2,592 results match your criteria required stand

Assessing the cone of economy in patients with spinal disease using only a force plate: an observational retrospective cohort study.

Eur Spine J 2021 Apr 20. Epub 2021 Apr 20.

Texas Back Institute, 6020 West Parker Road, Plano, TX, 75093, USA.

Study Design: This is a retrospective cohort with multiple regression modeling.

Objective: The aim is to develop a new method for estimating cone of economy (CoE) using a force plate rather than traditional motion capture.

Background: Currently, most spinal deformity surgeons rely on static radiographic parameters for alignment, balance, and outcomes data alongside patient-reported outcome measures. Read More

View Article and Full-Text PDF

Three PilZ domain proteins, PlpA, PixA and PixB, have distinct functions in regulation of motility and development in .

J Bacteriol 2021 Apr 19. Epub 2021 Apr 19.

Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043 Marburg, Germany

In bacteria, the nucleotide-based second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) binds to effectors to generate outputs in response to changes in the environment. In , c-di-GMP regulates type IV pili-dependent motility and the starvation-induced developmental program that results in formation of spore-filled fruiting bodies; however, little is known about the effectors that bind c-di-GMP. Here, we systematically inactivated all 24 genes encoding PilZ domain-containing proteins, which are among the most common c-di-GMP effectors. Read More

View Article and Full-Text PDF

Psychosocial characteristics and HIV-related sexual behaviors among cisgender, transgender, and gender non-conforming MSM in China.

BMC Psychiatry 2021 Apr 17;21(1):196. Epub 2021 Apr 17.

School of Health Sciences, Wuhan University, Wuhan, Hubei Province, China.

Background: While a growing number of studies focus on men who have sex with men (MSM), they typically ignore the heterogeneity of gender minorities within the MSM population. The recognition of new sub-groups among gender minorities (i.e. Read More

View Article and Full-Text PDF

Effect of standing and sitting positions on energy expenditure in people with transtibial amputation compared to age- and sex-matched controls.

Prosthet Orthot Int 2021 Mar 25. Epub 2021 Mar 25.

Department of Rehabilitation Medicine, University of Washington, Seattle, WA Department of Anthropology, University of Washington, Seattle, WA.

Background: Energy expenditure (EE) is often greater in people with lower-limb amputation, compared with healthy controls, because of the biomechanical compensations needed to walk with a prosthesis. Compensatory movements are required to stand with a prosthesis; however, little is known about whether standing with a prosthesis also requires greater EE.

Objective: The goal of this study was to examine the effect of standing and sitting positions on EE in people with transtibial amputation and matched controls. Read More

View Article and Full-Text PDF

Short-term multimodal prehabilitation improves functional capacity for colorectal cancer patients prior to surgery.

Asia Pac J Clin Oncol 2021 Apr 14. Epub 2021 Apr 14.

Concord Cancer Centre, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.

Aim: Evaluate feasibility and outcomes of a multimodal prehabiliation program in patients with stage I-III colorectal cancer (CRC) awaiting surgery.

Methods: Patients scheduled for elective CRC resection at Concord Repatriation General Hospital were recruited from pre-admission clinic between January and November 2018. Participants received a 2-4 week prehabilitation program consisting of supervised exercise sessions, nurse-led phone support, and written nutritional information. Read More

View Article and Full-Text PDF

Efficacy of a water-based botanical acaricide formulation applied in portable spray box against the southern cattle tick, Rhipicephalus (Boophilus) microplus (Acari: Ixodidae), infesting cattle.

Ticks Tick Borne Dis 2021 Apr 3;12(4):101721. Epub 2021 Apr 3.

USDA-ARS, Knipling-Bushland U.S. Livestock Insects Research Laboratory, and Veterinary Pest Genomics Center, 2700 Fredericksburg Rd, Kerrville, TX, 78028, United States.

Ectoparasitism result in annual losses to livestock producers estimated to reach billions of dollars in tropical and subtropical parts of the world where the southern cattle tick, Rhipicephalus (Boophilus) microplus, is established because this invasive pest is also a vector of pathogens causing bovine babesiosis and anaplasmosis. Reintroduction of R. microplus could be economically devastating for the cattle industry in the United States. Read More

View Article and Full-Text PDF

Clinical concern for necrotising fasciitis: a review of referrals to plastic surgery units at two tertiary centres.

ANZ J Surg 2021 Apr 12. Epub 2021 Apr 12.

