201,409 results match your criteria requiring


Large-Diameter Penetrating Keratoplasties are Mostly Due to Very Severe Infectious Keratitis and Cannot Always Prevent Secondary Enucleation.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Augenheilkunde, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg (Saar), Germany.

Purpose: To report the indications and outcomes of penetrating keratoplasties with a graft diameter > 8.5 mm in severe corneal diseases at the Department of Ophthalmology at Saarland University Medical Centre.

Study Design: Retrospective (6 years), descriptive, and observational. Read More

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Potential Risk Factors for Autism in Children Requiring Neonatal Intensive Care Unit.

Neuropediatrics 2021 Apr 14. Epub 2021 Apr 14.

Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.

Background:  The etiology of autism spectrum disorder (ASD) is complex and involves the interplay of genetic and environmental factors.

Aim:  We sought to identify potential prenatal, perinatal, and neonatal risk factors for ASD in a unique population of children who had perinatal complications and required care in a neonatal intensive care unit (NICU).

Methods:  This prospective cohort study included 73 patients discharged from a NICU who received long-term follow-up at the largest children's hospital in Brazil. Read More

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Transition Services for Paediatric Inflammatory Bowel Disease; A Multicentre Study of Practice in the United Kingdom.

J Pediatr Gastroenterol Nutr 2021 Apr 12. Epub 2021 Apr 12.

Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK Department of Paediatric Gastroenterology, Sheffield Children's NHS Foundation Trust, Sheffield, UK Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, Bristol, UK Department of Paediatric Gastroenterology, The Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, UK Department of Paediatric Gastroenterology, Royal Hospital for Children Glasgow, 1345 Govan Road, Glasgow, UK Department of Paediatric Gastroenterology, Oxford University Hospitals, Oxford, UK Department of Paediatric Gastroenterology, Addenbrooke's Hospital, Cambridge, UK Department of Paediatric Gastroenterology, The Royal London Hospital, Barts Health NHS Trust, London, UK Department of Paediatric Gastroenterology, Alderhey Children's Hospital NHS Foundation Trust, West Derby, Eaton road, Liverpool L12 2AP,UK Department of Paediatric Gastroenterology, Birmingham Children's Hospital, Birmingham, UK Department of Paediatric Gastroenterology, St. Georges University Hospital NHS Foundation Trust, London, UK Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, 369 Fulham Road, London, UK Department of Paediatric Gastroenterology, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK Department of Paediatric Gastroenterology, University Hospitals of North Staffordshire NHS Trust, Stoke-On-Trent, UK Department of Paediatric Gastroenterology, Leeds Children's Hospital, Leeds Teaching Hospitals NHS trust, Leeds, UK Department of Paediatric Gastroenterology, Manchester Children's Hospital, Manchester, UK Department of Paediatric Gastroenterology, Nottingham Children's Hospital, Queens Medical Centre, Nottingham, UK Department of Paediatric Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK Department of Paediatric Gastroenterology, Evelina London Children's Hospital, UK.

Objectives: Patients with paediatric inflammatory bowel disease (IBD) constitute one of the largest cohorts requiring transition from paediatric to adult services. Standardised transition care improves short and long-term patient outcomes. This study aimed to detail the current state of transition services for IBD in the United Kingdom (UK). Read More

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The role of radiation protection societies in tackling the skills shortage and development of young professionals and researchers.

J Radiol Prot 2021 Apr 14. Epub 2021 Apr 14.

Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Over the last 10 years there have been increasing concerns raised of a potential skills gap in field of radiation protection. Noting these concerns in 2019 the Society for Radiological Protection, the UK's Chartered Professional Body, launched a study to determine the radiation protection demand in the UK going forward along with the capacity of the profession. The initial results show that over 50% of the SRP membership retires in the next 10 -15 years, coupled with an increase in radiation protection demand across the nuclear fuel cycle, medical sector and advancement of new technologies or applications requiring radiation protection advice. Read More

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[Basic aspects of COVID-19 for management from primary care].

Aten Primaria 2020 Dec 26;53(6):101966. Epub 2020 Dec 26.

CS Ramón y Cajal, DA OESTE (SERMAS), Grupo de trabajo de enfermedades infecciosas de SoMaMFyC, Alcorcón, España.

