2,721 results match your criteria required mitigate


Optimised and systematic suitable climate modelling confirms future longitudinal-trends for growing oil palm in Africa.

Authors:
R R M Paterson

J Environ Manage 2021 Sep 22;300:113785. Epub 2021 Sep 22.

Centre for Biological Engineering, Gualtar Campus, University of Minho, Braga, 4710 057, Portugal; Faculty of Agriculture, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor D.E., Malaysia. Electronic address:

Palms are iconic plants. Oil palms are very important economically and originate in Africa where they can act as a model for palms in general. The effect of future climate on the growth of oil palm will be very detrimental. Read More

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September 2021

Structured Ensembles: An approach to reduce the memory footprint of ensemble methods.

Neural Netw 2021 Sep 16;144:407-418. Epub 2021 Sep 16.

Department of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Italy.

In this paper, we propose a novel ensembling technique for deep neural networks, which is able to drastically reduce the required memory compared to alternative approaches. In particular, we propose to extract multiple sub-networks from a single, untrained neural network by solving an end-to-end optimization task combining differentiable scaling over the original architecture, with multiple regularization terms favouring the diversity of the ensemble. Since our proposal aims to detect and extract sub-structures, we call it Structured Ensemble. Read More

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September 2021

Pubertal Probiotics Mitigate Lipopolysaccharide-Induced Programming of the Hypothalamic-Pituitary-Adrenal axis in Male Mice only.

Brain Res Bull 2021 Sep 21. Epub 2021 Sep 21.

NISE Laboratory, School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier Ottawa, Ontario, K1N 6N5, Canada; University of Ottawa Brain and Mind Research Institute, University of Ottawa, 136 Jean-Jacques Lussier Ottawa, Ontario, K1N 6N5, Canada. Electronic address:

Puberty is a period of rapid cortical and neuronal development. Stress exposure during puberty programs the hypothalamic-pituitary-adrenal (HPA) axis responsiveness to future stressors. However, programming can result in an enduring maladaptation of the HPA axis activity and can be associated with long-term anxiety- and depression-like behaviours. Read More

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September 2021

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials.

Lancet Haematol 2021 Oct;8(10):e711-e722

Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

Background: CNS relapse of acute lymphocytic leukaemia is difficult to treat. Durable remissions of relapsed or refractory B-cell acute lymphocytic leukaemia have been observed following treatment with CD19-directed chimeric antigen receptor (CAR) T cells; however, most trials have excluded patients with active CNS disease. We aimed to assess the safety and activity of CAR T-cell therapy in patients with a history of CNS relapsed or refractory B-cell acute lymphocytic leukaemia. Read More

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October 2021

Impact of early massive transfusion and blood component ratios in patients undergoing left ventricular assist device implantation.

J Card Surg 2021 Sep 23. Epub 2021 Sep 23.

Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: This study evaluates the impact of early massive transfusion and blood component ratios on outcomes following left ventricular assist device (LVAD) implantation.

Methods: Adults undergoing LVAD implantation between 2009 and 2018 at a single institution were included. Transfusions were analyzed during the intraoperative and the initial 24-h postoperative period. Read More

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September 2021

COVID-19 in the Gulf Cooperation Council Member States: An Evidence of Effective Response.

Oman Med J 2021 Sep 14;36(5):e300. Epub 2021 Sep 14.

Department of Public Health Medicine, University of KwaZulu Natal, Durban, South Africa.

Objectives: The World Health Organization (WHO) published a global strategic response plan in February 2020 aiming to mitigate the impact of the novel coronavirus disease 2019 (COVID-19) outbreak. It identified immediate activities required for global preparedness and response to the outbreak and set eight priority areas (pillars) essential for scaling up countries' operational readiness and response. Despite a semi-annual progress report on implementing the Global Strategic Plan in June 2020, there is limited granular information available on the extent of the national plan's content and implementation, particularly in the Member States of the Gulf Cooperation Council (GCC). Read More

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September 2021

Fatigue in Aviation: Safety Risks, Preventive Strategies and Pharmacological Interventions.