Plastic Surgery, Peninsula Health, Melbourne, Victoria, Australia.

Objectives: To evaluate the impact of clinical suspicion on the diagnosis of necrotising fasciitis (NF) in two inpatient plastic surgery units.

Methods: A multicentre retrospective audit of all referrals of adult patients to the inpatient plastic surgery units of two Melbourne metropolitan tertiary centres from 1 February 2018 to 31 December 2018.

Results: A total of 53 patients (37 male, 16 female) were referred to evaluate for NF. Read More

View Article and Full-Text PDF

Nanogels with High Loading of Anesthetic Nanocrystals for Extended Duration of Sciatic Nerve Block.

ACS Appl Mater Interfaces 2021 Apr 6;13(15):17220-17235. Epub 2021 Apr 6.

Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain.

The development of thermoresponsive nanogels loaded with nanocrystals of the local anesthetic bupivacaine nanocrystals (BNCs) for prolonged peripheral nerve pain relief is reported here. BNCs were prepared using the antisolvent precipitation method from the hydrophobic form of bupivacaine (bupivacaine free base). The as-prepared BNCs were used stand-alone or encapsulated in temperature-responsive poly(ethylene glycol) methyl ether methacrylate (OEGMA)-based nanogels, resulting in bupivacaine NC-loaded nanogels (BNC-nanogels) of monodisperse size. Read More

View Article and Full-Text PDF

Performance assessment and economic perspectives of integrated PEM fuel cell and PEM electrolyzer for electric power generation.

Heliyon 2021 Mar 19;7(3):e06506. Epub 2021 Mar 19.

Universidad del Norte, Department of Mechanical Engineering, km 5 Antigua vía Puerto Colombia, Barranquilla, Colombia.

The study presents a complete one-dimensional model to evaluate the parameters that describe the operation of a Proton Exchange Membrane (PEM) electrolyzer and PEM fuel cell. The mathematical modeling is implemented in Matlab/Simulink® software to evaluate the influence of parameters such as temperature, pressure, and overpotentials on the overall performance. The models are further merged into an integrated electrolyzer-fuel cell system for electrical power generation. Read More

View Article and Full-Text PDF

Identifying Fall Risk Predictors by Monitoring Daily Activities at Home Using a Depth Sensor Coupled to Machine Learning Algorithms.

Sensors (Basel) 2021 Mar 11;21(6). Epub 2021 Mar 11.

Department of Neuroscience & Movement Science, University of Fribourg, CH-1700 Fribourg, Switzerland.

Because of population ageing, fall prevention represents a human, economic, and social issue. Currently, fall-risk is assessed infrequently, and usually only after the first fall occurrence. Home monitoring could improve fall prevention. Read More

View Article and Full-Text PDF

Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones.

Front Neurosci 2021 15;15:613844. Epub 2021 Mar 15.

Division of Plastic Surgery, Department of Surgery, University of Wisconsin - Madison, Madison, WI, United States.

Sieve electrodes stand poised to deliver the selectivity required for driving advanced prosthetics but are considered inherently invasive and lack the stability required for a chronic solution. This proof of concept experiment investigates the potential for the housing and engagement of a sieve electrode within the medullary canal as part of an osseointegrated neural interface (ONI) for greater selectivity toward improving prosthetic control. are that (A) the addition of a sieve interface to a cuff electrode housed within the medullary canal of the femur as part of an ONI would be capable of measuring efferent and afferent compound nerve action potentials (CNAPs) through a greater number of channels; (B) that signaling improves over time; and (C) that stimulation at this interface generates measurable cortical somatosensory evoked potentials through a greater number of channels. Read More

View Article and Full-Text PDF

Use of indwelling catheters and preventing catheter-associated urinary tract infections.

Ann Wakefield

Nurs Stand 2021 Mar 31. Epub 2021 Mar 31.

Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, England.

Indwelling urinary catheters are considered an important healthcare intervention for many patients. However, these devices must be used with caution because they are associated with a risk of various potential complications such as catheter-associated urinary tract infections (CAUTIs), as well as a financial burden for healthcare organisations. This article outlines the various types of indwelling catheter that are available, explains the reasons for their use, and details the care required to prevent associated complications, particularly CAUTIs. Read More

View Article and Full-Text PDF

Community-Based Peer-Led Intervention for Healthy Ageing and Evaluation of the 'HAPPY' Program.