SARS-CoV-2 is transmitted from person to person by inhalation or contact with respiratory droplets and aerosols. The median incubation period is 5.1 days. Read More

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December 2020

Gender Affirming Surgeries in Transgender and Gender Diverse Adolescent and Yong Adults: A Pediatric and Adolescent Gynecology Primer.

J Pediatr Adolesc Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Center for Gender Surgery, Boston Children's Hospital, Boston, MA, USA; Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA, USA; Department of Surgery, Harvard Medical School, Boston, MA, USA.

Transgender and gender diverse adolescent and young adults (AYA) may seek gender affirming surgeries (GAS) as part of their gender affirmation. A number of GAS are related to reproductive and sexual health and pediatric and adolescent gynecology (PAG) clinicians are well positioned as sexual and reproductive health experts to provide care in this area. PAG clinicians may encounter patients presenting for preoperative counseling (including discussions regarding fertility, family building, future sexual function, and choice of oophorectomy at time of hysterectomy), requesting referrals to GAS clinicians, requiring GAS aftercare, or seeking general sexual and reproductive health care who have a history of GAS. Read More

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Determination of reference intervals for knee motor functions specific to patients undergoing knee arthroplasty.

PLoS One 2021 14;16(4):e0249564. Epub 2021 Apr 14.

Department of Rehabilitation, Hoshasen Daiichi Hospital, Imabari, Japan.

Background: In patients with knee osteoarthritis (KOA) undergoing knee arthroplasty (KA), lower-limb motor function tests are commonly measured during peri-surgical rehabilitation. To clarify their sources of variation and determine reference intervals (RIs), a multicenter study was performed in Japan.

Methods: We enrolled 545 KOA patients (127 men; 418 women; mean age 74. Read More

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How do we identify the crashing traumatic brain injury patient - the intensivist's view.

Curr Opin Crit Care 2021 Apr 14. Epub 2021 Apr 14.

Interdepartmental Division of Critical Care Medicine, University of Toronto Toronto Western Hospital, University Health Network Krembil Research Institute, Toronto Western Hospital Department of Critical Care Medicine, Sunnybrook Health Sciences Centre Department of Critical Care, St. Michael's Hospital Toronto, University of Toronto Department of Anesthesia, Keenan Research Centre for Biomedical Science, St. Michael's Hospital Toronto, University of Toronto, Toronto, Ontario, Canada.

Purpose Of Review: Over 40% of patients with severe traumatic brain injury (TBI) show clinically significant neurological worsening within the acute admission period. This review addresses the importance of identifying the crashing TBI patient, the difficulties appreciating clinical neurological deterioration in the comatose patient and how neuromonitoring may provide continuous real-time ancillary information to detect physiologic worsening.

Recent Findings: The latest editions of the Brain Trauma Foundation's Guidelines omitted management algorithms for adult patients with severe TBI. Read More

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Early Improvement in Clinical Status Following Ventricular Assist Device Implantation in Children: A Marker for Survival.

ASAIO J 2021 Apr 7. Epub 2021 Apr 7.

From the Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada The Johns Hopkins Hospital, Baltimore, Maryland Nationwide Children's Hospital, Columbus, Ohio Kirklin Institute for Research in Surgical Outcomes (KIRSO), The University of Alabama at Birmingham, Birmingham, Alabama Abbott Northwestern Hospital, Minneapolis, Minnesota Mayo Clinic College of Medicine, Rochester, Minnesota The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

While clinical status at the time of ventricular assist device (VAD) implant can negatively affect outcomes, it is unclear if early improvement after implant can have a positive effect. Therefore, the objectives of this study were to describe the clinical status of pediatric patients supported with a VAD and determine the impact of clinical status on the 1-month follow-up form on survival and ability to discharge. This was a retrospective analysis of data collected prospectively by the Pediatric Interagency Registry for Mechanical Circulatory Support Registry (Pedimacs) Registry. Read More

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Risk Factors for Persistent Pain Requiring Surgical Treatment in Adult Symptomatic Accessory Navicular.

Clin J Sport Med 2021 Mar 1. Epub 2021 Mar 1.

Department of Orthopaedic Surgery, Korea University Guro Hospital, Seoul, Korea.

Objective: Identifying the risk factors for persistent pain despite proper conservative treatment in adult symptomatic accessory navicular may reduce the need for surgical treatment. The aim of this study was to identify any such risk factors.

Design: Cohort study. Read More

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Four-Week Daily Calcipotriene/Betamethasone Dipropionate Foam Is Highly Efficacious in Patients With Psoriasis (PSO-LONG Lead-in Phase).