Front Physiol 2021 6;12:712628. Epub 2021 Sep 6.

Department of of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.

Fatigue poses an important safety risk to civil and military aviation. In addition to decreasing performance in-flight (chronic) fatigue has negative long-term health effects. Possible causes of fatigue include sleep loss, extended time awake, circadian phase irregularities and work load. Read More

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September 2021

Anti-VEGF antibody protects against alveolar exudate leakage caused by vascular hyperpermeability, resulting in mitigation of pneumonitis induced by immunotherapy.

Mol Cancer Ther 2021 Sep 22. Epub 2021 Sep 22.

Product Research Dept., Chugai Pharmaceutical Co., Ltd.

Immune-related pneumonitis is an important toxicity associated with checkpoint inhibitor therapy with anti-PD-1 or anti-PD-L1 antibodies, often necessitating discontinuation of treatment. Development of methods to mitigate checkpoint inhibitor-related pneumonitis is required. The contributions of PD-L1, PD-L2, and VEGF to the pathogenesis of pneumonitis were examined in an IL-2- plus IL-18-induced mouse pneumonitis model (IL pneumonitis model). Read More

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September 2021

Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults: A Systematic Review.

JAMA Netw Open 2021 Sep 1;4(9):e2126456. Epub 2021 Sep 1.

CDC COVID-19 Response, Division of Emergency Operations, Center for Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Multisystem inflammatory syndrome in adults (MIS-A) has not been well described. Improved diagnosis and treatment of MIS-A might mitigate COVID-19 morbidity and mortality.

Objective: To summarize the descriptive epidemiology and clinical characteristics of MIS-A. Read More

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September 2021

Decontamination of emerging pharmaceutical pollutants using carbon-dots as robust materials.

J Hazard Mater 2021 Sep 12;423(Pt B):127145. Epub 2021 Sep 12.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. Electronic address:

Environmental pollution is a critical issue that requires proper measures to maintain environmental health in a sustainable and effective manner. The growing persistence of several active pharmaceutical residues, such as antibiotics like tetracycline, and anti-inflammatory drugs like diclofenac in water matrices is considered an issue of global concern. Numerous sewage/drain waste lines from the domestic and pharmaceutical sector contain an array of toxic compounds, so-called "emerging pollutants" and possess adverse effects on entire living ecosystem and damage its biodiversity. Read More

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September 2021

Acute Radiation Effects, the H-ARS in the Non-human Primate: A Review and New Data for the Cynomolgus Macaque with Reference to the Rhesus Macaque.

Health Phys 2021 Oct;121(4):304-330

University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore.

Abstract: Medical countermeasure development under the US Food and Drug Administration animal rule requires validated animal models of acute radiation effects. The key large animal model is the non-human primate, rhesus macaque. To date, only the rhesus macaque has been used for both critical supportive data and pivotal efficacy trials seeking US Food and Drug Administration approval. Read More

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October 2021

Excess Body Weight and Gallstone Disease.

Visc Med 2021 Aug 15;37(4):254-260. Epub 2021 Jun 15.

Department of Medicine II, Saarland University Medical Center, University of Saarland, Homburg, Germany.

Background: Approximately one fifth of adults are diagnosed with gallstones worldwide. Of these, around 25% develop gallstone disease (indicated by the presence of symptoms) and undergo cholecystectomy.

Summary: The risk of gallstones is influenced by a combination of genetic and lifestyle factors, such as excess body weight. Read More

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"What Are You Really Doing in This Country?": Emigration Intentions of Nigerian Doctors and Their Policy Implications for Human Resource for Health Management.

J Int Migr Integr 2021 Sep 15:1-20. Epub 2021 Sep 15.

Department of Health Policy and Management, College of Medicine, University of Ibadan, Ibadan, Nigeria.

The emigration of doctors from Nigeria has been on the increase in recent years, with no obvious efforts to manage or mitigate the negative impacts of this growing trend on the already weak health system. This study assessed the emigration intentions of doctors undergoing residency training at the premier tertiary healthcare center in Nigeria and the factors that influence these intentions. This mixed-method study was cross-sectional in design. Read More

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September 2021

A probabilistic fuzzy goal programming model for managing the supply of emergency relief materials.