J Nutr Health Aging 2021 ;25(4):520-527

Associate Professor Reshma A Merchant, Division of Geriatric Medicine, Department of Medicine, National University Hospital, 1E Kent Ridge Road, Singapore 119228, Email: ORCID iD: 0000-0002-9032-0184.

Objectives: Population ageing impacts many areas of society from health and social care cost to housing and future workforce, and whole-of-society approach is required to promote healthy ageing. The Decade of Healthy Ageing report has called upon multi-sectoral collaboration to promote age-friendly communities. The Healthy Ageing Promotion Program for You (HAPPY) is a community-based dual-task exercise program for older adults led by health coaches (HC) or trained volunteers (HAPPY leaders) to promote healthy ageing. Read More

View Article and Full-Text PDF
January 2021

Effects of Wearable Powered Exoskeletal Training on Functional Mobility, Physiological Health and Quality of Life in Non-ambulatory Spinal Cord Injury Patients.

J Korean Med Sci 2021 Mar 29;36(12):e80. Epub 2021 Mar 29.

Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: Spinal cord injury (SCI) is a serious clinical condition that impacts a patient's physical, psychological, and socio-economic status. The aim of this pilot study was to evaluate the effects of training with a newly developed powered wearable exoskeleton (Hyundai Medical Exoskeleton [H-MEX]) on functional mobility, physiological health, and quality of life in non-ambulatory SCI patients.

Methods: Participants received 60 minutes of walking training with a powered exoskeleton 3 times per week for 10 weeks (total 30 sessions). Read More

View Article and Full-Text PDF

Feasibility of an online platform delivery of pulmonary rehabilitation for individuals with chronic respiratory disease.

BMJ Open Respir Res 2021 03;8(1)

Gloucestershire Health and Care NHS Foundation Trust, Brockworth, UK.

Introduction: SARS-CoV-2 has restricted access to face-to-face delivery of pulmonary rehabilitation (PR). Evidence suggests that telehealth-PR is non-inferior to outpatient PR. However, it is unknown whether patients who have been referred to face-to-face programmes can feasibly complete an online-PR programme. Read More

View Article and Full-Text PDF

What recording duration is required to provide physiologically valid and reliable dynamic cerebral autoregulation transfer functional analysis estimates?

Physiol Meas 2021 Mar 24. Epub 2021 Mar 24.

University of Calgary, Calgary, Alberta, CANADA.

Objective: Currently, a recording of 300-seconds is recommended to obtain accurate dynamic cerebral autoregulation estimates using transfer function analysis (TFA). Therefore, this investigation sought to explore the concurrent validity and the within- and between-day reliability of TFA estimates derived from shorter recording durations from squat-stand maneuvers.

Approach: Retrospective analyses were performed on 70 young, recreationally active or endurance-trained participants (17 females; age: 26±5 years, [range: 20-39 years]; body mass index: 24±3 kg/m2). Read More

View Article and Full-Text PDF

Feasibility and Performance of Elastin Trichrome as a Primary Stain in Colorectal Cancer Resection Specimens: Results of an Interobserver Variability Study.

Am J Surg Pathol 2021 Mar 24. Epub 2021 Mar 24.

Mount Sinai Hospital Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto Lakeridge Health, Oshawa Royal Victoria Regional Health Centre, Barrie Grey Bruce Health Services, Owen Sound Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.

Venous invasion (VI) is a powerful prognostic factor in colorectal cancer (CRC) that is widely underreported. The ability of elastin stains to improve VI detection is now recognized in several international CRC pathology protocols. However, concerns related to the cost and time required to perform and evaluate these stains in addition to routine hematoxylin and eosin (H&E) stains remains a barrier to their wider use. Read More

View Article and Full-Text PDF

A new simpler approach to measure the strength of toe plantar flexion requiring no mechanical restraint with a light-weight device.

Proc Inst Mech Eng H 2021 Mar 19:9544119211002932. Epub 2021 Mar 19.

Department of Cooperative Major in Human Centered Engineering, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan.

Conventionally, the strength of toe plantar flexion (STPF) is measured in a seated position, in which not only the target toe joints but also the knee and particularly ankle joints, are usually restrained. We have developed an approach for the measurement of STPF which does not involve restraint and considers the interactions of adjacent joints of the lower extremities. This study aimed to evaluate this new approach and comparing with the seated approach. Read More

View Article and Full-Text PDF

Nutrition in medical education in Latin America: Results of cross sectional survey.

