump, and a type K thermocouple. Read More

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September 2021

[A Case of Mucinous Adenocarcinoma Extending to Bladder Neck and Prostate].

Hinyokika Kiyo 2021 Aug;67(8):395-398

The Department of Pathology, Aichi Medecal University Hospital.

A 56-year-old man visited a clinic with the chief complaint of frequent micturition and residual sensation of urine. He was referred to our hospital for close examination. Cystoscopy showed a tumor protruding toward the bladder neck from the prostate with stones and debris on the surface. Read More

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Clinical predictors of severe late urinary toxicity after curative intensity-modulated radiation therapy for localized prostate cancer.

J Radiat Res 2021 Aug 31. Epub 2021 Aug 31.

Department of Radiation Oncology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Intractable late urinary toxicity is a serious complication after radiotherapy for patients with localized prostate cancer (LPC). We assessed clinical factors correlated with severe late urinary toxicity in LPC treated with curative image-guided intensity-modulated radiation therapy (IMRT). A total of 452 patients with LPC treated with IMRT between 2002 and 2016 were retrospectively analyzed. Read More

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A practical approach to bladder preservation with hypofractionated radiotherapy for localised muscle-invasive bladder cancer.

Clin Transl Radiat Oncol 2021 Nov 8;31:1-7. Epub 2021 Aug 8.

The Christie NHS Foundation Trust, Manchester, UK.

Bladder preservation with trimodality treatment (TMT) is an alternative strategy to radical cystectomy (RC) for the management of localised muscle invasive bladder cancer (MIBC). TMT comprises of transurethral resection of the bladder tumour (TURBT) followed by radiotherapy with concurrent radiosensitisation. TMT studies have shown neo-adjuvant chemotherapy with cisplatin-based regimens is often given to further improve survival outcomes. Read More

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November 2021

Monopolar Transurethral Resection of Prostate for Benign Prostatic Hyperplasia in Patients With and Without Preoperative Urinary Catheterization: A Prospective Comparative Study.

Cureus 2021 Jul 28;13(7):e16705. Epub 2021 Jul 28.

Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, NPL.

Background A significant proportion of patients undergo surgery for benign prostatic hyperplasia following acute urinary retention. Studies have reported conflicting results of improvement following transurethral surgery in these patients. Objective To compare perioperative complications and postoperative voiding parameters in patients undergoing monopolar transurethral resection of prostate with and without preoperative Foley catheterization. Read More

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Robotic Freyer's prostatectomy: Operative technique and single-center experience.

Indian J Urol 2021 Jul-Sep;37(3):247-253. Epub 2021 Jul 1.

Department of Pathology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.

Introduction: Transurethral resection of prostate replaced open surgery and remained the gold standard in surgical management of benign prostatic hyperplasia (BPH). Holmium laser enucleation and bipolar resection of prostate managed even larger glands. Open simple prostatectomy remains an option for large glands and concurrent pathologies. Read More

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The role of benign prostatic hyperplasia treatments in ejaculatory dysfunction.

Fertil Steril 2021 09;116(3):611-617

Division of Urology, Department of Surgery, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Ejaculatory dysfunction is not only psychologically distressing but can become a significant obstacle for men who wish to conceive. Dysfunction comes in the form of anejaculation, reduced ejaculation, retrograde ejaculation, painful ejaculation, or premature ejaculation. Most treatments for lower urinary tract symptoms related to benign prostatic hyperplasia, which commonly occurs in aging men, carry significant risks of absent, reduced, or retrograde ejaculation. Read More

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September 2021

Moderately Hypofractionated Radiotherapy and Androgen Deprivation Therapy for High-risk Localised Prostate Cancer: Predictors of Long-term Biochemical Control and Toxicity.

Clin Oncol (R Coll Radiol) 2021 Aug 26. Epub 2021 Aug 26.

Department of Radiation Oncology, Tata Medical Center, Newtown, Kolkata, West Bengal, India. Electronic address:

Aims: There is a paucity of long-term data on outcomes of high-risk prostatic adenocarcinoma after moderately hypofractionated radiotherapy with elective nodal treatment and long-term androgen deprivation therapy (ADT). We report long-term control and toxicity outcomes and analyse the predictors of failure and toxicity.

Materials And Methods: The records of 120 consecutive high-risk prostate cancer patients treated in a single institution between February 2012 and December 2016 were retrospectively analysed. Read More

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Aquablation of the prostate: a review and update.

Can J Urol 2021 Aug;28(S2):17-21

Department of Urology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

INTRODUCTION Historically, transurethral resection of the prostate (TURP) was considered the endoscopic "gold standard" surgical treatment of benign prostatic hyperplasia (BPH). Over the years, several other endoscopic procedures emerged, including the size-independent holmium laser enucleation of the prostate (HoLEP). In an effort to reduce the cost and morbidity associated with traditional endoscopic techniques, novel minimally invasive techniques have been developed, one of which is Aquablation. Read More

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HoLEP techniques - lessons learned.