J Drugs Dermatol 2021 Apr;20(4):436-441

Background: Psoriasis is a chronic disease requiring long-term treatment strategies. Optimal strategies should include initial rapid relief of symptoms followed by long-term management to maintain remission. This 4-week open-label phase of a long-term proactive management phase 3 trial aimed to select responders to once daily, fixed-dose combination calcipotriene 0. Read More

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[Fever of unknown origin : horse, zebra or unicorn ?]

Rev Med Suisse 2021 Apr;17(734):738-743

Service des maladies infectieuses, Département de médecine, HUG, 1211 Genève 14.

Despite the diagnostic means currently available, fever of unknown origin (FUO) remains a diagnostic challenge for the practitioner, requiring a detailed and systematic approach. The etiologies can be classified into 4 main groups: infectious diseases, systemic inflammatory diseases, neoplasia and various rarer entities such as drug-induced or endocrine fevers. A non-negligible percentage of FUOs remains without a clear etiology, generally with a spontaneously favorable evolution. Read More

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The impact of a virtual cardiology outpatient clinic in the COVID-19 era.

Ir J Med Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Cardiology, Tallaght University Hospital, Dublin, Ireland.

Background: Restrictions as a result of the COVID-19 pandemic have demanded an innovative approach to provide appropriate patient review. We have been running virtual cardiology clinics as per Health Service Executive guidance.

Aims: Our study aims to determine how virtual clinics change practice vs traditional clinics. Read More

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Tracheostomy decannulation to noninvasive positive pressure ventilation in congenital central hypoventilation syndrome.

Sleep Breath 2021 Apr 14. Epub 2021 Apr 14.

Division of Pediatric Pulmonology and Sleep Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta, 1400 Tullie Road NE, Atlanta, GA, 30329, USA.

Purpose: Noninvasive positive pressure ventilation (NPPV) may permit tracheostomy decannulation (TD) in patients with congenital central hypoventilation syndrome (CCHS) requiring nocturnal positive pressure ventilation via tracheostomy (PPV-T). There is limited evidence on optimal strategies for transitioning patients from PPV-T to NPPV. This study aimed to describe the clinical course and outcome of children with CCHS who underwent TD and transitioned from PPV-T to NPPV. Read More

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FRAX-based osteoporosis treatment guidelines for resource-poor settings in India.

Arch Osteoporos 2021 Apr 14;16(1):69. Epub 2021 Apr 14.

Department of Endocrinology, Amrita Institute of Medical Sciences, Cochin, Kerala, India.

Using the FRAX® model for India, thresholds for osteoporosis evaluation and treatment without bone mineral density measurement were derived and were validated in a cohort of 300 patients. We suggest the use of this newer age and ethnic-specific FRAX®-derived thresholds for management of osteoporosis in India.

Purpose: Our study aimed to formulate population-specific intervention thresholds for treatment of osteoporosis in India which can be used even without dual X-ray absorptiometry (DXA). Read More

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Severe infection risk in patients treated with biologics for rheumatoid arthritis: a systematic review protocol.

JBI Evid Synth 2021 Apr 12. Epub 2021 Apr 12.

Konan Women's University, Kobe, Japan The Japan Centre for Evidence Based Practice: A JBI Affiliated Group, Osaka, Japan Hyogo University of Health Sciences, Kobe, Japan.

Objective: To estimate the population-based incidence and determine the types of severe infection experienced by patients with rheumatoid arthritis who are taking biological agents.

Introduction: Since the late 1990 s, a variety of biological and synthetic drugs have been developed to treat rheumatoid arthritis. In recent years, the incidence of severe infection in patients with rheumatoid arthritis in Western nations has been reported by observational studies; however, no systematic review has been conducted on this topic. Read More

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Pelvic and acetabular fracture care in England: current workload and future directions.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Oxford University Hospitals NHS Foundation Trust, UK.

Introduction: Fractures of the pelvis and acetabulum (PAFs) are challenging injuries, requiring specialist surgical input. Since implementation of the major trauma network in England in 2012, little has been published regarding the available services, workforce organisation and burden of PAF workload. The aim of this study was to assess the recent trends in volume of PAF workload, evaluate the provision of specialist care, and identify variation in available resources, staffing and training opportunity. Read More

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Axonal Guillain-Barre syndrome associated with SARS-CoV-2 infection in a child.

