79,376 results match your criteria required technology

Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: Phase IIa and IIb multi-center clinical trials.

Eur J Pharm Sci 2021 Jun 8:105904. Epub 2021 Jun 8.

Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences Chengdu, China. Electronic address:

Objective: Ciprofol is a new intravenous anesthetic agent similar to propofol that has the pharmacodynamic characteristics of a rapid rate of onset and recovery in pre-clinical experiments. The aims of the present clinical trials were to compare the efficacy and safety of ciprofol emulsion for sedation or general anesthesia during colonoscopy and to define optimal doses for a subsequent phase III clinical trial.

Methods: A phase IIa multi-center, open-label, non-randomized, positive control, dose-escalating study was performed to determine a recommended phase IIb dose (RP2D) of ciprofol to induce sedation or anesthesia in patients undergoing colonoscopy. Read More

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The PHY domain dimer interface of bacteriophytochromes mediates cross-talk between photosensory modules and output domains.

J Mol Biol 2021 Jun 8:167092. Epub 2021 Jun 8.

Institute of Biochemistry, Graz University of Technology, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria. Electronic address:

Protein dynamics play a major role for the catalytic function of enzymes, the interaction of protein complexes or signal integration in regulatory proteins. In the context of multi-domain proteins involved in light-regulation of enzymatic effectors, the central role of conformational dynamics is well established. Light activation of sensory modules is followed by long-range signal transduction to different effectors; rather than domino-style structural rearrangements, a complex interplay of functional elements is required to maintain functionality. Read More

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Phosphatidylserine is Required for the Normal Progression of Cell Plate Formation in Arabidopsis Root Meristem.

Plant Cell Physiol 2021 Jun 11. Epub 2021 Jun 11.

Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.

Phosphatidylserine (PS) is involved in various cellular processes in yeast and animals. However, PS functions in plants remain unclear. In Arabidopsis, PS is relatively enriched in flower and root tissues, and the genetic disturbance of PS biosynthesis in PHOSPHATIDYLSERINE SYNTHASE1 (PSS1)/pss1 heterozygotes induces sporophytic and gametophytic defects during pollen maturation. Read More

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COVID-19 and Undergraduates with Disabilities: Challenges Resulting from the Rapid Transition to Online Course Delivery for Students with Disabilities in Undergraduate STEM at Large-Enrollment Institutions.

CBE Life Sci Educ 2021 Sep;20(3):ar36

Research for Inclusive STEM Education Center, School of Life Sciences, Arizona State University, Tempe, AZ 85281.

The COVID-19 pandemic caused nearly all colleges and universities to transition in-person courses to an online format. In this study, we explored how the rapid transition to online instruction during the COVID-19 pandemic affected students with disabilities. We interviewed 66 science, technology, engineering, and math (STEM) undergraduates with disabilities at seven large-enrollment institutions during Spring 2020. Read More

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September 2021

Iron Phthalocyanine/Two-Dimensional Metal-Organic Framework Composite Nanosheets for Enhanced Alkaline Hydrogen Evolution.

Inorg Chem 2021 Jun 11. Epub 2021 Jun 11.

School of Chemical Engineering, University of Queensland, Saint Lucia, Queensland 4072, Australia.

Hydrogen evolution reaction (HER) in alkaline medium is currently under scientific spotlight for generating clean H fuel from electrochemical water splitting. However, alkaline HER suffers from sluggish reaction kinetics because of the additional energy required for water dissociation from catalysts in contrast to acidic HER. Herein, we report the development of two-dimensional metal-organic framework (2D MOF) Ni-1,4-benzenedicarboxylic acid-based composite nanosheets for superior performance in HER electrocatalysis. Read More

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High-Performance Joule Heating and Electromagnetic Shielding Properties of Anisotropic Carbon Scaffolds.

ACS Appl Mater Interfaces 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, P. R. China.

Highly efficient electrical heaters along with excellent electromagnetic interference (EMI) shielding properties are urgently required for the progress of miniaturization electronics, artificial intelligence, and smart heating management setups. Herein, lignin removal, which comprises two efficient and versatile steps, followed by carbonization produces multifunctional carbon monoliths derived from natural wood. The obtained carbonized wood exhibits a high specific surface area (655. Read More

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Comparative in vitro study of commercially available products for alveolar ridge preservation.

J Periodontol 2021 Jun 11. Epub 2021 Jun 11.

Naval Medical Research Unit San Antonio, JBSA Fort Sam Houston, Texas.

Background: Ridge preservation is performed by placing a biocompatible product, following tooth extraction, to maintain bone volume. However, current ridge preservation therapies do not always maintain the volume required for future implant placement. Variations in surgical technique and material selection contribute to determining clinical outcomes. Read More

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Telehealth and Autism Prior to and in the Age of COVID-19: A Systematic and Critical Review of the Last Decade.