JPEN J Parenter Enteral Nutr 2021 Mar 18. Epub 2021 Mar 18.

Integrated Practice Unit on Intestinal Failure, Hospital San Javier, Guadalajara, Mexico.

Rationale: The gap between the nutrition education provided to medical students and the nutrition competences and attitudes needed for doctors to provide effective and efficient nutrition care is a global concern. The goal of this study was to investigate the curricular content on nutrition education in Latin American medical schools, and to evaluate the self-perceived knowledge, attitudes, and barriers to nutrition practice of final year medical students.

Methods: Eighty-five public and private medical schools from 17 Latin American and Caribbean countries were invited to participate in the study. Read More

View Article and Full-Text PDF

A rapid serial reversal learning assessment for age-related cognitive deficits in pet dogs.

Behav Processes 2021 Mar 12;186:104375. Epub 2021 Mar 12.

Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287-1104, United States.

Assessments for behavioral inhibition in pet dogs that can rapidly detect age-related cognitive deficits (ARCD) using inexpensive and accessible materials may aid in diagnosing canine dementia and may facilitate translational research on Alzheimer's disease in humans. In this study, we designed and deployed a spatial serial reversal learning test in which 80 pet dogs were required to learn which of two identical boxes contained a hidden food treat. Each time the dog chose the correct box in three consecutive trials the procedure was repeated using the other box. Read More

View Article and Full-Text PDF

Multifunctional and Sensitivity Enhancement of Hybrid Acoustoplasmonic Sensors Fabricated on 36XY-LiTaO with Gold Nanoparticles for the Detection of Permittivity, Conductivity, and the Refractive Index.

ACS Appl Mater Interfaces 2021 Mar 15;13(11):13822-13837. Epub 2021 Mar 15.

Graduate School of Science and Technology, Shizuoka University, 3-5-1 Johoku, Naka-Ku, Hamamatsu-shi, Shizuoka 432-8561, Japan.

Integration of high-sensitivity sensors with multiple sensing performance for the environmental detection of permittivity (ε), conductivity (σ), and the refractive index () is required to support Societies 5.0. However, there are still many sensors with low sensitivity that stand alone. Read More

View Article and Full-Text PDF

E-scooter injuries referred to the oral and maxillofacial surgical service at Christchurch Hospital: a retrospective observational study and cost analysis of 17-months of data.

Br J Oral Maxillofac Surg 2020 Sep 2. Epub 2020 Sep 2.

Department of Oral and Maxillofacial Surgery, Christchurch Hospital, 5th floor Riverside, 2 Riccarton Avenue, Christchurch 8011. Electronic address:

Personal and shared stand-up electronic scooters (e-scooters) have rapidly increased in popularity, leading to an increase in the number of patients with e-scooter-related trauma presenting to hospital Emergency departments. This study aimed to assess the patterns of oral and maxillofacial trauma directly related to e-scooter use and provide a cost-analysis related to the management of these patients. A retrospective, controlled interval study was conducted to examine all patients referred to the oral and maxillofacial surgical service at Christchurch Hospital, New Zealand, who sustained facial injury as a result of e-scooter accidents between 15 October 2018 and 15 April 2020. Read More

View Article and Full-Text PDF
September 2020

Plasma Polymerized SiCOH Films from Octamethylcyclotetrasiloxane by Dual Radio Frequency Inductively Coupled Plasma Chemical Vapor Deposition System.

J Nanosci Nanotechnol 2021 Aug;21(8):4477-4483

Department of Physics, Hankuk University of Foreign Studies, Yongin, 17035, Republic of Korea.

We have fabricated porous plasma polymerized SiCOH (ppSiCOH) films with low-dielectric constants (low-, less than 2.9), by applying dual radio frequency plasma in inductively coupled plasma chemical vapor deposition (ICP-CVD) system. We varied the power of the low radio frequency (LF) of 370 kHz from 0 to 65 W, while fixing the power of the radio frequency (RF) of 13. Read More

View Article and Full-Text PDF

A Step Toward Making VMAT TBI More Prevalent: Automating the Treatment Planning Process.

Pract Radiat Oncol 2021 Mar 10. Epub 2021 Mar 10.

Department of Radiation Oncology, Stanford University, Stanford, California. Electronic address:

Purpose: Our purpose was to automate the treatment planning process for total body irradiation (TBI) with volumetric modulated arc therapy (VMAT).