Can J Urol 2021 Aug;28(S2):11-16

Department of Urology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

INTRODUCTION Holmium laser enucleation of the prostate (HoLEP) with mechanical tissue morcellation is one of the most effective surgical modalities for the treatment of symptomatic BPH. HoLEP has many advantages over the historical gold standards open prostatectomy (OP) and transurethral resection of the prostate (TURP). HoLEP is an AUA guideline endorsed surgical treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH), independent of prostate size. Read More

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HoLEP: the new gold standard for surgical treatment of benign prostatic hyperplasia.

Can J Urol 2021 Aug;28(S2):6-10

Department of Urology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

INTRODUCTION Transurethral resection of the prostate (TURP) was considered the "gold standard" surgical treatment for medication-refractory benign prostatic hyperplasia (BPH) for decades. With the desire to reduce hospital stay, complications, and cost, less invasive procedures gained usage in the 1990's. With the advent of a soft tissue morcellator, holmium laser enucleation of the prostate (HoLEP) was introduced as an efficacious alternative to TURP and due to its advantageous side effect profile compared to TURP, has grown in popularity ever since. Read More

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UroLift and Rezum: minimally invasive surgical therapies for the management of benign prostatic hyperplasia.

Can J Urol 2021 Aug;28(S2):2-5

Department of Urology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

INTRODUCTION Minimally invasive surgical therapies for benign prostatic hyperplasia (BPH) are popular alternatives to the gold standard transurethral resection of the prostate (TURP). These procedures have fewer discernable side effects on urinary and sexual function, when compared to TURP, making it a desirable option for many patients.

Materials And Methods: We provide an updated literature review on the current landscape of minimally invasive modalities, specifically the prostatic urethral lift (UroLift) and water vapor thermal therapy (Rezum), for the surgical treatment of BPH. Read More

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Gene expression profiling in melanoma: A view from the clinic.

Cancer Treat Res Commun 2021 Aug 19;29:100447. Epub 2021 Aug 19.

School of Medicine & UCD Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; Department of Plastic & Reconstructive Surgery, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland; Mater Melanoma Research Group, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.

The treatment of Melanoma, one of the most aggressive human malignancies, has been revolutionised by the advent of novel targeted and immuno-therapies. However, methods utilised to detect early presentations, and to stratify risk for patients diagnosed with invasive melanoma in the clinical setting are lagging. The primary prognostic indicator is restricted to Breslow Thickness, or depth the tumour invades into the dermis. Read More

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Transurethral Microwave Thermotherapy for Benign Prostatic Hyperplasia: An Updated Cochrane Review.

World J Mens Health 2021 Aug 4. Epub 2021 Aug 4.

Urology Section, Minneapolis VA Health Care System, Minneapolis, MN, USA.

Purpose: To assess the effects of transurethral microwave thermotherapy (TUMT) for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH).

Materials And Methods: We performed a comprehensive search using multiple databases up to May 2021, with no language or publication status restrictions. We included parallel-group randomized controlled trials of participants with BPH who underwent TUMT. Read More

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Retrospective observation of the efficacy and safety of prostatic artery embolization combined with transurethral resection of the prostate and simple transurethral resection of the prostate in the treatment of large (> 100 mL) benign prostatic hyperplasia.

Abdom Radiol (NY) 2021 Aug 26. Epub 2021 Aug 26.

Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, China.

Purpose: To retrospectively compare the efficacy and safety of prostatic artery embolization (PAE) combined with transurethral resection of the prostate (TURP) and simple TURP in treating large (> 100 mL) benign prostatic hyperplasia (BPH).

Methods: We retrospectively analyzed the clinical data of 13 and 17 patients with large BPH who underwent TURP and PAE + TURP, respectively, from January 2016 to January 2020. The changes in various indices before and after surgery were compared between the two groups. Read More

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Persistent use of medical therapy after surgery for lower urinary tract symptoms: a retrospective database analysis.

World J Urol 2021 Aug 26. Epub 2021 Aug 26.

Department of Urology, University of Miami, 1150 NW 14th St, Suite 309, Miami, FL, 33136, USA.

Purpose: To determine how many men are able to remain off of medical therapy for lower urinary tract symptoms (LUTS) following surgery for benign prostatic obstruction (BPO).

Methods: The TriNetX Analytics Network was used to identify men who were taking medical therapy for BPO (at least one of: alpha-1 blockers, anticholinergics, B3 agonists, or 5-alpha-reductase inhibitors) and subsequently underwent surgery for BPO. They were then placed into one of six cohorts, classified based on the type of surgery they received: transurethral resection of the prostate (TURP), Laser vaporization of prostate (PVP), transurethral incision of the prostate (TUIP), prostatic urethral lift (PUL), water-vapor thermal therapy (WV), or Laser enucleation of the prostate (LEP). Read More

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Validation of the cell cycle progression score to differentiate indolent from aggressive prostate cancer in men diagnosed through transurethral resection of the prostate biopsy.