Clin Child Fam Psychol Rev 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychology, Louisiana State University, 236 Audubon Hall, Baton Rouge, LA, 70803, USA.

There has been growing interest in the use of telehealth; however, the COVID-19 pandemic and the subsequent isolation and restrictions placed on in-person services have fast-tracked implementation needs for these services. Individuals with autism spectrum disorder (ASD) have been particularly affected due to the often-intensive service needs required by this population. As a result, the aim of this review was to examine the evidence base, methodology, and outcomes of studies that have used telehealth for assessment and/or intervention with children and adolescents with ASD as well as their families over the last decade. Read More

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Albumin used in human IVF contain different levels of lipids and modify embryo and fetal growth in a mouse model.

J Assist Reprod Genet 2021 Jun 11. Epub 2021 Jun 11.

Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.

Purpose: Different commercial human embryo culture mediums can alter embryo quality and change birthweight. One component that could be contributing to variations but is not widely investigated is human serum albumin (HSA). HSA plays a multitude of roles during embryo culture and is a carrier for molecules including lipids. Read More

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Replication protein A plays multifaceted roles complementary to specialized helicases in processing G-quadruplex DNA.

iScience 2021 May 1;24(5):102493. Epub 2021 May 1.

State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China.

G-quadruplexes (G4s) are non-canonical DNA structures with critical roles in DNA metabolisms. To resolve those structures that can cause replication fork stalling and genomic instability, single-stranded DNA-binding proteins and helicases are required. Here, we characterized the interplay between RPA and helicases on G4s using single-molecule FRET. Read More

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Evaluating machine learning methodologies for identification of cancer driver genes.

Sci Rep 2021 Jun 10;11(1):12281. Epub 2021 Jun 10.

Department of Computer Science, School of Systems and Technology, University of Management and Technology, Lahore, Pakistan.

Cancer is driven by distinctive sorts of changes and basic variations in genes. Recognizing cancer driver genes is basic for accurate oncological analysis. Numerous methodologies to distinguish and identify drivers presently exist, but efficient tools to combine and optimize them on huge datasets are few. Read More

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Energy-efficient ultrafast nucleation of single and multiple antiferromagnetic skyrmions using in-plane spin polarized current.

Sci Rep 2021 Jun 10;11(1):12332. Epub 2021 Jun 10.

Department of Physics, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.

We numerically investigate the ultrafast nucleation of antiferromagnetic (AFM) skyrmion using in-plane spin-polarized current and present its key advantages over out-of-plane spin-polarized current. We show that the threshold current density required for the creation of AFM skyrmion is almost an order of magnitude lower for the in-plane spin-polarized current. The nucleation time for the AFM skyrmion is found to be [Formula: see text] ps for the corresponding current density of 1-[Formula: see text]. Read More

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Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics.

Nat Commun 2021 06 10;12(1):3514. Epub 2021 Jun 10.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.

3D culture of cells in designer biomaterial matrices provides a biomimetic cellular microenvironment and can yield critical insights into cellular behaviours not available from conventional 2D cultures. Hydrogels with dynamic properties, achieved by incorporating either degradable structural components or reversible dynamic crosslinks, enable efficient cell adaptation of the matrix and support associated cellular functions. Herein we demonstrate that given similar equilibrium binding constants, hydrogels containing dynamic crosslinks with a large dissociation rate constant enable cell force-induced network reorganization, which results in rapid stellate spreading, assembly, mechanosensing, and differentiation of encapsulated stem cells when compared to similar hydrogels containing dynamic crosslinks with a low dissociation rate constant. Read More

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FKBP4 integrates FKBP4/Hsp90/IKK with FKBP4/Hsp70/RelA complex to promote lung adenocarcinoma progression via IKK/NF-κB signaling.

Cell Death Dis 2021 Jun 10;12(6):602. Epub 2021 Jun 10.

Department of Central Lab, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

FKBP4 belongs to the family of immunophilins, which serve as a regulator for steroid receptor activity. Thus, FKBP4 has been recognized to play a critical role in several hormone-dependent cancers, including breast and prostate cancer. However, there is still no research to address the role of FKBP4 on lung adenocarcinoma (LUAD) progression. Read More

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Managing high frequency users of an electronic consultation system in primary care: a quality improvement project.

BMJ Open Qual 2021 Jun;10(2)

Whitechapel Health Centre, London, UK.

The COVID-19 pandemic prompted a rapid change in primary care provision. There was a significant shift from face-to-face appointments to remote methods such as electronic consultation (e-consultation). Patients from a primary care provider in London were actively encouraged to use an online consultation platform called 'Dr iQ'. Read More

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Interventions for the discharge of older people to their home from the emergency department: a systematic review.