J Med Virol 2021 Apr 14. Epub 2021 Apr 14.

University of the Health Sciences, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Pediatric Intensive Care Unit, Istanbul.

Background: The relation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and demyelinating Guillain Barre Syndrome (GBS) has been defined. We aim to report the clinical features of a child with axonal GBS associated with SARS-CoV-2.

Case: A 6-year-old male presented with symmetric ascending paralysis progressed over a 4-day course and 2-day of fever. Read More

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Expanding the substrate scope of nitrating cytochrome P450 TxtE by active site engineering of a reductase fusion.

Chembiochem 2021 Apr 14. Epub 2021 Apr 14.

University of Warwick, Department of Chemistry, Gibbet Hill Road, CV4 7AL, Coventry, UNITED KINGDOM.

Aromatic nitration reactions are a cornerstone of organic chemistry, but are challenging to scale due to corrosive reagents and elevated temperatures. The cytochrome P450 TxtE nitrates the indole 4-position of L-tryptophan at room temperature using NO, O 2 and NADPH, and has potential to be developed into a useful aromatic nitration biocatalyst. However, its narrow substrate scope (requiring both the alpha-amino acid and indole functionalities) have hindered this. Read More

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Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain.

J Clin Immunol 2021 Apr 13. Epub 2021 Apr 13.

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Background: In a recent study, autoantibodies neutralizing type I interferons (IFNs) were present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies neutralized most type I IFNs but rarely IFN-beta.

Objectives: We aimed to define the prevalence of autoantibodies neutralizing type I IFN in a cohort of patients with severe COVID-19 pneumonia treated with IFN-beta-1b during hospitalization and to analyze their impact on various clinical variables and outcomes. Read More

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Successful laparoscopic treatment for sustained abdominal pain due to fish bone migrating into the neck of the pancreas: a case report and thinking about surgical approach through the literature review.

Surg Case Rep 2021 Apr 13;7(1):91. Epub 2021 Apr 13.

Hepatic Biliary and Pancreatic Cancer Center, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba, Chongqing, 400030, People's Republic of China.

Background: The majority of ingested foreign bodies pass through the gastrointestinal tract smoothly, with less than 1% requiring surgery. Fish bone could perforate through the wall of stomach or duodenum and then migrate to other surrounding organs, like the pancreas and liver.

Case Presentation: We report herein the case of a 67-year-old male who presented with sustained mild epigastric pain. Read More

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ICU admission rates in Istanbul following the addition of favipiravir to the national COVID-19 treatment protocol.

North Clin Istanb 2021 22;8(2):119-123. Epub 2021 Mar 22.

Department of Public Health, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.

Objective: The objective of this study was to understand the observational relationship between adoption of favipiravir into the national COVID-19 treatment protocol and intensive care unit (ICU) admission rates in Istanbul due to COVID-19.

Methods: Data were harvested from the "Public Health Management System-HSYS," which collate centrally the records of all known cases of COVID-19. The total number of cases, numbers admitted to ICU, and number undergoing intubation were compared between 2 time periods: 11 of March, the date on which the first case in Turkey was confirmed, to 30 of March; and March 30, to 10 of April, 5 days after Favipiravir was introduced into the treatment algorithm when, the records were examined. Read More

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Subtrochanteric femoral fracture with postoperative chronic osteomyelitis treated successfully by 1-stage operation: a case report.

Ann Transl Med 2021 Mar;9(6):514

Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, China.

Chronic osteomyelitis is a chronic infectious disease of bone tissue, which can cause necrosis of bone and surrounding soft tissue, and is a common complication of open fracture, internal fixation, diabetic foot and blood-borne bone infection. Traumatic osteomyelitis is caused by bone tissue infection after open fracture surgery or open reduction of fracture or other bone and joint surgery. The lesion is near the fracture end. Read More

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Wire fracture in postoperative Nuss procedure: a problem that cannot be ignored.

Transl Pediatr 2021 Mar;10(3):569-578

Department of pediatrics, Chongqing University Three Gorges Hospital, Chongqing, China.