Ann Oper Res 2021 Sep 15:1-24. Epub 2021 Sep 15.

Operations Management Area, Indian Institute of Management Calcutta, Kolkata, WB 700104 India.

The post-disaster humanitarian logistic operations deal with the supply of emergency relief materials to mitigate damages in the affected areas. Immediately after the disaster, it is challenging to estimate the demand for emergency relief materials. As a result, the demand for such materials at the point of demand and the corresponding transportation costs for the entire supply chain network becomes uncertain. Read More

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September 2021

Readmission for pleural space complications after chest wall injury: Who is at risk?

J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.

Division of Trauma Services and Surgical Critical Care, Intermountain Medical Center, Murray, UT, USA Division of Trauma Services and Surgical Critical Care, Intermountain Medical Center, Murray, UT, USA Division of Trauma Services and Surgical Critical Care, Intermountain Medical Center, Murray, UT, USA Division of Trauma Services and Surgical Critical Care, Intermountain Medical Center, Murray, UT, USA Division of Trauma Services and Surgical Critical Care, Intermountain Medical Center, Murray, UT, USA.

Background: Little is known about patient characteristics predicting post-discharge pleural space complications (PDPSC) after thoracic trauma. We sought to analyze the patient population who required unplanned hospital readmission for PDPSC.

Methods: Retrospective review of adult patients admitted to a level I Trauma Center with a chest AIS score ≥ 2 between January 2015 and August 2020. Read More

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September 2021

Impact of the COVID-19 pandemic on adolescent vaccinations: projected time to reverse deficits in routine adolescent vaccination in the United States.

Curr Med Res Opin 2021 Sep 20. Epub 2021 Sep 20.

Merck & Co, Inc, Kenilworth, NJ, USA.

Objective: The COVID-19 pandemic has led to significant reductions in the administration of routinely recommended vaccines among adolescents in the US including tetanus, diphtheria, and acellular pertussis (Tdap); meningococcal (ACWY); and human papillomavirus (HPV) vaccines. The extent to which these deficits could persist in 2021 and beyond is unclear. To address this knowledge gap, this study estimated the cumulative deficits of routine vaccine doses among US adolescents during the COVID-19 pandemic, and estimated the time and effort needed to recover from those deficits. Read More

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September 2021

Shared medical appointments for weight loss: a systematic review.

Fam Pract 2021 Sep 18. Epub 2021 Sep 18.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.

Purpose: Shared medical appointments (SMAs) may help mitigate some of the barriers for managing obesity in primary care. The primary aim of this systematic review was to measure the effect of weight loss SMAs.

Methods: Systematic searches using keywords and Medical Subject Headings for overweight, obesity, and SMAs were conducted in the CENTRAL, Medline Complete, PsycINFO, Scopus, CINAHL, EMBASE, and Web of Science databases with no date limits. Read More

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September 2021

Impact of COVID-19 pandemic on accessibility of Taiwanese medical care.

Am J Manag Care 2021 09 1;27(9):e330-e335. Epub 2021 Sep 1.

Daichung Hospital, No. 304, Guangfu Rd, Zhunan Township, Miaoli, Taiwan. Email:

Objectives: Whether and how the COVID-19 pandemic affected utilization of routine medical care in areas with low infection risk, such as Taiwan, has not been widely addressed. We aimed to evaluate the impact of the COVID-19 pandemic on access to medical care.

Study Design: Before and after exposure (COVID-19 pandemic) design with a historical control group for comparison of clinical visits based on a retrospective cohort of 6722 customary patients of a community hospital in Zhunan, Taiwan. Read More

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September 2021

Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics.

J Biol Chem 2021 Sep 13:101196. Epub 2021 Sep 13.

Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808; Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106. Electronic address:

Mitochondria undergo continuous cycles of fission and fusion to promote inheritance, regulate quality control, and mitigate organelle stress. More recently, this process of mitochondrial dynamics has been demonstrated to be highly sensitive to nutrient supply, ultimately conferring bioenergetic plasticity to the organelle. However, whether regulators of mitochondrial dynamics play a causative role in nutrient regulation remains unclear. Read More

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September 2021

Mycophenolate Mofetil and Plasmapheresis: A Treatment Option for Severe Insulin Resistance caused by Insulin Antibodies.