Australas Emerg Care 2021 Jun 8. Epub 2021 Jun 8.

Nursing and Midwifery Research Centre, Nursing and Midwifery Directorate, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia; Faculty of Health, University of Technology Sydney, Ultimo, 2007 NSW, Australia.

Background: Clinicians have limited evidence on which to base their practice to effectively discharge older people from emergency. The aim of the review was to assess the effectiveness of interventions used for the discharge of older people from the emergency department to their home in the community by emergency clinicians.

Methods: The PRISMA guidelines were followed. Read More

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Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.

Int J Radiat Oncol Biol Phys 2021 May 25. Epub 2021 May 25.

Radiation and Cancer Biology Group. Electronic address:

Purpose: Autophagy and cell-cycle checkpoints act in concert to confer cellular radioresistance. We investigated the functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant human pancreatic ductal adenocarcinoma (PDAC) cells.

Methods And Materials: Four human PDAC cell lines (MIA PaCa-2, KP-4, Panc-1, and SUIT-2) were analyzed. Read More

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Role of the VirSR-VirAB system in biofilm formation of Listeria monocytogenes EGD-e.

Food Res Int 2021 Jul 8;145:110394. Epub 2021 May 8.

College of Chemistry and Materials Engineering, Xinxiang University, Xinxiang, China.

The ability of Listeria monocytogenes, an important foodborne pathogen, to form biofilms in food processing environments leads to increased opportunity for contamination of food products, which is a major concern for food safety. In this study, the role of a complex system composed of the VirSR two-component signal transduction system (TCS) and the ATP-binding cassette (ABC) transporter VirAB in biofilm formation of L. monocytogenes EGD-e was investigated. Read More

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Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones.

J Inflamm (Lond) 2021 Jun 10;18(1):23. Epub 2021 Jun 10.

Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, China.

Background: It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD). However, only a limited number of ICD-inducing compounds are well characterized at present; therefore, identification of novel ICD inducers is urgently needed for cancer drug discovery, and the need is becoming increasingly urgent.

Methods: Herein, we assessed the antitumour activity of bullatacin by MTS assay and apoptosis assay. Read More

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Internal validation and comparison of the prognostic performance of models based on six emergency scoring systems to predict in-hospital mortality in the emergency department.

BMC Emerg Med 2021 Jun 10;21(1):68. Epub 2021 Jun 10.

Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Medical scoring systems are potentially useful to make optimal use of available resources. A variety of models have been developed for illness measurement and stratification of patients in Emergency Departments (EDs). This study was aimed to compare the predictive performance of the following six scoring systems: Simple Clinical Score (SCS), Worthing physiological Score (WPS), Rapid Acute Physiology Score (RAPS), Rapid Emergency Medicine Score (REMS), Modified Early Warning Score (MEWS), and Routine Laboratory Data (RLD) to predict in-hospital mortality. Read More

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Associated risk factors with disease severity and antiviral drug therapy in patients with COVID-19.

BMC Infect Dis 2021 Jun 10;21(1):549. Epub 2021 Jun 10.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Background: Due to the latent onset of novel coronavirus disease 2019 (COVID-19), it is important to identify patients with increased probabilities for disease progression early in order to implement timely medical strategies. This study aimed to identify the factors associated with increased COVID-19 severity and evaluate the current antiviral drugs, especially in severe patients.

Methods: This was a retrospective observational study performed at the No. Read More

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A linearly extendible multi-artifact removal approach for improved upper extremity EEG-based motor imagery decoding.

J Neural Eng 2021 Jun 10. Epub 2021 Jun 10.

Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, 1068 Xueyuan Avenue, University Town, Xili, Nanshan, Shenzhen, Guangdong, Shenzhen, Guangdong, 518055, CHINA.

Background And Objective: Non-invasive multichannel Electroencephalography (EEG) recordings provide an alternative source of neural information from which motor imagery (MI) patterns associated with limb movement intent can be decoded for use as control inputs for rehabilitation robots. The presence of multiple inherent dynamic artifacts in EEG signals, however, poses processing challenges for brain-computer interface (BCI) systems. A large proportion of the existing EEG signal preprocessing methods focus on isolating single artifact per time from an ensemble of EEG trials and require calibration and/or reference electrodes, resulting in increased complexity of their application to MI-EEG controlled rehabilitation devices in practical settings. Read More

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Post-translational modification of factors involved in homologous recombination.

DNA Repair (Amst) 2021 Jun 7;104:103114. Epub 2021 Jun 7.

Institute of Innovative Research, Tokyo Institute of Technology, Tokyo, Japan; School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.