Methods And Materials: Two scripts were developed to facilitate autoplanning: the binary plug-in script automating the creation of optimization structures, plan generation, beam placement, and setting of the optimization constraints and the stand-alone executable performing successive optimizations. Ten patients previously treated in our clinic with VMAT TBI were used to evaluate the efficacy of the proposed autoplanning process. Read More

View Article and Full-Text PDF

Jumping Mechanography is a Suitable Complementary Method to Assess Motor Function in Ambulatory Boys with Duchenne Muscular Dystrophy.

Neuropediatrics 2021 Mar 11. Epub 2021 Mar 11.

Department of Paediatric Neurology and Developmental Medicine, LMU - University of Munich, Dr. v. Hauner Children's Hospital, Munich, Germany.

Objective:  The number of clinical trials for Duchenne muscular dystrophy (DMD) has increased substantially lately, therefore appropriate clinical instruments are needed to measure disease progression and drug efficacy. Jumping mechanography is a medical diagnostic method for motion analysis, which allows to quantify physical parameters. In this study, we compared mechanography with timed function tests (TFTs). Read More

View Article and Full-Text PDF

CD38 in Advanced Prostate Cancers.

Eur Urol 2021 Mar 1. Epub 2021 Mar 1.

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Sutton, UK. Electronic address:

Background: CD38, a druggable ectoenzyme, is involved in the generation of adenosine, which is implicated in tumour immune evasion. Its expression and role in prostate tumour-infiltrating immune cells (TIICs) have not been elucidated.

Objective: To characterise CD38 expression on prostate cancer (PC) epithelial cells and TIICs, and to associate this expression with clinical outcomes. Read More

View Article and Full-Text PDF

Can we predict which COVID-19 patients will need transfer to intensive care within 24 hours of floor admission?

Acad Emerg Med 2021 Mar 6. Epub 2021 Mar 6.

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Background: Patients with COVID-19 can present to the emergency department (ED) at any point during the spectrum of illness, making it difficult to predict what level of care the patient will ultimately require. Admission to a ward bed, which is subsequently upgraded within hours to an intensive care unit (ICU) bed, represents an inability to appropriately predict the patient's course of illness. Predicting which patients will require ICU care within 24 hours would allow admissions to be managed more appropriately. Read More

View Article and Full-Text PDF

Application of the MEMS Accelerometer as the Position Sensor in Linear Electrohydraulic Drive.

Sensors (Basel) 2021 Feb 20;21(4). Epub 2021 Feb 20.

Institute of Mechanical Technology, Poznan University of Technology, 60-965 Poznań, Poland.

Various distance sensors are used as measuring elements for positioning linear electrohydraulic drives. The most common are magnetostrictive transducers or linear variable differential transformer (LVDT) sensors mounted inside the cylinder. The displacement of the actuator's piston rod is proportional to the change in the value of the current or voltage at the output from the sensor. Read More

View Article and Full-Text PDF
February 2021

Five-Year Outcomes of Trabeculectomy and Phacotrabeculectomy.

Cureus 2021 Jan 27;13(1):e12950. Epub 2021 Jan 27.

Ophthalmology, University of Sydney, Sydney, AUS.

Purpose The purpose of this study is to examine five-year outcomes of trabeculectomy and compare the stand-alone procedure when combined with phacoemulsification. Patients and methods This study included 123 eyes of 109 patients, with 79 patients in the trabeculectomy group and 44 patients in the phacotrabeculectomy group. Non-randomized comparative cohort study with data collected retrospectively from an existing database compiled by a single surgeon operating in Sydney, Australia from 2007 to 2019. Read More

View Article and Full-Text PDF
January 2021

Monocyte-derived S1P in the lymph node regulates immune responses.

Nature 2021 Apr 3;592(7853):290-295. Epub 2021 Mar 3.

Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, NY, USA.

The lipid chemoattractant sphingosine 1-phosphate (S1P) guides cells out of tissues, where the concentration of S1P is relatively low, into circulatory fluids, where the concentration of S1P is high. For example, S1P directs the exit of T cells from lymph nodes, where T cells are initially activated, into lymph, from which T cells reach the blood and ultimately inflamed tissues. T cells follow S1P gradients primarily using S1P receptor 1 (ref. Read More

View Article and Full-Text PDF