AACE Clin Case Rep 2021 Sep-Oct;7(5):307-309. Epub 2021 Mar 13.

Division of Endocrinology, Diabetes and Metabolism, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective: Insulin antibody (IA)-mediated insulin resistance (IR) is a rare condition for which immunosuppressive regimens have been described. However, these raise the risk of infection, and the drugs may not be effectively metabolized in patients with liver disease. A 61-year old male with type 2 diabetes mellitus and antibody-mediated IR who required >800 units of daily insulin presented with acute decompensation of his preexisting cirrhosis from recurrent diabetic ketoacidosis. Read More

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Cognitive control promotes either honesty or dishonesty, depending on one's moral default.

J Neurosci 2021 Sep 13. Epub 2021 Sep 13.

Rotterdam School of Management, Erasmus University, 3062 PA Rotterdam, The Netherlands.

Cognitive control is crucially involved in making (dis)honest decisions. However, the precise nature of this role has been hotly debated. Is honesty an intuitive response or is willpower needed to override an intuitive inclination to cheat? A reconciliation of these conflicting views proposes that cognitive control enables dishonest participants to be honest, whereas it allows cheating for those who are generally honest. Read More

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September 2021

Clinical prediction models for hospital falls: a scoping review protocol.

BMJ Open 2021 Sep 13;11(9):e051047. Epub 2021 Sep 13.

Australian Centre for Health Services Innovation and Centre for Healthcare Translation, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

Introduction: Falls remain one of the most prevalent adverse events in hospitals and are associated with substantial negative health impacts and costs. Approaches to assess patients' fall risk have been implemented in hospitals internationally, ranging from brief screening questions to multifactorial risk assessments and complex prediction models, despite a lack of clear evidence of effect in reducing falls in acute hospital environments. The increasing digitisation of hospital systems provides new opportunities to understand and predict falls using routinely recorded data, with potential to integrate fall prediction models into real-time or near-real-time computerised decision support for clinical teams seeking to mitigate fall risk. Read More

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September 2021

Undergraduate Nursing Students and Management of Interruptions: Preparation of Students for Future Workplace Realities.

Nurs Educ Perspect 2021 Sep 8. Epub 2021 Sep 8.

About the Author Ginger Schroers, PhD, RNC, CNE, is an assistant professor, Loyola University Chicago School of Nursing, Chicago, Illinois. Jennifer Gunberg Ross, PhD, RN, CNE, is an associate professor, M. Louise Fitzpatrick College of Nursing, Villanova University, Villanova, Pennsylvania. Helene Moriarty, PhD, RN, FAAN, is a professor, Diane and Robert Moritz Jr. Endowed Chair in Nursing Research, M. Louise Fitzpatrick College of Nursing, Villanova University, and nurse scientist, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania. This work was supported by the International Nursing Association for Clinical Simulation in Nursing (2020 Debra Spunt/Laerdal Medical Grant), Jonas Philanthropies (2019-2020 NLN Jonas Scholar), and the National League for Nursing (2020 Mary Anne Rizzolo Doctoral Research Award). This article is based on the first author's dissertation, completed while she was a doctoral student at the M. Louise Fitzpatrick College of Nursing, Villanova University. For more information, contact Ginger Schroers at

Aim: The aim of this study was to investigate interruption management strategies and associative cues used by nursing students when interrupted during simulated medication administration.

Background: Interruptions occur with high frequency in health care settings and are associated with increased medication errors and decreased task efficiency. The Altmann and Trafton memory for goals model, a cognitive-science model, proposes use of associative cues during an interruption to mitigate these negative effects. Read More

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September 2021

Structure and roles of rapid response teams for adult care in high complexity hospitals: Scoping review

Rev Colomb Obstet Ginecol 2021 Jun 30;72(2):171-192. Epub 2021 Jun 30.