DNA is the molecule that stores the chemical instructions necessary for life and its stability is therefore of the utmost importance. Despite this, DNA is damaged by both exogenous and endogenous factors at an alarming frequency. The most severe type of DNA damage is a double-strand break (DSB), in which a scission occurs in both strands of the double helix, effectively dividing a single normal chromosome into two pathological chromosomes. Read More

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Modeling and simulation of static component generation of Lamb wave propagation in a layered plate.

Ultrasonics 2021 May 28;116:106473. Epub 2021 May 28.

School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Modeling of the acoustic-radiation-induced static component (SC) generation of primary Lamb wave tone burst propagating in a layered plate is conducted. Accompanying the propagation of primary Lamb wave tone burst, there are the finite-duration SC bulk driving force in the interior of the layered plate, and the finite-duration SC traction stress on each surface/interface. According to the modal analysis approach for waveguide excitation, the function of the finite-duration SC bulk driving force and traction stress is to generate the finite-duration SC of primary Lamb wave tone burst. Read More

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Opalescence Measurements: Improvements in Fundamental Knowledge, Identifying Sources of Analytical Biases, and Advanced Applications for the Development of Therapeutic Proteins.

J Pharm Sci 2021 Jun 7. Epub 2021 Jun 7.

Drug Product Development, Bristol Myers Squibb Company, New Brunswick, New Jersey, USA 08903.

Opalescence of biopharmaceutical solutions can indicate suboptimal colloidal stability and is therefore a generally undesirable attribute that requires investigation and potentially remediation. While there are numerous instrumentation options available for measuring opalescence, cross-instrument comparisons and detailed knowledge of analytical biases have been limited.  Here, we highlight key findings from a multi-instrument investigation where differences in reported opalescence values are explained with particular emphasis on how the optical configuration and detector properties of each instrument affect the response of the sample and the primary formazin standards required for instrument calibration. Read More

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Liquid Crystal-Mediated 3D Printing Process to Fabricate Nano-Ordered Layered Structures.

ACS Appl Mater Interfaces 2021 Jun 10. Epub 2021 Jun 10.

School of Chemical Engineering, University of New South Wales (UNSW), Sydney 2052, New South Wales, Australia.

The emergence of three-dimensional (3D) printing promises a disruption in the design and on-demand fabrication of smart structures in applications ranging from functional devices to human organs. However, the scale at which 3D printing excels is within macro- and microlevels and principally lacks the spatial ordering of building blocks at nanolevels, which is vital for most multifunctional devices. Herein, we employ liquid crystal (LC) inks to bridge the gap between the nano- and microscales in a single-step 3D printing. Read More

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PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development.

FASEB J 2021 Jul;35(7):e21728

Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Proliferation and differentiation of preadipocytes, and other cell types, is accompanied by an increase in glucose uptake. Previous work showed that a pulse of high glucose was required during the first 3 days of differentiation in vitro, but was not required after that. The specific glucose metabolism pathways required for adipocyte differentiation are unknown. Read More

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Interspecific competition in germination of bird-dispersed seeds in a habitat with sparse tree vegetation in South Africa.

Bot Stud 2021 Jun 10;62(1):10. Epub 2021 Jun 10.

Faculty of Health and Environmental Science, Central University of Technology, Private Bag X20539, Bloemfontein, 9300, South Africa.

Background: By transporting and scarifying the seeds during ingestion, avian frugivores reduce the competition with siblings, and may improve the germination which is critical for dispersal effectiveness and population recruitment. However, generally, there is limited knowledge on how deposited seeds interact/compete in the new microsite. We tested the hypothesis that the bird-dispersed seeds benefit from improved germination after their passage through the bird's gut; and we investigated the potential impact of seed density on competition at the microsites by determining whether seed density and species diversity influence germination in the Free State Province, South Africa. Read More

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High Yield Poly(ethylene--maleic acid) Grafting to Wood Pulp while Minimizing Fiber/Fiber Wet Adhesion.

Biomacromolecules 2021 Jun 10. Epub 2021 Jun 10.

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7.

Heating bleached kraft pulps treated with poly(ethylene--maleic acid) (PEMAc) can lead to high yields of carboxylated polymer grafted to fibers. However, in many cases, the cured, dry pulp cannot be effectively repulped (redispersed in water) because the wet strength is too high. Impregnation with PEMAc solutions at pH 4 followed by high temperature (120-180 °C), catalyst-free curing for short times can give fixation yields >85% while maintaining repulpability. Read More

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Mechano-regulation of Vascular Network Formation without Branches in 3D Bioprinted Cell-laden Hydrogel Constructs.

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215104, China.

Restoration of a wound is a common surgical procedure in clinic. Currently, the skin required for clinical use is taken from the patient's own body. However, it can be difficult to obtain enough skin sources for large-sized wounds and thus surgeons have started using commercial skin substitutes. Read More

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