Background: Surgical stainless wire has been widely used to stabilize pectus bar and ribs in Nuss procedure for pectus excavatum correction. However, wire fracture and its secondary complications are problems easily to be ignored but very important. The purpose of this article was to describe a series of cases with wire breakage, hoping to arouse the attention of worldwide thoracic surgeons to this potential threat, and to share our modifications on the fixation patterns and materials in Nuss procedure. Read More

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Current and future perspectives of digital microscopy with fluorescence confocal microscope for prostate tissue interpretation: a narrative review.

Transl Androl Urol 2021 Mar;10(3):1569-1580

Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.

Fluorescence confocal microscopy (FCM) is an optical imaging technique providing digital microscopical images of fresh tissue in a real time fashion, without conventional processing. FCM has been widely applied in several fields of dermatology, including the detection of basal cell carcinoma and of cutaneous inflammatory diseases. The aim of the paper is to provide an overview of FCM applications in the field of prostate tissue interpretation and prostate cancer (PCa) detection. Read More

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Comparative Evaluation of Mineral Trioxide Aggregate Pulpotomy and Laser-Assisted Mineral Trioxide Aggregate Pulpotomy: An Original Research Article.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):7-11. Epub 2021 Feb 9.

Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-graduate Research Institute, Parbhani, Maharashtra, India.

Context And Aim: Formocresol has been used as the material of choice (gold standard) for pulpotomy procedures because of the ease of use but was discouraged due to its potential immune sensitization and mutagenic effects. Laser irradiation was first applied for pulpotomy procedure in the year 1985. Recently, diode lasers have been used for pulpotomy in primary teeth and have shown clinical success rates comparable to formocresol. Read More

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February 2021

Effectiveness of isolation policies in schools: evidence from a mathematical model of influenza and COVID-19.

PeerJ 2021 30;9:e11211. Epub 2021 Mar 30.

Division of Hepatology, Department of Medicine, Loyola University of Chicago, Maywood, IL, USA.

Background: Non-pharmaceutical interventions such as social distancing, school closures and travel restrictions are often implemented to control outbreaks of infectious diseases. For influenza in schools, the Center of Disease Control (CDC) recommends that febrile students remain isolated at home until they have been fever-free for at least one day and a related policy is recommended for SARS-CoV-2 (COVID-19). Other authors proposed using a school week of four or fewer days of in-person instruction for all students to reduce transmission. Read More

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Pacemaker-induced ventricular fibrillation during radiofrequency catheter ablation for ventricular tachycardia.

J Arrhythm 2021 Apr 14;37(2):368-369. Epub 2021 Feb 14.

Department of Cardiology Royal Bournemouth and Christchurch Hospitals Bournemouth UK.

Prior to ventricular tachycardia ablation, this patient's cardiac implantable electronic device (CIED) was temporarily programmed to backup pacing mode with tachycardia therapies disabled. During radiofrequency energy delivery, the patient developed ventricular fibrillation requiring emergent cardioversion. Electrogram interrogation showed that the CIED switched to noise reversion mode during ablation. Read More

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Genetic counseling prior to assisted reproductive technology.

Reprod Med Biol 2021 Apr 31;20(2):133-143. Epub 2020 Dec 31.

Department of Obstetrics and Gynecology Faculty of Medicine Toho University Tokyo Japan.

Background: Reproductive medicine deals with fertility and is closely related to heredity. In reproductive medicine, it is necessary to provide genetic information for the patients prior to assisted reproductive technology (ART). Japan Society for Reproductive Medicine (JSRM) requires doctors involved in reproductive medicine to have standard knowledge of reproductive genetics and knowledge of reproductive medicine, which is covered in their publication, "required knowledge of reproductive medicine. Read More

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Assessment of the Need for Routine Distolingual Local Anesthetic Infiltration in Addition to Traditional Inferior Alveolar, Lingual and Long Buccal Nerve Blocks in Mandibular Third Molar Extractions.

Contemp Clin Dent 2020 Oct-Dec;11(4):367-370. Epub 2020 Dec 20.

Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, Mysuru, Karnataka, India.

Background And Objectives: Persistent pain during the removal of mandibular third molars is often due to accessory nerve supply causing inadequate local anesthesia. This study aims to assess the requirement of routine distolingual infiltration anesthesia in addition to traditional inferior alveolar, lingual, and long buccal nerve block in mandibular third molar extractions.

Methodology: Sixty patients requiring mandibular third molar extraction were randomly divided into two equal groups; Group A (Classic inferior alveolar, lingual, and buccal nerve block) and Group B (with an additional 0. Read More

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December 2020