Facultad de Medicina, Universidad Nacional de Colombia, Bogotá (Colombia).

Objective: A significant proportion of hospitalized patients experience severe clinical deterioration that may result in adverse events, unexpected cardiac arrest, or death. Rapid response teams (RRTs) have been created to reduce the frequency and prevent the consequences of these events. The objective of this scoping review is to describe the structure, role and results of the implementation of RRTs in the hospital context, with a focus on gynecological surgery and obstetric care. Read More

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Conditionally Rigorous Mitigation of Multiqubit Measurement Errors.

Authors:
Michael R Geller

Phys Rev Lett 2021 Aug;127(9):090502

Center for Simulational Physics, University of Georgia, Athens, Georgia 30602, USA.

Several techniques have been recently introduced to mitigate errors in near-term quantum computers without the overhead required by quantum error correcting codes. While most of the focus has been on gate errors, measurement errors are significantly larger than gate errors on some platforms. A widely used transition matrix error mitigation (TMEM) technique uses measured transition probabilities between initial and final classical states to correct subsequently measured data. Read More

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Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop.

Health Technol Assess 2021 Sep;25(53):1-52

Editorial Department, The Lancet, London, UK.

Background: The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. However, a placebo control is a complex type of comparison group in the surgical setting and, although powerful, presents many challenges.

Objectives: To provide a summary of knowledge on placebo controls in surgical trials and to summarise any recommendations for designers, evaluators and funders of placebo-controlled surgical trials. Read More

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September 2021

COVID-19 and post-traumatic stress disorder: The perfect 'storm' for mental health (Review).

Exp Ther Med 2021 Oct 11;22(4):1162. Epub 2021 Aug 11.

Second Department of Psychiatry, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens 12462, Greece.

Since its outbreak, in December, 2019, in the Chinese city of Wuhan, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into an ongoing global pandemic. Due to the novel antigenic properties of this virus, the world population could not develop immunity effectively and this led to the subsequent spread of COVID-19. This caused an unprecedented emergency situation with significant negative effects on health and well-being both on an individual and societal level. Read More

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October 2021

Security and Privacy for Mobile IoT Applications Using Blockchain.

Sensors (Basel) 2021 Sep 3;21(17). Epub 2021 Sep 3.

Centre for Informatics and Systems, University of Coimbra, 3030-290 Coimbra, Portugal.

Internet of Things (IoT) applications are becoming more integrated into our society and daily lives, although many of them can expose the user to threats against their privacy. Therefore, we find that it is crucial to address the privacy requirements of most of such applications and develop solutions that implement, as far as possible, privacy by design in order to mitigate relevant threats. While in the literature we may find innovative proposals to enhance the privacy of IoT applications, many of those only focus on the edge layer. Read More

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September 2021

Vitamin B (Cobalamin) and Micronutrient Fortification in Food Crops Using Nanoparticle Technology.

Front Plant Sci 2021 23;12:668819. Epub 2021 Aug 23.

School of Animal, Rural and Environmental Sciences, Nottingham Trent University, Nottingham, United Kingdom.

It is necessary to develop a resilient food supply that will withstand unexpected future shocks and deliver the required amounts of nutrients to consumers. By increasing the sustainability of food and agriculture, the food system will be able to handle challenges such as climate change, declining agricultural resources, growing population/urbanization, pandemics, and recessions/shortages. Micronutrient deficiency, otherwise called hidden hunger, is one of the major malnutrition consequences worldwide, particularly in middle- or low- income countries. Read More

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Contrasting Iran's air quality improvement during COVID-19 with other global cities.

J Environ Health Sci Eng 2021 Sep 3:1-6. Epub 2021 Sep 3.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background And Purpose: In late 2019, a novel infectious disease (COVID-19) was identified in Wuhan China, which turned into a global pandemic. Countries all over the world have implemented some sort of lockdown to slow down its infection and mitigate it. This study investigated the impact of the COVID-19 pandemic on air quality during 1st January to 30th April 2020 compared to the same period in 2016-2019 in ten Iranian cities and four major cities in the world. Read More

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September 2021