Cancer Rep (Hoboken) 2021 Aug 22:e1535. Epub 2021 Aug 22.

Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Background: Validation of biomarker-based prognostic models to improve risk stratification in men with localized prostate cancer (PrCa) remains a clinical need. It has previously been shown that the cell cycle progression (CCP) test provides significant, independent prognostic information for men who were incidentally diagnosed with PrCa after transurethral resection of the prostate (TURP) and were conservatively managed.

Aim: The results have been extended in a newly analyzed retrospective cohort of UK men diagnosed through TURP biopsy (TURP1B; N = 305). Read More

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Efficacy of tranexamic acid in decreasing primary hemorrhage in transurethral resection of the prostate: A novel combination of intravenous and topical approach.

Urol Ann 2021 Jul-Sep;13(3):238-242. Epub 2021 Jul 14.

Department of Urology and Renal Transplant, SMS Medical College and Hospital, Jaipur, Rajasthan, India.

Background: Transurethral resection of the prostate (TURP) is the gold standard for benign prostatic enlargement; however, hemorrhage still remains one of the major complications.

Objective: The primary aim of this study was to evaluate the effect of tranexamic acid (TXA) in reducing intraoperative blood loss and need for blood transfusion. Secondary parameters compared were operating time, volume of irrigation fluid used, and reduction in hemoglobin concentration. Read More

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Effect of preoperative finasteride on perioperative blood loss during transurethral resection of the prostate and on microvessel density in patients with benign prostatic hyperplasia: An open label randomized controlled trial.

Urol Ann 2021 Jul-Sep;13(3):199-204. Epub 2021 Jul 14.

Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Objective: Transurethral resection of the prostate (TURP) is a common procedure for the treatment of benign prostatic hyperplasia (BPH). Previous studies on the effect of 5-alpha reductase inhibitors on perioperative blood loss in TURP and microvessel density (MVD) in the prostate are equivocal. We evaluated whether pretreatment with finasteride for 2 weeks before surgery can reduce perioperative blood loss in TURP and MVD in the prostate. Read More

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Gamma-H2AX Foci Decay Ratio as a Stronger Predictive Factor of Late Radiation Toxicity than Dose-Volume Parameters in a Prospective Cohort of Prostate Cancer Patients.

Int J Radiat Oncol Biol Phys 2021 Aug 19. Epub 2021 Aug 19.

Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Meibergdreef, 1105 AZ Amsterdam, The Netherlands. Electronic address:

Purpose: Late radiation toxicity is a major dose-limiting factor in curative cancer radiotherapy. Previous studies identified several risk factors for late radiation toxicity, including both dose-volume factors and genetic predisposition. Herein, we investigated the contribution of genetic predisposition, particularly compared to dose-volume factors, to the risk of late radiation toxicity in patients treated with highly conformal radiotherapy. Read More

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Prostatic Artery Embolization: Indications, Preparation, Techniques, Imaging Evaluation, Reporting, and Complications.

Radiographics 2021 Sep-Oct;41(5):1509-1530. Epub 2021 Aug 20.

From the Departments of Radiology (U.S.D., M.R.L.d.M., P.C.C.V., A.S.Z.M., C.C.L., G.G.C.) and Interventional Radiology (M.R.L.d.M., P.C.C.V., A.M.d.A., A.M.M., F.C.C.), Hospital Sírio-Libanês, Adma Jafet 91, Bela Vista, São Paulo, SP 01308-050, Brazil; Departments of Radiology (M.R.L.d.M., P.C.C.V., C.C.L., G.G.C.) and Interventional Radiology (M.R.L.d.M., P.C.C.V., A.M.d.A., A.M.M., F.C.C.), University of São Paulo, São Paulo, Brazil; and Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (N.H.).

Benign prostatic hyperplasia (BPH) is a noncancerous growth of the transitional zone of the prostate, which surrounds the prostatic urethra. Consequently, it can cause lower urinary tract symptoms (LUTS) and bladder outlet obstruction symptoms that may substantially reduce a patient's quality of life. Several treatments are available for BPH, including medications such as α-blockers and 5α-reductase inhibitors and surgical options including transurethral resection of the prostate and prostatectomy. Read More

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Serum testosterone and prostate-specific antigen levels are major risk factors for prostatic volume increase among benign prostatic hyperplasia patients.

Asian J Urol 2021 Jul 7;8(3):289-297. Epub 2020 Jun 7.

Medical Faculty, Universitas Airlangga, Surabaya, East Java, Indonesia.

Objective: Benign prostatic hyperplasia (BPH) is one of the most common diseases found among elderly men. Even though multiple risk factors of BPH have been identified in the past, the risk factors which have a direct impact on prostate volume have not been identified. In this study, we aim to determine the most significant contributing risk factors to prostate volume enlargement by analyzing possible associated risk factors previously studied. Read More

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